Altered functional connectivity networks of hippocampal subregions in remitted late-onset depression:a longitudinal resting-state study

作     者：Zan Wang Yonggui Yuan Feng Bai Hao Shu Jiayong You Lingjiang Li Zhijun Zhang 

作者机构：Neurology DepartmentAffiliated ZhongDa HospitalNeuropsychiatric Institute and Medical School of Southeast University Department of Psychosomatics and PsychiatryAffiliated ZhongDa HospitalMedical School of Southeast University Department of PsychiatryNanjing Brain Hospital Affiliated to Nanjing Medical University Mental Health InstituteSecond Xiangya Hospital of Central South University 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2015年第31卷第1期

页      面：13-21页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (30825014,81061120529,30970814,81371488,91132727 and 30830046) the Key Program for Clinical Medicine and Science and Technology,Jiangsu Provincial Clinical Medical Research Center,China (BL2013025) 

主　　题：remitted late onset depression hippocampal subregional network functional connectivity functional magnetic resonance imaging cognitive dysfunction 

摘      要：The regional specifi city of hippocampal abnormalities in late-life depression（LLD） has been demonstrated in previous studies. In this study,we sought to examine the functional connectivity（FC） patterns of hippocampal subregions in remitted late-onset depression（r LOD）,a special subtype of LLD. Fourteen r LOD patients and 18 healthy controls underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans at baseline and at ~21 months of follow-up. Each hippocampus was divided into three parts,the cornu ammonis（CA）,the dentate gyrus,and the subicular complex,and then six seed-based hippocampal subregional networks were *** changes of the six networks over time were directly compared between the rL OD and control groups. From baseline to follow-up,the r LOD group showed a greater decline in connectivity of the left CA to the bilateral posterior cingulate cortex/precuneus（PCC/PCUN）,but showed increased connectivity of the right hippocampal subregional networks with the frontal cortex（bilateral medial prefrontal cortex/anterior cingulate cortex and supplementary motor area）. Further correlative analyses revealed thatthe longitudinal changes in FC between the left CA and PCC/PCUN were positively correlated with longitudinal changes in the Symbol Digit Modalities Test（r = 0.624,P = 0.017） and the Digit Span Test（r = 0.545,P = 0.044） scores in the r LOD group. These results may provide insights into the neurobiological mechanism underlying the cognitive dysfunction in r LOD patients.