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Orchestration between ILC2s and Th2 cells in shaping type 2 immune responses

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Cellular & Molecular Immunology 2019年第3期16卷 225-235页

作者： Rama Krishna Gurram jinfang zhu Molecular and Cellular Immunoregulation Section Laboratory of Immune System BiologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892USA

The type 2 immune response is critical for host defense against large parasites such as *** the other hand,dysregulation of the type 2 immune response may cause immunopathological conditions,including asthma,atopic dermatitis,rhinitis,and ***,a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding *** classical model of type 2 immunity mainly involves the differentiation of type 2 T helper(Th2)cells and the production of distinct type 2 cytokines,including interleukin-4(IL-4),IL-5,and *** 2 innate lymphoid cells(ILC2s)were recently recognized as another important source of type 2 *** eosinophils,mast cells,and basophils can also express type 2 cytokines and participate in type 2 immune responses to various degrees,the production of type 2 cytokines by the lymphoid lineages,Th2 cells,and ILC2s in particular is the central event during the type 2 immune *** this review,we discuss recent advances in our understanding of how ILC2s and Th2 cells orchestrate type 2 immune responses through direct and indirect interactions.

关键词： Type 2 immune response type 2 T helper cell(Th2) Group 2 innate lymphoid cell(ILC2) Allergy and asthma

呼吸肌训练应用于阻塞性睡眠呼吸暂停低通气综合征治疗的临床价值探讨

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中外医疗 2024年第18期43卷 38-41,65页

作者：朱洁祝晋芳金杨钱俊枫常熟市第一人民医院呼吸与危重症医学科江苏常熟215500

目的研究阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-hypopnea Syndrome,OSAHS)患者接受呼吸肌训练的临床效果。方法便利选取2021年1月—2022年12月常熟市第一人民医院门诊的106例OSAHS患者作为研究对象,采用数字表法分... 详细信息

目的研究阻塞性睡眠呼吸暂停低通气综合征(Obstructive Sleep Apnea-hypopnea Syndrome,OSAHS)患者接受呼吸肌训练的临床效果。方法便利选取2021年1月—2022年12月常熟市第一人民医院门诊的106例OSAHS患者作为研究对象,采用数字表法分成两组,每组53例,对照组(应用减重、运动锻炼等常规治疗方案),研究组(在常规治疗基础上展开呼吸肌训练),均给予8周的治疗。比较两组患者治疗前后的嗜睡情况[采用Epworth嗜睡量表(Epworth Sleepiness Scale,ESS)评估]、肺容量及功能、睡眠监测等相关指标。结果治疗8周后,研究组ESS评分为(6.75±2.05)分,低于对照组的(10.05±2.46)分,差异有统计学意义(t=7.502,P<0.05)。治疗8周后,研究肺容量及功能指标高于对照组,差异有统计学意义(P均<0.05)。治疗8周后,研究组呼吸暂停时间、最长低通气时间、睡眠呼吸暂停低通气指数、微觉醒次数均低于对照组,最低血氧饱和度高于对照组,差异有统计学意义(P均<0.05)。结论治疗OSAHS患者时,联合呼吸肌训练治疗有助于患者肺功能恢复,呼吸暂停低通气症状好转,可提升患者睡眠质量,具有一定的疗效。

关键词：呼吸肌训练阻塞性睡眠呼吸暂停低通气综合征临床价值

小白杏生理落果中多酚提取及体外抗氧化活性分析

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新疆农业科学 2024年第3期61卷 623-631页

作者：李硕尼格尔热依·亚迪卡尔朱金芳冯作山邓术升新疆农业大学食品科学与药学学院乌鲁木齐830052 新疆果品采后科学与技术重点实验室乌鲁木齐830052

【目的】优化小白杏生理落果中多酚提取工艺,并研究其提取物抗氧化活性。为小白杏生理落果抗自由基氧化功能食品的开发与利用奠定基础。【方法】以生理落果小白杏为原料,在单因素试验的基础上,采用响应面试验确定最佳工艺,并用分光光度... 详细信息

【目的】优化小白杏生理落果中多酚提取工艺,并研究其提取物抗氧化活性。为小白杏生理落果抗自由基氧化功能食品的开发与利用奠定基础。【方法】以生理落果小白杏为原料,在单因素试验的基础上,采用响应面试验确定最佳工艺,并用分光光度法测定多酚提取物的体外抗氧化活性。【结果】小白杏多酚的最佳提取工艺为提取时间34 min、提取温度60℃、液料比21∶1、乙醇浓度70%,小白杏生理落果多酚得率为12.50 mg/g。验证试验结果与预测值相对标准偏差为1.31%,回归模型适用于小白杏多酚的提取。小白杏多酚清除ABTS^(+)、DPPH、O_(2)^(-)的IC_(50)值分别为66.35、55.84和103.00μg/mL,其清除自由基的能力由强到弱依次为DPPH、ABTS^(+)、O_(2)^(-);小白杏生理落果多酚对NO^(2-)的清除能力较弱。【结论】小白杏生理落果多酚能不同程度地清除ABTS^(+)、DPPH、O_(2)^(-)、NO^(2-),具有一定的体外抗氧化活性,可用作抗自由基氧化功能食品的原料。

关键词：小白杏生理落果多酚提取响应面抗氧化

Study on the interaction between Jak3 and IL-2R γ using the yeast two-hybrid system

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Chinese Science Bulletin 1999年第18期44卷 1664-1669页

作者： jinfang zhu Wei Tang Hongbin Ji Zhongcheng Zheng Xinyuan Liu Shanghai Institute of Biochemistry Chinese Academy of Sciences Shanghai China

Both interleukin-2 (IL-2) receptor y subunit and non-receptor tyrosine kinase Jak3 play important roles in IL-2 physiological functions. Jak3 has been known to bind IL-2Ry and the interaction is very important for IL-2 signaling. In order to find the domains directly involved in the interaction between IL-2Ry and Jak3, various deletion mutants have been constructed

关键词： IL-2Rγ Jak3 yeast two-hybrid system interaction.

JAK3 mediates c-myc gene expression induced by interleukin-2

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Chinese Science Bulletin 1998年第4期43卷 308-311页

作者： zhu jinfang Lu Linrong Ji Hongbin Zheng Zhongcheng J. Thèze Liu Xinyuan Chinese Acad Sci Shanghai Inst Biochem Shanghai 200031 Peoples R China Inst Pasteur Paris France

C myc gene expression can be rapidly induced by IL 2 through intracellular signal transduction which is triggered by the interaction between IL 2 and its receptor （IL 2R）. JAK3 which associates to the intracellular domain of IL2R γ may play a critical role in this process. To reveal the action of JAK3 in c myc induction, a chimeric receptor gene IL2R α/γ/Δ NJAK3 is constructed which consists of extracellular domain derived from IL 2R α subunit （IL2R α）, the transmembrane sequence derived from IL2R γ and the cytoplasmic domain derived from the catalytic domain of JAK3 （Δ NJAK3）, and then transfected this chimeric gene into mouse fibroblast cell line L929 β which had been transfected with IL2R β gene and stably expressed IL2R β in high level. In the transfectants coexpressing IL2R β and α/γ/Δ NJAK3, the stimulation of IL2 could intensively induce c myc gene expression. Because the whole cytoplasmic domain of IL2R γ which could recruit signaling molecules was replaced by JAK3 and the c myc could be still induced by IL2 in this situation, the results here gave the direct evidence demonstrating that JAK3 plays an important role in c myc gene expression induced by IL2.

关键词： interleukin 2(IL 2) JAK3(Janus Kinase 3) c myc gene signal transduction.

褪黑素处理对采后‘赤霞珠’葡萄黑曲霉病抗性的影响

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植物生理学报 2024年第3期60卷 461-470页

作者：石淼张珍珍高琛瑜李飞飞董荣乔丹薛锋魏登攀武运黄文书朱金芳新疆农业大学食品科学与药学学院乌鲁木齐830052 吐鲁番楼兰酒庄股份有限公司新疆鄯善838299

为研究褪黑素(MT)对葡萄(Vitis vinifera)果实黑曲霉(Aspergillus subgenus Circumdati,section Nigri)病抗性的影响,本试验以‘赤霞珠’(‘Cabernet Sauvignon’)葡萄为试材,采用褪黑素采前喷施和采后浸泡的方法处理葡萄果实,初步探究... 详细信息

为研究褪黑素(MT)对葡萄(Vitis vinifera)果实黑曲霉(Aspergillus subgenus Circumdati,section Nigri)病抗性的影响,本试验以‘赤霞珠’(‘Cabernet Sauvignon’)葡萄为试材,采用褪黑素采前喷施和采后浸泡的方法处理葡萄果实,初步探究两次褪黑素处理提高葡萄果实黑曲霉病抗性的作用机制。结果表明,褪黑素可有效提高葡萄果实对黑曲霉病的抗性,采前喷施150μmol·L^(-1)褪黑素相较于对照可显著降低采后果实的发病率,但100~200μmol·L^(-1)褪黑素体外抑制炭黑曲霉(***)菌丝生长的效果不明显,采后150μmol·L^(-1)褪黑素处理相较于对照组接种炭黑曲霉的发病率降低了30.7%;采前结合采后150μmol·L^(-1)褪黑素处理可以降低果实失重率,提高葡萄果实中抗病相关酶活性,增加苯丙烷途径次生代谢物总酚、类黄酮和木质素含量。综上,采前结合采后褪黑素处理可通过提高抗病相关酶活性和次生代谢物含量来提高葡萄果实对黑曲霉病的抗性。

关键词： ‘赤霞珠’葡萄褪黑素炭黑曲霉抗病性

Co-loading combretastatin-A4 phosphate and doxorubicin in polymersomes for drug-resistance reversal

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Co-loading combretastatin-A4 phosphate and doxorubicin in po...

GATA3 quantitatively specifies the lineage fates of innate lymphoid cells

2016年中国药学大会暨第十六届中国药师周

作者： jinfang zhu Liyan Qiu College of Food Science and Pharmaceutical Science Xinjiang Agricultural University Department of Polymer Science and Engineering Zhejiang University

＜正＞Drug resistance is one of the most common factors to cause failure of chemotherapy in clinic. This study reported for the first time that combretastain-A4 phosphate（CA4 P） had potential to sensitize drug resistant tumor cells to doxorubicin（DOX）. We designed a novel polymersome Ps-DOX-CA4 P dual-loaded with CA4 P and DOX

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GATA3 quantitatively specifies the lineage fates of innate l...

第十三届全国免疫学学术大会

作者： Chao Zhong jinfang zhu Institute of Systems Biomedicine School of Basic Medical SciencesPeking University Health Science Center Molecular and Cellular Immunoregulation Unit Laboratory of ImmunologyNational Institute of Allergy and Infectious DiseasesNational Institutes of Health

Innate lymphoid cells(ILCs) corresponds the innate counterpart of CD4T helper cells given their paralleled functions. Current studies also revealed the similarity of development between these two lymphoid lineages. While the regulatory function of GATA3 during CD4 T cell development have been understudied, how GATA3 regulates different ILC progenitors is far from clear. Lymphoid tissue inducer(LTi) cells are a very earliest discovered ILC population, but a recent study tracing PLZF expression during ILC generation had shown that they developed in a distinct way from other ILCs. Here, we also found that the LTi cell development was independent of GATA3. In the opposite, the PLZF-expressing progenitors that give rise to other ILCs were completely absent under Gata3 deficiency. Moreover, the PLZFILC progenitor and the LTi progenitor also showed quantitative difference on GATA3 expression. While a GATA3 subset within previously reported common progenitors for all helper-like innate lymphocytes(ChILPs) is found consistent with the PLZF ILC progenitors in generating all non-LTi ILCs, the residual GATA3 subset is mainly composed of the GATA3-independent LTi progenitors, most of which also express RORγt and CCR6. A single cell gene expression analysis also confirmed these differences between the progenitors for LTi and other ILCs. Moreover, in the PLZF ILC progenitors, GATA3 expression positively correlate with most of its lineage specific genes, while negatively correlated with certain LTi lineage specific genes. Thus, GATA3 level in the ILC progenitors fundamentally dictates their developments.

关键词： ILC LTi lineage specification GATA3 Id2

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省直管县改革存在的问题与改进对策

中州学刊 2017年第5期 11-15页

作者：朱进芳信阳师范学院当代马克思主义研究所

近几年,省直管县改革向纵深推进,取得突破性进展,政策红利日益显现。但省直管县改革在发展定位、改革动力、实践方式、市县间关系处理等方面也面临着诸多问题。深入推进省直管县改革,需要着眼于新型城镇化这一大的时代背景,明晰其助力... 详细信息

近几年,省直管县改革向纵深推进,取得突破性进展,政策红利日益显现。但省直管县改革在发展定位、改革动力、实践方式、市县间关系处理等方面也面临着诸多问题。深入推进省直管县改革,需要着眼于新型城镇化这一大的时代背景,明晰其助力县域就地城镇化的定位;加快顶层制度设计,完善配套制度与工作机制;结合地方经济社会发展实际,构建省直管县改革的多元实践形式;协调利益关系,构建市县政府合作共享发展的新机制。

关键词：省直管县改革县域城镇化发展定位市县关系