Fusobacterium nucleatum enhances the efficacy of PD-L1 blockade in colorectal cancer

作     者：Yaohui Gao Dexi Bi Ruting Xie Man Li Jing Guo Hu Liu Xianling Guo Juemin Fang Tingting Ding Huiyuan Zhu Yuan Cao Meichun Xing Jiayi Zheng Qing Xu Qian Xu Qing Wei Huanlong Qin Yaohui Gao;Dexi Bi;Ruting Xie;Man Li;Jing Guo;Hu Liu;Xianling Guo;Juemin Fang;Tingting Ding;Huiyuan Zhu;Yuan Cao;Meichun Xing;Jiayi Zheng;Qing Xu;Qian Xu;Qing Wei;Huanlong Qin

作者机构：Department of PathologyShanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of OncologyShanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina Department of Gastrointestinal SurgeryShanghai Tenth People’s Hospital Affiliated to Tongji University200072 ShanghaiChina 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第12期

页      面：3730-3739页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work is supported by the National Natural Science Foundation of China(8177100280,81730102,81972221,and 81702037) Science and Technology Commission of Shanghai(20ZR1442800) Clinical research plan of SHDC(No.SHDC2020CR2069B,No.SHDC2020CR5006-002 and No.SHDC12019114) 

主　　题：colorectal cancer interferon 

摘      要：Given that only a subset of patients with colorectal cancer(CRC)benefit from immune checkpoint therapy,efforts are ongoing to identify markers that predict immunotherapeutic *** evidence suggests that microbes influence the efficacy of cancer *** nucleatum induces different immune responses in CRC with different microsatellite-instability(MSI)***,we investigated the effect of *** on anti-PD-L1 therapy in *** found that high *** levels correlate with improved therapeutic responses to PD-1 blockade in patients with ***,*** enhanced the antitumor effects of PD-L1 blockade on CRC in mice and prolonged *** *** supplementation with immunotherapy rescued the therapeutic effects of PD-L1 ***,*** induced PD-L1 expression by activating STING signaling and increased the accumulation of interferon-gamma(IFN-γ)^(+)CD8^(+)tumor-infiltrating lymphocytes(TILs)during treatment with PD-L1 blockade,thereby augmenting tumor sensitivity to PD-L1 ***,patient-derived organoid models demonstrated that increased *** levels correlated with an improved therapeutic response to PD-L1 *** findings suggest that *** may modulate immune checkpoint therapy for CRC.