E）NA sensor cGAS-mediated immune recognition

作     者：Pengyan Xia Shuo Wang Pu Gao Guangxia Gao Zusen Fan 

作者机构：Key Laboratory of Infection and Immunity of CAS CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2016年第7卷第11期

页      面：777-791页

核心收录：

学科分类：080202[工学-机械电子工程] 08[工学] 09[农学] 0802[工学-机械工程] 0902[农学-园艺学] 090201[农学-果树学] 

基　　金：国家自然科学基金 Youth Innovation Promotion Association of CAS to S.W China Postdoctoral Science Foundation to P.X Special Financial Grant from the China Postdoctoral Science Foundation to P.X 

主　　题：cGAS cGAMP innate immunity cytosolic DNAs DNA sensors 

摘      要：The host takes use of pattern recognition receptors （PRRs） to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFKB or TBKI-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types, cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate （cGAMP） from adenosine triphosphate and guanosine triphos- phate, cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon produc- tion. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.