检索结果-南通市图书馆

Journal of Rare Earths 2021年第9期39卷 1100-1107页

作者： Lihong Bao Jun Ning Narengerile zizhong liu College of Physics and Electronic Information.Inner Mongolia Normal University.Hohhot 010022 China Inner Mongolia Key Laboratory for Physics and Chemistry of Functional Materials.Inner Mongolia Normal University Hohhot 010022.China College of Chemistry and Enviormental Science

Binary nanocrystalline rare-earth hexaboride is regarded as one of the promising optical absorption materials that possess the high transparency for visible light and the strong absorption for NIR due to the effects of localized surface plasmon *** present work,we experimentally investigated the structural and optical absorption of ternary nanocrystalline Eu-doped SmB6 *** a result,it is found that the reaction temperature as an important factor not only refines the grain size,but also improves the powder dispersion of synthesized *** optical absorption results reveal that the transmittance wavelength of nanocrystalline SmB6 increases from 696 nm to exceeding 1000 nm with the Eu doping content increasing to x=*** retically,in order to study the transmittance wavele ngth tunable mechanisms of nanocrystalline Eu-doped SmB6,the electronic structure,density of states and energy loss function were calculated by first-principle *** shows that the En2+doping into SmB6 effectively reduces the plasma frequency excitation energy from 1.48 to 1.25 eV and leads to the transmittance wavelength redshift toward a higher *** on above meaningful studies,present work is helpful for extension of optical applications of nanocrystalline SmB6 powder.

关键词： Nanocrystalline SmB_(6) Optical property First-principles calculation Rare earths

化学核心素养评价研究进展——基于CiteSpace的可视化分析

在线全文

学校读者我要写书评

暂无评论

化学教学 2024年第8期 14-18页

作者：李苏杰刘子忠张凤英赵瑞生内蒙古师范大学化学与环境科学学院内蒙古呼和浩特010020 内蒙古师范大学教育学院内蒙古呼和浩特010020

查阅与化学核心素养评价相关的文献,利用CiteSpace软件对文献进行可视化分析,梳理出化学核心素养评价依据(理念)、评价理论基础、评价框架(指标体系)的构建等研究热点,并对所梳理出的热点研究领域的研究成果进行深入系统的汇总分析。

关键词：中学化学核心素养评价研究 CiteSpace

DFT study on nonlinear optical properties of lithium-doped corannulene

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2012年第34期57卷 4448-4452页

作者： JIANG YaJun liu zizhong liu HongXia CUI WenYing WANG Na liu DongSheng GE XiangWei Inner Mongolia Key Laboratory of Green Catalysis Chemistry and Environment Science CollegeInner Mongolia Normal UniversityHohhot 010022China Computer and lnformation Engineering College Inner Mongolia Normal UniversityHohhot 010022China

The effects of lithium doping on the nonlinear optical properties of new electrodes (lithium-doped corannulene) were investigated in detail. Nine dynamically stable geometries of Lin-C20H10 (n=1, 2) are predicted by B3LYP/6-31G(d,p). Among these nine structures, the largest first static hyperpolarizability (β0) is computed to be 15314 au, which is dramatically larger than the β0 value of 74 au for C20H10, indicating that Li doping plays an important role in elevating the first hyperpolarizability of corannulene.

关键词：非线性光学性质锂掺杂 DFT 超极化率几何形状动态稳定电极

阿尔茨海默病病变相关脑区Pgc-1alpha敲除小鼠模型的构建

在线全文

学校读者我要写书评

暂无评论

江苏大学学报（医学版） 2024年第5期34卷 423-427,450页

作者：史厚珍张维君翟鸿儒王贻界王雨欣刘子重王佳江苏大学医学院江苏镇江212013 江苏大学第四附属医院神经科江苏镇江212001 镇江杰胜瑞科技有限公司江苏镇江212013

目的:构建在阿尔茨海默病(Alzheimer′s disease,AD)病变相关脑区过氧化物酶体增殖物激活受体γ辅激活因子-1α(peroxisome proliferator-activated receptorγcoactivator-1 alpha,Pgc-1alpha)敲除小鼠。方法:引入Pgc-1alpha条件性敲除杂合子小鼠(Pgc-1alphafl/+),通过自交获得Pgc-1alpha条件性敲除纯合子小鼠(Pgc-1alphafl/fl)。将Pgc-1alphafl/fl纯合子小鼠和在AD病变脑区(皮层、海马)特异性表达Cre重组酶的Cre工具鼠(Calb1-Cre)杂交,提取子代转基因小鼠基因组DNA,行PCR鉴定,确定其基因型;采用蛋白免疫印迹技术检测转基因小鼠与野生型小鼠脑区及肾脏PGC-1α蛋白表达。结果:双重PCR鉴定结果显示,同时扩增出400 bp及444 bp条带的小鼠为AD病变脑区Pgc-1alpha敲除纯合子小鼠(Pgc-1alphafl/fl::Calb1-Cre,Pgc-1alpha-/-)。蛋白免疫印迹结果显示,与野生型小鼠相比,条件性敲除小鼠脑区PGC-1α蛋白表达明显减少(P<0.05)。结论:成功构建在AD病变相关脑区Pgc-1alpha敲除小鼠。

关键词：过氧化物酶体增殖物激活受体γ辅激活因子-1α(Pgc-1alpha) 条件性敲除小鼠阿尔茨海默病皮层海马

白癜风皮损表皮钙离子梯度与角质层板层脂膜超微结构观察

在线全文

学校读者我要写书评

暂无评论

中华医学杂志 2016年第14期96卷 1108-1111页

作者：刘子重雷铁池武汉大学人民医院皮肤科 430060

目的探讨白癜风皮损黑素脱失对表皮钙离子分布和角质层板层脂膜超微结构的影响。方法2014年8月至2015年2月于武汉大学人民医院皮肤科门诊招募稳定期寻常型白癜风患者和健康对照各5例。四氧化钌（RuO4）电子特染结合透射电子显微镜技术... 详细信息

目的探讨白癜风皮损黑素脱失对表皮钙离子分布和角质层板层脂膜超微结构的影响。方法2014年8月至2015年2月于武汉大学人民医院皮肤科门诊招募稳定期寻常型白癜风患者和健康对照各5例。四氧化钌（RuO4）电子特染结合透射电子显微镜技术观察皮肤标本角质层板层脂膜的超微结构；用钙离子化学捕捉技术结合透射电镜观察表皮钙沉淀颗粒的数量及分布。结果健康对照皮肤角质层细胞问隙可见排列规整、电子致密带和电子透明带重复交替排列的板层结构；白癜风皮损角质层细胞间隙扩大，板层脂膜分离断裂，出现空泡，空泡内填充有无形电子致密物。健康对照皮肤的颗粒层可见到粗大密集的钙沉淀颗粒，基底层细胞间可见细小的钙沉淀颗粒与Ⅳ期黑素小体；而白癜风皮损的颗粒层钙沉淀颗粒大小和数目较正常对照明显减少，基底层几乎完全缺乏黑素小体。结论白癜风皮损同时存在表皮钙离子梯度消失和板层脂膜结构紊乱，提示表皮黑素可能与表皮钙梯度形成与渗透性屏障结构完整性相关。

关键词：白癜风显微镜检查,电子,透射板层脂膜钙离子梯度表皮渗透性屏障

HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation

在线全文

学校读者我要写书评

暂无评论

Bone Research 2023年第4期11卷 803-818页

作者： Yuheng Li Weijia Sun Jianwei Li Ruikai Du Wenjuan Xing Xinxin Yuan Guohui Zhong Dingsheng Zhao zizhong liu Xiaoyan Jin Junjie Pan Youyou Li Qi Li Guanghan Kan Xuan Han Shukuan Ling Xiqing Sun Yingxian Li The Key Laboratory of Aerospace Medicine Ministry of EducationThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training CenterBeijingChina The Center of Space Bio-Medicine Beijing Institute of TechnologyBeijingChina Medical College of Soochow University SuzhouJiangsuChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiangChina

Bone marrow mesenchymal stem cell(BMSC)osteogenic differentiation and osteoblast function play critical roles in bone formation,which is a highly regulated *** noncoding RNAs(lncRNAs)perform diverse functions in a variety of biological processes,including BMSC osteogenic *** several studies have reported that HOX transcript antisense RNA(HOTAIR)is involved in BMSC osteogenic differentiation,its effect on bone formation in vivo remains ***,by constructing transgenic mice with BMSC(Prx1-HOTAIR)-and osteoblast(Bglap-HOTAIR)-specific overexpression of HOTAIR,we found that Prx1-HOTAIR and Bglap-HOTAIR transgenic mice show different bone phenotypes in ***,Prx1-HOTAIR mice showed delayed bone formation,while Bglap-HOTAIR mice showed increased bone *** inhibits BMSC osteogenic differentiation but promotes osteoblast function in ***,we identified that HOTAIR is mainly located in the nucleus of BMSCs and in the cytoplasm of *** displays a nucleocytoplasmic translocation pattern during BMSC osteogenic *** first identified that the RNA-binding protein human antigen R(HuR)is responsible for HOTAIR nucleocytoplasmic *** is essential for osteoblast function,and cytoplasmic HOTAIR binds to miR-214 and acts as a ceRNA to increase Atf4 protein levels and osteoblast *** mice,but not Prx1-HOTAIR mice,showed alleviation of bone loss induced by *** study reveals the importance of temporal and spatial regulation of HOTAIR in BMSC osteogenic differentiation and bone formation,which provides new insights into precise regulation as a target for bone loss.

关键词： HOTAIR precise function

The Seeing Observation at Gaomeigu Station

在线全文

学校读者我要写书评

暂无评论

天文研究与技术 1999年第S1期 147-152页

作者： liu zizhong, Luan Di, Shang Qiongzhen (Yunnan Observatory, The Chinese Academy of Sciences, Kunming 650011, China)

The Seeing observation at Gaomeigu station, Lijiang, Yunnan during March, 1995—December, 1996 is introduced in this paper, On the average Fried parameter is equal to 15 34cm (FWHM=0 72″). In the same time, the seeing observation in the 46 nights that the observation time was more than five hours is introduced. On the average Fried parameter is r 0=16 5cm (FWHM=0 67″). For the best seeing on an average r 0=22 36cm (FWHM=0 49″). The mininum on an average is r 0=12 95cm (FWHM=0 85″).

关键词： Site Survey Seeing

The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention

在线全文

学校读者我要写书评

暂无评论

Bone Research 2022年第2期10卷 338-353页

作者： Caizhi liu Xingcheng Gao Yuheng Li Weijia Sun Youjia Xu Yingjun Tan Ruikai Du Guohui Zhong Dingsheng Zhao zizhong liu Xiaoyan Jin Yinlong Zhao Yinbo Wang Xinxin Yuan Junjie Pan Guodong Yuan Youyou Li Wenjuan Xing Guanghan Kan Yanqing Wang Qi Li Xuan Han Jianwei Li Shukuan Ling Yingxian Li State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training CenterBeijingChina The Key Laboratory of Aerospace Medicine Ministry of EducationThe Fourth Military Medical UniversityXi’anShaanxiChina The Second Affiliated Hospital of Soochow University SuzhouJiangsuChina College of Life Sciences Hebei Normal UniversityShijiazhuangHebeiChina Medical College of Soochow University SuzhouJiangsuChina Medical School of Southeast University NanjingJiangsuChina

Mechanical stimulation plays an important role in bone remodeling. Exercise-induced mechanical loading enhances bone strength,whereas mechanical unloading leads to bone loss. Increasing evidence has demonstrated that long noncoding RNAs(lnc RNAs) play key roles in diverse biological, physiological and pathological contexts. However, the roles of lnc RNAs in mechanotransduction and their relationships with bone formation remain unknown. In this study, we screened mechanosensing lnc RNAs in osteoblasts and identified Neat1, the most clearly decreased lnc RNA under simulated microgravity. Of note, not only Neat1 expression but also the specific paraspeckle structure formed by Neat1 was sensitive to different mechanical stimulations, which were closely associated with osteoblast function. Paraspeckles exhibited small punctate aggregates under simulated microgravity and elongated prolate or larger irregular structures under mechanical loading. Neat1 knockout mice displayed disrupted bone formation, impaired bone structure and strength, and reduced bone mass. Neat1 deficiency in osteoblasts reduced the response of osteoblasts to mechanical stimulation. In vivo, Neat1 knockout in mice weakened the bone phenotypes in response to mechanical loading and hindlimb unloading stimulation. Mechanistically, paraspeckles promoted nuclear retention of E3 ubiquitin ligase Smurf1 m RNA and downregulation of their translation, thus inhibiting ubiquitination-mediated degradation of the osteoblast master transcription factor Runx2, a Smurf1 target. Our study revealed that Neat1 plays an essential role in osteoblast function under mechanical stimulation, which provides a paradigm for the function of the lnc RNA-assembled structure in response to mechanical stimulation and offers a therapeutic strategy for long-term spaceflight-or bedrest-induced bone loss and age-related osteoporosis.

关键词： stimulation mec impaired

在线全文

学校读者我要写书评

暂无评论

Au3催化甲酸分解反应机理的密度泛函研究

功能材料 2017年第8期48卷 142-150页

作者：刘雪云刘子忠刘红霞内蒙古师范大学化学与环境科学学院内蒙古自治区绿色催化重点实验室呼和浩特010022

采用密度泛函理论对trans-HCOOH在有无催化剂条件下的各反应通道进行了研究,在B3LYP/6-311+G(d,p)水平上优化了反应通道上各驻点的几何构型,并计算其振动频率和零点能,通过零点能校正计算了各反应通道的活化能。结果表明,trans-HCOOH分... 详细信息

采用密度泛函理论对trans-HCOOH在有无催化剂条件下的各反应通道进行了研究,在B3LYP/6-311+G(d,p)水平上优化了反应通道上各驻点的几何构型,并计算其振动频率和零点能,通过零点能校正计算了各反应通道的活化能。结果表明,trans-HCOOH分解存在着脱氢与脱水两种途径。在无催化剂条件下,脱氢及脱水路径最佳反应通道速控步骤活化能分别高达319.0和302.2kJ/mol,分子很稳定,很难分解。在Au3催化下,两条路径最佳反应通道速控步活化能明显降低,分别为43.6和82.5kJ/mol,trans-HCOOH更易按照生成CO2和H2的途径来进行分解,Au3催化剂的加入活化了C—H键及O—H键,使速控步骤的活化能显著降低。

关键词： Au3催化剂甲酸反应机理密度泛函理论 NBO分析

E_4^(2-),[CoE_4]^+和[P_4CoE_4]^-(E=N～Bi)结构和芳香性的理论预测

在线全文

学校读者我要写书评

暂无评论

化学学报 2010年第22期68卷 2297-2304页

作者：刘子忠王宇婷田维全刘东升葛湘巍内蒙古师范大学化学与环境科学学院内蒙古自治区功能材料物理与化学重点实验室呼和浩特010022 哈尔滨工业大学理论与模拟化学研究所基础与交叉科学研究院哈尔滨150080 内蒙古师范大学计算机工程与信息学院呼和浩特010022

用密度泛函理论杂化密度泛函B3LYP方法研究了E24-,[CoE4]+和[P4CoE4]-(E=N,P,As,Sb,Bi)几何结构、键能及芳香性.结果表明,E42-,[CoE4]+和[P4CoE4]-的基态结构分别具有D4h,C4v和C4v(交错型)对称性.三明治配合物中,金属与配体间存在σ,π... 详细信息

用密度泛函理论杂化密度泛函B3LYP方法研究了E24-,[CoE4]+和[P4CoE4]-(E=N,P,As,Sb,Bi)几何结构、键能及芳香性.结果表明,E42-,[CoE4]+和[P4CoE4]-的基态结构分别具有D4h,C4v和C4v(交错型)对称性.三明治配合物中,金属与配体间存在σ,π和δ三种成键方式,P4与E4间相互影响较小.E4对P4中的P—P键长影响随着N,P,As,Sb,Bi顺序逐渐变长,中心Co离子与E4间的键合能随N,P,As,Bi,Sb的顺序增大.N42-的环外具有弱芳香性,其它E42-环中心及环外均为反芳香性.除[CoN4]+外,其它[CoE4]+中的E4环均具有较强的中心和内芳香性及弱的外反芳香性.[P4CoE4]-中的P4和E4均具有较大的中心、内和外芳香性,且P4环芳香性随N,P,As,Sb,Bi顺序逐渐递增.

关键词：三明治配合物结构芳香性密度泛函