Anti-inflammatory Mechanism of Yao Medicine Laggerae Alatae Herba
作者机构：Guangxi International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese MedicineNanning 530201China Guangxi University of Chinese MedicineNanning 530200China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2024年第15卷第3期
页 面：71-74页
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine-Ethnic Minority Pharmacy (Zhuang Pharmacy) (zyyzdxk-2023165) Cultivation Project of Guangxi International Zhuang Medicine Hospital (2023GZYJKT008) Youth Fund of Natural Science Foundation of Guangxi (2024GXNSFBA010302) Young Talent Cultivation Program of Guangxi International Zhuang Medicine Hospital (2022001) Key R&D Project of Guangxi Science and Technology Department (Guike AB21196057) Guangxi Traditional Chinese Medicine Interdisciplinary Innovation Team Project (GZKJ2309) Funding Project of High-level Talent Cultivation and Innovation Team of Guangxi University of Chinese Medicine (2022A008) The Third Batch of"Qihuang Project"High-Level Talent Team Training Project of Guangxi University of Chinese Medicine (202414) Three-year Action Plan for the Construction of High-level Talents Team of Guangxi International Zhuang Medicine Hospital in 2023 (GZCX20231203)
主 题：Laggerae Alatae Herba Anti-inflammation Action mechanism
摘 要：[Objectives]To study the anti-inflammatory effect of Laggerae Alatae Herba extract and its mechanism.[Methods]Inflammation models of xylene-induced ear edema in mice,acetic acid-induced increased permeability of abdominal capillaries in mice,and carrageenan-induced paw edema in mice were established;xylene-induced ear swelling model in bilateral adrenalectomized mice was *** levels of MDA,NO and SOD in inflammatory tissues of paw were measured.[Results]Compared with the model group,the high and medium dose groups of Laggerae Alatae Herba extract had significant inhibitory effect on xylene-induced ear edema in mice,except for the low dose group(P0.05);Laggerae Alatae Herba extract inhibited the increase of celiac capillary permeability induced by acetic acid and paw edema induced by carrageenan in *** with the model group,in the mice model with bilateral adrenal glands removed,the high and medium dose groups of Laggerae Alatae Herba extract could significantly inhibit the xylene induced ear swelling of the *** high and medium dose groups of Laggerae Alatae Herba extract could significantly decrease the levels of MDA and NO,and significantly increase the level of SOD in the paw tissue.[Conclusions]The Laggerae Alatae Herba extracts have anti-inflammatory activity,and the anti-inflammatory effect of the extracts does not depend on the hypothalamic-pituitary-adrenal axis(HPAA)*** addition,the anti-inflammatory mechanism of Laggerae Alatae Herba extract is related to the decrease of MDA and NO and the increase of SOD.
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