Decreased TRPM7 alleviates high glucose-induced renal tubular epithelial cell injury by inhibiting the HMGB1/TLR4 signaling pathway
作者机构：Laboratory DepartmentMaternal and Child Health Hospital of Qijiang DistrictChongqing401429China Otolaryngology DepartmentPeople’s Hospital of Qijiang DistrictChongqing401420China Pharmacy DepartmentPeople’s Hospital of Qijiang DistrictChongqing401420China Science and Education DepartmentPeople’s Hospital of Qijiang DistrictChongqing401420China
出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)
年 卷 期：2023年第13卷第9期
页 面：393-402页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题：Diabetic nephropathy TRPM7 HMGB1/TLR4 High glucose Renal tubular epithelial cell
摘 要：Objective:To explore the regulatory mechanism of transient receptor potential melastatin-7(TRPM7)in high glucose-induced renal tubular epithelial cell ***:The expression of TRPM7 in the serum of diabetic nephropathy patients and high glucose-induced HK-2 cells was detected by ***,the TRPM7 interference vector was constructed,and the downstream high mobility group box 1(HMGB1)/Toll-like receptor 4(TLR4)signaling pathway proteins were ***,in addition to interference with TRPM7 expression,overexpression of HMGB1 in high glucose-induced HK-2 cells was *** activity,apoptosis,oxidative stress levels,and inflammation levels were determined by CCK8,TUNEL,Western blotting,immunofluorescence and related ***:TRPM7 expression was upregulated in the serum of diabetic nephropathy patients and high glucose-induced HK-2 *** with TRPM7 reduced cell damage,epithelial-mesenchymal transition,oxidative stress,and inflammatory response in high glucose-induced HK-2 cells via inhibiting the HMGB1/TLR4 signaling ***,the effects induced by TRPM7 silencing were abrogated by HMGB1 ***:Decreased TRPM7 alleviates high glucose-induced renal tubular epithelial cell injury by inhibiting the HMGB1/TLR4 signaling *** animal experiments and clinical trials are warranted to verify its effect.
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