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Low-coordination environment design of single Co atoms for efficient CO_(2) photoreduction

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Nano Research 2024年第5期17卷 3745-3751页

作者： Zhentao Ma Qingyu Wang Limin Liu Rong-ao zhang Qichen Liu Peigen Liu Lihui Wu Chengyuan Liu Yu Bai Yida zhang Haibin Pan Xusheng Zheng National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China College of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Photocatalytic carbon dioxide(CO_(2))to carbon monoxide(CO)offers a promising way for both alleviating the greenhouse effect and meeting the industrial ***,we constructed a Co single-atom catalyst with intentional low-coordination environment design on porous ZnO(denoted as Co1/ZnO).Impressively,Co1/ZnO exhibited a remarkable activity with a CO yield rate of 22.25 mmol·g^(-1)·h^(-1) and a selectivity of 80.2%for CO_(2) photoreduction reactions under visible *** incorporation of single Co atoms provided an additional photo-generated electron transfer channel,which suppressed the carrier recombination of ***,the unsaturated Co active sites were capable to adsorb CO_(2) molecule spontaneously,thus facilitating the activation of CO_(2) molecule during CO_(2) reduction course.

关键词： photocatalytic CO_(2)reduction single atoms low-coordination CO_(2)adsorption electron transfer

加快构建适应新质生产力发展的药学创新人才发展体系

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学术前沿 2024年第16期 28-34页

作者：张翱上海交通大学药学院

在全球经济低迷、科技快速迭代、国际竞争日益激烈的发展背景下,中国生物医药行业正经历一个关键的创新发展期,需要培养具有国际视野、创新意识和实践能力的药学创新人才。经过多年的不懈探索,我国基础学科拔尖人才培养经历了从“单校... 详细信息

在全球经济低迷、科技快速迭代、国际竞争日益激烈的发展背景下,中国生物医药行业正经历一个关键的创新发展期,需要培养具有国际视野、创新意识和实践能力的药学创新人才。经过多年的不懈探索,我国基础学科拔尖人才培养经历了从“单校试点推进”向“多校群体发力”的跨越式演进,实现了从“单兵作战”到有组织培养的全面升级,对我国储备国家战略人才力量发挥了重要支撑作用。应加快建设高水平师资队伍,扎实推进高能级实践平台建设,深化产教融合、科教融汇生态,着力培养突破学科边界、推动医药产业颠覆式创新发展的药学创新人才,助力我国新药研发从“跟跑”、“并跑”向“领跑”转变,为推动我国跨入世界制药强国行列作出应有的贡献。

关键词：新质生产力原创新药药学创新人才高质量发展交叉融合

Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie Liu Ming-Le Dou De-Feng Zhao ao zhang Heng-Kuan Li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei Yong zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： ao zhang Jingao Lu Shachuan Feng Huapeng Yu Tao Yu Shizheng Zhao Kemin Chen Zhibin Huang Jin Xu Jianan Y.Qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue *** integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult *** mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China

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Infectious Diseases of Poverty 2024年第1期13卷 42-52页

作者： Jian Wang Li Qiu Shuang Bai Wei Zhao ao zhang Jing Li Jun-Nan zhang Shan-Shan Zhou Ren Qiu Zhu Huang Jv-Xia Liu Ting-Bin Wang Xue Sun Jiang Wu Qun Zheng Bin He Min Lv Beijing Center for Disease Prevention and Control BeijingChina Beijing Research Center for Respiratory Infectious Diseases BeijingChina Hainan Provincial Center for Disease Control and Prevention HaikouChina Haikou Center for Disease Control and Prevention HaikouHainanChina Wanning Center for Disease Control and Prevention WanningHainanChina Baisha County Center for Disease Control and Prevention BaishaHainanChina Qiongzhong County Center for Disease Control and Prevention QiongzhongHainanChina

Background The thirteen-valent pneumococcal conjugate vaccine(PCV13)is not included in the national immu-nization program and is administered voluntarily with informed consent in *** preparation for assessing the impact of pilot introduction in Hainan Province,we conducted a carriage study among children under 5 years of age from four locations in Hainan Province,*** From March to June 2022,nasopharyngeal(NP)swabs,collected from healthy children aged younger than 59 months who lived in the 4 different locations(Haikou,Wanning,Baisha and Qiongzhong)in Hainan Province,were tested for pneumococcus using conventional *** isolates were serotyped using the Quel-lung *** factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age,daycare attendance and other *** Pneumococcus was isolated in 710(30.4%)of the 2333 children *** 737 pneumococci,29 serotypes were identifed;60.9%were PCV13 serotypes;the most common vaccine serotypes were 6B(20.4%),19F(13.0%),6A(11.9%)and 23F(6.1%);and the most common nonvaccine serotypes were 23A(12.9%),34(6.1%)and nontypeable(NT)pneumococci(5.6%).Children vaccinated with PCV13 had lower carriage(17.7%vs 32.5%;P=0.0001)and fewer PCV13 serotypes(41.9%vs 62.7%;P=0.0017)compared to unimmunized *** adjustment,NP carriage Was higher among children attending daycare(aoR=2.3,95%CI:1.7-3.2),living in rural areas(aoR=1.4,95%CI:1.1-1.8),living with siblings(aoR=1.3,95%CI:1.0-1.6)and whose mothers had completed senior high/technical sec-ondary school(aoR=1.5,95%CI:1.1-2.0).In contrast,completion of 3-4 doses of PCV13 were associated with a lower carriage rate(aoR=0.6,95%CI:0.4-0.9).Conclusions We established the baseline of pneumococcal carriage,serotype distribution and PCV13 immuni-zation rates among healthy children under 5 years of age in Hainan Province,prior to the introduction of PCV13 into th

关键词： Pneumococcus Nasopharyngeal carriage Serotypes distribution Children Hainan Province China

BFRP筋回收轮胎钢纤维混凝土短柱偏压性能试验

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华中科技大学学报（自然科学版） 2024年第2期52卷 112-119页

作者：范小春张澳罗聪张巍武汉理工大学土木工程与建筑学院湖北武汉430070 中南建筑设计院股份有限公司湖北武汉430071 湖北省建设工程质量安全监督总站湖北武汉430000

提出了玄武岩筋回收轮胎钢纤维混凝土(BRC)短柱新型材料构件,为研究BRC短柱偏压性能,制作6根混凝土短柱,并结合非接触式全场应变位移测量技术-数字图像(3D-DIC)技术进行试验测量,研究了回收轮胎钢纤维(RTSF)体积掺量和偏心距对短柱偏压... 详细信息

提出了玄武岩筋回收轮胎钢纤维混凝土(BRC)短柱新型材料构件,为研究BRC短柱偏压性能,制作6根混凝土短柱,并结合非接触式全场应变位移测量技术-数字图像(3D-DIC)技术进行试验测量,研究了回收轮胎钢纤维(RTSF)体积掺量和偏心距对短柱偏压性能和破坏模式的影响.研究结果表明:BRC短柱受压破坏为混凝土压碎、玄武岩纤维增强复合材料(BFRP)筋压断破坏,RTSF提高了混凝土短柱的受压性能,对限制试验柱裂缝和变形的发展具有显著作用,并能有效提高其开裂荷载、极限荷载、混凝土极限压应变和抗压强度.在相同偏心距下,与玄武岩筋普通混凝土短柱相比,BRC混凝土短柱的开裂荷载分别提高了20.46%,23.19%和38.36%,极限承载力分别提高了15.39%,21.55%和30.69%.由于现有的计算模型不足以准确计算BRC短柱受压承载力,提出了考虑RTSF混凝土抗拉强度的承载力计算模型,BRC短柱试验值与预测值符合较好.

关键词：玄武岩纤维增强复合材料回收轮胎钢纤维混凝土短柱偏压破坏模式受压承载力计算

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《中州集》四库提要的文本系统与学术重建

中国典籍与文化 2024年第1期 54-63页

作者：张傲上海大学

《中州集》四库提要在最初的翁方纲分纂稿、《四库全书荟要总目提要》、各阁书前提要与最终成型的《四库全书总目》之间存在较大差异,不同阶段的差异体现了四库提要定型的动态过程。在这一过程中,四库馆臣出于对《中州集》隐没的担忧,... 详细信息

《中州集》四库提要在最初的翁方纲分纂稿、《四库全书荟要总目提要》、各阁书前提要与最终成型的《四库全书总目》之间存在较大差异,不同阶段的差异体现了四库提要定型的动态过程。在这一过程中,四库馆臣出于对《中州集》隐没的担忧,通过有意识地舍弃、增补和替换,微妙地构建了《中州集》“集中之史”的地位。

关键词：中州集四库全书总目集中之史

Comparative study of different machine learning models in landslide susceptibility assessment: A case study of Conghua District, Guangzhou, China

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China Geology 2024年第1期7卷 104-115页

作者： ao zhang Xin-wen Zhao Xing-yuezi Zhao Xiao-zhan Zheng Min Zeng Xuan Huang Pan Wu Tuo Jiang Shi-chang Wang Jun He Yi-yong Li Wuhan Center China Geological SurveyMinistry of Natural Resources(Geosciences Innovation Center of Central South China)Wuhan 430205China Guangzhou Institute of Geological Survey Guangzhou 510080China Hubei Transportation Planning Design Institute Co. LtdWuhan 430050China

Machine learning is currently one of the research hotspots in the field of landslide *** clarify and evaluate the differences in characteristics and prediction effects of different machine learning models,Conghua District,which is the most prone to landslide disasters in Guangzhou,was selected for landslide susceptibility *** evaluation factors were selected by using correlation analysis and variance expansion factor *** four machine learning methods namely Logistic Regression(LR),Random Forest(RF),Support Vector Machines(SVM),and Extreme Gradient Boosting(XGB),landslide models were *** analysis and evaluation of the model were conducted through statistical indices and receiver operating characteristic(ROC)*** results showed that LR,RF,SVM,and XGB models have good predictive performance for landslide susceptibility,with the area under curve(AUC)values of 0.752,0.965,0.996,and 0.998,*** model had the highest predictive ability,followed by RF model,SVM model,and LR *** frequency ratio(FR)accuracy of LR,RF,SVM,and XGB models was 0.775,0.842,0.759,and 0.822,*** and XGB models were superior to LR and SVM models,indicating that the integrated algorithm has better predictive ability than a single classification algorithm in regional landslide classification problems.

关键词： Landslides susceptibility assessment Machine learning Logistic Regression Random Forest Support Vector Machines XGBoost Assessment model Geological disaster investigation and prevention engineering

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数字经济发展与新质生产力的生成逻辑

学术研究 2024年第5期 87-95页

作者：张翱孙久文中共浙江省委党校浙江省“八八战略”创新发展研究院浙江杭州311121 中国人民大学应用经济学院北京100872

全球正在经历数字化革命,以数据作为新型生产要素的数字经济变革传统生产方式,使生产力的突破性发展成为可能。本文将新质生产力作为一个整体概念,通过经济运行的资源配置模式和生产方式变革考察其生成逻辑。数字经济发展形成数据牵引,... 详细信息

全球正在经历数字化革命,以数据作为新型生产要素的数字经济变革传统生产方式,使生产力的突破性发展成为可能。本文将新质生产力作为一个整体概念,通过经济运行的资源配置模式和生产方式变革考察其生成逻辑。数字经济发展形成数据牵引,算法规制和算力驱动的资源配置新模式是生成新质生产力的基本逻辑。在传统生产力基础上,数字经济运行的“数据—算法—算力”机制发挥优化资源配置的作用,通过科技驱动的智能化,将传统生产力转变为新质生产力。在生产关系变化中,数字经济发展带来的规则和制度创新,对新质生产力发展起到促进作用。数字化已经成为摆脱传统经济增长模式和生产力发展路径的关键力量,应围绕数字经济构建新质生产力体系。

关键词：新质生产力数字经济数据要素