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Rates and associates of influenza and pneumococcus vaccination in diabetes mellitus:A nationwide cross-sectional study(TEMD vaccination study)

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World Journal of Diabetes 2021年第12期12卷 2107-2118页

作者： Ibrahim Demirci Cem Haymana Serpil Salman Ilker Tasci Demet Corapcioglu Ali Kirik İlhan Yetkin Mustafa Altay Tevfik Sabuncu Fahri Bayram Ilhan Satman Alper Sonmez 无 Department of Endocrinology and Metabolism Gulhane Training and Research HospitalAnkara 06190Turkey Department of Endocrinology and Metabolism Liv HospitalIstanbul 34000Turkey Department of Internal Medicine University of Health SciencesGulhane Faculty of MedicineAnkara 06018Turkey Department of Endocrinology and Metabolism Ankara UniversityFaculty of MedicineAnkara 06560Turkey Department of Internal Medicine Balıkesir UniversityFaculty of MedicineBalikesir 10145Turkey Department of Endocrinology and Metabolism Gazi UniversityFaculty of MedicineAnkara 06190Turkey Department of Endocrinology and Metabolism Kecioren Training and Research HospitalAnkara 06190Turkey Department of Endocrinology and Metabolism Harran UniversityFaculty of MedicineSanliurfa 63050Turkey Department of Endocrinology and Metabolism Erciyes UniversityFaculty of MedicineKayseri 38000Turkey Department of Endocrinology and Metabolism Istanbul UniversityFaculty of MedicineIstanbul 34000Turkey Department of Endocrinology and Metabolism University of Health SciencesGulhane Faculty of MedicineAnkara 06190Turkey TEMD Study Group

BACKGROUND Vaccination against influenza and pneumococcus is effective in reducing morbidity and mortality in patients with *** To investigate the prevalence of influenza and pneumococcal vaccinations and to search for the independent associates of vaccination in Turkish patients with *** In this cross-sectional,nationwide,multicenter study,adult patients with type 1 diabetes(T1DM)(n=454)and type 2 diabetes(T2DM)(n=4721),who were under follow-up for at least a year in the outpatient clinics,were consecutively ***,clinical,and laboratory parameters of patients were *** histories were documented according to the self-statements of the *** Patients with T1DM and T2DM had similar vaccination rates for influenza(23.6%vs 21.2%;P=0.240)and pneumococcus(8%vs 7%;P=0.451)*** diabetes duration and older age were the common independent associates of having vaccination for both types of diabetes *** education level,using statin treatment,and having optimal hemoglobin A1c levels were the common independent associates of influenza and pneumococcal vaccination in patients with *** TEMD Vaccination Study shows that patients with T1DM and T2DM had very low influenza and pneumococcal vaccination rates in *** lower rates of vaccination in certain populations urges the necessity of nationwide vaccination strategies targeting these populations.

关键词： Diabetes Influenza pneumococcus Vaccination Type 1 diabetes Type 2 diabetes

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Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China

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Infectious Diseases of Poverty 2024年第1期13卷 42-52页

作者： Jian Wang Li Qiu Shuang Bai Wei Zhao Ao Zhang Jing Li Jun-Nan Zhang Shan-Shan Zhou Ren Qiu Zhu Huang Jv-Xia Liu Ting-Bin Wang Xue Sun Jiang Wu Qun Zheng Bin He Min Lv Beijing Center for Disease Prevention and Control BeijingChina Beijing Research Center for Respiratory Infectious Diseases BeijingChina Hainan Provincial Center for Disease Control and Prevention HaikouChina Haikou Center for Disease Control and Prevention HaikouHainanChina Wanning Center for Disease Control and Prevention WanningHainanChina Baisha County Center for Disease Control and Prevention BaishaHainanChina Qiongzhong County Center for Disease Control and Prevention QiongzhongHainanChina

Background The thirteen-valent pneumococcal conjugate vaccine(PCV13)is not included in the national immu-nization program and is administered voluntarily with informed consent in *** preparation for assessing the impact of pilot introduction in Hainan Province,we conducted a carriage study among children under 5 years of age from four locations in Hainan Province,*** From March to June 2022,nasopharyngeal(NP)swabs,collected from healthy children aged younger than 59 months who lived in the 4 different locations(Haikou,Wanning,Baisha and Qiongzhong)in Hainan Province,were tested for pneumococcus using conventional *** isolates were serotyped using the Quel-lung *** factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age,daycare attendance and other *** pneumococcus was isolated in 710(30.4%)of the 2333 children *** 737 pneumococci,29 serotypes were identifed;60.9%were PCV13 serotypes;the most common vaccine serotypes were 6B(20.4%),19F(13.0%),6A(11.9%)and 23F(6.1%);and the most common nonvaccine serotypes were 23A(12.9%),34(6.1%)and nontypeable(NT)pneumococci(5.6%).Children vaccinated with PCV13 had lower carriage(17.7%vs 32.5%;P=0.0001)and fewer PCV13 serotypes(41.9%vs 62.7%;P=0.0017)compared to unimmunized *** adjustment,NP carriage Was higher among children attending daycare(aOR=2.3,95%CI:1.7-3.2),living in rural areas(aOR=1.4,95%CI:1.1-1.8),living with siblings(aOR=1.3,95%CI:1.0-1.6)and whose mothers had completed senior high/technical sec-ondary school(aOR=1.5,95%CI:1.1-2.0).In contrast,completion of 3-4 doses of PCV13 were associated with a lower carriage rate(aOR=0.6,95%CI:0.4-0.9).Conclusions We established the baseline of pneumococcal carriage,serotype distribution and PCV13 immuni-zation rates among healthy children under 5 years of age in Hainan Province,prior to the introduction of PCV13 into th

关键词： pneumococcus Nasopharyngeal carriage Serotypes distribution Children Hainan Province China

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Effects of Clarithromycin at Sub-Minimum Inhibitory Concentrations on Early ermB Gene Expression, Metabolic Activity and Growth of an erm(B)-Expressing Macrolide-Resistant Strain of Streptococcus pneumoniae

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Open Journal of Respiratory Diseases 2012年第1期2卷 1-8页

作者： Riana Cockeran H. C. Steel N. Wolter L. de Gouveia A. von Gottberg K. P. Klugman A. T. Leanord D. J. Inverarity T. J. Mitchell C. Feldman R. Anderson Division of Infection and Immunity Glasgow Biomedical Research Centre University of Glasgow Glasgow UK Division of Pulmonology Department of Internal Medicine Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand Johannesburg South Africa Hubert Department of Global Health Rollins School of Public Health and Division of Infectious Diseases School of Medicine Emory University Atlanta USA Medical Research Council (MRC) Unit for Inflammation and Immunity Department of Immunology Faculty of Health Sciences University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service Pretoria South Africa Microbiology Department Southern General Hospital Glasgow UK Respiratory and Meningeal Pathogens Research Unit National Institute for Communicable Diseases of the National Health Laboratory Service and Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa

Aim: To investigate the effects of exposure of a macrolide-resistant [erm (B)-expressing] strain of Streptococcus pneumoniae (strain 2507) to clarithromycin (0.5 and 5 mg/L) added at the outset and 6 hours after initiation of culture on early gene expression, energy metabolism, and growth. Methods: Bacterial growth was determined by turbidometric and colony counting procedures, energy metabolism by measurement of ATP, while analysis of gene expression was performed using reverse transcription-PCR and sequencing. Results: Addition of clarithromycin, at either concentration, at the outset of culture, caused transient suppression of growth of 10 - 12 hours duration, while delayed addition of antibiotic (during the logarithmic phase) resulted in an abrupt halt in growth followed by recovery. These inhibitory effects of clarithromycin on bacterial growth were associated with up-regulation of expression of erm(B), decreased ATP and protein synthesis, and were unaffected by inclusion of either catalase (500 and 1000 kunits/L), or competence-stimulating peptide (CSP-1, 0.5 mg/L). The inhibitory effects could, however, be overcome by pre-exposure of the bacteria to the antibiotic. Moreover, clarithromycin appeared to potentiate the antimicrobial actions of ceftriaxone, at sub-MIC concentrations, for strain 2507. Conclusions: Unlike several other common bacterial pathogens, the full expression of erm(B)-mediated macrolide resistance by the pneumococcus has a slow onset, which is associated with transient susceptibility to macrolides and inhibition of growth.

关键词： Clarithromycin Macrolide-Resistance pneumococcus

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Comparative Assessment of Growth and Gene Regulation between 4 Serotypes of Streptococcus pneumoniaein Broth and Cell Culture

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Advances in Microbiology 2018年第10期8卷 763-777页

作者： Ben Seabolt Jeff Brady Janice Speshock Department of Biological Sciences Tarleton State University Stephenville TX USA Texas A&M AgriLife Research and Extension Center Stephenville TX USA

Streptococcus pneumoniae is a medically important pathogen capable of causing human infections of pneumonia, bacteremia, otitis media, and meningitis. Although there are vaccinations available, infections with S. pneumoniae still remains a global problem. S. pneumoniae is a highly adaptable bacterial species with numerous serotypes based on capsular polysaccharides. The different serotypes vary in their ability to colonize and causing pathology. Here we compared the regulation of five different virulence factors from four common serotypes of S. pneumoniae that vary in their carriage, morbidity, and mortality rates in the human population using two different in vitro methods, broth and cell culture. We determine that there is variation of virulence factor gene regulation within a serotype using two different culture methods, and variation between the serotypes in the same culture condition. The regulation of genes appeared to have a correlation with the ability of the various serotypes to grow in broth culture, adhere to cultured lung cells, and invade the cultured lung cells, as serotypes that shared similar regulation of virulence factors tended to behave similarly in culture. Many studies with S. pneumoniae rely on the use of one selected serotype, but since there is a wide variation in the growth and regulatory mechanisms of these bacteria. As demonstrated here, future studies should utilize more strains in models before concluding mechanisms of pathobiology.

关键词： pneumococcus Serotypes Gene Expression Regulation

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Insights into Pneumococcal Pathogenesis and Antibiotic Resistance

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Advances in Microbiology 2014年第10期4卷 627-643页

作者： Eric S. Donkor Ebenezer V. Badoe Department of Child Health College of Health Sciences University of Ghana Medical School Accra Ghana Department of Microbiology College of Health Sciences University of Ghana Medical School Accra Ghana

Since its discovery in 1891, the pneumococcus has been one of the most extensively studied microbes, and was involved in several historical findings such as the discovery of genetic material that was later shown to be DNA. The pneumococcus is part of the normal bacterial flora of the nasopharynx, but can on occasions progress to sterile sites of the body and cause invasive diseases. There are about one million new invasive pneumococcal infections every year, majority of which occur in the developing world where children pneumococcus remains a pathogen of immense public health significance and understanding its biology, particularly the pathogenesis and antibiotic resistance is crucial to controlling pneumococcal disease.

关键词： pneumococcus Antibiotic Resistance Virulence Penicillin Genome

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