Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China

作     者：Jian Wang Li Qiu Shuang Bai Wei Zhao Ao Zhang Jing Li Jun-Nan Zhang Shan-Shan Zhou Ren Qiu Zhu Huang Jv-Xia Liu Ting-Bin Wang Xue Sun Jiang Wu Qun Zheng Bin He Min Lv Jian Wang;Li Qiu;Shuang Bai;Wei Zhao;Ao Zhang;Jing Li;Jun-Nan Zhang;Shan-Shan Zhou;Ren Qiu;Zhu Huang;Jv-Xia Liu;Ting-Bin Wang;Xue Sun;Jiang Wu;Qun Zheng;Bin He;Min Lv

作者机构：Beijing Center for Disease Prevention and ControlBeijingChina Beijing Research Center for Respiratory Infectious DiseasesBeijingChina Hainan Provincial Center for Disease Control and PreventionHaikouChina Haikou Center for Disease Control and PreventionHaikouHainanChina Wanning Center for Disease Control and PreventionWanningHainanChina Baisha County Center for Disease Control and PreventionBaishaHainanChina Qiongzhong County Center for Disease Control and PreventionQiongzhongHainanChina 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2024年第13卷第1期

页      面：42-52页

核心收录：

学科分类：0202[经济学-应用经济学] 02[经济学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 020205[经济学-产业经济学] 1001[医学-基础医学(可授医学、理学学位)] 

基　　金：This research was funded by Bill&Melinda Gates Foundation(No.INV-034554) Beijing Municipal Natural Science Foundation(No.L202007) Special funds for the construction of high-level public health technical personnel from Beijing Municipal Health Commission(No.2022-3-01-021) 

主　　题：Pneumococcus Nasopharyngeal carriage Serotypes distribution Children Hainan Province China 

摘      要：Background The thirteen-valent pneumococcal conjugate vaccine(PCV13)is not included in the national immu-nization program and is administered voluntarily with informed consent in *** preparation for assessing the impact of pilot introduction in Hainan Province,we conducted a carriage study among children under 5 years of age from four locations in Hainan Province,*** From March to June 2022,nasopharyngeal(NP)swabs,collected from healthy children aged younger than 59 months who lived in the 4 different locations(Haikou,Wanning,Baisha and Qiongzhong)in Hainan Province,were tested for pneumococcus using conventional *** isolates were serotyped using the Quel-lung *** factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age,daycare attendance and other *** Pneumococcus was isolated in 710(30.4%)of the 2333 children *** 737 pneumococci,29 serotypes were identifed;60.9%were PCV13 serotypes;the most common vaccine serotypes were 6B(20.4%),19F(13.0%),6A(11.9%)and 23F(6.1%);and the most common nonvaccine serotypes were 23A(12.9%),34(6.1%)and nontypeable(NT)pneumococci(5.6%).Children vaccinated with PCV13 had lower carriage(17.7%vs 32.5%;P=0.0001)and fewer PCV13 serotypes(41.9%vs 62.7%;P=0.0017)compared to unimmunized *** adjustment,NP carriage Was higher among children attending daycare(aOR=2.3,95%CI:1.7-3.2),living in rural areas(aOR=1.4,95%CI:1.1-1.8),living with siblings(aOR=1.3,95%CI:1.0-1.6)and whose mothers had completed senior high/technical sec-ondary school(aOR=1.5,95%CI:1.1-2.0).In contrast,completion of 3-4 doses of PCV13 were associated with a lower carriage rate(aOR=0.6,95%CI:0.4-0.9).Conclusions We established the baseline of pneumococcal carriage,serotype distribution and PCV13 immuni-zation rates among healthy children under 5 years of age in Hainan Province,prior to the introduction of PCV13 into th