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Silencing MFN2 Drives WNT/β-catenin Nucleation to Reduce Sorafenib Sensitivity in Hepatocellular Carcinoma Cells

当代医学科学（英文） 2024年第4期44卷 789-798页

作者： Chai-ming zeng Bin SHAO Yan-ping CHEN Gui-sheng DING Department of Geriatric Medicine Shengli Clinical Medical College of Fujian Medical University Fujian Key Laboratory of Geriatrics DiseasesFujian Provincial Center for GeriatricsFujian Provincial HospitalFuzhou 350001China Department of Rehabilitation Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou 350001China Department of Gynecology Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou 350001China Department of Ultrasonography Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou 350001China

Objective:Mitofusin-2(MFN2)is a mitochondrial membrane protein that plays a critical role in regulating mitochondrial fusion and cellular *** further elucidate the impact of MFN2,this study aimed to investigate its significance on hepatocellular carcinoma(HCC)cell function and its potential role in mediating ***:This study investigated the effects of silencing and overexpressing MFN2 on the survival,proliferation,invasion and migration abilities,and sorafenib resistance of MHCC97-L HCC *** experiments were conducted using XAV939(a β-catenin inhibitor)and HLY78(a β-catenin activator)to further validate these ***:Silencing MFN2 significantly promoted the survival and proliferation of MHCC97-L cells,enhanced their invasion and migration capacities,increased the IC50 of sorafenib,reduced the percentage of TUNEL-positive cells,and decreased the expression of proapoptotic ***,silencing MFN2 markedly induced the nuclear translocation of β-catenin,increased β-catenin acetylation levels and enhanced the expression of the downstream regulatory proteins Snail 1 and Vimentin while inhibiting E-cadherin ***,overexpressing MFN2 reversed the effects observed in MHCC97-L cells mentioned *** results confirmed that silencing MFN2 activated the β-catenin/epithelial-mesenchymal transition(EMT)pathway and reduced the sensitivity of cells to sorafenib,which could be reversed by XAV939 ***,overexpression of MFN2 inhibited the β-catenin/EMT pathway and increased the sensitivity of cells to sorafenib,which could be altered by ***:Low expression of MFN2 in HCC cells promotes the nuclear translocation of β-catenin,thereby activating the EMT pathway and mediating resistance to sorafenib.

关键词： apoptosis epithelial-mesenchymal transition hepatocellular carcinoma mitofusin-2 sorafenib resistance

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MusicFace: Music-driven expressive singing face synthesis

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Computational Visual Media 2024年第1期10卷 119-136页

作者： Pengfei Liu Wenjin Deng Hengda Li Jintai Wang Yinglin Zheng Yiwei Ding Xiaohu Guo ming zeng School of Informatics Xiamen UniversityXiamen361000China Department of Computer Science The University of Texas at DallasRichardsonTexas75080-3021USA

It remains an interesting and challenging problem to synthesize a vivid and realistic singing face driven by music. In this paper, we present a method for this task with natural motions for the lips, facial expression, head pose, and eyes. Due to the coupling of mixed information for the human voice and backing music in common music audio signals, we design a decouple-and-fuse strategy to tackle the challenge. We first decompose the input music audio into a human voice stream and a backing music stream. Due to the implicit and complicated correlation between the two-stream input signals and the dynamics of the facial expressions, head motions, and eye states, we model their relationship with an attention scheme, where the effects of the two streams are fused seamlessly. Furthermore, to improve the expressivenes of the generated results, we decompose head movement generation in terms of speed and direction, and decompose eye state generation into short-term blinking and long-term eye closing, modeling them separately. We have also built a novel dataset, SingingFace, to support training and evaluation of models for this task, including future work on this topic. Extensive experiments and a user study show that our proposed method is capable of synthesizing vivid singing faces, qualitatively and quantitatively better than the prior state-of-the-art.

关键词： face synthesis singing music generative adversarial network

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A chromosome-level genome assembly for Chinese plum‘Wushancuili'reveals the molecular basis of its fruit color and susceptibility to rain-cracking

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Horticultural Plant Journal 2024年第3期10卷 672-688页

作者： Kun Zhou Jingwen Wang Lin Pan Fang Xiang Yi Zhou Wei Xiong ming zeng Donald Grierson Wenbin Kong Lingyu Hu Wanpeng Xi College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Southwest UniversityChongqing 400715China Department of Pomology Chongqing Agricultural Technology Extension StationChongqing 401420China Plant and Crop Sciences Division School of BiosciencesUniversity of NottinghamSutton Bonington CampusLoughborough LE125RDUK Wuxi Economical Crop Technology Extension Station Chongqing 405800China

Chinese plum(Prunus salicina Lindl.)originates from China and makes a large contribution to the global production of *** ***‘Wushancuili'has a green coloration and high fruit quality and is economically important in eliminating poverty and protecting ecology in the Yangtze River Three Gorges ***,rain-induced cracking(rain-cracking,literally skin cracking caused by rain)is a limitation to‘Wushancuili'fruit production and causes severe *** study reported a high-quality‘Wushancuili'genome assembly consisting of a 302.17-Mb sequence with eight pseudo-chromosomes and a contig N50 of 23.59 Mb through the combination of Illumina sequencing,Pacific Biosciences HiFiⅢsequencing,and high-throughput chromosome conformation capture technology.A total of 25109 protein-coding genes are predicted and 54.17%of the genome is composed of repetitive sequences.‘Wushancuili'underwent a remarkable orthoselection during *** identification revealed that loss-of-function in four core MYB10 genes results in the anthocyanin deficiency and absence of red color,revealing the green coloration due to the residual high chlorophyll in fruit ***,the occurrence of cracking is assumed to be closely associated with cell wall modification and frequently rain-induced pathogen enrichment through transcriptomic *** loss of MYB10 genes might render fruit more susceptible to pathogen-mediated cracking by weakening the epidermal strength and reactive oxygen species(ROS)*** findings provided fundamental knowledge regarding fruit coloration and rain-cracking and will facilitate genetic improvement and cultivation management in Chinese plums.

关键词： Chinese plum Fruit coloration Fruit epidermis Genome MYB10 Rain-cracking

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Optimization of transverse unidirectional scattering by morphology modification of irregular V-shaped silicon nanoantennas

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Optoelectronics Letters 2024年

作者： zeng ming ZHAO Feng WANG Xianghui School of Electrical Engineering and Automation， Tianjin University Institute of Modern Optics， Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology， Nankai University

A scheme based on irregular V-shaped silicon nanoantennas is proposed to optimize transverse unidirectional scattering under plane wave irradiation. Traditional methods of designing regular shapes offer fewer parameters and higher search efficiency. However， due to the limitations of regular shapes， it is challenging to meet high-precision design requirements. Irregular shape design allows for a broader range of adjustments， but the complexity of shape parameters leads to lower search efficiency and a higher likelihood of converging to local optima. This paper proposes an irregular fine-tuning scheme for regular V-shaped silicon nanoscale antennas that combines the advantages of both approaches. Firstly， the regular V-shaped nanoantenna is tuned to generate transverse unidirectional scattering and then transformed into a binary image. Subsequently， the kernel geometry is fixed while the morphology is modified by a surface contour method to form irregular V-shapes. Finally， those irregular V-shapes are input into a pre-trained predictor cascaded by Bayesian optimization and the nanoantenna’s shape is progressively updated by minimizing the mean squared error between the target scattering and the predicted scattering of irregular nanostructures. The results demonstrate that the optimized irregular V-shaped nanoantennas exhibit perfecter transverse directional scattering and the scattering tail in the opposite direction is greatly shrunk， the mean square error of its scattering compared to the ideal unidirectional scattering has decreased by approximately 29% after optimization. Our findings can promote all-dielectric nanoantennas with specific directional scattering in integrated nanophotonics circuits and sensors.

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Optimized online filter stack spectrometer for ultrashort X-ray pulses

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Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma ming-Hai Yu Yu-Chi Wu Yong-Hong Yan Shao-Yi Wang Huai-Zhong Gao Lu-Shan Wang Yu-Gang Zhou Qiang Li Yue Yang Fang Tan Xiao-Hui Zhang Jie Zhang Wen-Bo Mo Jing-Qin Su Wei-Min Zhou Yu-Qiu Gu ming zeng Zong-Qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

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论苏轼书画艺术的“活法”思想

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西南民族大学学报（人文社会科学版） 2024年第2期45卷 151-157页

作者：曾明牛刚西南民族大学中国语言文学学院四川成都610041 长江师范学院

“活法”说既是中国古代诗论中的重要理论话题,又是中国古典美学中的一个重要范畴。诗学“活法”说对我国古代文学艺术有着极为深远的影响。苏轼深谙“活法”的真谛,并创造性地将这一思想贯通于书画艺术实践之中。在对待前人古法的态度... 详细信息

“活法”说既是中国古代诗论中的重要理论话题,又是中国古典美学中的一个重要范畴。诗学“活法”说对我国古代文学艺术有着极为深远的影响。苏轼深谙“活法”的真谛,并创造性地将这一思想贯通于书画艺术实践之中。在对待前人古法的态度上,他主张“变古法”“出新意”。在艺术法度的把握上,他推崇“出新意于法度之中,寄妙理于豪放之外”。在探求艺术创作规律的过程中,他讲求“随物赋形”“行云流水”。苏轼对于“法”与“活”的认识,在整个艺术领域具有方法论上的普适性,同时具有鲜明的辩证色彩和可贵的实践品格。在推进文化自信自强,加快构建中国特色哲学社会科学话语体系的当下,苏轼“活法”思想的理论意义与实践价值或许能给我们一些启示。

关键词：苏轼书画艺术 “活法”思想当代价值

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空间轨道辐射仿真模拟实验平台

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实验技术与管理 2024年第5期41卷 106-112页

作者：刘奇泽曾志曾鸣清华大学工程物理系北京100084

空间辐射是与航天器安全运行紧密相关的空间环境,与之相关的仿真模拟实验平台对于相关领域学生学习与理解空间辐射环境十分重要。该文编制了一个空间轨道辐射仿真模拟实验平台——SORA(simulator fororbitandradiation),介绍了SORA“输... 详细信息

空间辐射是与航天器安全运行紧密相关的空间环境,与之相关的仿真模拟实验平台对于相关领域学生学习与理解空间辐射环境十分重要。该文编制了一个空间轨道辐射仿真模拟实验平台——SORA(simulator fororbitandradiation),介绍了SORA“输入—计算—输出”的总体结构设计及数据流,描述了SORA所应用的基于轨道根数的在轨位置计算、基于AE(辐射带电子)/AP(辐射带质子)的辐射带模型计算和在轨通量计算方法,展示了SORA GUI界面的构成要素及使用方法。该文使用SORA以一组标准GTO轨道参数作为实例输入,演示了SORA的执行与运算流程,并验证了SORA计算结果与同类型计算平台的一致性。SORA设计简洁的GUI界面及其精细化采样参数调整、离线数据实时计算等特点使其成为相关领域学生能够快速上手使用的模拟实验平台,其内在设计的科学性也保证其计算结果可供学生用于空间轨道辐射对于航天器影响的后续评估。

关键词：空间辐射仿真模拟实验平台

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小米各级蛋白组分对淀粉糊化特性的影响

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中国食品学报 2024年第8期24卷 72-81页

作者：张凡付永霞曾鸣宋昊沈群北京一轻研究院有限公司北京101111 中国农业大学食品科学与营养工程学院北京100083 山西农业大学、山西功能食品研究院太原030024 北京北冰洋食品有限公司北京100162 北冰洋(北京)饮料食品有限公司北京100162

根据溶解度的不同,将4种蛋白组分从小米全粉体系中逐步去除,利用扫描电镜(SEM)、低场核磁共振(LF-NMR)、傅里叶变换红外光谱、快速黏度分析仪(RVA)探究样品结构及糊化特性的变化,并构建蛋白组分-淀粉重组体系进行反向验证。结果表明:整... 详细信息

根据溶解度的不同,将4种蛋白组分从小米全粉体系中逐步去除,利用扫描电镜(SEM)、低场核磁共振(LF-NMR)、傅里叶变换红外光谱、快速黏度分析仪(RVA)探究样品结构及糊化特性的变化,并构建蛋白组分-淀粉重组体系进行反向验证。结果表明:整体而言,醇溶蛋白对淀粉糊化特性的影响最为显著,其次为谷蛋白;清、球蛋白的影响程度较小。SEM结果显示,醇溶蛋白对复粒淀粉无连接、包裹作用,对淀粉糊化不构成物理屏障,而谷蛋白则明显包围连接了淀粉颗粒。结合蛋白组分特性及RVA、LF-NMR试验结果,可知醇溶蛋白的高疏水性引发了憎水效应,增加了体系内水分子移动性,促进淀粉颗粒吸水溶胀,提高淀粉各项糊化特性值;谷蛋白降低淀粉糊化的峰值黏度及崩解值,延长糊化峰值时间,限制糊化进程。

关键词：小米蛋白组分淀粉糊化特性

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职业教育岗位实习课程思政话语体系构建的四重路向

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职业技术教育 2024年第20期45卷 61-66页

作者：孙长坪曾鸣卢宇湖南商务职业技术学院马克思主义学院长沙410205 湖南商务职业技术学院职业教育法治研究所湖南商务职业技术学院电商学院湖南商务职业技术学院经贸学院长沙410205

在全面推进课程思政建设背景下,作为职业教育人才培养的重要必修实践课程,岗位实习也应开展课程思政建设。推进岗位实习课程思政,需要建立相应的话语体系。话语内核、话语主体、话语内容和话语环境共同构成了话语体系的四个基本维度。... 详细信息

在全面推进课程思政建设背景下,作为职业教育人才培养的重要必修实践课程,岗位实习也应开展课程思政建设。推进岗位实习课程思政,需要建立相应的话语体系。话语内核、话语主体、话语内容和话语环境共同构成了话语体系的四个基本维度。岗位实习课程思政话语体系的构建应当紧扣岗位实习作为实践课的特点,遵循课程思政建设的一般规律,从话语体系构成的基本维度把握好其路向选择。岗位实习课程思政话语体系构建的话语内核路向应坚持“思”“政”“德”的统一;话语主体路向应坚持“政”“校”“企”“生”的统一;话语内容路向应坚持“德”与“技”的统一;话语环境路向应坚持“显”与“隐”的统一。

关键词：岗位实习课程思政话语体系职业教育

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新时代教师教育一体化的理论创新与实践探索——《教师教育一体化研究》书评

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闽南师范大学学报（哲学社会科学版） 2024年第2期38卷 150-155页

作者：曾鸣闽南师范大学教育与心理学院福建漳州363000

教师教育一体化是世界各国教师教育改革与发展的基本策略。李建辉教授的专著《教师教育一体化研究》,聚焦教师教育一体化的理论与实践,既有翔实厚重的理论分析,也有可资借鉴的案例探讨,为推进新时代教师队伍建设提供了学理支撑和实践范... 详细信息

教师教育一体化是世界各国教师教育改革与发展的基本策略。李建辉教授的专著《教师教育一体化研究》,聚焦教师教育一体化的理论与实践,既有翔实厚重的理论分析,也有可资借鉴的案例探讨,为推进新时代教师队伍建设提供了学理支撑和实践范式,是教师教育学科迄今为止具有较高学术价值与实践意义的一部学术著作。

关键词：教师教育一体化教师队伍建设理论创新实践探索

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