DNA repair capacity correlates with standardized uptake values from 18F-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer

作     者：Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao Jiang Xin (Eric);Xu Ting;Wei Qingyi;Li Peng;Gomez Daniel R.;Court Laurence E.;Liao Zhongxing

作者机构：Department of Radiation OncologyThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Duke UniversityDurhamNC 27708USA Duke Cancer InstituteDuke University Medical CenterDurhamNC 27710USA Department of Medical OncologyHenan Cancer HospitalZhengzhouHenan 450008China Department of Radiation PhysicsThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA 

出 版 物：《Chronic Diseases and Translational Medicine》 (慢性疾病与转化医学（英文版）)

年 卷 期：2018年第4卷第2期

页      面：109-116页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the U.S. National Institutes of Health (Q.W.) Cancer Center Core (MD Anderson Cancer Center) 

主　　题：DNA repair capacity Standardized uptake value 18F-fluorodeoxyglucose positron emission tomography Outcome Non-small-cell lung cancer 

摘      要：Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on 18 F-fluorodeoxyglucose positron emission tomography (FDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reac-tivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox pro-portional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r＝－0.175, P＝0.032), particularly among patients with advanced disease (r ＝ －0.218, P ＝ 0.015). However, △SUVmax of primary tumor was not significantly associated with DRC (r＝0.005, P＝0.968). SUVmax of regional lymph nodes at diagnosis (r＝－0.307, P＝0.0008) and after (chemo)radiation treatment (r＝－0.329, P＝0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r＝－0.253, P＝0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with △SUVmax after (chemo)radiation.