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Effect of the extrahepatic bile duct anatomy on choledocholithiasis and its clinical significance

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1363-1370页

作者： zheng cao Jia Zhou Li Wei Hai-Yu He Jun Li Department of Gastroenterology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND A comprehensive understanding of the extrahepatic bile duct anatomy is vital to guide surgical procedures and perform endoscopic retrograde *** irregularities within the extrahepatic bile duct may increase susceptibility to bile duct *** To investigate the anatomical risk factors associated with extrahepatic bile ducts in patients diagnosed with choledocholithiasis,with a specific focus on preventing stone recurrence after surgical intervention and endoscopic *** We retrospectively analyzed the medical records of 124 patients without choledocholithiasis and 108 with confirmed choledocholithiasis who underwent magnetic resonance cholangiopancreatography examinations at our center between January 2022 and October *** regression analyses were conducted to identify the anatomical risk factors influencing the incidence of common bile duct *** Multivariate logistic regression analysis revealed that several factors independently contributed to choledocholithiasis *** independent risk factors for choledocholithiasis were diameter of the common hepatic[adjusted odds ratio(aOR)=1.43,95%confidence interval(CI):1.07-1.92,adjusted P value=0.016]and common bile(aOR=1.68,95%CI:1.27-2.23,adjusted P value<0.001)ducts,length of the common hepatic duct(aOR=0.92,95%CI:0.84-0.99,adjusted P value=0.034),and angle of the common bile duct(aOR=0.92,95%CI:0.89–0.95,adjusted P value<0.001).The anatomical features of the extrahepatic bile duct were directly associated with choledocholithiasis *** risk factors include an enlarged diameter of the common hepatic and bile ducts,a shorter length of the common hepatic duct,and a reduced angle of the common bile duct.

关键词： Bile ducts Extrahepatic Choledocholithiasis Cholangiopancreatography Magnetic resonance Cholangiopancreatography Endoscopic retrograde

Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： Sheng-Jie Du Xiu-Xia Li Yang Tian Yuan-Yuan Liu Ke Jia Zhong-zheng Tang Jian-Ping Cheng Zhi Deng Yu-Lan Li zheng-cao Li Sha-Sha Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low Radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China Department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPGe)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPGe has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of Ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the Ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/Ge_(2)ON_(2)/Ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPGe detector surface passivation technology to reduce the detector leakage currents.

关键词： Surface passivation High purity germanium detector Germanium nitrogen oxide Interface state density

Island biogeography theory and the habitat heterogeneity jointly explain global patterns of Rhododendron diversity

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Plant Diversity 2024年第5期46卷 565-574页

作者： Yanwei Guan Yongru Wu zheng cao Zhifeng Wu Fangyuan Yu Haibin Yu Tiejun Wang School of Geographical Sciences and Remote Sensing Guangzhou UniversityGuangzhou 510006China School of Life Sciences Guangzhou UniversityGuangzhou 510006China Department of Natural Resources Faculty of Geo-Information and Earth Observation(ITC)University of TwenteDrienerlolaan 5Enschede 7522 NBthe Netherlands

Mountain biodiversity is of great importance to biogeography and ***,it is unclear what ecological and evolutionary processes best explain the generation and maintenance of its high levels of species *** this study,we determined which of six common hypotheses(e.g.,climate hypotheses,habitat heterogeneity hypothesis and island biogeography theory)best explain global patterns of species diversity in *** found that Rhododendron diversity patterns were most strongly explained by proxies of island biogeography theory(i.e.,mountain area)and habitat heterogeneity(i.e.,elevation range).When we examined other relationships important to island biogeography theory,we found that the planimetric area and the volume of mountains were positively correlated with the Rhododendron diversity,whereas the‘mountains-to-mainland’distance was negatively correlated with Rhododendron diversity and shared *** findings demonstrate that Rhododendron diversity can be explained by island biogeography theory and habitat heterogeneity,and mountains can be regarded as islands which supported island biogeography theory.

关键词： Mountain biodiversity Rhododendron Island biogeography theory Habitat heterogeneity Biogeographical hypotheses Plant diversity

Research Progress on the Anti-Atherosclerotic Effect and Mechanism of Tetramethylpyrazine

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Journal of Clinical and Nursing Research 2024年第6期8卷 94-99页

作者： Shengyang Gong zheng cao Department of Cardiology Taihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina

Atherosclerosis is a chronic vascular disease and the most common pathological change of cardiovascular *** pathogenesis is closely related to inflammation,oxidative stress,lipid accumulation,and *** plays an anti-atherosclerotic role by regulating lipid metabolism,inhibiting foam cell formation,alleviating inflammation,inhibiting vascular calcification and abnormal platelet activation,and has a cardiovascular protective ***,this paper summarized the research progress of the anti-atherosclerosis effect and mechanism of tetramethylpyrazine.

关键词： Atherosclerosis Chinese medicine Tetramethylpyrazine Mechanism of action Research progress

Cocktail nano-adjuvant enhanced cancer immunotherapy based on NIR-Ⅱ-triggered in-situ tumor vaccination

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Chinese Chemical Letters 2024年第3期35卷 346-351页

作者： Lilin Fan Yanwen Feng Jiang Bian Anhong Chen Donglin Xie zheng cao Jun Yue Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials School of Materials Science and EngineeringJiangsu Collaborative Innovation Center of Photovoltaic Science and EngineeringChangzhou UniversityChangzhou 213164China School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

Second near-infrared(NIR-Ⅱ)light triggered in-situ tumor vaccination(ISTV)represents one of the most promising strategies in boosting the whole-body antitumor *** most of previously developed nano-adjuvants for NIR-Ⅱ-triggered ISTV are“all-in-one”formulations,which may indiscriminately damage both the tumor cells and the immune cells,limiting the overall effect of immune *** overcome this obstacle,we designed a“cocktail”nano-adjuvant by physically mixing hyaluronidases(HAase)-decorated gold nanostars(HA)for NIR-Ⅱlight triggered in situ production of tumor-associated antigens and CpG functionalized gold nanospheres(CA)for immune cells *** to“all-in-one”formulation,the“cocktail”nano-adjuvants displayed a significantly stronger immune response on NIR-Ⅱlight induced dendritic cells(DCs)mutation and T cells differentiation,greater effect on tumor-growth inhibition,and higher efficacy in inhibition of pulmonary *** is more,increasing the molar ratio of HA to CA led to an enhanced anticancer immune *** study highlight the nano-adjuvant formulation effects on the treatment of tumors with multiple targets.

关键词： Nano-adjuvant Cocktail formulation In-situ tumor vaccination NIR-Ⅱphotothermal effect Anticancer immune response

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2020年全球鱿钓捕捞的时空特征分析

地球信息科学学报 2024年第4期26卷 1110-1122页

作者：刘广源吴志峰吴波郑子豪曹峥广州大学地理科学与遥感学院广州510006 自然资源部大湾区地理环境监测重点实验室深圳518060 惠州学院地理与旅游学院惠州516000

了解全球鱿钓捕捞的时空特征可为鱿鱼资源的评估与管理提供参考。本文选取2020年全球鱿钓船AIS轨迹数据与VIIRS夜间灯光影像,以FAO major Fishing Areas的19个海洋主要捕鱼区为捕捞分区依据,结合GIS空间分析方法开展了全球鱿钓捕捞的时... 详细信息

了解全球鱿钓捕捞的时空特征可为鱿鱼资源的评估与管理提供参考。本文选取2020年全球鱿钓船AIS轨迹数据与VIIRS夜间灯光影像,以FAO major Fishing Areas的19个海洋主要捕鱼区为捕捞分区依据,结合GIS空间分析方法开展了全球鱿钓捕捞的时空特征分析。结果表明:(1)鱿钓捕捞主要分布在西南大西洋阿根廷专属经济区周边、西北太平洋日本东北部远海、东南太平洋秘鲁西部远海、西北印度洋阿拉伯海以及中西太平洋阿拉弗拉海,集中在中、低纬度离陆地100 km以内和400~700 km范围内,呈现以条带式为主的分布模式;(2)全球鱿钓捕捞的时间规律表现出“两峰两谷”的变化态势,分别于1—4月、6—8月呈上升趋势,而在4—6月、8—12月呈下降趋势。中纬度的鱿钓捕捞于夏秋呈上升趋势,而在冬春呈下降趋势;低纬度的鱿钓捕捞在秋冬季节呈增加态势,而在春季呈减少态势;(3)鱿钓捕捞的时空特征受洋流、鱿鱼繁殖特性及各国远洋鱿钓政策影响,其空间分布走向与主要洋流流向一致,捕捞强度在鱿鱼产卵高峰期、休渔期时减弱;(4)AIS轨迹密度与夜间灯光亮度在鱿钓捕捞信号上有良好的时空相关性,AIS轨迹密度与夜间灯光亮度的空间相关性越大,则时间变化规律也越相似。研究工作证明了夜间灯光遥感具备良好的鱿钓捕捞度量能力,能与船舶轨迹互补,实现高精度的鱿钓捕捞评估。

关键词：鱿钓捕捞全球联合国粮食及农业组织划分的19个主要海洋捕鱼区 AIS轨迹夜间灯光时空特征鱿钓影响因素时空相关

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超声与碱性氨基酸联合改善大豆分离蛋白功能

精细化工 2024年第7期41卷 1599-1605页

作者：李静罗灿李长春郑操特色果蔬质量安全控制湖北省重点实验室湖北孝感432000 湖北工程学院生命科学技术学院湖北孝感432000

为考察超声和碱性氨基酸(BAA)联合处理(简称联合处理)对大豆分离蛋白(SPI)结构和功能性质的影响,对比了超声或BAA单独处理对SPI表面疏水性和荧光光谱、Zeta电位、平均粒径、游离巯基、总巯基、相对溶解度、二级结构、十二烷基硫酸钠-聚... 详细信息

为考察超声和碱性氨基酸(BAA)联合处理(简称联合处理)对大豆分离蛋白(SPI)结构和功能性质的影响,对比了超声或BAA单独处理对SPI表面疏水性和荧光光谱、Zeta电位、平均粒径、游离巯基、总巯基、相对溶解度、二级结构、十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、乳化性、乳化稳定性进行了测试,并对其中部分测定结果进行了相关性分析。结果表明,联合处理后SPI的乳化性和相对溶解度均比BAA单独处理显著提高(差异显著性P<0.05);联合处理提升了SPI表面电荷量,增强了粒子之间的静电斥力;使更多的疏水基团暴露在极性环境中,改善了SPI的亲水/疏水基团比例,有利于提升SPI乳化能力;使游离巯基暴露量增加,总巯基含量下降;有利于SPI向有序分子结构转变。超声或BAA单独处理和联合处理均不会引起SPI亚基结构的改变。表面疏水性与相对溶解度和乳化性的相关度分别为0.960和0.861,呈极显著正相关性,Zeta电位与相对溶解度的相关度为–0.974,呈极显著负相关性。

关键词：超声碱性氨基酸大豆分离蛋白乳化性质相关性食品用化学品

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高导热相变水凝胶的制备及温度响应性

高分子材料科学与工程 2024年第5期40卷 144-153页

作者：符浩曹正李震杨孟晓刘琳浙江理工大学材料科学与工程学院浙江杭州310018 浙江-捷克先进纤维材料联合实验室浙江理工大学浙江杭州310018

传统的相变水凝胶用于温度监测时会面临响应时间长、力学性能不佳、导电性能差、相变焓低等问题。因此,文中以黄原胶和聚乙烯醇为主要原料,利用黄原胶分子的多官能团活性和分散性,对石蜡进行乳化,结合Zn2+和纳米氧化铝的离子导电性和高... 详细信息

传统的相变水凝胶用于温度监测时会面临响应时间长、力学性能不佳、导电性能差、相变焓低等问题。因此,文中以黄原胶和聚乙烯醇为主要原料,利用黄原胶分子的多官能团活性和分散性,对石蜡进行乳化,结合Zn2+和纳米氧化铝的离子导电性和高导热性,制备了兼具高热焓、高导热、高导电和强力学的双网络交联黄原胶/石蜡/聚乙烯醇/硼酸/锌离子/纳米氧化铝(XPPB-Zn^(2+)-Al_(2)O_(3))相变水凝胶。扫描电镜图片显示,相变微粒均匀嵌入到水凝胶的微结构中;力学测试结果显示,双交联网络赋予相变水凝胶优异的力学性能,其拉伸强度达到(0.38±0.01) MPa;差示扫描量热分析显示,水凝胶相变焓高达(180.98±3.12) J/g。此外,相变水凝胶展现出高的导热性,其热传导系数达到(0.558±0.035)W/(m·K),电阻温度系数达到1.23%℃-1,在25~60℃范围内,显示出良好的温度循环稳定性。文中所制备的高性能相变水凝胶在温度监测领域具有良好的应用前景。

关键词：黄原胶石蜡相变水凝胶温度响应性

考虑地震事件内空间相关性的区域概率地震危险性分析

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工程力学 2024年第S01期41卷 117-128页

作者：丁佳伟吕大刚曹正罡哈尔滨工业大学结构工程灾变与控制教育部重点实验室黑龙江哈尔滨150090 哈尔滨工业大学土木工程学院智能防灾减灾工业与信息化部重点实验室黑龙江哈尔滨150090

一次地震事件不同地点的地震动强度参数与结构响应参数之间是空间相关的,相关的地震效应将导致地震损失急剧集中与积累,从而造成灾难性事件,但是现有的区域尺度地震风险评估并没有考虑地震动的空间相关性。该文采用地统计学方法表征地... 详细信息

一次地震事件不同地点的地震动强度参数与结构响应参数之间是空间相关的,相关的地震效应将导致地震损失急剧集中与积累,从而造成灾难性事件,但是现有的区域尺度地震风险评估并没有考虑地震动的空间相关性。该文采用地统计学方法表征地震事件内地震动强度参数的空间相关性,提出了理论半变异函数的几何稳健估计方法,并采用加权最小二乘法实现对短距离空间相关性的准确高效评估。以新潟越冲地震为例,基于指数半变异函数模型,采用加权最小二乘法对几何稳健估计半变异函数值进行拟合,得到了PGA、PGV和0 s~10 s谱加速度的空间相关性函数,提出了变程b值的预测模型,结果表明:相比于短周期谱加速度,长周期谱加速度的空间相关性衰减速率更小,且在T=0.45 s处存在拐点。将所开发的空间相关性模型应用于区域概率地震危险性分析,采用Monte Carlo方法实现了空间相关随机场的区域地震动强度参数的模拟,改进了传统区域地震危险性分析的方法,发现绝大多数情况下考虑空间相关性的年超越概率大于未考虑空间相关性的年超越概率,表明考虑空间相关性对于建筑群落及基础设施风险评估、韧性城市建设等具有重要的指导意义。

关键词：事件内残差空间相关性几何稳健估计加权最小二乘法半变异函数区域危险性分析