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Cancer Communications 2023年第5期43卷 625-629页

作者： Ling Peng Yawen Bin Peng Ding Lingjuan Chen Hao Zeng Zelong Xu Liyan Ji Xuan Gao Pian Liu Ye Wang Sheng Zhang zhongxing liao Xuefeng Xia Ruiguang Zhang Fan Tong Xiaorong Dong Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Geneplus-Beijing BeijingP.R.China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijingP.R.China GenePlus-Shenzhen Clinical Laboratory ShenzhenGuangdongP.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Dear editor,The scarcity of routinemetastatic biopsies or resection limits the finding of biomarkers of diagnosis and prognosis in patients with brain *** from necrosis,apoptosis,and secretion of tumor cells,circulating tumor DNA(ctDNA)is widely distributed in various body fluids,including peripheral blood and cerebrospinal fluid(CSF),as an alternative biomarker for tumor-associated analysis[1].Fortunately,genomic alterations of blood ctDNA and CSF ctDNA have been proven as prognostic markers in non-small cell lung cancer(NSCLC)patients with brain metastasis[2,3].

关键词： metastasis patients routine

Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma

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Chinese Journal of Cancer Research 2013年第2期25卷 128-129页

作者： Alexander Chi Sijin Wen Nam P. Nguyen Geraldine Jacobson Scot Remick William Tse zhongxing liao Department of Radiation Oncology West Virginia University Department of Biostatistics West Virginia University Department of Radiation Oncology University of Arizona Mary Babb Randolph Cancer Center Department of Hematology Oncology West Virginia University Department of Radiation Oncology the University of Texas MD Anderson Cancer Center

Although declining in the US due to restrictions of asbestos exposure, malignant pleura/mesothelioma （MPP） remains a very serious thoracic malignancy that is rising in incidence worldwide （1）. Trirnodality therapy with chemotherapy and radiotherapy combined with extrapleural pneumonectomy （EPP） has gained acceptance given the acceptable mortality rate （〈5%） and long term survival reported in patients with epithelial histology, negative margins, and no extrapleural lymph node involvement after trimodalitv treatment （2）.

关键词： Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma

Functional promoter rs189037 variant of ATM is associated with decrease in lung diffusing capacity after irradiation for nonesmall-cell lung cancer

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Chronic Diseases and Translational Medicine 2018年第1期4卷 59-66页

作者： Jose Luis Lopez Guerra Yi-Peng Song Quynh-Nhu Nguyen Daniel R. Gomez zhongxing liao Ting Xu Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Radiation Oncology Virgen del Rocío University HospitalSeville 41013Spain Department of Radiation Oncology Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiShandong 264000China

Objective: Single-nucleotide polymorphisms (SNPs) in the ataxia telangiectasiaemutated gene ATM have been linked with pneumonitis after radiotherapy for lung cancer but have not been evaluated in terms of pulmonary function impairment. Here we investigated potential associations between SNPs in ATM and changes in diffusing capacity of the lung for carbon monoxide (DLCO) in patients with nonesmall-cell lung cancer (NSCLC) after radiotherapy. Methods: From November 1998 through June 2009, 448 consecutive patients with inoperable primary NSCLC underwent definitive (≥60 Gy) radiotherapy, with or without chemotherapy. After excluding patients with a history of thoracic surgery, ra-diation, or lung cancer; without DNA samples available for analysis; or without pulmonary function testing within the 12 months before and the 12 months after radiotherapy, 100 patients were identified who are the subjects of this study. We genotyped two SNPs of ATM previously found to be associated with radiation-induced pneumonitis (rs189037 and rs228590) and evaluated potential correlations between these SNPs and impairment (decreases) in DLCO by using logistic regression analysis. Results: Univariate and multivariate analyses showed that the AA genotype of ATM rs189037 was associated with decreased DLCO after definitive radiotherapy than the GG/AG genotypes (univariate coefficient, -0.122; 95％ confidence interval (CI),-0.236 to -0.008; P = 0.037; and multivariate coefficient, -0.102; 95％ CI, -0.198 to -0.005; P = 0.038)No such correlations were found for rs228590 (univariate coefficient, -0.096; 95％ CI, -0.208 to 0.017; P = 0.096). Conclusions: The AA genotype of ATM rs189037 was associated with higher risk of lung injury than were the GG/AG genotypes in patients with NSCLC treated with radiotherapy. This finding should be validated prospectively with other patient populations.

关键词： Nonesmall-cell lung cancer Radiation therapy Ataxia telangiectasia-mutated gene Single-nucleotide polymorphisms

DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer

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Chronic Diseases and Translational Medicine 2018年第2期4卷 109-116页

作者： Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court zhongxing liao Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Duke University DurhamNC 27708USA Duke Cancer Institute Duke University Medical CenterDurhamNC 27710USA Department of Medical Oncology Henan Cancer HospitalZhengzhouHenan 450008China Department of Radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on 18 F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reac-tivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox pro-portional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r＝－0.175, P＝0.032), particularly among patients with advanced disease (r ＝－0.218, P ＝ 0.015). However, △SUVmax of primary tumor was not significantly associated with DRC (r＝0.005, P＝0.968). SUVmax of regional lymph nodes at diagnosis (r＝－0.307, P＝0.0008) and after (chemo)radiation treatment (r＝－0.329, P＝0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r＝－0.253, P＝0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with △SUVmax after (chemo)radiation.

关键词： DNA repair capacity Standardized uptake value 18F-fluorodeoxyglucose positron emission tomography Outcome Non-small-cell lung cancer

ⅢA期非小细胞肺癌术后三维适形放疗与二维放疗疗效的初步比较分析

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ⅢA期非小细胞肺癌术后三维适形放疗与二维放疗疗效的初步比较分析

非小细胞肺癌术后三维适形放疗与常规放疗的疗效比较(英文)

第三届中国肿瘤学术大会

作者：林原 zhongxing liao Risuko Komaki James D.Cox 复旦大学附属肿瘤医院放疗科美国M.D.安德森癌症研究中心放疗科美国M.D.安德森癌症研究中心放疗科美国M.D.安德森癌症研究中心放疗科

＜正＞目的:回顾性分析比较ⅢA期非小细胞肺癌术后采用常规二维放疗和三维适形放疗的近期疗效及副反应的差异。方法:本文收集1994年12月2日至2002年2月12日美国M.D.安德森癌症研究中心放疗科收治的167例非小细胞肺癌患者,对其中114例... 详细信息

＜正＞目的:回顾性分析比较ⅢA期非小细胞肺癌术后采用常规二维放疗和三维适形放疗的近期疗效及副反应的差异。方法:本文收集1994年12月2日至2002年2月12日美国M.D.安德森癌症研究中心放疗科收治的167例非小细胞肺癌患者,对其中114例经手术证实病理分期为ⅢA期的非小细胞肺癌患者的术后放疗资料进行回顾性分析。其中行二维术后放疗的共63例（简称2D组）,行三维适形放疗的共51例（简称3D组）。末次随访时间为2002年10月1日。

关键词：非小细胞肺癌术后三维适形放疗

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The Chinese-German Journal of Clinical Oncology 2007年第6期6卷 514-518页

作者： Yuan Lin zhongxing liao Ritsuko Komaki Pamela Allen James D. Cox Department of Radiation Oncology Cancer Hospital Fudan University Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China Department of Radiation Oncology The University of Texas M.D. Anderson Cancer Center Houston TX 77030 USA

Objective: To compare the survival fractions and radiation-induced complications of conventional radiotherapy (CV) vs. conformal radiotherapy (CF) for non-small-cell lung cancer (NSCLC) after surgical resection. Methods: Between 1990 and 2002, 167 patients underwent post-radiotherapy either CV (n = 90) or CF (n = 77) for pathological IIIA NSCLC at the University of Texas M.D. Anderson Cancer Center. Patients and tumor characteristics were balanced in the two treatment groups. Surgical resection mainly consisted of lobectomy and mediastinal lymph node dissection. In the CV group, postop- erative radiotherapy was delivered to 54.3 Gy (range 22-69.6 Gy) in 27 fractions (range 11-58 f) for 5-6 weeks, while the CF group with RT to 53.9 Gy (range 50-63 Gy) in 26 fractions (range 25-33 f) for 5-6 weeks. Overall survival, disease-free survival, local control and distant metastasis-free survival were calculated using the Kaplan-Meier method. The complications of radiotherapy were also compared between the two groups. The median follow-up duration was 36 months in the CV group while 24 months in the CF group. Results: No statistically significant differences were found in terms of disease-free survival, local-regional control and distant metastasis-free survival in the two treatment groups. However, the overall survival was found statistically significant different in the two groups (P = 0.014). Postoperative radiotherapy complications such as weight loss, skin reaction, dysphagia, and cardiac related complication were similar in the two groups although the lung fibrosis, cardiac complications and hematologic complications were significantly different, and 8 cases of death in the CV group associated with cardiac complications while none was observed in the CF group. Conclusion: The treatment of stage IIIA NSCLC using either CV or CF postoperative radiotherapy resulted in similar outcomes in terms of local control, disease-free survival and most of complications. However, CF c

关键词：放射线疗法图象处理技术肺癌细胞

Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer

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World Journal of Gastroenterology 2006年第34期12卷 5501-5508页

作者： Shu-Lian Wang zhongxing liao Helen Liu( Jaffer Ajani Stephen Swisher James D Cox Ritsuko Komaki Department of Radiation Oncology Cancer Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Radiation Oncology the University of Texas M D Anderson Cancer Center United States Department of Gastrointestinal Medical Oncology the University of Texas M D Anderson Cancer CenterUnited States Department of Cardiovascular and Thoracic Surgical Oncology the University of Texas M D Anderson Cancer Center United States

AIM: To evaluate the dosimetry, efficacy and toxicity of intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy for patients with locally advanced cervical and upper thoracic esophageal cancer. METHODS: A retrospective study was performed on 7 patients who were definitively treated with IMRT and concurrent chemotherapy. Patients who did not receive IMRT radiation and concurrent chemotherapy were not included in this analysis. IMRT plans were evaluated to assess the tumor coverage and normal tissue avoidance. Treatment response was evaluated and toxicities were assessed. RESULTS: Five- to nine-beam IMRT were used to deliver a total dose of 59.4-66 Gy (median: 64.8 Gy) to the primary tumor with 6-MV photons. The minimum dose received by the planning tumor volume (PTV) of the gross tumor volume boost was 91.2%-98.2% of the prescription dose (standard deviation [SD]: 3.7%-5.7%). The minimum dose received by the PTV of the clinical tumor volume was 93.8%-104.8% (SD: 4.3%-11.1%) of the prescribed dose. With a median follow-up of 15 mo (range: 3-21 mo), all 6 evaluable patients achieved complete response. Of them, 2 developed localrecurrences and 2 had distant metastases, 3 survived with no evidence of disease. After treatment, 2 patients developed esophageal stricture requiring frequent dilation and 1 patient developed tracheal-esophageal fi stula. CONCLUSION: Concurrent IMRT and chemotherapy resulted in an excellent early response in patients with locally advanced cervical and upper thoracic esophageal cancer. However, local and distant recurrence and toxicity remain to be a problem. Innovative approaches are needed to improve the outcome.

关键词：放射治疗化学治疗子宫颈癌食管癌

Investigation of Target Minimum and Maximum Dosimetric Criteria for the Evaluation of Standardized Radiotherapy Plan <br/>—Target Minimum and Maximum Evaluation

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2020年第2期9卷 43-51页

作者： Jialu Yu Huazhi Geng Yutao Gong Mitchell Machtay Himanshu R. Lukka zhongxing liao Ying Xiao Wei Zou Department of Radiation Oncology University of Pennsylvania Philadelphia USA Department of Radiation Oncology University Hospitals of Cleveland Cleveland USA Department of Radiation Oncology Juravinski Cancer Centre at Hamilton Health Sciences Hamilton USA Department of Radiation Oncology M D Anderson Cancer Center Houston USA

Purpose: Standardization of tumor dosimetric coverage is essential for the evaluation of radiotherapy treatment plan quality. National clinical trials network RTOG protocols include tumor target dosimetric criteria that specify the prescription dose and minimum and maximum dose (Dmin and Dmax) coverages. This study investigated the impact of various minimum and maximum dose definitions using tumor control probability (TCP) models. Methods and Materials: Three disease sites (head and neck, lung, and prostate) were studied using target volume dosimetric criteria from the RTOG 0920, 1308, and 0938 protocols. Simulated target dose-volume histograms (DVHs) of Dmin and Dmax were modeled using the protocol specifications. Published TCP models for the three disease sites were applied to the DVH curves. The effects of various dose definitions on TCP were studied. Results: While the prescription dose coverage was maintained, a -3.7% TCP difference was observed for head and neck cancer when the target doses varied by 3.5% of the tumor volume from the point dose. For prostate and lung cancers, -3.3% and -2.2% TCP differences were observed, respectively. The TCPs for head and neck and prostate cancers were more negatively affected by deviations in the Dmin than the TCP for lung cancer. The lung TCP increased to a greater extent with a change in the Dmax compared with the head and neck and prostate TCPs. Conclusions: These results can be used to evaluate plan quality when the target dose only slightly deviates from the dosimetric criteria. When the overall target prescription dose coverage is maintained, the Dmax is recommended to be within 3% of the target volume: 98% (for head and neck and prostate) and 97% (for lung) of the target volume, satisfying the Dmin needed to maintain TCP variations at less than 2.1%. Using 0.03 cc instead of a point dose for Dmin and Dmax criteria minimally impacts TCPs.

关键词： Rodiotherapy Target Dosimetric Criteria

应用最大似然率及随机效应模型探讨非小细胞肺癌放化疗中急性放射性食管炎与照射剂量和疗程的关系

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中国癌症杂志 2006年第12期16卷 1028-1033页

作者：章真 Helen Liu zhongxing liao Ritsuko Komaki James D Cox 德州大学M.D.Andson癌症中心放疗科Houston TX77030美国

背景与目的：局部晚期非小细胞肺癌的治疗疗效差，增加治疗强度如同期放化疗是提高疗效的方法，但毒性反应较大。本研究探讨非小细胞肺癌同期放化疗的治疗方式中，应用最大似然率及随机效应模型探讨非小细胞肺癌放化疗中急性放射性食管... 详细信息

背景与目的：局部晚期非小细胞肺癌的治疗疗效差，增加治疗强度如同期放化疗是提高疗效的方法，但毒性反应较大。本研究探讨非小细胞肺癌同期放化疗的治疗方式中，应用最大似然率及随机效应模型探讨非小细胞肺癌放化疗中急性放射性食管炎的发生率与照射剂量和疗程时间因素的关系。方法：本研究中的39例病例资料来自于1998年3月-2000年11月间在***癌症治疗中心进入随机临床Ⅲ期的同期放化疗治疗研究不能手术的Ⅱ期和Ⅲ期非小细胞肺癌患者。所有的患者在放疗前均接受顺铂和口服依托泊苷（VP-16）的化疗。放疗方案为每次1．2Gy，bid，前后野对照治疗至肿瘤剂量达40～50Gy后，采用避开脊髓的斜野放疗至总剂量69．6Gy。病例分布为amifostine治疗组，19例；非amifostine治疗组，20例。还原三维治疗计划设计并计算了剂量-体积直方图（DVHs）。治疗开始后每周对急性放射性食管炎程度评估1次，在放疗结束后1个月再随访评估1次。评分的标准是根据美国放射治疗研究组（RTOG）的急性反应的标准。采用了多因素的随机效应模型及最大似然率的分析以研究在这39例病例中急性放射性食管炎的严重程度与照射剂量和疗程时间因素的关系，并考虑了不同病例个体间的敏感性差异。结果：在amifostine治疗组有11％（2／19），非amifostine治疗组有30％（6／20）的患者发生Ⅲ度的急性食管炎。在这两组中，急性食管炎的发生率在开始治疗后第4周（累计剂量为48Gy）达高峰并呈一稳定状态。随治疗后期剂量的进一步增加，急性食管炎发生的危险性并不明显增加。原因可能是食管粘膜上皮组织的修复和在治疗后的上皮细胞加速再增殖。疗程中的周剂量或累计周剂量要比整个疗程的总剂量更好地预测急性食管炎的发生。结论：肿瘤累积剂量和患者的内在敏感性与Ⅲ度急性放射性食管炎的发生率有关。欲将发生急性食管炎的危险性降低至10％以下，需限制第4周的累计剂量在36Gy以下，或9Gy／周。这可能为开展IMRT等新技术的治疗提供有用的参考信息。

关键词：非小细胞肺癌最大似然率随机效应模型急性食管炎同期放化疗

应用随机效应模型探讨肺癌放化疗中影响食管炎的剂量和容积因素

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中国癌症杂志 2004年第6期14卷 527-531页

作者：章真 LIU Helen liao zhongxing Ritsuko KOMAKI James DCOX 德州大学M.D.Andson癌症中心放疗科

目的 :应用随机效应模型分析非小细胞肺癌同期放化疗中的急性放射性食管炎发生率与食管受到的照射剂量和容积关系。方法 :6 2例不能手术的Ⅱ期和Ⅲ期非小细胞肺癌患者于 1998年 3月至 2 0 0 0年 11月间在M .D .Anderson癌症治疗中心进... 详细信息

目的 :应用随机效应模型分析非小细胞肺癌同期放化疗中的急性放射性食管炎发生率与食管受到的照射剂量和容积关系。方法 :6 2例不能手术的Ⅱ期和Ⅲ期非小细胞肺癌患者于 1998年 3月至 2 0 0 0年 11月间在M .D .Anderson癌症治疗中心进入随机、临床Ⅲ期的同期放化疗治疗研究 ,比较应用或未用阿米福汀 (amifostine)时对食管毒性反应的作用。对其中 39例有三维治疗计划的病例进行回顾性分析 ,阿米福汀组和非阿米福汀组分别为 19和 2 0例。急性食管炎程度的评估为每周 1次 ,在放疗结束后的 1个月再随访评估 1次。评分的标准根据RTOG急性反应的标准。放疗的方式为 1.2Gy/次 ,2次 /d ,前后野对照治疗至 4 0～ 5 0Gy后采用避开脊髓的斜野放疗 ,至总剂量 6 9.6Gy/ 6周。所有的患者在放疗前均接受顺铂和口服依托泊苷 (VP 16 )的化疗。采用多因素的随机效应模型分析急性食管炎的评分 (严重程度 )与不同的剂量容积因素的关系。结果 :39例中 ,阿米福汀组中 2例(11% ) ,非阿米福汀组 6例 (30 % )患者发生了Ⅲ度的急性食管炎。Ⅲ度急性食管炎最早出现在治疗的第 3周末 ,即累计肿瘤量达 36Gy时。第 4周后 ,呈一平缓的趋势 ,其发生率并不随以后剂量的增加而明显提高。在所有与Ⅲ度食管炎发生有关的剂量和容积因素中 ,以?

关键词：食管炎放疗容积剂量肺癌随机效应模型