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Over-starvation aggravates intestinal injury and promotes bacterial and endotoxin translocation under high-altitude hypoxic environment

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World Journal of Gastroenterology 2011年第12期17卷 1584-1593页

作者： Qi-quan Zhou Ding-Zhou Yang Yong-Jun Luo Su-Zhi li Fu-Yu liu Guan-Song Wang Department of High Altitude Disease College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine Ministry of EducationThird Military Medical universityChongqing 400038China Research Center of Mountain Sickness General Hospital of Tibetan Military Area CommandLhasa 850007Tibet Autonomous RegionChina Institute of Respiratory Diseases Xinqiao HospitalThird Military Medical UniversityChongqing 400037China

AIM:To study whether over-starvation aggravates intestinal mucosal injury and promotes bacterial and endotoxin translocation in a high-altitude hypoxic ***:Sprague-Dawley rats were exposed to hy-pobaric hypoxia at a simulated altitude of 7000 m for 72 *** nitrate was used as a tracer to detect intestinal *** apoptosis was observed with terminal deoxynucleotidyl transferase dUTP nick end labeling *** levels of diamino oxidase(DAO),malondialdehyde(MDA),glutamine(Gln),superoxide dismutase(SOD) and endotoxin were measured in intestinal *** translocation was detected in blood culture and intestinal *** addition,rats were given Gln intragastrically to observe its protective effect on intestinal ***:Apoptotic epithelial cells,exfoliated villi and inflammatory cells in intestine were increased with edema in the lamina propria accompanying effusion of red blood *** particles were found in the intercellular space and intracellular *** translocation to mesenteric lymph nodes(MLN) and spleen was *** serum endotoxin,DAO and MDA levels were significantly higher while the serum SOD,DAO and Gln levels were lower in intestine(P< 0.05).The bacterial translocation number was lower in the high altitude hypoxic group than in the high altitude starvation group(0.47±0.83 vs 2.38±1.45,P<0.05).The bacterial translocation was found in each organ,especially in MLN and spleen but not in peripheral *** bacterial and endotoxin translocations were both markedly improved in rats after treatment with ***:High-altitude hypoxia and starvation cause severe intestinal mucosal injury and increase bacterial and endotoxin translocation,which can be treated with Gln.

关键词： High altitude Hypoxia Starvation Intestinal mucosal injury Bacterial translocation Endotoxin Glutamine

循环肿瘤细胞联合中性粒细胞/淋巴细胞比值预测晚期胃癌疗效

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中国临床研究 2024年第2期37卷 206-211页

作者：阮露晞郭仁宏张全安雷靖陈美丽杨晖袁忆航李惠子南京医科大学附属江宁医院肿瘤科江苏南京211100 江苏省肿瘤医院肿瘤内科江苏南京210009

目的探索循环肿瘤细胞(circulating tumor cell,CTC)联合中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)对晚期胃癌疗效的预测作用。方法收集2022年6月至2023年1月在南京医科大学附属江宁医院及江苏省肿瘤医院接受一线... 详细信息

目的探索循环肿瘤细胞(circulating tumor cell,CTC)联合中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)对晚期胃癌疗效的预测作用。方法收集2022年6月至2023年1月在南京医科大学附属江宁医院及江苏省肿瘤医院接受一线治疗的36例晚期胃癌患者的临床病理资料。通过X-tile软件计算CTC和NLR的最佳截断值,将患者分为高CTC组(CTC>15,n=21)和低CTC组(CTC≤15,n=15),高NLR组(NLR>2.32,n=20)和低NLR组(NLR≤2.32,n=16)。COX回归分析和生存曲线用于分析CTC,NLR与无进展生存期(progression free survival,PFS)的关系。受试者工作特征(ROC)曲线比较CTC、NLR和两者联合对晚期胃癌疗效的预测效能。结果多因素COX回归分析显示,CTC(HR=7.441,P=0.045)和NLR(HR=4.690,P=0.011)与晚期胃癌患者的PFS有关。低CTC组和低NLR组患者的PFS分别长于高CTC组和高NLR组(P<0.01)。同时具有高CTC和高NLR的患者PFS最短(P<0.01)。与CTC和NLR单一因素预测相比,两者联合预测晚期胃癌一线治疗疗效最佳(AUC=0.746)。结论CTC和NLR是影响晚期胃癌患者PFS的独立预后因子,CTC联合NLR能更好地预测晚期胃癌疗效。

关键词：循环肿瘤细胞中性粒细胞/淋巴细胞比值胃癌,晚期一线治疗无进展生存期

《四库全书总目》医家类采进本与清代医学知识之共享

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图书馆杂志 2024年第8期43卷 143-154,135页

作者：李瑞金华中师范大学历史文化学院湖北武汉430079

《四库全书总目》医家类著存医学典籍197部,文献来源主要为敕撰本、永乐大典本、内府藏本、通行本、各省采进本、私人进献本六类,各省采进本和私人进献本分别占48.71%和25.41%,构成医家类文献的主要来源。对采进本地域归属及医者籍贯的... 详细信息

《四库全书总目》医家类著存医学典籍197部,文献来源主要为敕撰本、永乐大典本、内府藏本、通行本、各省采进本、私人进献本六类,各省采进本和私人进献本分别占48.71%和25.41%,构成医家类文献的主要来源。对采进本地域归属及医者籍贯的量化考察,可以反映自明以来到清中叶以江苏、安徽、浙江三省为主的江南医学发展的繁盛。由政府主导的《四库全书总目》的纂修将散布在各地的历代书籍聚拢于中央,进行统一整理与编纂,作为一部大型知识集成承担了清代知识社会的“智库”角色。江浙地区私人藏书家医学书籍的进献,从秘不外借到公开阅读,使得医学经典得以重现。“南三阁”面向社会的开放亦广开医学知识共享之便利,进而推动了清代江南医学的发展。《四库全书总目》医家类以书籍为主体构建起来的医学知识共享,为习医人士把握医学典籍和医学学术研究提供了门径。

关键词：《四库全书总目》医家类采进本医学知识知识共享

Multianion Transition Metal Compounds:Synthesis,Regulation,and Electrocatalytic Applications

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Accounts of Materials Research 2021年第11期2卷 1082-1092页

作者： Chang-Xin Zhao Hao-Fan Wang Bo-quan li Qiang zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory(ChEM-OIL) National Institute of Advanced Industrial Science and Technology(AIST)Kyoto 606-8501Japan Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

CONSPECTUS:Energy electrocatalysis is an essential part for the modern energy network serving as the core technique in many electrochemical energy devices such as batteries,fuel cells,electrolyzers,*** high-performance electrocatalysts,especially the pursuit for higher intrinsic electrocatalytic activity,is the eternal theme for high-efficiency energy *** metal compounds are highly considered as promising highperformance electrocatalysts due to their facile fabrication,well-defined structure,and encouraging intrinsic ***,further promotion on intrinsic electrocatalytic activity of conventional transition metal compounds encounters an unavoidable bottleneck originated from the rigid homoanion structure with limited choice of *** the above issue,heteroanion substitution on pristine transition metal compounds has been proposed in some recent *** unique structure and properties that distinguish them from routine transition metal compounds have attracted wide attention to reveal distinct electronic structures,synthesis methodologies,and functions in energy electrocatalysis for future application.

关键词： anion Transition intrinsic

Relationships between Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases： Clinical Assessments, Biomarkers, and Treatment

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Chinese Medical Journal 2018年第8期131卷 966-973页

作者： Min li li Wang Jiang-Hong liu Shu-Qin zhan Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

Objective： Rapid eye movement sleep behavior disorder （RBD） is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson＇s disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions. Data Sources： Using the combined keywords：＂RBD＂, ＂neurodegenerative disease＂, ＂Parkinson disease＂, and ＂magnetic resonance imaging＂, the PubMed/MEDliNE literature search was conducted up to January 1, 2018. Study Selection： A total of 150 published articles were initially identified citations. Of the 150 articles, 92 articles were selected after further detailed review. This study referred to all the important English literature in full. Results： Single-nucleotide polymorphisms in SCARB2 （rs6812193） and MAPT （rs12185268） were significantly associated with RBD. The olfactory loss, autonomic dysfunction, marked electroencephalogram slowing during both wakefulness and rapid eye movement sleep, and cognitive impairments were potential predictive markers for RBD conversion to neurodegenerative diseases. Traditional structural imaging studies reported relatively inconsistent results, whereas reduced functional connectivity between the left putamen and substantia nigra and dopamine transporter uptake demonstrated by functional imaging techniques were relatively consistent findings. Conclusions： More longitudinal studies should be conducted to evaluate the predictive value of biomarkers of RBD. Moreover, because the glucose and dopamine metabolisms are not specific for assessing cognitive cognition, the molecular metabolism directly related to cognition should be investigated. There is a need for m

关键词： Dementia with Lewy Bodies Multiple System Atrophy Neurodegenerative Disease Parkinson's Disease Rapid EyeMovement Sleep Behavior Disorder

清代样米的内涵及应用研究——兼论样斛的应用及其制度

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中国农史 2024年第1期43卷 28-39页

作者：李富强西南大学科学教育研究中心重庆400715

样米在税粮的征收、运输、存储、支放与民间粮食流通过程中,起到了标准和规范作用。本文以《钦定户部漕运全书》《钦定大清会典》《钦定大清会典则例》《清实录》及相关地方志资料为基础,集中研究样米的内涵、应用、弊端及制度。此外,... 详细信息

样米在税粮的征收、运输、存储、支放与民间粮食流通过程中,起到了标准和规范作用。本文以《钦定户部漕运全书》《钦定大清会典》《钦定大清会典则例》《清实录》及相关地方志资料为基础,集中研究样米的内涵、应用、弊端及制度。此外,还讨论了规范粮食流通的关键标准量器——样斛。研究认为:干、圆、洁、净是清代乃至传统社会中甄别粮食质量的最高标准,有效保障了粮食的征收与流通;多方评估、签订契约等制度在一定程度上弥补了样米标准自身的不足;官斛校验及严禁淋尖踢斛等措施在一定程度上保障了样米乃至粮食流通的公平与公正。

关键词：干圆洁净样米样斛清代

NUMERICAL SIMULATION OF HORIZONTAL MIGRATION OF PROPPANT

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Journal of Hydrodynamics 2008年第1期20卷 74-80页

作者： ZHAO Zheng-chao CUI Bin YUE Yu-quan WANG li-yang WU Ying-xiang Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China liao＇he Oilfield Panjing 124010 China

The horizontal migration of proppant was numerically investigated with a two-fluid model, in which the interaction between fracturing fluid and proppant, along with that among proppants was taken into account through interphase forces. The migration process and the volumetric concentration of the proppant were examined under various conditions, and the averaged volumetric concentration of the proppant was obtained. The present research might be useful in the process design of the hydraulic fracturing in the oilfields.

关键词： numerical simulation,two-fluid model two-phase flow,hoirzontal migration

Boron-containing Thermally Activated Delayed Blue Fluorescence Materials via Donor Tuning:a Theoretical Study

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Chinese Journal of Chemical Physics 2022年第3期35卷 499-508,I0002页

作者： Yan-lin Ji quan-Song li Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Based on the boron-containing thermally activated delayed fuorescence(TADF)compound p-AC(AC:acridine)5,9-dioxa-13 b-boranaphtho[3,2,1-de]anthracene(a),a series of new TADF molecules b1-b4 were designed via adding two nitrogen atoms at the AC donor *** functional theory and time-dependent density functional theory calculations were performed on the frontier orbital energy levels,emission spectra,singlet-triplet states energy gaps(?EST),reverse intersystem crossing(RISC)rate constant(kRISC)for compounds a and *** calculation results show that the maximum emission wavelengths of b1-b4 are significantly blue-shifted by47-125 nm compared with that of *** b1 and b3 exhibit dark-blue emission,while molecules b2 and b4 display light-blue emission,indicating that these four derivatives could be potential organic light-emitting diode(OLED)candidates with blue-light ***,we found the RISC processes in a,b2,and b4 can occur not only from T_(1) state to S_(1) state,but also from T_(2) state to S_(1) state significantly,while the RISC processes in b1 and b3 mainly take place via the T_(2)→S_(1) hot exciton ***,the T_(1)→S_(1) kRISC values of b2 and b4 are predicted to be two to three times of that of a,indicating enhanced TADF *** results not only provide two promising boron-based TADF candidates(b2 and b4),but also offer useful theoretical basis for the design of blue OLED materials.

关键词： Excited state Thermally activated delayed fuorescence Theoretical study

First Principle Calculation of Electromagnetic Mechanism for Fe_2Si Bulk Material

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Journal of Wuhan University of Technology(Materials Science) 2019年第1期34卷 64-68页

作者： li Ruijie YANG Yinye College of Big Data and Information Engineering Guizhou University Special and Key Laboratory of Guizhou Provincial Higher Education for Photoelectric Information Analysis and Processing Guizhou Minzu University School of Materials Science and Engineering Guizhou Minzu University

The electronic structure and the magnetic properties of Fe_2Si bulk have been calculated by the first-principle density function theory method. The band structure shows that the hexagonal Fe^2 Si bulk is ferromagnetic which is a metal structure under spin-up, and a semiconductor with the band gap of 0.518 eV under spin-down. The density of states shows the Fe^1 3d–spin and Fe^3 3d–spin in the electronic system are the main factors that is the source of the ferromagnetic properties of Fe_2Si bulk. The electronic structure Si-ions is 3s23p6 and that of Fe-ions is e_g^2↑e_g^(*1)↓t_(2g)~3↑. The molecular magnetic moment of Fe_2Si is 2.00 μB. The potential diagram of Fe_2Si bulk shows the formation of covalent and ionic bonds between the Fe atom and the Si atom, it leads to the center charge of Fe is polarized and off center position. These special properties of Fe_2Si bulk are mainly caused by d-d exchange and p-d hybridization. The results offer a certain reference for the magnetic semiconductor Fe_2Si material.

关键词： Fe2Si electronic structure magnetic property first-principle