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Transcriptomic analyses of humans and mice provide insights into depression

Zoological Research 2020年第6期41卷 632-643页

作者： Hui-Juan Li xi Su Lu-Wen Zhang Chu-Yi Zhang Lu Wang Wen-Qiang Li Yong-Feng Yang Lu-xian Lv Ming Li xiao xiao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Henan Mental Hospital Second Affiliated Hospital of Xin xiang Medical UniversityXinxiangHenan 453002China Henan Key Lab of Biological Psychiatry International Joint Research Laboratory for Psychiatry and Neuroscience of HenanXinxiang Medical UniversityXinxiangHenan 453002China Henan Province People's Hospital ZhengzhouHenan 450003China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Accumulating studies have been conducted to identify risk genes and relevant biological mechanisms underlying major depressive disorder(MDD).In particular,transcriptomic analyses in brain regions engaged in cognitive and emotional processes,e.g.,the dorsolateral prefrontal cortex(DLPFC),have provided essential *** on three independent DLPFC RNA-seq datasets of 79 MDD patients and 75 healthy controls,we performed differential expression analyses using two alternative approaches for *** also conducted transcriptomic analyses in mice undergoing chronic variable stress(CVS)and chronic social defeat stress(CSDS).We identified 12 differentially expressed genes(DEGs)through both analytical methods in MDD patients,the majority of which were also dysregulated in stressed ***,the mRNA level of the immediate early gene FOS(Fos proto-oncogene)was significantly decreased in both MDD patients and CVS-exposed mice,and CSDSsusceptible mice exhibited a greater reduction in Fos expression compared to resilient *** findings suggest the potential key roles of this gene in the pathogenesis of MDD related to stress *** transcriptomes in the DLPFC of MDD patients might be,at least partially,the result of stress exposure,supporting that stress is a primary risk factor for MDD.

关键词： Major depressive disorder Stressed mice Dorsolateral prefrontal cortex Transcriptomic analysis FOS

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Hot electron assisted photoelectrochemical water splitting from Audecorated ZnO@TiO_(2) nanorods array

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Nano Research 2022年第7期15卷 5824-5830页

作者： Hongdong Li Hongyan Liu Fei Wang Guodong Li xiaoli Wang Zhiyong Tang cas Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Eco-chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Beijing Institute of Aeronautical Materials Beijing 100095China

Engineering of semiconductor nanomaterials is critical to enhance the photoelectrochemical(PEC)performance for water ***,semiconductors often show the low light absorption,slow charge transfer,and easy recombination of carriers,thus leading to the low catalytic *** this work,we show facile synthesis of ZnO@TiO_(2) core–shell nanorods(NRs)arrays modified with Au nanoparticles(NPs)as the photoelectrode for PEC water ***,the obtained ZnO@TiO_(2)(15 nm)/Au(8 nm)array shows the maximum photocurrent density of 3.14 mA/cm^(2) at 1.2 V *** hydrogen electrode(RHE),2.6 times and 1.7 times higher than those obtained from ZnO NRs and ZnO@TiO_(2)(15 nm)*** electric-field simulation and transient absorption spectroscopy show that the Au-decorated core–shell nanostructures have an enhanced hot electron generation and prolonged decay time,indicating effective charge transfer and recombination inhibition of *** work provides an efficient preparation strategy for photoelectrodes as well as great potential for the large-scale development of this technology.

关键词： surface plasmon resonance energy transfer transient absorption hot electron water splitting

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E）NA sensor cGAS-mediated immune recognition

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Protein & Cell 2016年第11期7卷 777-791页

作者： Pengyan xia Shuo Wang Pu Gao Guangxia Gao Zusen Fan Key Laboratory of Infection and Immunity of cas CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049China

The host takes use of pattern recognition receptors （PRRs） to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFKB or TBKI-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types, cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate （cGAMP） from adenosine triphosphate and guanosine triphos- phate, cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon produc- tion. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.

关键词： cGAS cGAMP innate immunity cytosolic DNAs DNA sensors

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The histone H3K27 demethylase REF6/JMJ12 promotes thermomorphogenesis in Arabidopsis

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National Science Review 2022年第5期9卷 142-153页

作者： Kaixuan He Hailiang Mei Jiaping Zhu Qi Qiu xiaofeng Cao xian Deng State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Hainan Yazhou Bay Seed Lab Center for Excellence in Molecular Plant Sciences Chinese Academy of Sciences

Dynamic trimethylation of histone H3 at Lys27(H3 K27 me3) affects gene expression and controls plant development and environmental *** Arabidopsis thaliana,RELATIVE OF EARLY FLOWERING 6(REF6)/JUMONJI DOMAIN-CONTAINING PROTEIN 12 demethylates H3 K27 me3 by recognizing a specific DNA ***,little is known about how REF6 activates target gene expression after recognition,especially in environmental *** response to warm ambient temperature, plants undergo thermomorphogenesis, which involves accelerated growth,early flowering and changes in *** we show that REF6 regulates thermomorphogenesis and cooperates with the transcription factor PHYTOCHROME INTERACTING FACTOR 4 to synergistically activate thermoresponsive genes under warm ambient *** ref6 loss-of-function mutants exhibited attenuated hypocotyl elongation at warm temperature,partially due to downregulation of GIBBERELLIN20-OxIDASE 2 and BASIC HELIx-LOOP-HELIx ***6 enzymatic activity is necessary for warm ambient temperature ***,our results provide direct evidence of an epigenetic modifier and a transcription factor working together to respond to the environment.

关键词： H3K27me3 histone demethylation thermomorphogenesis

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A cytochrome c551 mediates the cyclic electron transport chain of the anoxygenic phototrophic bacterium Roseiflexus castenholzii

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Plant Communications 2024年第2期5卷 79-93页

作者： Lu Yu Zhenzhen Min Menghua Liu Yueyong xin Aokun Liu Jian Kuang Wenping Wu Jingyi Wu Huimin He Jiyu xin Robert EBlankenship Changlin Tian xiaoling xu Department of Biochemistry and Molecular Biology School of Basic Medical Sciences and Affiliated HospitalKey Laboratory of Aging and Cancer Biology of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121China High Magnetic Field Laboratory Chinese Academy of SciencesHefei 230031China Photosynthesis Research Center College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China The First Affiliated Hospital of USTC Division of Life Sciences and MedicineCenter for Bioanalytical ChemistryHefei National Laboratory of Physical Science at MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Departments of Biology and Chemistry Washington University in St.LouisSt.LouisMO 63130USA

Roseiflexus castenholzii is a gram-negativefilamentous phototrophic bacterium that carries out anoxygenic photosynthesis through a cyclic electron transport chain(ETC).The ETC is composed of a reaction center(RC)–light-harvesting(LH)complex(rcRC–LH);an alternative complex III(rcACIII),which functionally re-places the cytochrome bc1/b6f complex;and the periplasmic electron acceptor auracyanin(rcAc).Although compositionally and structurally different from the bc1/b6f complex,rcACIII plays similar essential roles in oxidizing menaquinol and transferring electrons to the ***,rcACIII-mediated electron transfer(which includes both an intraprotein route and a downstream route)has not been clearly elucidated,nor have the details of cyclic ***,we identify a previously unknown monoheme cytochrome c(cyt c551)as a novel periplasmic electron acceptor of *** reduces the light-excited rcRC–LH to complete a cyclic *** also reveal the molecular mechanisms involved in the ETC using electron paramagnetic resonance(EPR),spectroelectrochemistry,and enzymatic and structural *** that electrons released from rcACIII-oxidized menaquinol are transferred to two alternative periplasmic electron acceptors(rcAc and cyt c551),which eventually reduce the rcRC to form the complete cyclic *** work serves as a foundation for further studies of ACIII-mediated electron transfer in anoxygenic photosynthesis and broadens our under-standing of the diversity and molecular evolution of prokaryotic ETCs.

关键词： cytochrome c menaquinol oxidoreductase electron transport chain electron paramagnetic reso-nance light-harvesting complex

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Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19

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National Science Review 2021年第11期8卷 88-91页

作者： Yang Qiu Di Wu Wanshan Ning Jiqian xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li xiaobo Yang Yaxin Wang xiaojing Zou Shangwen Pan Chaolin Huang Yu xue You Shang xi Zhou State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology and Wuhan Jinyintan Hospital Wuhan Institute of Virology Chinese Academy of Sciences Center for Translational Medicine Wuhan Jinyintan Hospital MOE Key Laboratory of Molecular Biophysics Hubei Bioinformatics and Molecular Imaging Key Laboratory Center for Artificial Intelligence Biology College of Life Science and Technology Huazhong University of Science and Technology Department of Clinical Laboratory Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology and Wuhan Jinyintan Hospital Wuhan Jinyintan Hospital Institute of Anesthesiology and Critical Care Medicine Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology

Multi-organ injuries are a major complication of severe Coronavirus Disease2019 (COVID-19).However,its pathogenesis is barely ***,we profile host responses to fatal SARSCoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney,

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Rare earth element geochemistry in soils along arid and semiarid grasslands in northern China

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Ecological Processes 2022年第1期11卷 386-399页

作者： Yi‑Wen Cao xiao‑Ming Liu Chao Wang Edith Bai Nanping Wu cas Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Marine and Environmental SciencesUniversity of North Carolina‑Chapel HillChapel HillNC 27515USA Key Laboratory of Geographical Processes and Ecological Security of Changbai Mountains School of Geographical SciencesNortheast Normal UniversityChangchun 130024China Institute of Deep‑Sea Science and Engineering Chinese Academy of SciencesSanya 572000China

Background:Rare earth elements(REE)are a group of trace elements that behave geochemically *** fractionation patterns normalized to reference materials provide a powerful tool for documenting *** processes are particularly difficult to illustrate with respect to contemporary and past climate *** this study,we characterize the rare earth element(REE)contents in bulk soils and respective geochemical fractions(e.g.,exchangeable,carbonate‑bound,reducible,and oxidizable fractions)and to decipher the relationships between REE geochemistry components and climatic factors across a large‑scale northern China transect(NCT).Results:Across the NCT,bulk REE concentrations ranged from 55.2 to 241.1μg g^(−1)with a main portion in the residual fraction(49–79%),followed by oxidizable fraction(2–40%),reducible fraction(3–22%),carbonate‑bound fraction(0.1–16%),and negligible exchangeable *** REE contents of geochemical components(carbonate‑bound,reducible,and oxidizable)in topsoils correlated to climate factors(mean annual precipitation,mean annual temperature,potential evaporation,and aridity index(AI)).The normalized abundances to the upper continental crust(UCC)composition show that the middle REE was generally enriched than the light REE and heavy REE in topsoils along the *** overall UCC‑normalized bulk REE patterns in topsoils and subsoils were similar,characterized by weak negative Ce anomalies and positive Eu ***:Our data in topsoils and depth profiles collectively suggest that cycling of REE was primarily regulated by abiotic processes in area with AI*** similar UCC normalized patterns in topsoils suggest that the REE was originated from a common source with limited influences from other sources(e.g.,atmospheric dusts and anthropogenic contribu‑tions).Our results to some extent provide evidence for

关键词： Rare earth elements Soil Grassland Northern China Aridity index

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High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice

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National Science Review 2019年第6期6卷 1223-1238页

作者： xiaochuan Zhang xianzhen Yin Jingjing Zhang Anan Li Hui Gong Qingming Luo Haiyan Zhang Zhaobing Gao Hualiang Jiang School of Pharmacy East China University of Science and Technology cas Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and Technology MoE Key Laboratory for Biomedical Photonics School of Engineering Sciences Huazhong University of Science and Technology Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghai Tech University

Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer’s disease(AD). However, systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare. Using an image-optimization method for analysing Micro-Optical Sectioning Tomography(MOST) data, we generated cross-scale whole-brain 3 D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution,for both wild-type mice and a transgenic(APP/PS1) mouse model of AD. In addition to distinct vascular patterns in different brain regions, we found that the main vessels of the molecular layer of the hippocampal dentate gyrus(DG-ml) undergo abrupt changes in both diameter and branch angle, spreading a unique comb-like pattern of capillaries. By using a quantitative analysis workflow, we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter, volume fraction and branch angle, with most significant impairment in the DG-ml. In addition, virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice, potentially contributing to the impairment of blood flow. Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis.

关键词： Micro-Optical Sectioning Tomography image optimization Alzheimer’s disease impaired hippocampal vasculature virtual vascular endoscopy

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Polyprenylated acylphloroglucinols from the fruits of Hypericum henryi

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Science China Chemistry 2016年第9期59卷 1216-1223页

作者： Yang Liao Shu-Ya Yang xiao-Nian Li xing-Wei Yang Gang xu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China University of Chinese Academy of Sciences Beijing 100049 China

Hyphenrones R–x(1–7), seven new polyprenylated acylphloroglucinols derivatives, were isolated from the fruits of Hypericum henryi, together with eight know analogues. Compounds 1 and 2 were elucidated to possess complex caged skeleton, while compounds 3–6 shared a common 3,9-epoxy moiety deriving from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core. The new structures were elucidated on the basis of the interpretation of nuclear magnetic resonance(NMR) data, circular dichroism(CD) comparison, and single-crystal x-ray diffraction. In the bioassay, several compounds exhibited inhibitory activities against human tumor cell lines in vitro.

关键词： polyprenylated acylphloroglucinols Hypericum henryi hyphenrones R-x antitumor

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Fish ACE2 is not susceptible to SARS-CoV-2

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Virologica Sinica 2022年第1期37卷 142-144页

作者： Shi-Zhe xie Mei-Qin Liu Ren-Di Jiang Hao-Feng Lin Wei Zhang Bei Li Jia Su Fei Ke Qi-Ya Zhang Zheng-Li Shi xing-Lou Yang cas Key Laboratory of Special Pathogens Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan430072China

Dear Editor,The ongoing pandemic of coronavirus disease 2019(COVID-19)has reshaped our daily life and caused>4 million deaths worldwide(https://***/).Although lockdown and vaccination have improved the situation in many countries,imported cases and sporadic outbreaks pose a constant stress to the prevention and control of COVID-19.

关键词： ACE2 prevention vaccination

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