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Prognostic value of pre-and post-transplantation 18f-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation

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Chinese Journal of Cancer Research 2017年第6期29卷 561-571页

作者： Zhitao Ying Lan Mi Xuejuan Wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei Wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China

Objective： High-dose chemotherapy （HDC） followed by autologous stem cell transplantation （ASCT） is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma （NHL）. However, a proportion of patients do not respond to ASCT. lSf-fluorodeoxyglueose （fDG） positron emission tomography （PET）/computed tomography （CT） has been widely used for staging, response evaluation, and prognosis prediction. Here, we investigated the prognostic role of PET/CT in NHL patients before and after ASCT. Methods： A retrospective study was conducted at Peking University Cancer Hospital. All NHL patients who underwent ASCT between March 2010 and July 2016 were identified. Patients who had PET/CT scan before and after ASCT were included. Deauville criteria （5-point scale） were used to interpret PET scans. Univariate and multivariate survival analyses were performed using Cox regression. The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic （ROC） curve. Results： In total, 79 patients were enrolled in this study. In univariate analysis, pre- and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival （PfS） and overall survival （OS）. Patients with negative pre-ASCT PET result demonstrated significantly better PfS （84.2% vs. 54.2%） and OS （89.2% vs. 63.6%） than patients with positive pre-ASCT PET result. PfS （91.6% vs. 25.3%） and OS （96.5% vs. 36.8%） were also significantly different between patients with negative and positive post-ASCT PET result. Multivariate analysis also showed a significant association between survival and post-ASCT PET result. ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone. Combined pre- and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation. Deauville criteria score 〉3 was identified as the best cutof

关键词： 18f-fluorodeoxyglucose positron emission tomography computed tomography autologous stem celltransplantation high-dose chemotherapy non-Hodgkin lymphoma

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DNA repair capacity correlates with standardized uptake values from 18f-fluorodeoxyglucose positron emission tomography/CT in patients with advanced non-small-cell lung cancer

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Chronic Diseases and Translational Medicine 2018年第2期4卷 109-116页

作者： Xin (Eric) Jiang Ting Xu Qingyi Wei Peng Li Daniel R. Gomez Laurence E. Court Zhongxing Liao Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Duke University DurhamNC 27708USA Duke Cancer Institute Duke University Medical CenterDurhamNC 27710USA Department of Medical Oncology Henan Cancer HospitalZhengzhouHenan 450008China Department of Radiation Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Objective: The DNA repair capacity (DRC) of tumor cells is an important contributor to resistance to radiation and platinum-based drugs. Because DRC may be affected by tumor cell metabolism, we measured DRC in lymphocytes from patients with non-small-cell lung cancer (NSCLC) and compared the findings with the maximum standardized uptake value (SUVmax) on 18 f-fluorodeoxyglucose positron emission tomography (fDG PET) after (chemo)radiation therapy. Methods: This study included 151 patients with stage IA-IV NSCLC who had fDG PET at a single institution and donated blood samples before chemotherapy. We assessed the correlation of DRC, measured in peripheral T lymphocytes by a host-cell reac-tivation assay with SUVmax and their associations with overall survival (OS) time by hazards ratios calculated with a Cox pro-portional hazards regression model. Results: SUVmax of the primary tumor at diagnosis was inversely associated with lymphocyte DRC (r＝－0.175, P＝0.032), particularly among patients with advanced disease (r ＝－0.218, P ＝ 0.015). However, △SUVmax of primary tumor was not significantly associated with DRC (r＝0.005, P＝0.968). SUVmax of regional lymph nodes at diagnosis (r＝－0.307, P＝0.0008) and after (chemo)radiation treatment (r＝－0.329, P＝0.034) and SUVmax of the primary tumor after (chemo)radiation treatment (r＝－0.253, P＝0.045) were also inversely associated with OS time. Conclusion: DRC was inversely associated with primary tumor SUVmax before treatment but not with △SUVmax after (chemo)radiation.

关键词： DNA repair capacity Standardized uptake value 18f-fluorodeoxyglucose positron emission tomography Outcome Non-small-cell lung cancer

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feasibility of sentinel lymph node biopsy omission after integration of ^(18)f-fDG dedicated lymph node PET in early breast cancer: a prospective phase II trial

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Cancer Biology & Medicine 2022年第7期19卷 1100-1108页

作者： Junjie Li Jingyi Cheng Guangyu Liu Yifeng Hou Genghong Di Benglong Yang Yizhou Jiang Liang Huang feilin Qu Sheng Chen Yan Wang Keda Yu Zhimin Shao Department of Breast Surgery Fudan University Shanghai Cancer Centerand Department of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Department of Nuclear Medicine Fudan University Shanghai Cancer CenterShanghai 200032China

Objective:Sentinel lymph node biopsy(SLNB)is currently the standard of care in clinically node negative(cN0)breast *** present study aimed to evaluate the negative predictive value(NPV)of 18f-fDG dedicated lymph node positron emission tomography(LymphPET)in cN0 ***:This was a prospective phase II trial divided into 2 stages(NCT04072653).In the first stage,cN0 patients underwent axillary LymphPET followed by *** the second stage,SLNB was omitted in patients with a negative preoperative axillary assessment after integration of ***,we report the results of the first *** primary outcome was the NPV of LymphPET to detect macrometastasis of lymph nodes(LN-macro).Results:A total of 189 patients with invasive breast cancer underwent LymphPET followed by surgery with definitive pathological *** patients had LN-macro,and 16 patients had only lymph node *** the 131 patients with a negative LymphPET result,16 patients had LN-macro,and the NPV was 87.8%.After combined axillary imaging evaluation with ultrasound and LymphPET,100 patients were found to be both LymphPET and ultrasound negative,9 patients had LN-macro,and the NPV was 91%.Conclusions:LymphPET can be used to screen patients to potentially avoid SLNB,with an NPV>90%.The second stage of the SOAPET trial is ongoing to confirm the safety of omission of SLNB according to preoperational axillary evaluation integrating LymphPET.

关键词： Breast cancer sentinel lymph node biopsy 18f-fluorodeoxyglucose LymphPET negative predictive value

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^(18)f-fluorodeoxyglucose positron emission tomography/computed tomography comparison of gastric lymphoma and gastric carcinoma

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World Journal of Gastroenterology 2016年第34期22卷 7787-7796页

作者： Xiao-feng Li Qiang fu You-Wen Dong Jian-Jing Liu Xiu-Yu Song Dong Dai Cong Zuo Wen-Gui Xu Department of Molecular Imaging and Nuclear Medicine Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy

AIM To compare ^(18)f-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)f-fDG PET/CT) features in gastric lymphoma and gastric *** Patients with newly diagnosed gastric lymphoma or gastric carcinoma who underwent ^(18)f-fDG PET/CT prior to treatment were included in this study. We reviewed and analyzed the PET/CT features of gastric wall lesions,including fDG avidity,pattern(focal/diffuse),and intensity [maximal standard uptake value:(SUVmax)]. The correlation of SUVmax with gastricclinicopathological variables was investigated by χ~2 test,and receiver-operating characteristic(ROC) curve analysis was performed to determine the differential diagnostic value of SUVmax-associated parameters in gastric lymphoma and gastric carcinoma. RESULTS fifty-two patients with gastric lymphoma and 73 with gastric carcinoma were included in this study. Abnormal gastric fDG accumulation was found in 49 patients(94.23%) with gastric lymphoma and 65 patients(89.04%) with gastric carcinoma. Gastric lymphoma patients predominantly presented with type Ⅰ and type Ⅱ lesions,whereas gastric carcinoma patients mainly had type Ⅲ lesions. The SUVmax(13.39 ± 9.24 vs 8.35 ± 5.80,P formance of SUVmax/THKmax in the evaluation of gastric lesions between gastric lymphoma and gastric carcinoma in comparison with that of SUVmax *** PET/CT features differ between gastric lymphoma and carcinoma,which can improve PET/CT evaluation of gastric wall lesions and help differentiate gastric lymphoma from gastric carcinoma.

关键词： Gastric lymphomas Gastric carcinomas 18f-fluorodeoxyglucose positron emission tomography/ computed tomography Maximal standard uptake value Maximal thickness Differential diagnosis

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Dynamic ^(18)f-fluorodeoxyglucose positron emission tomography/CT in hibernoma: enhanced tracer uptake mimicking liposarcoma

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World Journal of Radiology 2013年第12期5卷 498-502页

作者： Christos Sachpekidis Safwan Roumia Matthias Schwarzbach Antonia Dimitrakopoulou-Strauss Medical Positron Emission Tomography Group-Biological Imaging Clinical Cooperation Unit Nuclear Medicine German Cancer Research Center Surgical Clinic Klinikum Frankfurt Hchst

We report on two cases of patients with fat-equivalent masses in computed tomography(CT),referred to our department for dynamic positron emission tomography/CT(dPET/CT)with18f-fluorodeoxyglucose(18ffDG)in order to investigate their *** qualitative and quantitative information,as derived from dPET/CTs,couldn’t exclude a high-grade liposarcoma:Visual evaluation,revealed a large hypermetabolic focus of intense18f-fDG uptake in each patient(average SUVs 8.3 and 11.3).Regression-based parametric imaging demonstrated an enhanced distribution volume,which correlates to perfusion,and a high phosphorylation rate that correlates to cell *** analysis,based on a two-tissue compartment model demonstrated an enhanced fDG transport k1and an enhanced phosphorylation rate k3.A non-compartmental approach based on fractal dimension revealed also enhanced ***,final diagnosis was based on biopsy,which revealed hibernoma,a benign brown fat *** adipose contains increased numbers of mitochondria and a high-rate of glucose ***,they have increased fDG *** evaluation of lipomatous lesions on CT,with high fDG uptake,should include the possibility of hibernoma as a differential diagnosis.

关键词： Hibernoma Dynamic positron emission tomography/CT 18f-fluorodeoxyglucose Kinetic Modeling Parametric imaging

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Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT

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Neural Regeneration Research 2012年第36期7卷 2937-2943页

作者： Xia Bai Xuemei Wang Hongwei Wang Shigang Zhao Xiaodong Han Linjun Hao Xiangcheng Wang Department of Nuclear Medicine Affiliated Hospital of Inner Mongolia Medical College Department of Gamma Knife Center Affiliated Hospital of Inner Mongolia Medical College Department of Neurology Affiliated Hospital of Inner Mongolia Medical College Department of MRI Center Affiliated Hospital of Inner Mongolia Medical College Department of Emergency Medical Center Affiliated Hospital of Inner Mongolia Medical College

A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The loci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser＇s classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser＇s classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser＇s classification score was significantly higher in the single-focus group as compared with the multiple-foci group.

关键词： epilepsy seizure positron emission tomography/CT gamma knife radiosurgery metabolism 18f-fluorodeoxyglucose neural regeneration

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Multiple primary malignant tumors of upper gastrointestinal tract:A novel role of ^(18)f-fDG PET/CT

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World Journal of Gastroenterology 2010年第31期16卷 3964-3969页

作者： Long Sun Yong-Hong Sun Long Zhao Zuo-Ming Luo Hua Wu Ying Wan Qin Lin Minnan PET Center the first Affiliated Hospital of Xiamen University Xiamen 361003 fujian Province China College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei Province China Department of Radiation Xiamen 316003 China

AIM: To evaluate the capacity of 18f-fluorodeoxyglucose positron emission tomography/computed tomography (18f-fDG PET/CT) for detecting multiple primary cancer of upper gastrointestinal (UGI) tract. METHODS: fifteen patients (12 without cancer histories and 3 with histories of upper GI tract cancer) were investigated due to the suspicion of primary cancer of UGI tract on X-ray barium meal and CT scan. Subsequent whole body 18f-fDG PET/CT scan was carried out for initial staging or restaging. All the patients were fi nally confi rmed by endoscopic biopsy or surgery. The detection rate of multiple primary malignant cancers was calculated based on 18f-fDG PET/CT and endoscopic ***: 18f-fDG PET/CT scan was positive in 32 suspicious lesions, 30/32 were true positive primary lesions, and 2/32 were false positive. In 15 suspicious lesions with negative 18f-fDG PET/CT scan, 12/15 were true negative and 3/15 were false negative. Among the 15 patients, 12 patients had 29 primary synchronous tumors confirmed by pathology, including 8 cases of esophageal cancers accompanied with gastric cancer and 4 of hypopharynx cancers with esophageal cancer. The other 3 patients had 4 new primary metachronous tumors, which were multiple primary esophageal cancers. PET/CT imaging detected local lymph node metastases in 11 patients. Both local lymph node metastases and distant metastases were detected in 4 patients. On a per-primary lesion basis, the sensitivity, specificity, accuracy, negative predictive value and positive predictive value of 18f-fDG PET/CT for detecting multiple primary cancer of UGI tract were 90.9%, 85.7%, 89.4%, 80% and 93.7%, respectively. CONCLUSION: The whole body 18f-fDG PET/CT may play an important role in evaluating the multiple primary malignant tumors of UGI tract cancer.

关键词： Upper gastrointestinal tract cancer Esophageal cancer Gastric cancer Positron emission tomography/computed tomography 18f-fluorodeoxyglucose

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Role of pre-transplant 18f-fDG PET/CT in predicting hepatocellular carcinoma recurrence after liver transplantation

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World Journal of Gastrointestinal Oncology 2018年第10期10卷 336-343页

作者： Onur Yaprak Sencan Acar Gokhan Ertugrul Murat Dayangac Medipol University Hospital Center for Organ Transplantation Atasehir Memorial Hospital Center for OrganTurkeyTransplantation

The last two decades have seen a paradigm shift in the selection of patients with hepatocellular carcinoma(HCC)for liver *** invasion and differentiation have been the most significant factors affecting post-transplant recurrence;however,because of inherent disadvantages of pre-transplant biopsy,histological criteria never gained ***,the selection criteria evolved from morphological to biological criteria,such as biomarkers and response to loco-regional *** the introduction of multimodality imaging,combination of computed tomography with nuclear medicine imaging,particularly,18f-fluorodeoxyglucose positron emission tomography fulfilled an unmet need and rapidly became a critical component of HCC *** review article will focus on the use of 18f-fluorodeoxyglucose positron emission tomography combined with computed tomography in the pre-transplant evaluation of HCC patients with special discussion on its ability to predict HCC recurrence after liver transplantation.

关键词： 18f-fluorodeoxyglucose positron emission tomography Hepatocellular carcinoma Recurrence Liver transplantation

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Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging

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World Journal of Radiology 2019年第5期11卷 62-73页

作者： Keren Bachi Venkatesh Mani Audrey E Kaufman Nadia Alie Rita Z Goldstein Zahi A fayad Nelly Alia-Klein Department of Psychiatry Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Translational and Molecular Imaging Institute Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States Children's Hospital of Philadelphia 3401 Civic Center BlvdPhiladelphiaPA 19104United States Department of Neuroscience Icahn School of Medicine at Mount SinaiOne Gustave L.Levy PlaceNew YorkNY 10029United States

BACKGROUND Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease (i.e., atherosclerosis). Little is known about the pre-clinical signs of cardiovascular risk in iCUD and early signs of vascular disease are undetected in this underserved population. AIM To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. METHODS The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18f-fluorodeoxyglucose (18f-fDG) evaluated vascular inflammation and 3-D dark-blood MRI assessed plaque burden including wall area and thickness. Drug use and severity of addiction were assessed with standardized instruments. RESULTS The majority of iCUD and controls had carotid fDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. CONCLUSION These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and prevent

关键词： 3-D dark-blood magnetic resonance imaging 18f-fluorodeoxyglucose positron emission tomography Simultaneous positron emission tomography Magnetic resonance Substance use disorder Cocaine addiction Atherosclerosis Plaque burden Vascular inflammation

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Developments in auxiliary examination of Creutzfeldt-Jakob disease

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Neuroimmunology and Neuroinflammation 2017年第7期4卷 136-144页

作者： Wei Zhao Jiao-Jiao Jiang Jia-Tang Zhang Department of Neurology Chinese People’s Liberation Army General HospitalBeijing100853China Shijingshan Teaching Hospital of Capital Medical University Beijing Shijingshan HospitalBeijing100043China

Creutzfeldt-Jakob disease (CJD), which is caused by prion scrapie protein, is a rare, chronic, transmissible and fatal disease. Clinical manifestations of CJD include rapidly progressive dementia, cerebellar ataxia, visual disturbance, as well as pyramidal and extrapyramidal tract signs. four subtypes of CJD have been reported, including sporadic, familial or genetic, iatrogenic and variant. Given the infectiousness and high mortality of the disease, it is imperative that earlier and more accurate diagnostic methods are developed. In the past years, 14-3-3 protein testing and periodic sharp wave complexes in electroencephalogram have been widely used in CJD clinical diagnosis;and the abnormal hyper-intensity in diffusion weighted imaging has also been used. Recently, there has been a focus on the diagnostic value of 18f-fluorodeoxyglucose positron emission tomography/computed tomography. New findings of potential biomarkers in cerebrospinal fluid and decreases in diffusion tensor imaging measures have emerged as having an association with CJD. Magnetic resonance spectroscopy has also drawn attention as an emerging method for diagnosis. In this review, the progress in auxiliary examinations of CJD is discussed and the potential, future diagnostic methods are introduced.

关键词： Creutzfeldt-Jakob disease 14-3-3 protein electroencephalogram diffusion weighted imaging diffusion tensor imaging magnetic resonance spectroscopy 18f-fluorodeoxyglucose positron emission tomography/computed tomography

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