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Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

当代医学科学（英文） 2024年第4期44卷 809-819页

作者： Chen-guang YAO zi-jia zhao Ting TAN jiang-ning YAN Zhong-wei CHEN Jun-tao XIONG Han-luo LI Yan-hong WEI Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education & Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National"111"Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan 430068China Centerfor Evaluation of Hubei Medical Products Administration Wuhan 430068China

Objective:Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying ***:Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related ***:MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 ***:Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer mitochondria mitophagy polyoxometalate

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激光选区熔化制备纯钽高温拉伸性能研究

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稀有金属与硬质合金 2024年第3期52卷 48-54页

作者：闫超吕绪明贾子朝粒子输运与富集技术全国重点实验室天津300180 核工业理化工程研究院天津300180

对采用激光选区熔化(SLM)技术横、纵向成形的纯钽试样开展力学性能研究。采用SEM、XRD对所制备钽试样的微观组织及物相组成进行研究,并采用显微硬度计、万能试验机对其硬度及室温和高温拉伸性能进行研究。结果表明,SLM横向成形钽试样的... 详细信息

对采用激光选区熔化(SLM)技术横、纵向成形的纯钽试样开展力学性能研究。采用SEM、XRD对所制备钽试样的微观组织及物相组成进行研究,并采用显微硬度计、万能试验机对其硬度及室温和高温拉伸性能进行研究。结果表明,SLM横向成形钽试样的组织为等轴晶粒;SLM纵向成形钽试样的组织为拉长晶粒。SLM钽试样的物相组织为BCC-Ta,Ta含量大于99.995%,平均致密度为99.87%,平均显微硬度为191 HV。在室温条件下,SLM钽试样展现出优异的强度和延展性。随着拉伸温度的升高,SLM钽试样的强度和延展性均下降,600℃下由于动态应变时效其延展性最差。SLM钽试样的室温断口形貌为韧性断裂特征,随着拉伸温度的升高,其断口解理特征越来越明显,在1 200℃下断口出现严重的氧化腐蚀,呈沿晶氧化腐蚀开裂的特征。在室温至1 200℃范围内,SLM纵向成形钽试样的拉伸性能略优于SLM横向成形钽试样。

关键词：钽激光选区熔化高温拉伸硬度力学性能断口形貌

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真空电子束熔炼炉用坩埚冷却装置的抗震试验研究

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真空 2024年第3期61卷 84-89页

作者：成成贾子朝李菊闫超核工业理化工程研究院天津300180

自主研制了一种坩埚冷却装置,用于真空电子束熔炼炉中坩埚的安全冷却。本文对该坩埚冷却装置进行了抗震鉴定试验,测试了坩埚冷却装置在抗震试验前后的共振频率,并利用地震台进行了5次运行基准地震试验和1次安全停堆地震试验。试验结果表... 详细信息

自主研制了一种坩埚冷却装置,用于真空电子束熔炼炉中坩埚的安全冷却。本文对该坩埚冷却装置进行了抗震鉴定试验,测试了坩埚冷却装置在抗震试验前后的共振频率,并利用地震台进行了5次运行基准地震试验和1次安全停堆地震试验。试验结果表明:该坩埚冷却装置具有足够的抗震强度,能够在规定的地震条件下正常运行,满足抗震性能要求。

关键词：坩埚冷却装置共振频率抗震试验地震台抗震性能

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电子束熔炼用水冷铜坩埚研制

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真空 2024年第2期61卷 78-85页

作者：闫超张涛贾子朝成成赵国华核工业理化工程研究院天津300180 粒子输运与富集技术全国重点实验室天津300180

电子束熔炼作为一种优异的真空冶炼技术,其核心部件水冷坩埚的结构设计尤为重要,坩埚的冷却性能将直接影响电子束熔炼的效果及安全。通过理论分析、数值模拟、试验考核,研究了坩埚水道结构、熔池形貌对坩埚冷却能力的影响。通过坩埚选... 详细信息

电子束熔炼作为一种优异的真空冶炼技术,其核心部件水冷坩埚的结构设计尤为重要,坩埚的冷却性能将直接影响电子束熔炼的效果及安全。通过理论分析、数值模拟、试验考核,研究了坩埚水道结构、熔池形貌对坩埚冷却能力的影响。通过坩埚选材、熔池利用率分析、能量损耗分析和冷却计算确定了坩埚结构,建立了数值仿真模型,采用模拟计算方式对比了两种熔池形貌的坩埚在不同装料量下的冷却性能,并针对性能优异的坩埚开展了试验考核。结果表明:模拟不同锭厚条件下,坩埚B的冷却水温度和坩埚表面温度较坩埚A均偏低,坩埚B的熔池形状和水道结构匹配更合理,散热效果更好。试验考核过程中坩埚B状态稳定,满足设计要求。

关键词：水冷坩埚水道设计熔池形貌数值模拟电子束熔炼

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高精度电子束偏转系统优化建立与仿真研究

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真空 2024年第2期61卷 47-52页

作者：贾子朝郭志伟高学林核工业理化工程研究院天津300180 粒子输运与富集技术全国重点实验室天津300180

电子束的高精度传输控制对于确保电子枪在金属熔炼、蒸发镀膜及电子束焊接等领域的可靠应用具有重要意义。针对电子束在金属物料蒸发环境中的传输控制技术开展研究,基于CST粒子仿真分析软件建立了30 kV电子束偏转模型,分析了偏转装置结... 详细信息

电子束的高精度传输控制对于确保电子枪在金属熔炼、蒸发镀膜及电子束焊接等领域的可靠应用具有重要意义。针对电子束在金属物料蒸发环境中的传输控制技术开展研究,基于CST粒子仿真分析软件建立了30 kV电子束偏转模型,分析了偏转装置结构及位置参数变化对电子束分布的影响规律,通过仿真设计优化得到了满足需求的电子束偏转控制参数与结构。试验验证表明该结构下的电子束传输轨迹可控,建立的30 kV电子束偏转系统满足要求。

关键词：电子束传输 CST仿真偏转装置优化

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一种电子束熔炼用供料、熔铸拖锭装置研制

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真空 2024年第1期61卷 78-82页

作者：闫超张涛贾子朝成成许文强核工业理化工程研究院天津300180

电子束熔炼具有高真空、高能量密度、可精准控制等特点,被广泛应用于难熔金属行业。本文依托核工业理化工程研究院电子枪技术和LT102真空装置,设计研制了一套难熔金属电子束熔炼用供料、熔铸拖锭装置。主要阐述了供料、熔铸拖锭装置的... 详细信息

电子束熔炼具有高真空、高能量密度、可精准控制等特点,被广泛应用于难熔金属行业。本文依托核工业理化工程研究院电子枪技术和LT102真空装置,设计研制了一套难熔金属电子束熔炼用供料、熔铸拖锭装置。主要阐述了供料、熔铸拖锭装置的设计技术要求,针对难熔金属进行了熔炼功率计算,并对结构设计功能进行了详细介绍。所研制的供料装置具有多工位、换料功能,拖锭装置具备水冷、下拉、旋转功能。最终装配测试的供料、熔铸拖锭装置性能满足设计要求,整体熔炼实验中设备运行良好。

关键词：电子束熔炼供料装置熔铸拖锭装置真空熔炼炉难熔金属

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Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo zhao jia-Wei Wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing *** such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth *** intrinsic phenology is primarily genetic and can be altered by environmental *** evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round *** proportion,however,is reversed in ***,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate *** significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further *** findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle *** implies that engineering plant life history strategy can be achieved by manipulating only a few key *** this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

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Stacking MoS_(2) flower-like microspheres on pomelo peels-derived porous carbon nanosheets for high-efficient X-band electromagnetic wave absorption

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Nano Research 2024年第3期17卷 1607-1615页

作者： jia zhao Zhe Gu Qingguo Zhang College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China

The key to solve increasingly severe electromagnetic(EM)pollution is to explore sustainable,easily prepared,and cost-effective EM wave absorption materials with exceptional absorption ***,instead of anchoring on carbon materials in single layer,MoS_(2) flower-like microspheres were stacked on the surface of pomelo peels-derived porous carbon nanosheets(C)to fabricate MoS_(2)@C nanocomposites by a facile solvothermal *** wave absorption performances of MoS_(2)@C nanocomposites in X-band were systematically investigated,indicating the minimum reflection loss(RLmin)of-62.3 dB(thickness of 2.88 mm)and effective absorption bandwidth(EAB)almost covering the whole X-band(thickness of 2.63 mm)with the filler loading of only 20 wt.%.Superior EM wave absorption performances of MoS_(2)@C nanocomposites could be attributed to the excellent impedance matching characteristic and dielectric loss capacity(conduction loss and polarization loss).This study revealed that the as-prepared MoS_(2)@C nanocomposites would be a novel prospective candidate for the sustainable EM absorbents with superior EM wave absorption performances.

关键词： pomelo peels-derived porous carbon nanosheets(C) MoS_(2)@C nanocomposites stacked structure electromagnetic(EM)wave absorption

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Prediction model establishment and validation for enteral nutrition aspiration during hospitalization in patients with acute pancreatitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2583-2591页

作者： Ping Hou Hao-Jun Wu Tang Li jia-Bin Liu Quan-Qing zhao Hong-jiang zhao zi-Ming Liu Division II of General Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Surgery West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Department of Thyroid Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospital-Chengdu Shangjin NanfuWest China HospitalSichuan UniversityChengdu 611730Sichuan ProvinceChina Division of Biliary Tract Surgery Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease caused by abnormal activation of pancreatic enzymes and can lead to self-digestion of pancreatic tissues and dysfunction of other *** nutrition plays a vital role in the treatment of AP because it can meet the nutritional needs of patients,promote the recovery of intestinal function,and maintain the barrier and immune functions of the ***,the risk of aspiration during enteral nutrition is high;once aspiration occurs,it may cause serious complications,such as aspiration pneumonia,and suffocation,posing a threat to the patient’s *** study aims to establish and validate a prediction model for enteral nutrition aspiration during hospitalization in patients with *** To establish and validate a predictive model for enteral nutrition aspiration during hospitalization in patients with *** A retrospective review was conducted on 200 patients with AP admitted to Chengdu Shangjin Nanfu Hospital,West China Hospital of Sichuan University from January 2020 to February *** data were collected from the electronic medical record *** were randomly divided into a validation group(n=40)and a modeling group(n=160)in a 1:4 ratio,matched with 200 patients from the same time *** modeling group was further categorized into an aspiration group(n=25)and a non-aspiration group(n=175)based on the occurrence of enteral nutrition aspiration during *** and multivariate logistic regression analyses were performed to identify factors influencing enteral nutrition aspiration in patients with AP during hospitalization.A prediction model for enteral nutrition aspiration during hospitalization was constructed,and calibration curves were used for *** operating characteristic curve analysis was conducted to evaluate the predictive value of the *** There was no statistically significant difference in general data between the validation and mode

关键词： Acute pancreatitis Hospitalization Enteral nutrition Predictive model Aspiration

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Barrier Option Pricing in Regime Switching Models with Rebates

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 849-861页

作者： Yue-xu zhao jia-yong BAO School of Economics Hangzhou Dianzi UniversityHangzhou 310018China School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China

This paper is concerned with the valuation of single and double barrier knock-out call options in a Markovian regime switching model with specific *** integral formulas of the rebates are derived via matrix Wiener-Hopf factorizations and Fourier transform techniques,also,the integral representations of the option prices are ***,the first-passage time density functions in two-state regime model are *** applications,several numerical algorithms and numerical examples are presented.

关键词： option pricing Markovian regime switching Wiener-Hopf factorization Fourier transform

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