Risk factors for hepatocellular carcinoma in cirrhosis:A comprehensive analysis from a decade-long study

作     者：Da-Qiong Zhou Jiang-Yu Liu Feng Zhao Jing Zhang Li-Li Liu Jian-Ru Jia Zhen-Huan Cao 

作者机构：Department of HepatologyBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Hepatology CenterBaoding People’s HospitalBaoding 071000Hebei ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文）)

年 卷 期：2024年第16卷第12期

页      面：4625-4635页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cirrhosis Hepatocellular carcinoma Risk factors Hepatitis B virus Competing risk analysis 

摘      要：BACKGROUND Cirrhosis is a significant risk factor for the development of hepatocellular carcinoma(HCC).Variability in HCC risk among patients with cirrhosis is notable,particularly when considering the diverse etiologies of *** To identify specific risk factors contributing to HCC development in patients with *** This retrospective study analyzed data from cirrhotic patients at Beijing Youan Hospital from January 1,2012 to September 30,2022 with at least 6 mo of *** demographics,medical histories,etiologies,and clinical characteristics were *** regression analysis was used to analyze correlations of the above parameters with hepatocarcinogenesis,while competing risk regression was used to estimate their adjusted hazard ratios accounting for *** cumulative incidence was plotted over *** Overall,5417 patients with cirrhosis(median age:54 years;65.8%males)were *** B virus(HBV)was the most common etiology(23.3%),with 25%(n=1352)developing HCC over a 2.9-year follow-up *** with multiple etiologies had the HCC highest incidence(30.3%),followed by those with HBV-related cirrhosis(29.5%).Significant risk factors included male sex,advanced age,hepatitis C virus(HCV)infection,elevated blood ammonia,and low platelet *** had a higher 5-year HCC risk than women(37.0%vs 31.5%).HBV,HCV,and HBV/HCV co-infected patients had 5-year risks of HCC of 45.8%,42.9%,and 48.1%,respectively,compared to 29.5%in nonviral hepatitis cases,highlighting the significant HCC risk from viral hepatitis,especially HBV,and underscores the importance of monitoring these high-risk *** In conclusion,HBV-related cirrhosis strongly correlates with HCC,with male sex,older age,viral hepatitis,elevated blood ammonia,and lower albumin and platelet levels increasing the risk of HCC.