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Hypoxia-controlled matrix metalloproteinase-9 hyperexpression promotes behavioral recovery after ischemia

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Neuroscience Bulletin 2015年第5期31卷 550-560页

作者： Hongxia Cai Zhihao Mu Zhen Jiang Yongting Wang Guo-Yuan Yang zhijun zhang Department of Neurology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Neuroscience and Neuroengineering Center Med-X Research Institute Shanghai Jiao Tong University

Matrix metalloproteinase-9（MMP-9） plays a beneficial role in the sub-acute phase after ischemic ***,unrestrained MMP-9 may disrupt the blood-brain barrier（BBB）,which has limited its use for the treatment of brain *** the present study,we constructed lentivirus mediated hypoxiacontrolled MMP-9 expression and explored its role after *** response element（HRE）was used to confine MMP-9 expression only to the hypoxic region of mouse brain after 120-min transient middle cerebral artery *** were injected into the peri-infarct area on day 7 after transient *** found hyperexpression of exogenous HRE-MMP-9 under the control of hypoxia,and its expression was mainly located in neurons and astrocytes without aggravation of BBB damage compared to the CMV ***,mice in the HRE-MMP-9 group showed the best behavioral recovery compared with the normal saline,GFP,and SB-3CT ***,hypoxia-controlled MMP-9 hyperexpression during the sub-acute phase of ischemia may provide a novel promising approach of gene therapy for stroke.

关键词： blood-brain barrier hypoxia response element matrix metalloproteinase 9 stroke

基于云边协同计算的多AGV导航与避障技术的研究

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辽宁科技学院学报 2024年第4期26卷 44-47页

作者：于会敏韩宏飞韩召张志军辽宁科技学院电气与自动化工程学院辽宁本溪117004 株洲中车时代电气股份有限公司湖南株洲412000

AGV(Automated Guided Vehicle)作为数字化工厂中主要的运输载体,其自主导航与避障是重要技术之一。由于其任务指派及导航算法复杂且计算量巨大,导致了加工车间的多AGV物流配送会产生延迟问题。为了提高AGV运输的效率,文章提出了基于云... 详细信息

AGV(Automated Guided Vehicle)作为数字化工厂中主要的运输载体,其自主导航与避障是重要技术之一。由于其任务指派及导航算法复杂且计算量巨大,导致了加工车间的多AGV物流配送会产生延迟问题。为了提高AGV运输的效率,文章提出了基于云边协同计算技术的解决方案,利用人工智能和工业物联网技术,将AGV运输车辆、加工环境与工艺联系起来,中心云接受来自边缘云节点的信息,并将AGV任务指派及全局规划路径信息送给边缘云,边缘侧的AGV负责现场环境信息的收集与局部路径规划。使用云边协同计算技术后,多AGV导航与避障中遇到的延迟问题得到了缓解,且在物流配送过程中响应速度更快,资源利用更加合理。

关键词：云边协同计算路径规划动态避障

多端柔性直流系统中配电电压下垂自动化控制系统

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自动化与仪表 2024年第1期39卷 71-74页

作者：赵丽萍李永刚张志军国网冀北电力有限公司张家口075000

针对多端柔性直流系统安全稳定运行的问题,提出一种通过电压下垂控制结合潮流最优模型的控制方式。通过电压下垂控制进行交流侧有功功率的计算,以解决换流器产生的损耗与有功功率之间的耦合。经过分析验证,该方法能够提高电压下垂控制... 详细信息

针对多端柔性直流系统安全稳定运行的问题,提出一种通过电压下垂控制结合潮流最优模型的控制方式。通过电压下垂控制进行交流侧有功功率的计算,以解决换流器产生的损耗与有功功率之间的耦合。经过分析验证,该方法能够提高电压下垂控制下潮流最优系统的适用性、有效性以及准确性。

关键词：多端柔性直流系统雅可比矩阵有功功率潮流模型电压下垂控制

冠状动脉周围脂肪CT密度特征联合心电图对冠心病患者病情严重程度的诊断价值

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中国医学装备 2024年第9期21卷 47-52页

作者：刘晋文李学文吴山张亚运张志军山西白求恩医院(山西医学科学院同济山西医院)山西医科大学第三医院介入治疗室太原030032

目的:探讨双源CT冠状动脉血管造影(CCTA)冠状动脉周围脂肪CT密度特征联合心电图对冠心病患者病情严重程度的诊断价值。方法:收集2021年3月至2023年3月山西白求恩医院收治的120例冠心病患者,根据美国纽约心脏协会(NYHA)心功能分级进行分... 详细信息

目的:探讨双源CT冠状动脉血管造影(CCTA)冠状动脉周围脂肪CT密度特征联合心电图对冠心病患者病情严重程度的诊断价值。方法:收集2021年3月至2023年3月山西白求恩医院收治的120例冠心病患者,根据美国纽约心脏协会(NYHA)心功能分级进行分组,其中86例Ⅱ~Ⅲ级患者纳入Ⅱ~Ⅲ级组,34例Ⅳ级患者纳入Ⅳ级组。所有患者均行双源CT和心电图检测。双源CT检测包括冠状动脉左前降支近端(pLAD)、左前降支中段(mLAD)、左回旋支近端(pLCX)、右冠状动脉近端(pRCA)、右冠状动脉中段(mRCA)以及右冠状动脉远段(dRCA)不同分支的平均冠状动脉周围脂肪组织(PCAT)密度。记录患者心电图检查QRS波电压值和时限值以及QTc间期。观察并比较两组pLAD、mLAD、pLCX、pRCA、mRCA及dRCA的平均PCAT密度及心电图检查时的QRS电压和时限,以及QTc间期,采用受试者工作特征(ROC)曲线分析上述指标单独及联合诊断冠心病患者病情严重程度的效能。结果:Ⅱ~Ⅲ级组患者的pLAD、mLAD、pLCX、pRCA、mRCA及d RCA的平均PCAT密度、QRS时限及QTc间期明显低于Ⅳ级组,QRS电压明显高于Ⅳ级组,差异有统计学意义(t=58.681、5.097、5.902、13.513,P0.5,且联合诊断的AUC最高,为0.966;Pearson线性相关性分析结果显示,平均PCAT密度、QRS电压、QRS时限及QTc间期之间存在相关性,且QRS电压与平均PCAT密度、QRS时限及QTc间期均存在显著负相关关系(r=-0.754,-0.280,-0.452,P<0.05),平均PCAT密度、QRS时限及QTc间期与冠心病患者病情严重程度之间存在显著正相关关系(r=0.983、0.435、0.547,P<0.05),QRS电压与冠心病患者病情严重程度之间存在显著负相关关系(r=-0.776,P<0.05)。结论:冠状动脉CTA冠周脂肪CT密度特征联合心电图QRS波群检测有助于冠心病患者病情严重程度的诊断,可以提高诊断的准确率,具有一定的应用价值。

关键词：冠状动脉CTA 冠周脂肪CT密度心电图冠心病病情严重程度诊断价值

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Nanoformulation of metal complexes： Intelligent stimuli- responsive platforms for precision therapeutics

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Nano Research 2018年第10期11卷 5474-5498页

作者： Ming Hu Xiangzhao Ai Zhimin Wang zhijun zhang Haolun Cheong Wenmin zhang Jun Lin Juan Li Huanghao Yang Bengang Xing Division of Chemistry & Biological Chemistry School of Physical & Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore College of Chemistry Fuzhou University Fuzhou 350116 China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Precision medicine is a potential effective therapeutic for various human diseases. Currently, metal complex-based drugs are being successfully used in clinical applications owing to diverse properties such as multiple redox states, photo-induced ligand exchange, and preferential ligand and coordination numbers, which facilitate drug design and development. However, drawbacks such as toxicity, lack of specificity, and severe side effects have hampered their therapeutic outcome. Therefore, innovative strategies for improving the specificity and pharmacokinetics of conventional metal complex-based therapeutic agents are required. Recently, nanotechnology, which provides a unique toolbox for developing effective and safer medicine, has attracted considerable attention, mainly because of their ability to reduce side effects and enhance drug loading efficiency and pharmacokinetics. Considering the promising chemical and physical properties of diverse nanostructures, nanoformulation of metal complexes can be used to effectively address the problems associated with current metallodrug complexes, especially those based on stimuli-responsive therapeutic strategies, with excellent spatial, temporal, and dosage control. In this review, we have mainly focused on the specificity and environment-responsiveness of metallodrug nanoformulations as therapeutics, and summarized the recent strategies being used for developing metal complex-functionalized intelligent nanoplatforms, which respond to various types of stimuli, including endogenous signals （pH, redox condition,s, and enzyme activities） or external triggers （light irradiation and magnetic field manipulations）. In addition, we have also discussed the potential challenges associated with use of metallodrugs and their nanoformulations as effective precision therapy with improved specificity and minimal side effects.

关键词： precision therapeutics metal drug complex multifunctionalnanomaterials stimuli-responsive

不同表型支气管扩张症患者急性加重期的炎症水平、临床特点及预后分析

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蛇志 2024年第3期36卷 343-347,361页

作者：简勇何成刘阳潘冬青章志俊江西省新余市人民医院呼吸与危重症医学科江西新余338000

目的分析不同表型支气管扩张症患者急性加重期的炎症水平、临床特点及预后情况。方法回顾性分析2021年1月至2023年6月在我院就诊的支气管扩张症急性加重期患者80例的临床资料,根据病因不同将患者分为非感染后支气管扩张症组(非感染组)25... 详细信息

目的分析不同表型支气管扩张症患者急性加重期的炎症水平、临床特点及预后情况。方法回顾性分析2021年1月至2023年6月在我院就诊的支气管扩张症急性加重期患者80例的临床资料,根据病因不同将患者分为非感染后支气管扩张症组(非感染组)25例,感染后支气管扩张症组(感染组)25例、特发性支气管扩张症组(特发性组)30例,观察3组患者的临床特点(咳嗽、咳痰、咯血、发热、呼吸困难、乏力、干啰音及湿啰音)、炎症指标[白介素-6(IL-6)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)及降钙素原(PCT)]、肺功能指标[第一秒用力呼气容积(FEV1)、时间肺活量(FEV1/FVC)]及预后情况[病死率、支气管扩张症严重程度指数(BSI)评分及支气管扩张症严重程度分级评分(FACED)]情况。结果3组患者在咳嗽、咳痰、发热、乏力、湿啰音方面比较,差异均无统计学意义(P>0.05)。感染组的咯血发生率高于非感染组,乏力发生率高于特发性组(均P0.05)。感染组的BSI评分与FACED评分均高于非感染组与特发性组,感染组患者的死亡率高于非感染组与特发性组,差异均具有统计学意义(均P<0.05)。结论不同表型支气管扩张症患者急性加重期的炎症指标、BSI及FACED评分方面有所差异,感染后患者的血清炎症因子水平、BSI及FACED评分更高,可作为判断支气管扩张症病情的参考指标;在临床症状方面也有所差异,能够为区分不同表型与个体化治疗提供依据。

关键词：支气管扩张症表型急性加重期炎症水平

Altered functional connectivity networks of hippocampal subregions in remitted late-onset depression:a longitudinal resting-state study

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Neuroscience Bulletin 2015年第1期31卷 13-21页

作者： Zan Wang Yonggui Yuan Feng Bai Hao Shu Jiayong You Lingjiang Li zhijun zhang Neurology Department Affiliated ZhongDa HospitalNeuropsychiatric Institute and Medical School of Southeast University Department of Psychosomatics and Psychiatry Affiliated ZhongDa HospitalMedical School of Southeast University Department of Psychiatry Nanjing Brain Hospital Affiliated to Nanjing Medical University Mental Health Institute Second Xiangya Hospital of Central South University

The regional specifi city of hippocampal abnormalities in late-life depression（LLD） has been demonstrated in previous studies. In this study,we sought to examine the functional connectivity（FC） patterns of hippocampal subregions in remitted late-onset depression（r LOD）,a special subtype of LLD. Fourteen r LOD patients and 18 healthy controls underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans at baseline and at ~21 months of follow-up. Each hippocampus was divided into three parts,the cornu ammonis（CA）,the dentate gyrus,and the subicular complex,and then six seed-based hippocampal subregional networks were *** changes of the six networks over time were directly compared between the rL OD and control groups. From baseline to follow-up,the r LOD group showed a greater decline in connectivity of the left CA to the bilateral posterior cingulate cortex/precuneus（PCC/PCUN）,but showed increased connectivity of the right hippocampal subregional networks with the frontal cortex（bilateral medial prefrontal cortex/anterior cingulate cortex and supplementary motor area）. Further correlative analyses revealed thatthe longitudinal changes in FC between the left CA and PCC/PCUN were positively correlated with longitudinal changes in the Symbol Digit Modalities Test（r = 0.624,P = 0.017） and the Digit Span Test（r = 0.545,P = 0.044） scores in the r LOD group. These results may provide insights into the neurobiological mechanism underlying the cognitive dysfunction in r LOD patients.

关键词： remitted late-onset depression hippocampal subregional network functional connectivity functional magnetic resonance imaging cognitive dysfunction

Application of entropy-based fuzzy matter-element analysis in seepage monitoring of RCC dam

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Frontiers of Structural and Civil Engineering 2011年第1期5卷 105-111页

作者： Chongshi GU zhijun zhang Xin CAI Yue HOU State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai UniversityNanjing 210098China

Taking account of the fuzzy results of the seepage monitoring analysis of roller compacted concrete(RCC)dam and uncertainties of the individual indicator evaluation,the fuzzy matter-element model of seepage monitoring of RCC dam analysis has been established with the use of the fuzzy matter-element analysis theory and the concept of euclid approach *** use of entropy theory can calculate the weighting factor through the disorder utility values of the information reflected by the data itself,which can effectively avoid the problems of weight distribution and uncertainties of subjective judgments of the seepage monitoring analysis of roller compacted concrete *** further the example shows that the analysis of entropy-based fuzzy matter-element analysis model of the seepage monitoring of roller compacted concrete dam is in accordance with the actual situation,which verifies the effectiveness of the method.

关键词： information entropy fuzzy matter-element roller compacted concrete(RCC)dam seepage analysis

抑郁症与双相障碍患者昼夜节律通路基因多态性的差异分析

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中华精神科杂志 2024年第8期57卷 495-501页

作者：陈磊陈子木沈甜谈婷婷高晨洁陈素珍陈炳为袁勇贵张志珺徐治东南大学附属中大医院心理精神科南京210009 东南大学公共卫生学院南京210009 东南大学医学院附属中大医院神经内科南京210009 东部战区总医院南京大学医学院附属金陵医院精神心理科工作南京210002

目的探究抑郁症和双相障碍患者昼夜节律通路基因多态性的差异,以为两者的鉴别诊断提供遗传学依据。方法前瞻性收集2012至2018年在东南大学附属中大医院住院的70例5年随访间一直诊断为抑郁症的患者(简称抑郁症组)和68例诊断为双相障碍的... 详细信息

目的探究抑郁症和双相障碍患者昼夜节律通路基因多态性的差异,以为两者的鉴别诊断提供遗传学依据。方法前瞻性收集2012至2018年在东南大学附属中大医院住院的70例5年随访间一直诊断为抑郁症的患者(简称抑郁症组)和68例诊断为双相障碍的患者(简称双相障碍组)。选取昼夜节律通路基因单核苷酸多态性(single nucleotide polymorphisms,SNPs)进行昼夜节律通路基因检测,分析每个SNP的基因型频率、等位基因频率和单倍型在抑郁症和双相障碍间的差异。结果基因型频率分析发现,2组患者中的PER1rs2253820、PER1rs2735611、PER3rs12566042、PER3rs17031614、PER3rs79372391基因型频率的差异有统计学意义[OR(95%CI)分别为2.386(1.173~4.854)、2.357(1.166~4.764)、0.351(0.176~0.703)、0.389(0.196~0.773)、0.389(0.196~0.773);均P<0.05];单倍型分析发现,CLOCK位点rs12505266、rs2272073、rs3817444、rs11133389和rs12505265构成的单倍型中,T-C-C-T-G单倍型在2组患者中的差异有统计学意义[OR(95%CI)=0.108(0.010~1.185),P=0.027]。结论昼夜节律基因多态性在抑郁症和双相障碍患者间差异具有统计学意义,携带PER1rs2253820TT、PER1rs2735611GG基因型是双相障碍的危险因素。

关键词：抑郁症双相情感障碍昼夜节律通路基因多态性