Cocktail nano-adjuvant enhanced cancer immunotherapy based on NIR-Ⅱ-triggered in-situ tumor vaccination

作     者：Lilin Fan Yanwen Feng Jiang Bian Anhong Chen Donglin Xie Zheng Cao Jun Yue Lilin Fan;Yanwen Feng;Jiang Bian;Anhong Chen;Donglin Xie;Zheng Cao;Jun Yue

作者机构：Jiangsu Key Laboratory of Environmentally Friendly Polymeric MaterialsSchool of Materials Science and EngineeringJiangsu Collaborative Innovation Center of Photovoltaic Science and EngineeringChangzhou UniversityChangzhou 213164China School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第3期

页      面：346-351页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.52273163) the Science Technology and Innovation Commission of Shenzhen Municipality(No.JCYJ20190807163003704) Open Research Fund of Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials(No.PML2201) 

主　　题：Nano-adjuvant Cocktail formulation In-situ tumor vaccination NIR-Ⅱphotothermal effect Anticancer immune response 

摘      要：Second near-infrared(NIR-Ⅱ)light triggered in-situ tumor vaccination(ISTV)represents one of the most promising strategies in boosting the whole-body antitumor *** most of previously developed nano-adjuvants for NIR-Ⅱ-triggered ISTV are“all-in-oneformulations,which may indiscriminately damage both the tumor cells and the immune cells,limiting the overall effect of immune *** overcome this obstacle,we designed a“cocktailnano-adjuvant by physically mixing hyaluronidases(HAase)-decorated gold nanostars(HA)for NIR-Ⅱlight triggered in situ production of tumor-associated antigens and CpG functionalized gold nanospheres(CA)for immune cells *** to“all-in-oneformulation,the“cocktailnano-adjuvants displayed a significantly stronger immune response on NIR-Ⅱlight induced dendritic cells(DCs)mutation and T cells differentiation,greater effect on tumor-growth inhibition,and higher efficacy in inhibition of pulmonary *** is more,increasing the molar ratio of HA to CA led to an enhanced anticancer immune *** study highlight the nano-adjuvant formulation effects on the treatment of tumors with multiple targets.