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Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma

World Journal of Gastroenterology 2024年第21期30卷 2763-2776页

作者： Li He Wan-Sheng Ji Hai-Long Jin Wen-Jing Lu Yuan-Yuan Zhang Hua-Guang Wang Yu-Yu Liu Shuang Qiu Meng Xu zi-peng lei Qian Zheng Xiao-Li Yang Qing Zhang Department of Organ Transplantation The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China School of Clinical Medicine Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Clinical Research Center The Affiliated Hospital of Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of Laboratory Medicine The Third Medical Centre of Chinese PLA General HospitalBeijing 100039China Physiatry Department Naval Aviation UniversityYantai 100071Shandong ProvinceChina

BACKGROUND At present,liver transplantation(LT)is one of the best treatments for hepatocellular carcinoma(HCC).Accurately predicting the survival status after LT can significantly improve the survival rate after LT,and ensure the best way to make rational use of liver *** To develop a model for predicting prognosis after LT in patients with *** Clinical data and follow-up information of 160 patients with HCC who underwent LT were collected and *** expression levels of alphafetoprotein(AFP),des-gamma-carboxy prothrombin,Golgi protein 73,cytokeratin-18 epitopes M30 and M65 were measured using a fully automated chemiluminescence *** best cutoff value of biomarkers was determined using the Youden *** regression analysis was used to identify the independent risk factors.A forest model was constructed using the random forest *** evaluated the accuracy of the nomogram using the area under the curve,using the calibration curve to assess consistency.A decision curve analysis(DCA)was used to evaluate the clinical utility of the *** The total tumor diameter(TTD),vascular invasion(VI),AFP,and cytokeratin-18 epitopes M30(CK18-M30)were identified as important risk factors for outcome after *** nomogram had a higher predictive accuracy than the Milan,University of California,San Francisco,and Hangzhou *** calibration curve analyses indicated a good *** survival and recurrence-free survival(RFS)of high-risk groups were significantly lower than those of low-and middle-risk groups(P<0.001).The DCA shows that the model has better clinical *** The study developed a predictive nomogram based on TTD,VI,AFP,and CK18-M30 that could accurately predict overall survival and RFS after *** can screen for patients with better postoperative prognosis,and improve longterm survival for LT patients.

关键词： Hepatocellular carcinoma Liver transplantation Liver cancer Nomogram Prognosis

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Two-Stage Online Debiased Lasso Estimation and Inference for High-Dimensional Quantile Regression with Streaming Data

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Journal of Systems Science & Complexity 2024年第3期37卷 1251-1270页

作者： peng Yanjin WANG lei School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

In this paper,the authors propose a two-stage online debiased lasso estimation and statistical inference method for high-dimensional quantile regression(QR)models in the presence of streaming *** the first stage,the authors modify the QR score function based on kernel smoothing and obtain the online lasso smoothed QR estimator through iterative *** estimation process only involves the current data batch and specific historical summary statistics,which perfectly accommodates to the special structure of streaming *** the second stage,an online debiasing procedure is carried out to eliminate biases caused by the lasso penalty as well as the accumulative approximation error so that the asymptotic normality of the resulting estimator can be *** authors conduct extensive numerical experiments to evaluate the performance of the proposed *** experiments demonstrate the effectiveness of the proposed method and support the theoretical *** application to the Beijing PM2.5 Dataset is also presented.

关键词： Adaptive tuning asymptotic normality debiased lasso online updating quantile regres-sion

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Diffractive neural networks with improved expressive power for gray-scale image classification

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Photonics Research 2024年第6期12卷 1159-1166页

作者： MINJIA ZHENG WENZHE LIU lei SHI JIAN zi State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-Photonic Structures(Ministry of Education)and Department of PhysicsFudan UniversityShanghai 200433China Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Shanghai Research Center for Quantum Sciences Shanghai 210315China

In order to harness diffractive neural networks(DNNs)for tasks that better align with real-world computer vision requirements,the incorporation of gray scale is ***,DNNs are not powerful enough to accomplish gray-scale image processing tasks due to limitations in their expressive *** our work,we elucidate the relationship between the improvement in the expressive power of DNNs and the increase in the number of phase modulation layers,as well as the optimization of the Fresnel number,which can describe the diffraction *** demonstrate this point,we numerically trained a double-layer DNN,addressing the prerequisites for intensitybased gray-scale image ***,we experimentally constructed this double-layer DNN based on digital micromirror devices and spatial light modulators,achieving eight-level intensity-based gray-scale image classification for the MNIST and Fashion-MNIST data *** optical system achieved the maximum accuracies of 95.10%and 80.61%,respectively.

关键词： process mirror limitations

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Weyl Type Theorem for Bounded Linear Operator and Its Functional Calculus

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Acta Mathematica Sinica,English Series 2024年第2期40卷 528-536页

作者： Gao Hui zi FENG peng Tong LI School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China

Let H be a complex infinite dimensional Hilbert space and B(H)be the algebra of all bounded linear operators on *** this paper,we mainly study the operators that satisfy both a-Weyl's theorem and property(R).Also,the operators whose functional calculus satisfies the two properties are also *** give the features for the operator or its functional calculus for which both a-Weyl's theorem and property(R)hold.

关键词： a-Weyl's theorem property(R) functional calculus

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Modulation of d-orbital to realize enriched electronic cobalt sites in cobalt sulfide for enhanced hydrogen evolution in electrocatalytic water/seawater splitting

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Rare Metals 2024年第2期43卷 511-521页

作者： Jian-peng Sun Yu Zheng zi-Sheng Zhang Xiang-Chao Meng zi-Zhen Li Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao266100China Shanxi Institute of Energy Taiyuan030600China Department of Chemical and Biological Engineering Faculty of EngineeringUniversity of OttawaOttawaONK1N6 N5Canada

Herein,a novel single-atomic Pt doping and interface-rich CoS/Co(OH)_(2)(Pt-CoS/Co(OH)_(2)/C)electrocatalyst has been successfully *** from precise regulation of d-orbital electronic structure modulation on Co site,Pt-CoS/Co(OH)_(2)/C exhibited remarkable HER activity and high stability for hydrogen evolution in splitting both water(73 mV@10 mA·cm^(−2)) and seawater(87 mV@10 mA·cm^(−2)).Notably,atomic Pt doping was introduced into CoS/Co(OH)_(2),which could produce local unbalanced Coulombic force and significantly increased the number of S vacancies,and then expose abundant Co ***,Co(OH)_(2) in Pt-CoS/Co(OH)_(2)/C could act as the adsorption sites for H_(2)O in hydrogen evolution reaction *** functional theory results also proved that atomic Pt doping,S vacancies and Co(OH)_(2) coupling could result in the formation of enriched electronic Co sites and optimize d_(z2) orbital electronic structure,and then realize the depth upward shift of d-band center and enhance the adsorption of H*on Co sites.

关键词： Electrocatalysts Hydrogen evolution reaction Pt-CoS/Co(OH)_(2) d-band center Electronic structure Water/seawater electrolysis

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Enhancing force sensing in a squeezed optomechanical system with quantum nondemolition measurement

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Communications in Theoretical Physics 2024年第1期76卷 49-60页

作者： Shi-lei Chao zi-Hao Li Xin-You Lü School of Physics Huazhong University of Science and Technology430074 WuhanChina

A theoretical scheme is proposed to enhance the sensitivity of force sensors with quantum nondemolition measurement(QND)in an optomechanical setup assisted by four-tone optical driving and an optical parametric amplifier(OPA).With the help of special drive,the system can be simplified as the typical type of QND for force sensing,so that the backaction noise can be evaded to surpass the standard quantum ***,the added noise can be suppressed owing to the modified optical susceptibility resulting from the *** introducing two oscillators coupling with two charged bodies respectively,the signal can be enhanced with the nonlinearity caused by Coulomb interaction,while the noise presents an exponential ***,considering the homodyne detection effect,the range of system parameters and frequency bands will be *** present investigation may provide a route toward simultaneously evading backaction noise,reducing the mechanical thermal noise,and enhancing the external signal,which can be an alternative design for sensitive devices.

关键词： force sensing optical parametric amplifier quantum non-demolition measurement optomechanical system

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Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan QIU Sheng-lei SHANG Ju-ju WANG zi LAI Xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

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Realizing high initial Coulombic efficiency in manganese-based layered oxide cathodes for sodium-ion batteries via P2/O'3 biphasic structure optimization

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Rare Metals 2024年第5期43卷 2093-2102页

作者： Bo peng zi-Hao Zhou Ping Xuan Jie Xu Lian-Bo Ma School of Materials Science and Engineering Anhui University ofTechnologyMa'anshan 243002China Anhui Product Quality Supervision&Inspection Research Institute Hefei 230051China

Mn-based layered oxides are among the most promising cathode materials for sodium-ion batteries owing to the advantages of abundance,environmenta friendliness,low cost and high specific capacity.P2 and O'3 are two representative structures of Mn-based layered ***,the P2 structure containing insufficien Na generally exhibits low initial charge capacity,while O'3structure with sufficient Na delivers high initial charge capacity but poor cycle *** study prepared a multitude of Na_(x)MnO_(2)(x=0.7,0.8,0.9)cathode materials with varying P2/O'3 ratios and further investigated their electrochemical *** optimized Na_(0.8)MnO_(2) comprising 69.9 wt%O'3 and 30.1 wt%P2 phase,exhibited relatively balanced specific capacity,Coulombic efficiency and cycle ***,it achieved a high specific capacity of 128.9 mAh·g^(-1) with an initia Coulombic efficiency of 98.2%in half-cell configuration The Na_(0.8)MnO_(2)//hard carbon full cell also achieved a high specific capacity of 126.7 mAh·g^(-1) with an initia Coulombic efficiency of 98.9%.Moreover,the capacity fading mechanism was revealed by combining in-situ and ex-situ X-ray *** findings of this study provide theoretical guidance for further modification design of Mnbased layered cathodes.

关键词： Sodium-ion batteries Cathode materials Mn-based layered oxides P2/0'3 composites

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Feature-Grounded Single-Stage Text-to-Image Generation

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Tsinghua Science and Technology 2024年第2期29卷 469-480页

作者： Yuan Zhou peng Wang lei Xiang Haofeng Zhang School of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing 210044China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Recently,Generative Adversarial Networks(GANs)have become the mainstream text-to-image(T2I)***,a standard normal distribution noise of inputs cannot provide sufficient information to synthesize an image that approaches the ground-truth image ***,the multistage generation strategy results in complex T2I ***,this study proposes a novel feature-grounded single-stage T2I model,which considers the“real”distribution learned from training images as one input and introduces a worst-case-optimized similarity measure into the loss function to enhance the model's generation *** results on two benchmark datasets demonstrate the competitive performance of the proposed model in terms of the Frechet inception distance and inception score compared to those of some classical and state-of-the-art models,showing the improved similarities among the generated image,text,and ground truth.

关键词： text-to-image(T2I) feature-grounded single-stage generation Generative Adversarial Network(GAN)

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Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu Wang Mei-Yu Lv Xiang-peng Li peng Zhang Yue-Ze Wang lei Shen Xiu-Hai Wu Bo Fu peng-Yu Guo zi-Qi Wang Dong-Bing Cheng Hao Wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

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