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Risk factors for hepatocellular carcinoma in cirrhosis:A comprehensive analysis from a decade-long study

World Journal of Gastrointestinal Oncology 2024年第12期16卷 4625-4635页

作者： Da-Qiong Zhou Jiang-Yu Liu Feng Zhao Jing Zhang Li-Li Liu Jian-Ru Jia zhen-huan cao Department of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Hepatology Center Baoding People’s HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Cirrhosis is a significant risk factor for the development of hepatocellular carcinoma(HCC).Variability in HCC risk among patients with cirrhosis is notable,particularly when considering the diverse etiologies of *** To identify specific risk factors contributing to HCC development in patients with *** This retrospective study analyzed data from cirrhotic patients at Beijing Youan Hospital from January 1,2012 to September 30,2022 with at least 6 mo of *** demographics,medical histories,etiologies,and clinical characteristics were *** regression analysis was used to analyze correlations of the above parameters with hepatocarcinogenesis,while competing risk regression was used to estimate their adjusted hazard ratios accounting for *** cumulative incidence was plotted over *** Overall,5417 patients with cirrhosis(median age:54 years;65.8%males)were *** B virus(HBV)was the most common etiology(23.3%),with 25%(n=1352)developing HCC over a 2.9-year follow-up *** with multiple etiologies had the HCC highest incidence(30.3%),followed by those with HBV-related cirrhosis(29.5%).Significant risk factors included male sex,advanced age,hepatitis C virus(HCV)infection,elevated blood ammonia,and low platelet *** had a higher 5-year HCC risk than women(37.0%vs 31.5%).HBV,HCV,and HBV/HCV co-infected patients had 5-year risks of HCC of 45.8%,42.9%,and 48.1%,respectively,compared to 29.5%in nonviral hepatitis cases,highlighting the significant HCC risk from viral hepatitis,especially HBV,and underscores the importance of monitoring these high-risk *** In conclusion,HBV-related cirrhosis strongly correlates with HCC,with male sex,older age,viral hepatitis,elevated blood ammonia,and lower albumin and platelet levels increasing the risk of HCC.

关键词： Cirrhosis Hepatocellular carcinoma Risk factors Hepatitis B virus Competing risk analysis

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Dual modulation of homogeneous nanomaterialization and electrochemical activation enhancing zinc ion storage

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Science China Chemistry 2025年第01期 385-393页

作者： Jianwei Wang huan Wang Kangning Wang Wenhui Wang Wenlin Zhang Yanzhong zhen School of Chemistry & Chemical Engineering Yan'an University

Vanadium-based electrode materials are widely investigated,but the low specific capacity and slow electrochemical kinetics in aqueous zinc-ion batteries still limit their commercial ***,the VS2/Ca V4O9material with the morphology of nanoflower was synthesized by a one-step hydrothermal *** to the blocky structure of pure VS2material,the VS2/Ca V4O9material is composed of thinner homogeneous *** open structures could provide abundant electrochemical active sites and ion transport channels,and then promote the electrochemical reaction *** addition,they can also buffer the bulk strain during the reaction *** improve the utilization of vanadium elements,an in-situ electrochemical activation strategy is used to explore the storage performance of the VS2/Ca V4O9material,the different activation voltage range of 0.4–1.6 and 0.4–1.4 V are selected,*** with the longer activation plateau of activated-VS2,the VS2/Ca V4O9cathode could quickly reach the activation state in the range of 1.4–1.6 V and cause the release of additional Zn storage sites *** VS2/Ca V4O9cathode delivers a higher power density of 37,000 W kg-1and a significant energy density of 423 Wh *** the high current density of 15 A g-1,the VS2/Ca V4O9cathode still has a discharge capacity of 183.9m Ah g-1after 5,000 cycles,and the capacity decay rate per cycle is only 0.0042%.Continuous cyclic voltammetry （CV） curves,electrochemical impedance spectroscopy （EIS） measurements,density functional theory （DFT） calculation and galvanostatic intermittent titration technique （GITT） measurements demonstrate that the VS2/Ca V4O9cathode has a faster ion diffusion/charge transfer ***,the assembled flexible device has an excellent mechanical stability.

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： zhen-Nan Pan Hao-Lin Zhang Kun-huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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干扰素诱导抗病毒蛋白基因多态性与慢性丙型肝炎疗效的相关性

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世界华人消化杂志 2008年第19期16卷 2175-2180页

作者：邹梦娜黄雁翔李卓马丽娜林尊慧郭向华曹振环陈新月首都医科大学附属北京佑安医院国际医疗部北京市100069 首都医科大学附属北京佑安医院北京市卫生局肝炎研究所北京市100069

目的:探讨干扰素(IFN)诱导抗病毒蛋白基因多态性对慢性丙型肝炎抗(CHC)病毒治疗疗效的影响.方法:168例CHC患者给予IFN:包括聚乙二醇IFN(PEGIFN)和普通IFN,联合利巴韦林治疗52wk,随访26wk,评价持续病毒学应答(SVR)情况.于基线时留取患者... 详细信息

目的:探讨干扰素(IFN)诱导抗病毒蛋白基因多态性对慢性丙型肝炎抗(CHC)病毒治疗疗效的影响.方法:168例CHC患者给予IFN:包括聚乙二醇IFN(PEGIFN)和普通IFN,联合利巴韦林治疗52wk,随访26wk,评价持续病毒学应答(SVR)情况.于基线时留取患者外周血标本,应用多聚酶链反应(PCR)检测病毒基因型,荧光定量聚合酶链反应法测定病毒载量,同时采用多聚酶链反应-限制片段长度多态性(PCR-RFLP)的分析方法,检测患者抗病毒蛋白的MxA-88,-123位点及eIF-2α-reg2的SNP.结果:CHC患者中GT型、TT型与GG型疗效比较,差异均有统计学意义(χ2=6.862,P=0.012;χ2=12.941,P=0.001).GT型与TT型的比较,差异不显著.CA型和AA型与CC型患者疗效比较,差异均有统计学意义(χ2=5.818,P=0.020;χ2=4.498,P=0.046).但CA型与AA型的比较,差异不显著.eIF-2α-reg2位点(A/G),基因型AA与基因型为AG或GG的患者IFN疗效比较,差异没有统计学意义.结论:MxA-88为TT或GT型比GG型患者对IFN反应性好,MxA-123为AA或AC型比CC型疗效好.eIF-2α-reg2位点基因型与CHC IFN疗效无相关性.

关键词：慢性丙型肝炎干扰素单核苷酸多态性黏病毒抵抗蛋白A 真核细胞起始因子

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Condition monitoring and fault diagnosis of industrial robots: A review

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Science China Technological Sciences 2025年第1期 121-145页

作者： Yaguo LEI huan LIU Naipeng LI Junyi cao Yuting QIAO Hongbo WANG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Xi'an Jiaotong University

Health management of industrial robots is paramount for maintaining effective operations, ensuring consistent performance, minimizing downtime, and ultimately enhancing the safety and productivity of robotic systems. Since the invention of industrial robots, significant efforts have been dedicated to their health management. In recent years, thanks to advances in condition monitoring and fault diagnosis technologies of industrial robots, robot health management has shifted from scheduled maintenance to condition-based maintenance. This paper aims to comprehensively review the evolution of condition monitoring and fault diagnosis technologies that are critical for implementing condition-based maintenance of industrial robots. A brief introduction to robotic systems is given first to analyze the robot failure modes and their corresponding root causes. Next, the data acquisition strategies and commonly used sensors of industrial robots are ***, the development of robot condition monitoring and fault diagnosis technologies are reviewed, with an emphasis on the remarkable achievements and challenges in model-based and data-driven methods. Finally, the paper summarizes the challenges facing this research field and provides potential avenues for future advancements.

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Rh2O3/hexagonal CePO4 nanocatalysts for N2O decomposition

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 586-593页

作者： Liu, huan Ma, zhen Fudan Univ Dept Environm Sci & Engn Shanghai Key Lab Atmospher Particle Pollut & Prev Shanghai 200433 Peoples R China

Hexagonal CePO4 nanorods were prepared by a precipitation method and hexagonal CePO4 nanowires were prepared by hydrothermal synthesis at 150 ℃. Rh （NO3）3 was then used as a precursor for the impregnation of Rh203 onto these CePO4 materials. The Rh203 supported on the CePO4 nanowires was much more active for the catalytic decomposition of N20 than the RhzO3 supported on CePO4 nanorods. The stability of both catalysts as a function of time on stream was studied and the influence of the co-feed （CO2, O2, H20 or O2/H20） on the N20 decomposition was also investigated. The samples were characterized by N2 adsorption-desorption, induc- tively coupled plasma optical emission spectroscopy, X- ray diffraction, transmission electron microscopy, X-ray photoelectron microscopy, hydrogen temperature-pro- grammed reduction, oxygen temperature-programmed desorption, and CO2 temperature-programmed desorption in order to correlate the physicochemical and catalytic properties.

关键词： Rh2O3 CePO4 N2O decomposition

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Rh_2O_3/monoclinic CePO_4 composite catalysts for N_2O decomposition and CO oxidation

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Chinese Journal of Chemical Engineering 2018年第1期26卷 109-115页

作者： huan Liu zhen Ma Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan University

CePO4 （in particular, monoclinic CePO4） has been rarely used to make supported catalysts. Herein, monoclinic CeP04 nanoparticles were prepared by calcining hexagonal CePO4 nanomds （prepared by precipitation） in air at 900 ℃. Monoclinic CePO4 nanowires were prepared by calcining hexagonal CePO4 nanowires （prepared by hydrothermal synthesis at 150 ℃） in air at 900 ℃. Both monoclinic CePO4 materials were used to support Rh2O3 by impregnation using Rh（NO3）3 as a precursor （followed by calcination）. The catalytic performance of Rh2O3/monoclinic CePO4 composite materials in N2O decomposition and CO oxidation was investigated. It was found that Rh2O3 supported on monoclinic CePO4 nanowims was much more active than Rh2O3 supported on monoclinic CePO4 nanoparticles. The stability of catalysts as a function of reaction time on stream was studied in both reactions. The influence of co-fed CO2, O2, and H2O on the catalytic activity in N20 decomposition was also studied. These catalysts were characterized by employing N2 adsorption-desorption, ICP-OES, XRD, TEM, XPS, H2-TPR, O2-TPD, and CO2-TPD. The correlation between physicochemical properties and catalytic properties was discussed.

关键词： Rh2O3 CePO4 N2O decomposition CO oxidation Catalyst

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AN EXPANDED CHARACTERISTIC-MIXED FINITE ELEMENT METHOD FOR A CONVECTION-DOMINATED TRANSPORT PROBLEM

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Journal of Computational Mathematics 2005年第5期23卷 479-490页

作者： Ling Guo huan-zhen Chen Department of Mathematics Shanghai Jiao Tong UniversityShanghai 200030China Department of Mathematics Shandong Normal UniversityJinan 250014China

In this paper, we propose an Expanded Characteristic-mixed Finite Element Method for approximating the solution to a convection dominated transport problem. The method is a combination of characteristic approximation to handle the convection part in time and an expanded mixed finite element spatial approximation to deal with the diffusion part. The scheme is stable since fluid is transported along the approximate characteristics on the discrete level. At the same time it expands the standard mixed finite element method in the sense that three variables are explicitly treated： the scalar unknown, its gradient, and its flux. Our analysis shows the method approximates the scalar unknown, its gradient, and its flux optimally and simultaneously. We also show this scheme has much smaller time-truncation errors than those of standard methods. A numerical example is presented to show that the scheme is of high performance.

关键词： Convection diffusion problems Expanded characteristic mixed finite elementmethod Optimal error estimates Numerical test

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Synthetic fungal melanin UV absorbers

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Science China Chemistry 2024年第9期67卷 3098-3110页

作者： Chao Wang Rong Zhang Jianhua Zhang Xueqian Zhang Hengjie Zhang huan cao zhen Yang Yiwen Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Department of Radiology Huaxi MR Research CenterFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

Agents with robust ultraviolet(UV)absorption capabilities play a vital role in safeguarding organisms and inorganic materials from UV ***,the synthetic procedures towards these UV absorbers are usually lengthy and complicated,accompanied by undesirable side reactions and the generation of toxic *** nature,allomelanin,a class of melanins variant found in melanized fungi near the Chernobyl nuclear power plant,plays crucial roles in the cell wall of melanized fungi,offering resistance to harsh external environments and promising UV resistance ***,allomelanin can be rapidly biosynthesized via the polymerization of 1,8-dihydroxynaphthalene in presence of enzymes in *** by this,we report here a green enzymatic polymerization strategy to efficiently and eco-friendly synthesize polydihydroxynaphthalene(PDHN)-based artificial allomelanin nanoparticles(NPs)with interesting *** calculations and experimental results demonstrated that the PDHN NPs exhibited excellent UVabsorption capacity,surpassing another widely used artificial melanin,polydopamine(PDA).Moreover,the light absorption mechanism of PDHN NPs was systematically elucidated for the first ***,the PDHN NPs were incorporated with polyvinyl alcohol(PVA)to create an anti-aging composite film with significantly enhanced UV shielding *** potential of these composite films in safeguarding plants from UV damage was meticulously ***,these PDHN NPs were first found to produce hydroxyl radicals(·OH)under UV irradiation,offering antibacterial properties that expand their potential applications.

关键词： melanin artificial allomelanin nanoparticles green synthesis UV absorption antibacterial

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Cerium phosphate-supported Au catalysts for CO oxidation

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Chinese Journal of Chemical Engineering 2018年第10期26卷 2055-2063页

作者： Yulin Wang huan Liu zhen Ma Shanghai Key Lahoratory of Atmospheric Particle Pollution & Prevention ( IAP^3 ) Department of Environmental Sdence & Engineering Fudan University Shanghai 200433 China

LaPO_4 and hydroxyapatite(Ca_(10)(PO_4)_6(OH)_2)are typical metal phosphates recently found to be useful for making supported metal or metal oxide catalysts,but CePO_4(also belonging to the metal phosphate family)has been rarely used to make supported *** would be interesting to develop CePO_4-supported catalysts and explore their catalytic ***,hexagonal CePO_4 nanorods(denoted as CePO_4-H),hexagonal CePO_4 nanowires(CePO_4-HNW),monoclinic CePO_4 nanoparticles(CePO_4-M),and monoclinic CePO_4 nanowires(CePO_4-MNW)prepared by different methods were used to support gold via deposition-precipitation with urea(DPU).The gold contents of these catalysts were all around 1 wt%.The catalytic activities of these Au/CePO_4 catalysts in CO oxidation were found to follow the sequence of Au/CePO_4-MNW>Au/CePO_4-HNW> Au/CePO_4-M>Au/CePO_*** catalysts were characterized by inductively coupled plasma-optical emission spectroscopy(ICP-OES),N_2 adsorption–desorption,X-ray diffraction(XRD),transmission electron microscopy(TEM),X-ray photoelectron spectroscopy(XPS),oxygen temperature-programmed desorption(O_2-TPD),and CO_2 temperature-programmed desorption(CO_2-TPD)to find possible correlations between the physicochemical properties and catalytic activities of these catalysts.

关键词： Gold Catalysis Catalyst support CePO4 Carbon monoxide Oxidation

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