Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

作     者：Ao Zhang Jingao Lu Shachuan Feng Huapeng Yu Tao Yu Shizheng Zhao Kemin Chen Zhibin Huang Jin Xu Jianan Y.Qu Zilong Wen Ao Zhang;Jingao Lu;Shachuan Feng;Huapeng Yu;Tao Yu;Shizheng Zhao;Kemin Chen;Zhibin Huang;Jin Xu;Jianan Y.Qu;Zilong Wen

作者机构：Division of Life ScienceHong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of CellDevelopmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology and MicrobiologySchool of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research InstituteShenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer EngineeringHong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay Biomedical InnocenterShenzhen Bay LaboratoryShenzhenGuangdong 518067China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2024年第51卷第3期

页      面：359-362页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China/Research Grants Council Joint Research Scheme(31961160726) the National Key Research and Development Program of China(2018YFA0800200) the Major Program of Shenzhen Bay Laboratory(S201101002) the Research Grants Council of Hong Kong(RGC/NFSC N_HKUST603/19,16102022,16101621,T13-605/18-W,T13-602/21-N) 

主　　题：fish macrophage homeostasis 

摘      要：Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue *** integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult *** mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.