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Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method

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Journal of Traditional Chinese Medicine 2022年第3期42卷 389-399页

作者： QIN Luxue GUO Changqing zhao ruili WANG Tong WANG Junmei GUO Yan ZHANG Wei HU Tingyao CHEN Xilin ZHANG Qian ZHANG Dian XU Yue School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China the First People's Hospital of Dongcheng District Beijing 100050China Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China the Third Affiliated Hospital of Beijing Universality of Chinese Medicine Beijing 100029China

OBJECTIVE:To investigate the effects of acupotomy on inhibiting abnormal formation of subchondral bone in rabbits with knee osteoarthritis(KOA).METHODS:A total of 24 New Zealand rabbits were randomly divided into four groups of 6 rabbits each[control,model,electroacupuncture(EA)and acupotomy].Eighteen KOA model rabbits were established using a modified Videman *** in EA and acupotomy groups received the intervention for 3 ***,the cartilage and subchondral bone unit were obtained and the histomorphological changes were ***(OPG)and receptor activator of nuclear factor-κB ligand(RANKL)in subchondral bone were evaluated by Western blotting,real-time polymerase chain reaction and ***:Compared with the model group,both the acupotomy and EA groups showed a significant decrease in the Lequesne index(both P<0.01)and Mankin score(P<0.01,<0.05).In addition,both EA and acupotomy groups had a higher expression of total articular cartilage(TAC)(P<0.05,<0.01)and lower expression of articular calcified cartilage(ACC)/TAC(P<0.05,<0.05)compared with the model *** thickness of the subchondral bone plate in EA and acupotomy groups were decreased(both P<0.01)compared to the model ***,trabecular bone volume(BV/TV),protein and relative expression of OPG and the ratio of OPG/RANKL in the subchondral bone of acupotomy group were decreased statistically significant,while these parameters were not significantly changed in the EA group compared with the model ***:In the rabbit model of KOA,acupotomy inhibits aberrant formation of subchondral bone by suppressing OPG/RANKL ratio as a potential therapy for KOA.

关键词： acupuncture therapy osteogenesis osteoarthritis,knee subchondral bone

Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats

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Journal of Traditional Chinese Medicine 2018年第2期38卷 227-241页

作者： Guo Yan Lu Juan Liang Jingrong zhao ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma Liangxiao Department of Acupuncture and Moxibustion First Hospital Affiliated to Tianjin College of Traditional Chinese Medicine College of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Acupuncture-Moxibustion and Tuina Second School of Clinical Medical of Nanjing University of Traditional Chinese Medicine Department of Acupuncture and Moxibustion Jiangsu Province Hospital

OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) ***: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. Acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) ***: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip ***: Acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism.

关键词： Essential hypertension Point ST 9(Re-nying) Oligonucleotide array sequence analysis Hypothalamus

Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin(Manis javanica)

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Integrative Zoology 2023年第2期18卷 289-298页

作者： Fang JI Shelan LIU Xue WANG Jianan zhao Jiayue ZHU Jianchun YANG Chenglin ZHANG Zhongxin JIA ruili zhao Guocheng HU Jing WANG Jianhua QIN Gang LI Bin WU Chengmin WANG Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of ScienceGuangzhouChina Department of Infectious Diseases Zhejiang Center of Disease Control and PreventionHangzhouZhejiangChina School of Bioengineering East China University of Science and TechnologyShanghaiChina Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijingChina College of Animal Science and Veterinary Medicine Tianjin Agricultural UniversityTianjinChina South China Institute of Environmental Sciences Ministry of Ecology and EnvironmentGuangzhouChina Department of Infectious Diseases Hangzhou Center of Disease Control and PreventionHangzhouChina College of Veterinary Medicine Agricultural University of HebeiBaodingChina

Potential zoonotic pathogens may be transmitted from wildlife to humans through the illegal wild meat trade,which has become a pressing ***,research on the antimicrobial resistance genes(ARGs)of Malayan pangolin(Manis javanica)intestinal bacteria is ***,multidrug-resistant Escherichia coli M172-1(ST354)isolated from Malayan pangolin feces in 2019 was found to be resistant to 13 *** analysis revealed 4 plas-mids,namely,pM172-1.1,pM172-1.2,pM172-1.3,and pM172-1.4,in the *** pM172-1.2,pM172-1.3,and pM172-1.4 plasmids carried ARGs,namely,IncHI2-HI2A,IncX1-X1,and IncX1,***172-1.3 and pM172-1.4 contained intact IntI1 integrons(Is26/IntI1/arr2/cmlA5/blaOXA-10/ant(3′′)-IIA/dfrA14/Is26).No-tably,pM172-1.3 resulted from the fusion of 2 pM172-1.4 copies and carried many more *** addition to pM172-1.3 from the same host,other drug-resistant bacteria(*** M159-1(ST48),*** S171-1(ST206),and Klebsiella pneumoniae S174-1(ST2354))in the same Malayan pangolin fecal samples also carried 3 plasmids with 100%gene coverage of pM172-1.4 and 99.98%***,ARGs in IncX1 might spread in the intestinalﬂora of Malayan pangolin and between species via the illegal food chain,posing a potential threat to public health and safety.

关键词： ARG Manis javanica multiple-replicon plasmid IncX1-X1 plasmid IncX1

Effect of immunopotentiator of the Chinese herbal medicine on the quantity of T lymphocyte in chicken

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Journal of Northeast Agricultural University(English Edition) 2007年第2期14卷 120-124页

作者： SHI Qiumei SHEN Ping GAO Guisheng zhao ruili TANG Shengling College of Animal Husbandry and Veterinary Medicine Jilin University Changchun 130062 China Department of Animal Science Hebei Normal College of Science and Technology Qirthuangdao 066004 Hebei China

In order to study the mechanism of immunopotentiator, the quantity of T lymphocyte was observed. Total 240 1-day chikens were divided into 3 groups randomly： one contrast group and two groups being drunk immunopotentiator according to the concentration 10 mL·L^-1 and 5 mL·L^-1 lasting for 48 d. The number of T lymphocyte in blood was measured by E-rosette when the chikens were at 12-, 24-, 36-, and 48-day. The results showed that the percent ofT lymphocyte in the trial group was obviously higher than that of the contrast, and the 10 mL·L^-1 group was higher than that of the 5 mL·L^-1 group; the quantity distribution of T lymphocyte in intestinal mucosa lymphoid tissue of 14-day, 21-day chiken was surveyed in the contrast group and the10 mL·L^-1 group with the method of routine histology-slices and ANAE, the results showed that the quantity of T lymphocyte in the 10 mL·L^-1 group was significantly higher than that of the contrast, which indicated that immunopotentiator increased markedly the quantity of T lymphocyte, and the 10 mL·L^-1 group was higher than that of the 5 mL·L^-1 group.

关键词： immunopotentiator T lymphocyte E-rosette histology

Survivin在喉癌组织中的表达及其与细胞凋亡的相关性

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天津医药 2006年第7期34卷 459-461页

作者：赵瑞力河北医科大学附属第四医院 050011

目的:研究Survivin基因在喉癌发生发展中的作用。方法:应用RT-PCR及流式细胞术检测42例喉癌组织细胞中survivinmRNA、蛋白及细胞凋亡率(AP)。结果:SurvivinmRNA及蛋白在喉癌组织中尤其是Ⅲ、Ⅳ期中高度表达;在survivin表达组中AP明显降... 详细信息

目的:研究Survivin基因在喉癌发生发展中的作用。方法:应用RT-PCR及流式细胞术检测42例喉癌组织细胞中survivinmRNA、蛋白及细胞凋亡率(AP)。结果:SurvivinmRNA及蛋白在喉癌组织中尤其是Ⅲ、Ⅳ期中高度表达;在survivin表达组中AP明显降低,且survivin蛋白定量与AP呈负相关。结论:Survivin基因可能通过抑制细胞凋亡参与了喉癌的发生、发展,提示喉癌的高侵袭性和预后不良。

关键词：喉肿瘤细胞凋亡逆转录聚合酶链反应流式细胞术

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埃洛石纳米管改性水性聚氨酯的制备及性能

印染 2023年第8期49卷 35-38页

作者：赵小亮赵瑞丽西安工程大学材料工程学院陕西西安710048

以氨基化的埃洛石纳米管(HNTs)、异佛尔酮二异氰酸酯(IPDI)、聚丙二醇2000(PPG2000)、1,4-丁二醇(BDO)、三羟甲基丙烷(TMP)、2,2-双羟甲基丙酸(DMPA)以及3-氨丙基三乙氧基硅烷(KH550)等作为主要原料,制备氨基化HNTs改性水性聚氨酯(WPU)... 详细信息

以氨基化的埃洛石纳米管(HNTs)、异佛尔酮二异氰酸酯(IPDI)、聚丙二醇2000(PPG2000)、1,4-丁二醇(BDO)、三羟甲基丙烷(TMP)、2,2-双羟甲基丙酸(DMPA)以及3-氨丙基三乙氧基硅烷(KH550)等作为主要原料,制备氨基化HNTs改性水性聚氨酯(WPU)材料。通过红外分析、力学测试、热重分析、流变分析、接触角及吸水率等方法,研究氨基化HNTs含量对WPU性能的影响。结果表明:与纯WPU相比,随氨基化HNTs含量的增加,HNTs改性WPU乳液黏度增大,胶膜热稳定性得到改善,疏水性能提高。当氨基化HNTs质量分数为2.5%时,改性WPU胶膜接触角达到95.15°,吸水率仅为11.11%;进一步提高氨基化HNTs质量分数到5%时,改性WPU力学性能最优,拉伸强度和断裂伸长率分别提高271%和38%。

关键词：水性聚氨酯埃洛石纳米管 KH550 氨基化疏水性

不同菌种发酵对诺丽果酵素的抗氧化性及风味物质的影响

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食品工业科技 2023年第4期44卷 129-137页

作者：刘倩袁越张杰赵瑞丽赵黎明华东理工大学生物工程学院上海200237 华东理工大学生物工程学院发酵工业分离提取技术研发中心生物反应器工程国家重点实验室上海200237 上海皇润食品科技有限公司上海201815

为比较不同菌种发酵对诺丽果酵素品质的影响,选用鼠李糖乳杆菌12(LGG)、植物乳杆菌08(LP-08)、植物乳杆菌K11(LP-K11)、戊糖片球菌03(PP)、乳双歧杆菌36(BLA)分别对诺丽果汁进行发酵,比较不同菌种发酵对诺丽果汁的理化性质、抗氧化活性... 详细信息

为比较不同菌种发酵对诺丽果酵素品质的影响,选用鼠李糖乳杆菌12(LGG)、植物乳杆菌08(LP-08)、植物乳杆菌K11(LP-K11)、戊糖片球菌03(PP)、乳双歧杆菌36(BLA)分别对诺丽果汁进行发酵,比较不同菌种发酵对诺丽果汁的理化性质、抗氧化活性及风味物质的影响。结果显示:LP-08发酵后产酸能力最强,其次是BLA;LP-08利用还原糖的能力最强;发酵第5 d时,LP-08和LP-K11多酚含量显著提升29.74%和28.54%(P<0.05);BLA发酵3 d后SOD酶活力显著提高44.59%,LP-08发酵5 d时显著提高43.58%(P<0.05)。LP-08、LP-K11和BLA发酵3~7 d时有利于诺丽果酵素抗氧化活性的提升。BLA发酵后乳酸含量显著提高23.89倍(P<0.05),其次是LP-K11和LP-08。LP-08发酵后总体感官品质最好,发酵后增加了10种小分子有机酸、5种醇及其衍生物、4种醛类和3种酯类,赋予了诺丽果酵素奶酪香、花香和果香。与其它菌株相比,LP-08发酵产酸、产SOD酶能力较强,具有较高的抗氧化活性和良好的感官品质,在诺丽果酵素的生产中具有更大的研究和应用潜力。

关键词：诺丽果酵素乳酸菌双歧杆菌抗氧化活性风味物质

基于硬件损伤的智能反射面辅助安全通信系统能效优化算法

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电子与信息学报 2022年第7期44卷 2349-2357页

作者：高俊鹏周继华赵涛徐勇军赵瑞莉重庆邮电大学通信与信息工程学院重庆400065 航天新通科技有限公司重庆401332 复杂环境通信重庆市重点实验室重庆400030

为了克服阴影衰落和障碍物阻挡的影响,智能反射面(IRS)已经成为一种提高无线通信系统能量效率(EE)和降低硬件成本的有效技术。然而,传统无线资源分配(RA)算法忽略了系统收发机硬件损伤(HIs)的影响,由于放大器非线性、相位噪声的影响使... 详细信息

为了克服阴影衰落和障碍物阻挡的影响,智能反射面(IRS)已经成为一种提高无线通信系统能量效率(EE)和降低硬件成本的有效技术。然而,传统无线资源分配(RA)算法忽略了系统收发机硬件损伤(HIs)的影响,由于放大器非线性、相位噪声的影响使得接收信号失真,从而使得这类算法的系统性能下降。为解决该问题,通过考虑收发机的硬件损伤和网络窃听者的影响,该文研究基于硬件损伤的IRS辅助安全通信系统能效优化问题。首先,基于基站的最大发射功率约束和用户的最小安全速率约束,建立一个含硬件损伤的能效最大资源优化问题。其次,采用辅助变量替换、半正定松弛以及Dinkelbach等方法,将原非凸问题转化为凸问题进行求解。最后,数值仿真结果表明,该算法与传统资源分配算法相比,合法用户的平均中断概率降低了43.5%,该算法中系统的安全能效提高了8.3%,因此,该算法具有较好的抗硬件损伤性和安全性。

关键词：安全通信智能反射面能效最大化硬件损伤

最低工资标准对企业创新行为的影响——兼论企业间创新资源的再配置

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南开经济研究 2021年第1期 184-204页

作者：赵瑞丽何欢浪上海对外经贸大学国际经贸学院 201600

本文使用1998—2009年中国工业企业数据库,从创新投入和创新产出双重维度探讨了要素驱动增长模式下最低工资标准上涨对企业创新行为的影响。研究发现,最低工资标准上调显著抑制了企业研发投入和新产品产值的提高。这一影响对不同类型的... 详细信息

本文使用1998—2009年中国工业企业数据库,从创新投入和创新产出双重维度探讨了要素驱动增长模式下最低工资标准上涨对企业创新行为的影响。研究发现,最低工资标准上调显著抑制了企业研发投入和新产品产值的提高。这一影响对不同类型的企业存在异质性。具体而言,相较于低生产率、低加成率、低工资和融资约束较紧的企业,最低工资上涨对高生产率、高加成率、高工资和融资约束较松企业创新行为的负向影响较小。由于后者在创新投入和创新产出上均存在显著优势,最低工资上涨显著扩大了同一行业内企业之间在创新投入和创新产出的差距,进而使行业内创新资源配置的不平等态势扩大。此外,企业所有权的异质性影响结果表明,最低工资上涨对企业创新行为的负向冲击主要体现于民营企业样本。整体上,由劳动力成本上涨引致的融资约束收紧是导致这一负向冲击的主要原因。

关键词：最低工资标准企业创新行为创新资源再配置