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Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3730-3739页

作者： Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin Department of Pathology Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of Oncology Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina

Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic *** evidence suggests that microbes influence the efficacy of cancer *** nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)***,we investigated the effect of *** on anti-PD-L1 therapy in *** found that high *** levels correlate with improved therapeutic responses to PD-1 blockade in patients with ***,*** enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged *** *** supplementation with immunotherapy rescued the therapeutic effects of PD-L1 ***,*** induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 ***,patient-derived organoid models demonstrated that increased *** levels correlated with an improved therapeutic response to PD-L1 *** findings suggest that *** may modulate immune checkpoint therapy for CRC.

关键词： colorectal cancer interferon

Successful adult-to-pediatric liver transplantation of discarded partial liver allograft with benign caudate lobe tumor

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 92-95页

作者： Jia-Hao Pei Cong-Huan Shen Rui-Dong Li Yi-Feng Tao Lu Lu Zheng-Xin Wang Department of General Surgery Huashan Hospital of Fudan UniversityShanghai 200040China

To the Editor:Pediatric liver transplantation is the only treatment option for end-stage liver disease in children,and the 5-year and 20-year survival rates after living donor liver transplantation(LDLT)can reach 91.5% and 84.2%[1].Many Asian countries,including China,have begun to develop LDLT and achieved good ***,the shortage of donor livers in children remains a serious problem.

关键词： liver pediatric donor

Immune evasion mechanisms and therapeutic strategies in gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 216-229页

作者： En-Si Ma Zheng-Xin Wang Meng-Qi Zhu Jing Zhao Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China Institute of Organ Transplantation Fudan UniversityShanghai 200040China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Cancer Metastasis Institute Fudan UniversityShanghai 200040China

Gastric cancer(GC)is a malignancy with a high incidence and *** tumor immune microenvironment plays an important role in promoting cancer development and supports GC *** evidence shows that GC cells can exert versatile mechanisms to remodel the tumor immune microenvironment and induce immune *** this review,we systematically summarize the intricate crosstalk between GC cells and immune cells,including tumor-associated macrophages,neutrophils,myeloid-derived suppressor cells,natural killer cells,effector T cells,regulatory T cells,and B *** focus on how GC cells alter these immune cells to create an immunosuppressive microenvironment that protects GC cells from immune *** conclude by compiling the latest progression of immune checkpoint inhibitor-based immunotherapies,both alone and in combination with conventional ***-cytotoxic Tlymphocyte-associated protein 4 and anti-programmed cell death protein 1/programmed death-ligand 1 therapy alone does not provide substantial clinical benefit for GC ***,the combination of immune checkpoint inhibitors with chemotherapy or targeted therapy has promising survival advantages in refractory and advanced GC *** review provides a comprehensive understanding of the immune evasion mechanisms of GC,and highlights promising immunotherapeutic strategies.

关键词： Gastric cancer Immune evasion Immune checkpoint Immunotherapy Microenvironment

Stability of computed tomography densitometry in patients with otosclerosis:a two-year follow-up

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Journal of Otology 2022年第1期17卷 39-45页

作者： Yanqing Fang Wei Chen Liu-Jie Ren Sebastian Kiehn Yilai Shu Bing Chen ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200031China NHC Key Laboratory of Hearing Medicine Fudan UniversityShanghai200031PR China Department of Radiology Eye and ENT HospitalFudan UniversityShanghai200031China Laryngeal Physiology Laboratory University of Wisconsin e MadisonMadisonWIUnited States Institutes of Biomedical Sciences Fudan UniversityNO.83 Fenyang RoadXuhui DistrictShanghai200031China

Objectives:To quantify the progression of otosclerosis in the unoperated ear between two stapedotomy procedures for patients with bilateral otosclerosis which can help to determine whether a HRCT scan should be re-performed before the second surgery for patients who already received HRCT imaging before the initial ***:35 patients who underwent bilateral stapedotomy were *** rounds of HRCT examination and audiometry were performed at the time of the first surgery and second surgery on the ear that was not operated on during the initial *** relationship between the changes in HRCT densitometry and audiometry over time was ***:The second round of HRCT did not add significant information about the changes to the otosclerosis lesions in either the imaging diagnosis or the HRCT density values except for small changes in the HRCT densitometry readings at the area anterior to the inner auditory(P=0.01).While the changes in HRCT manifestation are small,changes near the fissula ante fenestram(FAF)were still positively correlated with the air bone gap(ABG)of patients(p=0.031,r=0.388).Conclusions:The progression of lesions in otosclerosis is slow resulting in small and insignificant changes to the HRCT ***,a repeat HRCT evaluations prior to surgery is not necessary for patients who have had a previous HRCT evaluation within 2 years of the *** small changes in HRCT manifestation near the FAF were still correlated with negative effects on the ABG which could cause worsened hearing thresholds over this timeframe。

关键词： Otosclerosis Fissula ante fenestram(FAF) High reconstruction-computed tomography (HRCT) Auditory CT densitometry

Application of 3D Printing and WebGL-Based 3D Visualisation Technology in Imaging Teaching of Ankle Joints

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 319-324页

作者： LI Xiaomin DAI Xiaoqing GUO Jiuhong QU Yang WU Bing LIU Siyu WAN Daqian AI Songtao Department of Radiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Orthopedics Tongji Hospital Affiliated to Tongji University School of MedicineShanghai200065China

With the rapid development of medical technology,3D printing technology with realistic representation can perfectly display static human anatomy,while 3D visualisation technology based on Web Graphics Library(WebGL)can promote the rigid replication characteristics of traditional teaching models and express the dynamic spatial relationship between different anatomical *** students traditionally have less cognition of ankle ligament *** this study,computed tomography(CT)and magnetic resonance imaging(MRI)data of the ankle joints of volunteers were used to print models of the ankle bone,tendon,and ligament using 3D printing technology,and a real-time interactive 3D digital model of the functional ankle joint was designed using 3D visualisation based on WebGL and 2D image real-time rendering technology for interactive *** utility of the 3D printing model combined with the WebGL-based 3D digital teaching model was evaluated in comparison with traditional teaching methods in 24 medical *** results showed that the total score of students in the experimental group(mean±SD,79.48±12.93)was significantly better than that of the control group(61.00±14.94)with P<*** practical test scores of the experimental group(18.00±2.70)were significantly higher than those of the control group(13.67±4.96)with P<*** the satisfaction survey,the feedback questionnaire showed that the interactive teaching model of 3D printing technology combined with WebGL-based 3D visualisation technology was recognised by students in terms of quality and overall *** addition,female students who used 3D printing combined with WebGL-based 3D visualisation technology as learning aids had a greater difference in practical test scores from the control group than male *** study has demonstrated that the interactive teaching mode of 3D printing combined with WebGL-based 3D visualisation technology is beneficial to the teaching of medical imaging,e

关键词： visualisation 3D printing Web Graphics Library(WebGL) medical imaging ankle ligaments medical education interactive teaching

Progress on haptoglobin and metabolic diseases

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World Journal of Diabetes 2021年第3期12卷 206-214页

作者： Bao-Nian Wan Shi-Gao Zhou Miao Wang Xiao Zhang Guang Ji Department of TCM Demonstration Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Institute of Digestive Disease Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Haptoglobin(Hp)is an acidic glycoprotein,existing in the serum and other body fluids of human beings and a variety of *** is produced in the liver,white adipose tissue,and the *** genetic polymorphisms and different phenotypes of Hp have different biological *** has antibacterial,antioxidant,and angiogenic effects and is associated with multiple diseases including simple obesity,vascular complications of diabetes mellitus,nonalcoholic fatty liver disease,hypertension,blood diseases,autoimmune diseases,and malignant *** also participates in many life activities,indicating the importance of Hp in further ***,we found that the expression of serum Hp changed after treatment of simple obesity patients in clinical ***,the specific mechanism of Hp in patients with simple obesity is still *** purpose of this article is to introduce recent research progress on Hp,emphasizing the relationship between Hp and the development of metabolic disease,which will improve the understanding of the functions of Hp underlying metabolic diseases and discuss future research directions.

关键词： Haptoglobin Polymorphism Metabolic diseases Simple obesity Inflammation CD163

Diverse functions of sox9 in liver development and homeostasis and hepatobiliary diseases

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Genes & Diseases 2024年第4期11卷 170-187页

作者： Taiyu Shang Tianyi Jiang Xiaowen Cui Yufei Pan Xiaofan Feng Liwei Dong Hongyang Wang School of Life Sciences Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China National Center for Liver Cancer The Naval Medical UniversityShanghai 201805China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteThe Second Military Medical UniversityShanghai 200438China Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer Second Military Medical University&Ministryof EducationShanghai 200438China

The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative *** hepatobiliary system originates from the foregut endoderm,in which cells undergo multiple events of cell proliferation,migration,and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription *** on liver development and diseases have revealed that SRY-related high-mobility group box 9(SOx9)plays an important role in liver embryogenesis and the progression of hepatobiliary ***9 is not only a master regulator of cell fate determination and tissue morphogenesis,but also regulates various biological features of cancer,including cancer stemness,invasion,and drug resistance,making Sox9 a potential biomarker for tumor prognosis and *** review systematically summarizes the latest findings of sox9 in hepatobiliary development,homeostasis,and *** also highlight the value of sox9 as a novel biomarker and potential target for the clinical treatment of major liverdiseases.

关键词： Biliary system Cancer Homeostasis Liver diseases SOX9

Image Registration Technique for Assessing the Accuracy of Intraoperative Osteotomy for Pelvic Tumors by 3D-Printed Patient-Specific Templates

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 306-311页

作者： QU Yang YAN Mengning LI Xiaomin WU Bing LIU Siyu WANG Liao WU Wen AI Songtao Department of Radiology Shanghai Jiao Tong University School of MedicineShanghai200011China Shanghai Key Laboratory of Orthopaedic Implants Department of OrthopaedicsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

The study aimed to explore the feasibility of an image registration technique for assessing the accuracy of intraoperative osteotomy of pelvic tumors by 3-dimensional(3D)-printed patient-specific *** with malignant pelvic tumors who were admitted to our hospital between March 2014 and December 2020 were retrospectively *** underwent hemi-pelvic resection and reconstruction by 3D-printed individualized *** registration between the designed model and the postoperative segmented model of the prosthesis was used to obtain the intraoperative osteotomy plane and reduce metal artifacts in postoperative computed tomography(CT)*** distance and angle between the planned and actual osteotomy planes were then used to assess the accuracy of the intraoperative *** patients with 13 osteotomy planes were enrolled,including four males and four *** median age at the time of imaging examination was 44 years(range,33–54 years).All intraoperative osteotomy planes were assessed *** mean distance between the planned and true intraoperative osteotomy planes was−0.69 cm(−7.5–7.35 cm),and the mean angle was 6.57°±3.36°(1.05°–11.88°).This new assessment method of registering the designed model and the postoperative CT segmented model of the prosthesis may be used to assess the accuracy of intraoperative osteotomy for pelvic tumors,using 3D printed patient-specific templates.

关键词： pelvic tumor image registration 3D-printed patient-specific template intraoperative osteotomy

“Zero ischemia”laparoscopic partial nephrectomy by high-power GreenLight laser enucleation for renal carcinoma:A single-center experience

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World Journal of clinical Cases 2022年第17期10卷 5646-5654页

作者： Xiang-Min Zhang Ji-Dong Xu Jian-Min Lv Xiu-Wu Pan Jian-Wei Cao Jian Chu Xin-Gang Cui Department of Urology Xinhua HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200092China Department of Urology Shanghai Baoshan Luodian HospitalShanghai 201908China Department of Urology Gongli Hospital of The Second Military Medical UniversityShanghai 200135China Department of Urology Shanghai The Seventh People's HospitalShanghai 200137China

BACKGROUND Laparoscopic partial nephrectomy has been widely used in renal cell carcinoma *** efficacy of GreenLight laser on Laparoscopic partial nephrectomy is still *** To present the first series of laparoscopic partial nephrectomy(LPN)by GreenLight laser enucleation without renal artery *** to the excellent coagulation and hemostatic properties of the laser,laser-assisted LPN(LLPN)makes it possible to perform a“zero ischemia”*** Fifteen patients with T1a exogenous renal tumors who received high-power GreenLight laser non-ischemic LPN in our hospital were retrospectively *** clinical information,surgical and post-operative data,complications,pathological and functional outcomes were *** Surgery was successfully completed in all patients,and no open or radical nephrectomy was *** renal artery was not clamped,leading to no ischemic *** blood transfusions were required,the average hemoglobin level ranged from 96.0 to 132.0 g/L and no postoperative complications *** mean operation time was 104.3±8.2 *** postoperative removal of negative pressure drainage time ranged from 5.0 to 7.0 d,and the mean postoperative hospital stay was 6.5±0.7 *** serious complications *** pathological results showed clear cell carcinoma in 12 patients,papillary renal cell carcinoma in 2 patients,and hamartoma in 1 *** mean creatinine level was 75.0±0.8μmol/L(range 61.0-90.4μmol/L)at 1 mo after surgery,and there were no statistically significant differences compared with pre-operation(P>0.05).The glomerular filtration rate ranged from 45.1 to 60.8 mL/min,with an average of 54.0±5.0 mL/min,and these levels were not significantly different from those before surgery(P>0.05).CONCLUSION GreenLight laser has extraordinary cutting and sealing advantages when used for small renal tumors(exogenous tumors of stage T1a)during ***,use of this technique can lead to the generation

关键词： GreenLight laser Zero ischemia Partial nephrectomy Laparoscopy Renal tumor