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Spatiotemporal characteristics and remote sensing estimation of colored dissolved organic matter around the Leizhou Peninsula

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Journal of Oceanology and Limnology 2023年第4期41卷 1405-1424页

作者： Dongyang FU Shiyun wei Guo YU Yafei LUO Huabing XU Zhaoguang chen College of Electronic and Information Engineering Guangdong Ocean UniversityZhanjiang 524088China Guangdong Provincial Engineering and Technology Research Center of Marine Zhanjiang 524088China

Colored dissolved organic matter(CDOM)is an important optically active substance in marine *** biochemical conservatism makes it an important indicator to offshore pollution *** the content,composition,and diffusion process of CDOM is a good approach to analyze the terrestrial input,optical properties,and ecological environment of offshore *** spatiotemporal characteristics of CDOM around the Leizhou Peninsula were analyzed based on field observation data collected in the autumn 2020 and spring 2021,and an empirical inversion model of the ag(355)(absorption coefficient at 355 nm)and spectral slope(Sg)(g stands for gelbstoff/gilvin,which is called CDOM)based on Sentinel-3A ocean and land color instrument(OLCI)images was *** results show(1)the order of average ag(355)value around the Leizhou Peninsula was east coast(0.503/m)>Qiongzhou Strait(0.502/m)>west coast(0.365/m);(2)the best band combinations of CDOM inversion in spring and autumn were(B4+B11)/B3 and(B7-B1)/B6(B stands for the band of spectral images),and the final inversion results are close to the measured results,indicating that the model has good accuracy;(3)the S_(g)value of the CDOM absorption spectrum was fitted to the hyperbolicexponential *** fitting accuracy of the model was higher than those of the exponential model and the hyperbolic model,and the best S_(g)inversion model was constructed by selecting Sg(275-295)and Sg(250-295)in spring and autumn;(4)the spatial distributions of ag(355)and S_(g)were inverted,and CDOM in the waters around the Leizhou Peninsula originated from terrestrial organic matter carried by coastal aquaculture zones and runoff in the northeast Zhanjiang and the northern Beibu Gulf.

关键词： colored dissolved organic matter(CDOM) ocean and land color instrument(OLCI) spectral slope hyperbolic-exponential model inversion

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Microscopic study on the key process and influence of efficient synthesis of natural gas hydrate by in situ Raman analysis of water microstructure in different systems with temperature drop

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Journal of Energy Chemistry 2023年第7期82卷 317-333,I0008页

作者： wei Zhang Chun-Gang Xu Xiao-Sen Li Zhuo-Yi Huang Zhao-Yang chen School of Engineering Science University of Science and Technology of ChinaHefei 230023AnhuiChina Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640GuangdongChina CAS Key Laboratory of Gas Hydrate Guangzhou 510640GuangdongChina Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640GuangdongChina School of Energy Science and Engineering University of Science and Technology of ChinaHefei 230023AnhuiChina

Gas hydrate technology has considerable potential in many ***,due to the lack of understanding of the micro mechanism of hydrate formation,it has not been commercially applied so *** hydrate formation is essentially a gas-liquid-solid phase transition of water and gas molecules at a certain temperature and *** key to the hydrate formation is the transformation of water molecule from disordered arrangement to ordered *** this process,weakly hydrogen bonded water will be correspondingly converted to strongly hydrogen bonded *** in situ Raman analysis and experiments,the position change of the corresponding peaks of the strongly hydrogen bonded water and the weakly hydrogen bonded water was compared in this work,and the key microscopic process and influence of gas hydrate formation in different systems were comprehensively studied and *** is found that,with the decrease of temperature,the OAH of the weakly hydrogen bonded water remains unchanged when the temperature drops to a certain value,which is the key to the transformation of water into cage hydrate rather than *** conversion from the weakly hydrogen bonded water to the strongly hydrogen bonded water is closely related to the gas-liquid interface force,the hydrophilicity/hydrophobicity of the promoter,the ionization degree of liquid,and the electrostatic field of the *** the four most common promoters,tetrahydrofuran(THF)has the highest efficiency in promoting methane(CH4)hydrate ***,this study provides a scientific direction and basis for the development of high efficient hydrate formation promoters,which can effectively weaken the hydrogen bond of weakly hydrogen bonded water and promote the conversion of weakly hydrogen bonded water to strongly hydrogen bonded water.

关键词： Hydrate Conversion Hydrogen bonded water Promoter Micro mechanism

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Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia–reperfusion injury

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Journal of Molecular Cell Biology 2023年第6期15卷 65-67页

作者： Lixia Zheng Yuanyuan chen Zhengyuan Wu Xiaojun Zhu Jing-wei Xiong Beĳing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular MedicineCollege of Future Technologyand State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeĳing 100871China PKU-Nanjing Institute of Translational Medicine Nanjing 211800China

Dear Editor,Myocardial infarction(MI)is one of the leading causes of cardiovascular-related mortality *** restoration of the blood supply to ischemic my-ocardium by thrombolysis or percuta-neous coronary intervention ... 详细信息

关键词： mortality cardiovascular ischemia

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Mesh relationship modeling and dynamic characteristic analysis of external spur gears with gear wear

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Frontiers of Mechanical Engineering 2022年第1期17卷 160-177页

作者： zhixian SHEN Laihao YANG Baijie QIAO wei LUO Xuefeng chen Ruqiang YAN School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Manufacturing Systems Engineering Xi’an Jiaotong UniversityXi’an 710061China

Gear wear is one of the most common gear failures,which changes the mesh relationship of normal gear.A new mesh relationship caused by gear wear affects meshing excitations,such as mesh stiffness and transmission error,and further increases vibration and noise *** paper aims to establish the model of mesh relationship and reveal the vibration characteristics of external spur gears with gear wear.A geometric model for a new mesh relationship with gear wear is proposed,which is utilized to evaluate the influence of gear wear on mesh stiffness and unloaded static transmission error(USTE).Based on the mesh stiffness and USTE considering gear wear,a gear dynamic model is established,and the vibration characteristics of gear wear are numerically *** with the experimental results verifies the proposed dynamic model based on the new mesh *** numerical and experimental results indicate that gear wear does not change the structure of the spectrum,but it alters the amplitude of the meshing frequencies and their *** condition indicators,such as root-mean-square,kurtosis,and first-order meshing frequency amplitude,can be regarded as important bases for judging gear wear state.

关键词： gear wear mesh relationship mesh stiffness transmission error vibration characteristics

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Decreased TRPM7 alleviates high glucose-induced renal tubular epithelial cell injury by inhibiting the HMGB1/TLR4 signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2023年第9期13卷 393-402页

作者： wei Feng Zheng-Yong Cao Fu-Min Guan Hong chen Laboratory Department Maternal and Child Health Hospital of Qijiang DistrictChongqing401429China Otolaryngology Department People’s Hospital of Qijiang DistrictChongqing401420China Pharmacy Department People’s Hospital of Qijiang DistrictChongqing401420China Science and Education Department People’s Hospital of Qijiang DistrictChongqing401420China

Objective:To explore the regulatory mechanism of transient receptor potential melastatin-7(TRPM7)in high glucose-induced renal tubular epithelial cell ***:The expression of TRPM7 in the serum of diabetic nephropathy patients and high glucose-induced HK-2 cells was detected by ***,the TRPM7 interference vector was constructed,and the downstream high mobility group box 1(HMGB1)/Toll-like receptor 4(TLR4)signaling pathway proteins were ***,in addition to interference with TRPM7 expression,overexpression of HMGB1 in high glucose-induced HK-2 cells was *** activity,apoptosis,oxidative stress levels,and inflammation levels were determined by CCK8,TUNEL,Western blotting,immunofluorescence and related ***:TRPM7 expression was upregulated in the serum of diabetic nephropathy patients and high glucose-induced HK-2 *** with TRPM7 reduced cell damage,epithelial-mesenchymal transition,oxidative stress,and inflammatory response in high glucose-induced HK-2 cells via inhibiting the HMGB1/TLR4 signaling ***,the effects induced by TRPM7 silencing were abrogated by HMGB1 ***:Decreased TRPM7 alleviates high glucose-induced renal tubular epithelial cell injury by inhibiting the HMGB1/TLR4 signaling *** animal experiments and clinical trials are warranted to verify its effect.

关键词： Diabetic nephropathy TRPM7 HMGB1/TLR4 High glucose Renal tubular epithelial cell

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Highly Thermally Conductive Polymer/Graphene Composites with Rapid Room‑Temperature Self‑Healing Capacity

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Nano-Micro Letters 2022年第8期14卷 194-207页

作者： Huitao Yu Can chen Jinxu Sun Heng Zhang Yiyu Feng Mengmeng Qin wei Feng School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin UniversityTianjin 300350People’s Republic of China Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002People’s Republic of China

Composites that can rapidly self-healing their structure and function at room temperature have broad application ***,in view of the complexity of composite structure and composition,its self-heal is facing *** this article,supramolecular effect is proposed to repair the multistage structure,mechanical and thermal properties of composite materials.A stiff and tough supramolecular frameworks of 2-[[(butylamino)carbonyl]oxy]ethyl ester(PBA)–polydimethylsiloxane(PDMS)were established using a chain extender with double amide bonds in a side chain to extend prepolymers through ***,by introducing the copolymer into a folded graphene film(FGf),a highly thermally conductive composite of PBA–PDMS/FGf with self-healing capacity was *** ratio of crosslinking and hydrogen bonding was optimized to ensure that PBA–PDMS could completely self-heal at room temperature in 10 ***,PBA–PDMS/FGf exhibits a high tensile strength of 2.23±0.15 MPa at break and high thermal conductivity of 13±0.2 W m^(−1)K^(−1);of which the self-healing efficiencies were 100%and 98.65%at room temperature for tensile strength and thermal conductivity,*** excellent self-healing performance comes from the efficient supramolecular interaction between polymer molecules,as well as polymer molecule and *** kind of thermal conductive self-healing composite has important application prospects in the heat dissipation field of next generation electronic devices in the future.

关键词： Carbon/polymer composites Self-healing capacity High thermal conductivity Molecular simulation Room temperature

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The role of tumor-associated macrophages(TAMs) in tumor progression and relevant advance in targeted therapy

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2156-2170页

作者： Qiyao Yang Ningning Guo Yi Zhou Jiejian chen Qichun wei Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China

Macrophages have a leading position in the tumor microenvironment(TME)which paves the way to ***,monocytes and macrophages are recruited to the sites where the tumor *** the guidance of different microenvironmental signals,macrophages would polarize into two functional phenotypes,named as classically activated macrophages(M1)and alternatively activated macrophages(M2).Contrary to the anti-tumor effect of M1,M2 exerts anti-inflammatory and tumorigenic *** progressive tumor,M2 tumor-associated macrophages(TAMs)are in the majority,being vital regulators reacting upon *** review elaborates on the role of TAMs in tumor ***,prospective macrophage-focused therapeutic strategies,including drugs not only in clinical trials but also at primary research stages,are summarized followed by a discussion about their clinical application *** systems with efficient drug delivery and improved antitumor effect are also summed up in this article.

关键词： Tumor-associated macrophages Tumor microenvironment Targeted drug delivery Tumor treatment Combined therapy Immunotherapy Extracellular vesicles Nano-drug

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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang wei chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Downregulation of miR-181a-5p alleviates oxidative stress and inflammation in coronary microembolization-induced myocardial damage by directly targeting XIAP

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Journal of Geriatric Cardiology 2021年第6期18卷 426-439页

作者： You ZHOU Man-Yun LONG zhi-Qing chen Jun-Wen HUANG Zhen-Bai QIN Lang LI Department of Cardiology the First Affiliated Hospital of Guangxi Medical UniversityNanningChina Guangxi Key Laboratory of Precision Medicine in Cardio-cerebrovascular Diseases Control and Prevention NanningChina

BACKGROUND Coronary microembolization(CME)is a complicated problem that commonly arises in the context of coronary *** play crucial roles in cardiovascular ***,the role and mechanism of miR-181a-5p in CME-induced myocardial injury remains *** We established CME rat *** function was detected by ***-basic fuchsin-picric acid staining was used to measure micro-infarction *** samples and cell culture supernatants were evaluated via enzyme-linked immunosorbent *** reactive oxygen species were determined by dichloro-dihydro-fluorescein diacetate assay,and the other oxidative stress related parameters were assayed by *** dual-luciferase reporter(DLR)assay and RNA pulldown were conducted to validate the association between miR-181a-5p and X-linked inhibitor of apoptosis protein(XIAP).The expression of miR-181a-5p and XIAP mRNA were determined by quantitative reverse transcription polymerase chain *** were evaluated via *** viability of the cell was evaluated via cell counting kit-8 *** The miR-181a-5p level was significantly increased in CME myocardial *** of miR-181a-5p improved CME-induced cardiac dysfunction and alleviated myocardial oxidative stress and inflammatory injury,whereas miR-181a-5p exhibited the opposite ***,the DLR assay and RNA pulldown results revealed that miR-181a-5p directly targeting on *** XIAP level was found to be remarkably decreased after *** overexpression attenuated CME-induced myocardial oxidative stress and inflammatory ***,in vitro rescue experiments revealed that knockdown of XIAP could abolish the protective effects of miR-181a-5p knockdown on hypoxia-induced cardiomyocyte oxidative stress and inflammatory *** Downregulation of miR-181a-5p alleviates CME-induced myocardial damage by suppressing myocardial oxidative stress and

关键词： damage XIAP Down

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The effect of friction block hole configurations on the brake tribological performance of high-speed trains

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Friction 2024年第10期12卷 2241-2258页

作者： Yuanke WU wei chen Youguang ZHU Zaiyu XIANG Honghua QIAN Jiliang MO Zhongrong ZHOU Tribology Research Institute School of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China China Railway Engineering Equipment Group Co. Ltd.Zhengzhou 450016China

Three triangular friction block configurations are commonly employed in high-speed train brake systems,namely,unperforated,perforated configuration with one circular hole,and perforated with three circular *** this study,we adopted these friction block types to investigate the effect of perforated friction block configurations on the brake performance of high-speed trains based on a self-developed brake test *** results indicate the significant impact of the number of the holes on the wear behavior,temperature distribution,and vibration characteristics of the brake *** friction surface of the unperforated block is covered by wear debris,while the perforated blocks produce less wear ***,the one-hole block exhibits a more uniform temperature distribution and better vibration behavior than that with three *** friction brake is a dynamic process,during which separation and attachment between the pad and disc alternatively occur,and the perforated structure on the friction block can both trap and expel the wear debris.

关键词： high-speed train block brake performance wear debris flow

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