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Taurine attenuates activation of hepatic stellate cells by inhibiting autophagy and inducing ferroptosis

World Journal of Gastroenterology 2024年第15期30卷 2143-2154页

作者： Sen Li Qian-Jun Ren Can-Hao Xie Yang Cui Li-Tao Xu Yi-Dan Wang Su Li Xing-Qiu Liang Bin Wen Ming-Kun Liang Xiao-Fang Zhao Department of Basic Science Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Department of Science and Technology Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina Traditional chinese medicine Specialty Office Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanning 541100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury,and finally leads to liver cirrhosis or even hepatocellular *** pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells(HSCs),which can transdiffer-entiate into myofibroblasts to produce an excess of the extracellular matrix(ECM).Myofibroblasts are the main source of the excessive ECM responsible for hepatic ***,activated hepatic stellate cells(aHSCs),the principal ECM producing cells in the injured liver,are a promising therapeutic target for the treatment of hepatic *** To explore the effect of taurine on aHSC proliferation and the mechanisms *** Human HSCs(LX-2)were randomly divided into five groups:Normal control group,platelet-derived growth factor-BB(PDGF-BB)(20 ng/mL)treated group,mmol/L,respectively)with PDGF-BB(20 ng/mL)treated *** Counting Kit-8 method was performed to evaluate the effect of taurine on the viability of ***-linked immunosorbent assay was used to estimate the effect of taurine on the levels of reactive oxygen species(ROS),malondialdehyde,glutathione,and iron *** electron microscopy was applied to observe the effect of taurine on the autophagosomes and ferroptosis features in *** real-time polymerase chain reaction and Western blot analysis were performed to detect the effect of taurine on the expression ofα-SMA,Collagen I,Fibronectin 1,LC3B,ATG5,Beclin 1,PTGS2,SLC7A11,and *** Taurine promoted the death of aHSCs and reduced the deposition of the *** with taurine could alleviate autophagy in HSCs to inhibit their activation,by decreasing autophagosome formation,downregulating LC3B and Beclin 1 protein expression,and upregulating p62 protein ***,treatment with taurine triggered ferroptosis and ferritinophagy to eliminate aHSCs characterized b

关键词： Hepatic stellate cells Autophagy Ferroptosis Molecular docking Taurine

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Therapeutic effects of Lingguizhugan decoction in a rat model of high-fat diet-induced insulin resistance

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World Journal of Diabetes 2024年第6期15卷 1291-1298页

作者： Xiao-Ming Liu Shi-Qing Yuan Ying Ning Shi-Jia Nie Xu-Qiong Wang Hong-Yi Jia Xiu-Li Zheng Department of Basic medicine School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137Sichuan ProvinceChina Department of Clinical medicine Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Lingguizhugan(LGZG)decoction is a widely used classic chinese medicine formula that was recently shown to improve high-fat diet(HFD)-induced insulin resistance(IR)in animal *** To assess the therapeutic effect of LGZG decoction on HFD-induced IR and explore the potential underlying *** To establish an IR rat model,a 12-wk HFD was administered,followed by a 4-wk treatment with *** determination of IR status was achieved through the use of biochemical tests and oral glucose tolerance *** a targeted metabolomics platform to analyze changes in serum metabolites,quantitative real-time PCR(qRT-PCR)was used to assess the gene expression of the ribosomal protein S6 kinase beta 1(S6K1).RESULTS In IR rats,LGZG decreased body weight and indices of hepatic *** effectively controlled blood glucose and food intake while protecting islet *** analysis revealed significant differences between the HFD and HFDLGZG *** intervention reduced branched-chain amino acid *** of IR-related metabolites such as tryptophan,alanine,taurine,and asparagine decreased *** may be linked to amino acids due to the contemporaneous increase in S6K1 expression,as shown by *** Our study strongly suggests that LGZG decoction reduces HFD-induced *** may activate S6K1 via metabolic *** findings lay the groundwork for the potential of LGZG as an IR treatment.

关键词： Lingguizhugan decoction High-fat diet-induced insulin resistance Amino acid metabolism S6K1

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Pharmacognostic Identification of Hedyotis auricularia and Mitracarpus villosus

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Medicinal Plant 2024年第1期15卷 24-27,34页

作者： Piaoling HUANG Feipeng HUANG Xinxin LU Zhonghua DAI Hailin LU guangxi university of chinese medicine Nanning 530001China

[Objectives]To conduct the pharmacognostic identification of Hedyotis auricularia and Mitracarpus villosus in guangxi and provide a scientific basis for their identification.[Methods]The characteristics of original plants were studied by origin identification method;the properties and characteristics were studied by character identification method;and the microscopic features of the roots,stems,leaves and medicinal powder of *** and *** in guangxi were studied by paraffin method and powder slicing method.[Results](i)Origin ***:Leaves leathery,apex acuminate,base cuneate;petiole shorter;cyme axillary;corolla hairy at throat;fruit indehiscent at maturity;testa black after ***:Leaf apex short pointed,base attenuate,blade sessile;flowers small,clustered in axillary;fruits dehiscent by lid at or below middle at maturity,seeds dark brown.(ii)Character *** surface of *** uneven,white in outer layer and sepia in inner *** surface of *** hollow,uneven and white.(iii)Microscopic ***:Root phloem thick,cambium visible,duct cells quasi-polygonal,large;rays *** transection quasi-circular square,often with non-glandular hairs on epidermis;calcium oxalate raphides present in leaf parenchymal *** grayish brown,starch granules single-grained;calcium oxalate raphides frequent,calcium oxalate clustered crystals occasional;catheter spiral,rarely annular,stomata ***:Root parenchyma cells with scattered calcium oxalate raphides,calcium oxalate clustered crystals and brownish red substances *** transection quasi-square,edge angle with 4 short narrow *** brown,simple starch granules numerous,compound starch granules also present;calcium oxalate raphides numerous,calcium oxalate clustered crystals and calcium oxalate square cubic crystals also present;catheter spiral,stomata paracytic.[Conclusions]The above trans

关键词： Hedyotis auricularia Mitracarpus villosus Pharmacognostic Identification

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Pharmacodynamic Experiment of Dachengqi Decoction and Separated Decoction on Incomplete Intestinal Obstruction in Rats

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Medicinal Plant 2024年第4期15卷 107-110页

作者： Jiangcun WEI Xiumei MA Bing QING Meiyan QIU Qingmei DENG Hong LEI Zengyan YANG Zujie QIN guangxi International Zhuang medicine Hospital Affiliated to guangxi university of chinese medicine Nanning 530201China guangxi university of chinese medicine Nanning 530200China

[Objectives]To investigate the effect and mechanism of Dachengqi Decoction and separated decoction on incomplete intestinal obstruction in rats.[Methods]80 healthy SD rats were selected to establish incomplete intestinal obstruction model by silk *** dosage was 20 mL/kg for 3 d,and the damage index of ileocecal mucosa was analyzed;the morphology of ileocecal mucosa was observed by HE staining;the serum levels of IL-1α,IL-1β,IL-6,IL-18,Ach,NO,ET,IL-1,TNF-αand ultra-micro Na+-K+-ATPase were detected by ELISA.[Results]Compared with the model group,the mucosal damage index of Dachengqi Decoction and each separated decoction group decreased significantly(P<0.05);compared with the normal group and sham operation group,the serum level of IL-1,IL-6,TNF-αand other factors in the model group increased significantly(P<0.05);compared with the model group,the serum IL-1,IL-6 and TNF-αsecretion levels of rats in Dachengqi Decoction group and separated decoction group decreased(P<0.01).[Conclusions]Dachengqi Decoction and each separated decoction can effectively improve intestinal tissue pathological damage in the incomplete intestinal obstruction model rats,and reduce the inflammatory reaction in the rat body.

关键词： Dachengqi Decoction Separated decoction Incomplete intestinal obstruction Inflammatory factor

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Efficacy and safety of Huzhang Granule,a compound chinese herbal medicine,for acute gouty arthritis:A double-blind,randomized controlled trial

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Journal of Integrative medicine 2024年第3期22卷 270-278页

作者： Hao Wang Si-ting Chen Xiao-jie Ding Le Kuai Liang Hua Xin Li Yi-fei Wang Ming Zhang Bin Li Rui-ping Wang Mi Zhou Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai 201203China Department of Dermatology the Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330000Jiangxi ProvinceChina Shanghai Skin Disease Hospital School of MedicineTongji UniversityShanghai 200443China Institute of Dermatology School of MedicineTongji UniversityShanghai 200443China

Background:Acute gouty arthritis(AGA)is an inflammatory joint disease with a high *** medical interventions,including nonsteroidal anti-inflammatory drugs,colchicine and glucocorticoids,can have serious adverse *** Granule(HZG),a compound chinese herbal medicine,has been used to treat AGA for more than 30 years with satisfactory effects and no significant adverse ***,the efficacy and safety of HZG in AGA patients remains ***:The present investigation was designed to examine the efficacy and safety profile of HZG in managing AGA ***,setting,participants and interventions:The current study was conducted as a noninferiority,randomized controlled clinical trial on 180 eligible enrolled *** were randomly assigned into the HZG and etoricoxib *** were administered for 5 d,during which the HZG group received HZG and placebo etoricoxib,while the etoricoxib group received etoricoxib and placebo HZG in the same ratio(1:1).Main outcome measures:The primary outcome was pain experienced by the patient in the gout-afflicted joint from days 2 to 5 of the treatment *** pain level was measured via a visual analogue scale,ranging from 0 mm to 100 *** secondary outcomes comprised joint tenderness and swelling,reduction of inflammatory biomarkers,and the patient’s and investigator’s global evaluations of therapeutic ***:The mean reduction in pain was-51.22 mm(95%confidence interval[CI],[-53.42,-49.03]mm)for the HZG and-52.00 mm(95%CI,[-54.06,-49.94]mm)for the etoricoxib *** mean difference between the two groups was 0.78 mm(95%CI,[-2.25,3.81]mm).All additional efficacy endpoints,covering decreased inflammation and pain relief,yielded compelling proof of *** in the HZG group exhibited a comparatively lower rate of adverse events compared to those in the etoricoxib group(4.44%vs 13.33%;P≤0.05).Conclusion:HZG and etoricoxib groups demons

关键词： Acute gouty arthritis Huzhang Granule Randomized controlled trial Blind

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TLC Identification and Extraction Process of Rubiasin-1-methyl Ether from Yao medicine Chuanlianzhu

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Medicinal Plant 2024年第3期15卷 35-38页

作者： Jingrong LU Jiangcun WEI Xiumei MA Bing QING Meiyan QIU Wen ZHONG guangxi International Zhuang medicine Hospital Nanning 530201China

[Objectives]To establish a thin-layer chromatography(TLC)method for the determination of rubiadin-1-methyl ether in Yao medicine Chuanlianzhu(Damnacanthus giganteus).[Methods]A silica gel G thin-layer plate was adopted for *** ether(60-90℃)-chloroform-methanol-water(7:15:3:1)was used as the developing solvent and inspected under ultraviolet lamp(365 nm).The content was determined by Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm),mobile phase:acetonitrile-0.2%phosphoric acid gradient elution,detection wavelength 277 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The spots of 10 Chuanlianzhu samples from different origins showed the same color at the same position as the control,and the spots were clear and *** injection volume of rubiadin-1-methyl ether showed a good linear relationship in the range of 2.90-145μg(R=0.9996).The average recovery rate of rubiadin-1-methyl ether in the low,medium and high dose groups of Yao medicine Chuanlianzhu was 98.72%,and RSD=1.78%.[Conclusions]This method can effectively identify Yao medicine Chuanlianzhu medicinal materials and accurately determine the content of rubiadin-1-methyl ether in the medicinal *** provides a scientific basis for the development and utilization of Yao medicine Chuanlianzhu medicinal resources.

关键词： Chuanlianzhu Thin-layer chromatography (TLC) Extraction process Rubiadin-1-methyl ether Content determination

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Anti-inflammatory Effect of Polysaccharide from Embelia parviflora *** Rheumatoid Arthritis in Rats

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Medicinal Plant 2024年第3期15卷 41-44页

作者： Jiangcun WEI Yong CHEN Xiumei MA Meiyan QIU Bing QING Leimin JIANG Wen ZHONG Zujie QIN guangxi International Zhuang medicine Hospital Nanning 530201China guangxi university of chinese medicine Nanning 530200China

[Objectives]To investigate the anti-inflammatory effect of Embelia parviflora *** on rheumatoid arthritis(RA)in rats.[Methods]RA rat model was induced by type II *** successful modeling,the rats were divided into model group,positive group,low,medium and high dose of *** *** groups,and normal control *** mass,toe volume and arthritis index were measured,and thymus index and spleen index were *** levels of interleukin-1β,interleukin-6 and tumor necrosis factor-αin serum and synovial tissue of ankle joint were detected by ELISA.[Results]Compared with the normal control group,the pathological changes such as synovial hyperplasia and unclear layer were observed in the model group,the body mass was decreased(P0.05).[Conclusions]*** *** can reduce the body's inflammatory response and improve RA,which may be related to the inhibition of the activation of inflammatory cytokines IL-1β,IL-6 and TNF-α.

关键词： Polysaccharide from Embelia parviflora Wall. Rheumatoid arthritis (RA) Anti-inflammatory effect

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Anti-inflammatory Mechanism of Yao medicine Laggerae Alatae Herba

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Medicinal Plant 2024年第3期15卷 71-74页

作者： Leimin JIANG Xiumei MA Wen ZHONG Jingrong LU Bing QING Qingmei DENG Hong LEI Jiangcun WEI guangxi International Zhuang medicine Hospital Affiliated to guangxi university of chinese medicine Nanning 530201China guangxi university of chinese medicine Nanning 530200China

[Objectives]To study the anti-inflammatory effect of Laggerae Alatae Herba extract and its mechanism.[Methods]Inflammation models of xylene-induced ear edema in mice,acetic acid-induced increased permeability of abdominal capillaries in mice,and carrageenan-induced paw edema in mice were established;xylene-induced ear swelling model in bilateral adrenalectomized mice was *** levels of MDA,NO and SOD in inflammatory tissues of paw were measured.[Results]Compared with the model group,the high and medium dose groups of Laggerae Alatae Herba extract had significant inhibitory effect on xylene-induced ear edema in mice,except for the low dose group(P>0.05);Laggerae Alatae Herba extract inhibited the increase of celiac capillary permeability induced by acetic acid and paw edema induced by carrageenan in *** with the model group,in the mice model with bilateral adrenal glands removed,the high and medium dose groups of Laggerae Alatae Herba extract could significantly inhibit the xylene induced ear swelling of the *** high and medium dose groups of Laggerae Alatae Herba extract could significantly decrease the levels of MDA and NO,and significantly increase the level of SOD in the paw tissue.[Conclusions]The Laggerae Alatae Herba extracts have anti-inflammatory activity,and the anti-inflammatory effect of the extracts does not depend on the hypothalamic-pituitary-adrenal axis(HPAA)*** addition,the anti-inflammatory mechanism of Laggerae Alatae Herba extract is related to the decrease of MDA and NO and the increase of SOD.

关键词： Laggerae Alatae Herba Anti-inflammation Action mechanism

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TLC Identification of Yao medicine Pileostegia tomentellal and Extraction Technology and Content Determination of Umbelliferone

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Medicinal Plant 2024年第2期15卷 15-17,20页

作者： Jiangcun WEI Xiumei MA Meiyan QIU Bing QING Jingrong LU Hong LEI Xiaodong HUANG Wen ZHONG guangxi International Zhuang Medical Hospital Nanning 530201China guangxi university of chinese medicine Nanning 530200China

[Objectives]To establish a TLC and content determination method of Pileostegia tomentellal,with umbelliferone as the indicator component.[Methods]TLC identification was performed by silica gel G thin layer plate with n-hexane-ethyl acetate(4:3)as the developing agent,and the plate was examined by UV lamp(365 nm).The umbelliferone content was determined by HPLC:Inertsil ODS-3 C 18 column(4.60 mm×250 mm,5μm);mobile phase acetonitrile-0.2%phosphoric acid gradient elution;detection wavelength 320 nm,flow rate 1.0 mL/min,column temperature 30℃,injection volume 10μL.[Results]The chromatogram of *** showed the same color spot in the same position as that of reference medicinal material,and the spot was clear with good *** showed a good linear relationship when the injection volume was 2.63-131.27μg/mL(R^(2)=0.9997).The average recovery of umbelliferone in the low,middle and high adding groups of *** was 99.57%and the RSD was 2.15%.[Conclusions]The method can effectively identify Yao medicine *** and accurately determine the content of umbelliferone in medicinal materials,which will provide a scientific basis for the development and utilization of medicinal resources of Yao medicine ***.

关键词： Pileostegia tomentellal TLC identification Extraction technology Umbelliferone Content determination

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Research Overview of Zhuang medicine Fumigation Lotions

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Medicinal Plant 2024年第1期15卷 35-37页

作者： Bing QING Jiangcun WEI Fangmei LI Xianyi SHI Li LONG Xian PENG Meiyan QIU Wen ZHONG Zujie QIN guangxi International Zhuang Medical Hospital Nanning 530201China

At present,there is little research on the application of Zhuang medicine fumigation lotions in skin diseases,and there is no research on related preparation processes and quality *** this paper,the characteristics of its formulation and the research progress in skin diseases are reviewed,in order to deepen the understanding of Zhuang medicine fumigation lotions and provide a more detailed theoretical basis for its clinical research,development and application.

关键词： Zhuang medicine fumigation lotions Ilicis Rotundae Cortex Eiliae Herba Polygoni Perfoliati Herba Rhei Radix Et Rhizoma

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