Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure
作者机构：Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China
出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)
年 卷 期：2024年第30卷第5期
页 面：458-467页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：Supported by the National Key Research&Development Program (No.2019YFC1708602)
主 题：botanical drugs chronic heart failure myocardial metabolism pharmacological effects review
摘 要：Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.
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