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神经解剖学杂志 2001年第B7期17卷 103-103页

作者： zhen li and jun chen department of anatomy and k.k.leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: To study the roles of spinal cyclooxygenase (COX) -2 in the development of persistent spontaneous nociception and mechanical and thermal hyperalgesia induced by subcutaneous(s.c.) bee venom injection, the effects of intrathecal (i.t.) administration of a selective COX-2 inhibitor, etodolac was evaluated in the conscious rat. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre-and post-application

关键词：大白鼠脊髓环氧化酶2 持续性自发性损伤感受痛觉过敏蜂毒皮下注射

ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

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神经解剖学杂志 2001年第B7期17卷 104-105页

作者： kai-cheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: It has been shown that spinal protein kinases (Pigs) such as PkC and PkA may play important roles in induction or maintenance of persistent nociception and hyperagesia. In the present study, we examined the spinal roles of PkC and cAMP-dependent PkA in development and maintenance of the bee venom(BV)-induced persistent spontaneous nociception and hyperalgesia in conscious rats with chronically intrathecal catheterization.

关键词：蜂毒诱发持续性自发性损伤感受痛觉过敏脊髓蛋白激酶作用 PkC PkA

THE BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN ELDERLY RATS

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神经解剖学杂志 2001年第B7期17卷 107-108页

作者： Wei GE~2, Hui-Sheng chen~1, Yuan li~2, jun chen~1 ~1 department of anatomy and k.k. leung brain research centre, ~2 department of Geriatrics, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model in adult rats has been well established. However, the BV-induced multiple aspects of pathological pain have not been studied in elderly (age >22 months) rats. The present study was designed to investigate: (1) response pattern and time course of the BV-indueed persistent spontaneous nociception (PSN) and hyperalgesia in elderly rats; (2) Laminar distribution and time course of the

关键词：老龄大白鼠蜂毒诱发持续性自发性损伤感受痛觉过敏

THE ROLES OF SPINAL N- AND L-TYPE VOLTAGE-DEPENDENT CALCIUM CHANNELS IN DEVELOPING AND MAINTAINING PROCESSES OF BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA IN RATS

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神经解剖学杂志 2001年第B7期17卷 102-102页

作者： zheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

Aim: To further study the roles of spinal N-or L-type voltage-dependent calcium channel (VDCC) in induction and maintenance of both persistent spontaneous nociception (PSN) and hyperalgesia induced by subcutaneous (s.c.) bee venom injection, the effects of intrathecal (i.t.) pre- or post-treatment with VDCC blockers of N-type (ω-Conotoxin-GVIA) and L-type (verapamil) were evaluated in conscious rats.

关键词：大鼠蜂毒诱导持续性自发性损伤感受痛觉过敏脊髓钙通道 N型 T型电位依赖性

CONTRIBUTION OF CAPSAICIN-SENSITIVE PRIMARY AFFERENT-MEDIATED NEUROGENIC RESPONSES TO THE BEE VENOM-INDUCED INFLAMMATION IN RATS

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神经解剖学杂志 2001年第B7期17卷 99-99页

作者： Hui-sheng chen, zhen li and jun chen department of anatomy & k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: The bee venom (BV) model has been proved to be a good one to study the inflammatory pain, because subcutaneous injection of BV into one hind paw in rats could produce typical inflammatory responses such as rednes... 详细信息

关键词：大白鼠蜂毒诱发炎症辣椒素敏感性神经性反应初级传入调制

DIFFERENTIAL ROLES OF SPINAL NITRIC OxiDE IN DEVELOPMENT OF HEAT AND MECHANICAL HYPERALGESIA INDUCED BY INTRAPLANTAR INJECTION OF BEE VENOM IN CONSCIOUS RATS

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神经解剖学杂志 2001年第B7期17卷 105-105页

作者： Hui-li li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an 710032

Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and

关键词：大白鼠足底皮注蜂毒热痛觉过敏机械性痛觉过敏脊髓一氧化氮 NO 作用

ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

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神经解剖学杂志 2001年第S1期 104-104页

作者： kai-cheng li and jun chen department of anatomy and k.k. leung brain research centre, the fourth military medical university, xi’an, 710032

关键词： BV PkC heat ROLES OF SPINAL PROTEIN kINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain

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Science China(life Sciences) 2024年第1期67卷 67-82页

作者： Chun-kui Zhang Pan Wang Yuan-Yuan Ji Jian-Shuai Zhao jun-xiang Gu xian-xia Yan Hong-Wei Fan Ming-Ming Zhang Yu Qiao xiao-Die liu Bao-Juan li Ming-Hui Wang Hai-Long Dong Hao-Hong li Peng-cheng Huang Yun-Qing li Wu-Gang Hou Jin-lian li Tao chen department of anatomy and k.k.leung brain research centre Fourth Military Medical UniversityXi’an 710032China Beijing Institute of Basic medical Sciences Beijing 100850China key Laboratory of Ministry of Public Health for Forensic Science Xi’an Jiaotong UniversityXi’an 710061China department of Anesthesiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China department of Neurosurgery the Second Affiliated Hospital of Xian Jiaotong UniversityXi’an 710004China School of Biomedical Engineering Fourth Military Medical UniversityXi’an 710032China Affiliated Mental Health centre and Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhou 310013China The MOE Frontier research Center of brain&brain-machine Integration Zhejiang University School of Brain Science and Brain MedicineHangzhou 310058China department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China department of anatomy School of MedicineNorthwest UniversityXi’an 710069China

Chronic pain often develops severe mood changes such as ***,how chronic pain leads to depression remains elusive and the mechanisms determining individuals’responses to depression are largely *** we found that depression-like behaviors could only be observed in 67.9%of mice with chronic neuropathic pain,leaving 32.1%of mice with depression *** determined that the spike discharges of the ventral tegmental area(VTA)-projecting lateral habenula(LHb)glutamatergic(Glu)neurons were sequentially increased in sham,resilient and susceptible mice,which consequently inhibited VTA dopaminergic(DA)neurons through a LHbGlu-VTAGABA-VTADA ***,the LHbGlu-VTADA excitatory inputs were dampened via GABAB receptors in a pre-synaptic *** of LHb-VTA pathway largely affected the development of depressive symptoms caused by chronic *** study thus identifies a pivotal role of the LHb-VTA pathway in coupling chronic pain with depression and highlights the activity-dependent contribution of LHbGlu-to-VTADA inhibition in depressive behavioral regulation.

关键词： chronic pain depression lateral habenula ventral tegmental area dopamine susceptibility

POSTNATAL DEVELOPMENT OF PERSISTENT SPONTANEOUS PAIN AND HYPERALGESIA INDUCED BY SUBCUTANEOUS INTRAPLANTAR BEE VENOM INJECTION IN RATS

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神经解剖学杂志 2001年第B7期17卷 106-106页

作者： Meng-Meng li~2, Hui-Sheng chen~1, Ying-Min ZHANG~2 and jun chen~1 ~1department of anatomy and k.k. leung brain research centre, ~2department of Anesthesiology, the fourth military medical university, xi’an 710032

Aim: The present study was designed to investigate the postnatal development of persistent spontaneous pain and hyperalgesia induced by subcutaneous (s. c. ) intraplantar bee venom (BV) injection in pup rats and changes in pain behaviors in the mature rats receiving postnatal BV injection. Methods: Twenty four litters of pup rats were divided into six groups: P1 (postnatal day), P4, P7, P14, P21, P28.

关键词：大鼠足底皮注蜂毒持续性自状性疼痛痛觉过敏生后发育

ANTINOCICEPTIVE EFFECTS OF INTRATHECAL PROPOFOL ON THE BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

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神经解剖学杂志 2001年第B7期17卷 109-109页

作者： li-Yun WANG~(2,3), Ying-Min ZHANG~2, jun chen~1 ~1department of anatomy & k.k. leung brain research centre, ~2department of Anesthesiology, xijing Hospital, the fourth military medical university ~3department of Anesthesiology, PLA 464 Hospital of Tianjin

Aim: Propofol, a widely used alkyphenol intravenous anesthetic, has been proven to be a shortly acting, less toxic and high safe coefficient in clinic application. However, whether the drug has analgesic action is still not clear. To further answer this question, the effects of i. t. propofol on persistent spontaneous nociception (PSN) and hyperalgesia induced by chemical tissue injury were examined.

关键词：髓鞘内注射 Propofol 蜂毒诱发性持续性自发性损伤感受痛觉过敏抑制作用