DIFFERENTIAL ROLES OF SPINAL NITRIC OXIDE IN DEVELOPMENT OF HEAT AND MECHANICAL HYPERALGESIA INDUCED BY INTRAPLANTAR INJECTION OF BEE VENOM IN CONSCIOUS RATS

作     者：Hui-Li LI and Jun CHEN Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi’an 710032 

出 版 物：《神经解剖学杂志》 (Chinese Journal of Neuroanatomy)

年 卷 期：2001年第17卷第B7期

页      面：105-105页

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

主　　题：大白鼠 足底皮注蜂毒 热痛觉过敏 机械性痛觉过敏 脊髓 一氧化氮 NO 作用 

摘      要：Aim: To study the roles of nitric oxide (NO) of spinal cord in induction and maintenance of the bee venom (BV)-induced persistent spontaneous nociception (PSN) and hyperalgesia to heat and mechanical stimulation. Methods: Chronic intrathecal (i.t.) catheterization was performed and effects of i.t. pre- and post-application of NO synthase inhibitor, N^G-nitro-L-arginine-methyl-ester hydrochloride (L-NAME), at does of 0.01, 0.1, 1 and