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New insight into the stability and dynamics of fluid-conveying supported pipes with small geometric imperfections

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Applied Mathematics and Mechanics(English Edition) 2021年第5期42卷 703-720页

作者： Kun ZHOU Qiao NI Wei CHEN Huliang DAI zerui PENG lin WANG Department of Mechanics School of Aerospace EngineeringHuazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074China Department of Mechanical Engineering Technische Universitat DarmstadtDarmstadt 64293Germany

In several previous studies,it was reported that a supported pipe with small geometric imperfections would lose stability when the internal flow velocity became sufficiently ***,however,it has become clear that this conclusion may be at best incomplete.A reevaluation of the problem is undertaken here by essentially considering the flow-induced static deformation of a *** the aid of the absolute nodal coordinate formulation(ANCF)and the extended Lagrange equations for dynamical systems containing non-material volumes,the nonlinear governing equations of a pipe with three different geometric imperfections are introduced and *** on extensive numerical calculations,the static equilibrium configuration,the stability,and the nonlinear dynamics of the considered pipe system are determined and *** results show that for a supported pipe with the geometric imperfection of a half sinusoidal wave,the dynamical system could not lose stability even if the flow velocity reaches an extremely high value of ***,for a supported pipe with the geometric imperfection of one or one and a half sinusoidal waves,the first-mode buckling instability would take place at high flow ***,based on a further parametric analysis,the effects of the amplitude of the geometric imperfection and the aspect ratio of the pipe on the static deformation,the critical flow velocity for buckling instability,and the nonlinear responses of the supported pipes with geometric imperfections are analyzed.

关键词： supported pipes conveying fluid geometric imperfection absolute nodal coordinate formulation(ANCF) static equilibrium configuration critical flow velocity nonlinear dynamics

Utilization of nonlinear vibrations of soft pipe conveying fluid for driving underwater bio-inspired robot

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Applied Mathematics and Mechanics(English Edition) 2022年第7期43卷 1109-1124页

作者： Huliang DAI Yixiang HE Kun ZHOU zerui PENG lin WANG P.HAGEDORN Department of Mechanics Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074China Department of Mechanical Engineering Technische Universität at DarmstadtDarmstadt 64293Germany State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024Liaoning ProvinceChina

Creatures with longer bodies in nature like snakes and eels moving in water commonly generate a large swaying of their bodies or tails,with the purpose of producing significant frictions and collisions between body and fluid to provide the power of consecutive forward *** swaying can be idealized by considering oscillations of a soft beam immersed in water when waves of vibration travel down at a constant *** present study employs a kind of large deformations induced by nonlinear vibrations of a soft pipe conveying fluid to design an underwater bio-inspired snake robot that consists of a rigid head and a soft *** the head is fixed,experiments show that a second mode vibration of the tail in water occurs as the internal flow velocity is beyond a critical *** the corresponding theoretical model based on the absolute nodal coordinate formulation(ANCF)is established to describe nonlinear vibrations of the *** the head is free,the theoretical modeling is combined with the computational fluid dynamics(CFD)analysis to construct a fluid-structure interaction(FSI)simulation *** swimming speed and swaying shape of the snake robot are obtained through the FSI simulation *** are in good agreement with experimental *** importantly,it is demonstrated that the propulsion speed can be improved by 21%for the robot with vibrations of the tail compared with that without oscillations in the pure jet *** research provides a new thought to design driving devices by using nonlinear flow-induced vibrations.

关键词： soft pipe conveying fluid underwater bio-inspired robot flutter fluidstructure interaction(FSI) absolute nodal coordinate formulation(ANCF)

Boosting the cell performance of the SiO_(x)@C anode material via rational design of a Si-valence gradient

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Carbon Energy 2022年第2期4卷 129-141页

作者： Jianming Tao zerui Yan Jiangshao Yang Jiaxin Li Yingbin lin Zhigao Huang Fujian Provincial Solar Energy Conversion and Energy Storage Engineering Technology Research Center College of Physics and EnergyFujian Normal UniversityFuzhouChina Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials FuzhouChina Fujian Provincial Collaborative Innovation Center for Advanced High-Field Superconducting Materials and Engineering FuzhouChina

Relieving the stress or strain associated with volume change is highly desirable for high-performance SiOx anodes in terms of stable solid electrolyte interphase(SEI)-film ***,a Si-valence gradient is optimized in SiOx composites to circumvent the large volume strain accompanied by lithium insertion/***_(x)@C annealed at 850℃ has a gentle Si-valence gradient along the radial direction and excellent electrochemical performances,delivering a high capacity of 506.9 mAh g^(−1) at 1.0 A g^(−1) with a high Coulombic efficiency of~99.8%over 400 *** with the theoretical prediction,the obtained results indicate that the gentle Si-valence gradient in SiO_(x)@C is useful for suppressing plastic deformation and maintaining the inner connection integrity within the SiO_(x)@C ***,a gentle Si-valence gradient is expected to form a stress gradient and affect the distribution of dangling bonds,resulting in local stress relief during the lithiation/delithiation process and enhanced Li-ion kinetic ***,the lowest interfacial stress variation ensures a stable SEI film at the interface and consequently increases cycling ***,rational design of a Si-valence gradient in SiOx can provide further insights into achieving high-performance SiOx anodes with large-scale production.

关键词： lithium-ion battery SEI film growth SiO_(x)@C stress valence gradient

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变压器差动保护励磁涌流的分析

计量与测试技术 2016年第4期43卷 1-3页

作者：李惜玉袁润坚黄烁漫廖聪李选平林泽锐广东工业大学自动化学院广东广州510000

变压器励磁涌流的鉴别是变压器差动保护的难题。众多研究人员对变压器的励磁涌流鉴别做了大量研究,从波形、算法等方面寻求解决方法。本文对鉴别励磁涌流的一些方法进行整理,并对各自的优缺点进行对比。

关键词：电力变压器励磁涌流波形

Junction matters in hydraulic circuit bio-design of microfluidics

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Bio-Design and Manufacturing 2023年第1期6卷 38-50页

作者： Yao lin Dongliang He zerui Wu Yurou Yao Zhanhao Zhang Yuheng Qiu Shan Wei Guangzhu Shang Xingyue Lei Ping Wu Weiping Ding Liqun He Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHefei 230027China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230027China GeneMind Biosciences Company Limited Shenzhen 518023China Department of Electronic Engineering and Information Science University of Science and Technology of ChinaHefei 230027China

Microfluidic channels are at micrometer scales;thus,their fluid flows are laminar,resulting in the linear dependence of pressure drop on flow rate in the length of the *** ratio of the pressure drop to flow rate,referred to as resistance,depends on channel size and dynamic ***,a microfluidic chip is analogous to an electric circuit in design,but the design is adjusted to optimize channel ***,whereas voltage loss is negligible at the nodes of an electric circuit,hydraulic pressure drops at the nodes of microfluidic chips by a magnitude are comparable to the pressure drops in the straight ***,we prove by experiment that one must fully consider the pressure drops at nodes so as to accurately design a precise microfluidic *** the process,we numerically calculated the pressure drops at hydraulic nodes and list their resistances in the range of flows as *** resorted to machine learning to fit the calculated results for complex ***,we obtained a library of node resistances for common junctions and used them to design three established chips that work for single-cell analysis and for precision allocation of solutes(in gradient and averaging concentration microfluidic networks).Endothelial cells were stimulated by generating concentrations of adriamycin hydrochloride from the last two microfluidic networks,and we analyzed the response of endothelial *** results indicate that consideration of junction resistances in design calculation brings experimental results closer to the design values than *** approach may therefore contribute to providing a platform for the precise design of organ chips.

关键词： Junctions Hydraulics Microfluidic chip design

Tumor immune checkpoints and their associated inhibitors

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第10期23卷 823-843页

作者： zerui GAO Xingyi linG Chengyu SHI Ying WANG Aifu lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Chu Kochen Honors College of Zhejiang University Hangzhou 310058China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of Medicinethe Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China ZJU-QILU Joint Research Institute Hangzhou 310058China

Immunological evasion is one of the defining characteristics of cancers,as the immune modification of an immune checkpoint(IC)confers immune evasion capabilities to tumor *** ICs,such as programmed cell death protein-1(PD-1)and cytotoxic T-lymphocyte-associated antigen-4(CTLA-4),can bind to their respective receptors and reduce tumor immunity in a variety of ways,including blocking immune cell activation *** blockade(ICB)therapies targeting these checkpoint molecules have demonstrated significant clinical *** is because antibody-based IC inhibitors and a variety of specific small molecule inhibitors can inhibit key oncogenic signaling pathways and induce durable tumor remission in patients with a variety of *** the roles and regulatory mechanisms of these IC molecules will provide crucial theoretical guidance for clinical *** this review,we summarize the current knowledge on the functional and regulatory mechanisms of these IC molecules at multiple levels,including epigenetic regulation,transcriptional regulation,and post-translational *** addition,we provide a summary of the medications targeting various nodes in the regulatory pathway,and highlight the potential of newly identified IC molecules,focusing on their potential implications for cancer diagnostics and immunotherapy.

关键词： Immune checkpoint Immune checkpoint inhibitor Programmed cell death-ligand 1(PD-L1) Cytotoxic T-lymphocyteassociated antigen-4(CTLA-4) Lymphocyte activation gene-3(LAG-3) T-cell immunoglobulin and immunoreceptor tyrosinebased inhibitory motif(ITIM)domain(TIGIT) B7 family

MicroRNA-93 mediates cabergoline-resistance by targeting ATG7 in prolactinoma

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MicroRNA-93 mediates cabergoline-resistance by targeting ATG...

Fibrin sealant for the prevention of anastomotic leakage after esophagectomy for esophageal or esophagogastric junction cancer:interim report of a prospective,phase III,randomized controlled study

2018年浙江省神经外科学学术年会

作者： zerui Wu lin Cai Jianglong Lu Zhipeng Su First Affiliated Hospital of Wenzhou Medical University

Objective Our previous study found that expression of miRNA-93 increased obviously in DA-resistant prolactinomas, however, the role of miRNA-93 in DA-resistance was largely unexplored. This study is to find regulatory mechanism underlyingmiRNA-93 inhibits CAB *** The expression of miRNAs in human pituitary tumors was analyzed by microarray and RT-PCR. Cell viability and proliferation was determined by MTS assays.

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Holistic Integrative Oncology 2023年第1期2卷 270-277页

作者： zerui Zhao Zhichao Li Weizhao Huang Geng Wang Teng Mao Wenqiang Lv lin Peng Jiyang Chen Hong Yang Department of Thoracic Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteSun Yat-sen University Cancer CenterGuangzhouGuangdong ProvinceChina Department of Cardiothoracic Surgery Zhongshan Hospital of Sun Yat-Sen University(Zhongshan People’s Hospital)ZhongshanGuangdong ProvinceChina Department of Thoracic Surgery Cancer Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiaotong UniversityShanghaiChina Department of Thoracic Surgery People’s Hospital of JieyangJieyangGuangdong Prov-inceChina Department of Thoracic Surgery School of MedicineSichuan Cancer CenterSichuan Cancer Hospital&InstituteUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina

Purpose Anastomotic leakage(AL)is one of the most pernicious complications after esophagectomy for patients with esophageal or esophagogastric junction cancer(EC or EJC).The application of fibrin sealant(FS)may be advantageous for reducing the incidence of *** study aims to evaluate the safety and effectiveness of FS in preventing AL in patients undergoing McKeown *** In this multicenter,prospective,randomized controlled trial,we planned to recruit 360 patients aged 18–75 years with resectable EC or EJC and the interim analysis was performed when the number of participants reaches *** assigned to the FS group received McKeown esophagectomy with 2.5ml FS applied to the cervical anastomosis,while patients in the control group received surgery *** primary endpoint was the incidence of cervical AL within the first 3 months *** From February 2019 to November 2021,180 patients were recruited,with 89 in the FS group and 91 in the control *** was no statistically difference between the incidence of AL between the two groups[6.7%(6/89)in the FS vs.14.3%(13/91)in the control group,P=0.16].Complications was comparable(P=0.76)between the FS group(42 of 89,47.2%)and the control group(45 of 91,49.5%).No adverse events related to FS or deaths occurred *** The application of FS intraoperatively is feasible and does not increase the risk of complications,and its effectiveness for the prevention of AL needs to be revalidated after the completion of patient *** registration This trial was registered at ***(NCT03847857)on February 19th,2019.

关键词： Esophageal cancer McKeown esophagectomy Fibrin sealant Anastomotic leakage Postoperative complications

无功能垂体腺瘤中杀菌/渗透增强折叠家族蛋白B1基因的表达及其对肿瘤侵袭性的作用研究

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中华神经外科杂志 2021年第6期37卷 598-604页

作者：陈贤斌吴泽睿卢江龙蔡霖苏志鹏温州医科大学附属第一医院神经外科浙江325000

目的探讨无功能垂体腺瘤中杀菌/渗透增强折叠家族蛋白Bl(BPIFBl)基因的表达情况及其对垂体腺瘤增殖和侵袭性的影响;方法利用高通量基因表达(GEO)公共数据库垂体腺瘤芯片的数据,通过生物信息学分析方法筛选出侵袭性相关基因;然后选取5例... 详细信息

目的探讨无功能垂体腺瘤中杀菌/渗透增强折叠家族蛋白Bl(BPIFBl)基因的表达情况及其对垂体腺瘤增殖和侵袭性的影响;方法利用高通量基因表达(GEO)公共数据库垂体腺瘤芯片的数据,通过生物信息学分析方法筛选出侵袭性相关基因;然后选取5例侵袭性无功能垂体腺瘤和5例非侵袭性无功能垂体腺瘤的组织标本,通过实时荧光定量PCK和免疫组织化学染色检测BPIFBI基因和蛋白的表达情况。在垂体腺瘤GH3细胞株中通过siRNA敲减BPIFB1的表达,采用细胞活性和细胞划痕实验等检测肿瘤细胞的增殖和迁移能力;采用实时荧光定量PCR测定基质金属蛋白酶(MMP)-2和MMP-9 mRNA的表达水平;采用蛋白质免疫印迹技术检测上皮间质转化(EMT)相关蛋白的表达水平t结果生物信息学分析结果提示,侵袭性垂体腺瘤中BPIFB1的表达水平低于非侵袭性垂体腺瘤(log2FC=-5.29,P<0.01);免疫组织化学染色结果显示,侵袭性无功能垂体腺瘤中BPIFB1的表达水平(0.53±0.10)明显低于非侵袭性无功能垂体腺瘤(1.02±0.44)(P<0.05);实时荧光定量PCR结果显示,BIMFBl mRNA的表达水平与肿瘤KnSp分级呈负相关(r_(s)=-0.88,P<0.01)。细胞活性实验结果显示,BPIFB1敲减GH3细胞的细胞活性(2.98±0.14)高于正常GH3细胞(2.14±0.05)(P<0.01);细胞划痕实验结果显示,BPIFB1敲减GH3细胞的迁移率[(43.82±3.74)%]高于正常0113细胞[(17.53±2.05)%](P<0.01)。实时荧光定量PCR结果显示,BPIFBI敲减GH3细胞MMP-2和MMP-9 mRNA的表达水平均高于正常GH3细胞(均P<0.05);蛋白质免疫印迹实验显示,BPIFB1敲减GH3细胞中EMT相关蛋白的表达水平与正常GH3细胞比较差异均有统计学意义(均P<0.05)。结论侵袭性无功能垂体腺瘤中BPIFBI的表达水平降低,BPIFB1可能通过调控MMP的表达及EMT来抑制肿瘤的增殖和侵袭能力。

关键词：垂体肿瘤基因表达肿瘤侵润基质金属蛋白酶杀菌/渗透增强折叠家族蛋白B1