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Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress

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Neural Regeneration Research 2020年第6期15卷 1150-1159页

作者： Yun-Ling Huang Ning-Xi zeng jie Chen jie Niu Wu-Long Luo ping Liu Can Yan Li-Li Wu Research Center for Basic Integrative Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Department of Pharmacology PLA General HospitalBeijingChina

The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant *** present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression *** unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food *** unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of *** open-field test was used to evaluate locomotor activity and anxiety *** with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 *** unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 *** addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of *** observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by *** with the control group,neurogenesis and

关键词： chronic unpredictable mild stress model continuous observation depression depression-like behavior dynamic changes hippocampus miR-124 neurogenesis dysfunction neuronal loss

Blackboard Mechanism Based Ant Colony Theory for Dynamic Deployment of Mobile Sensor Networks

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Journal of Bionic Engineering 2008年第3期5卷 197-203页

作者： Guang-ping Qi ping Song Ke-jie Li School of Aerospace Science and Engineering Beij＇ing Institute of Technology Beo＇ing 100081 P. R. China

A novel bionic swarm intelligence algorithm, called ant colony algorithm based on a blackboard mechanism, is proposed to solve the autonomy and dynamic deployment of mobiles sensor networks effectively. A blackboard mechanism is introduced into the system for making pheromone and completing the algorithm. Every node, which can be looked as an ant, makes one information zone in its memory for communicating with other nodes and leaves pheromone, which is created by ant itself in naalre. Then ant colony theory is used to find the optimization scheme for path planning and deployment of mobile Wireless Sensor Network （WSN）. We test the algorithm in a dynamic and unconfigurable environment. The results indicate that the algorithm can reduce the power consumption by 13% averagely, enhance the efficiency of path planning and deployment of mobile WSN by 15% averagely.

关键词： ant colony algorithm wireless sensor network blackboard mechanism bionic swarm intelligence algorithm

Theory of Critical Phenomena with Memory

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Chinese Physics Letters 2022年第12期39卷 1-7页

作者： Shaolong zeng Sue ping Szeto Fan Zhong State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen UniversityGuangzhou 510275China

Memory is a ubiquitous characteristic of complex systems,and critical phenomena are one of the most intriguing phenomena in ***,we propose an Ising model with memory,develop a corresponding theory of critical phenomena with memory for complex systems,and discover a series of surprising novel *** show that a naive theory of a usual Hamiltonian with a direct inclusion of a power-law decaying long-range temporal interaction violates radically a hyperscaling law for all spatial dimensions even at and below the upper critical *** entails both indispensable consideration of the Hamiltonian for dynamics,rather than the usual practice of just focusing on the corresponding dynamic Lagrangian alone,and transformations that result in a correct theory in which space and time are inextricably interwoven,leading to an effective spatial dimension that repairs the hyperscaling *** theory gives rise to a set of novel mean-field critical exponents,which are different from the usual Landau ones,as well as new universality *** exponents are verified by numerical simulations of the Ising model with memory in two and three spatial dimensions.

关键词： critical Hamiltonian scaling

Monitor of Polymerization of Inverse Microemulsions Containing Methyl Methacrylate and Acrylic Acid

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Chinese Chemical Letters 2006年第2期17卷 247-250页

作者： Xiao LI Sheng ping XIA Wei jie zeng Wei Ying ZHANG Sheng Xiong DONG College of Chemistry and Chemical Engineering FuzhouUniversity Fuzhou350002

The polymerization of the inverse microemulsions composed of methyl methacrylate,acrylic acid, sodium dodecyl sulfate and water was monitored by refractometer, conductometer and time-resolved light scattering device. The results showed that refractive index, conductivity or intensity distribution of scattered light changed along with polymerization, and different processes of polymerization could be identified.

关键词： Polymerization monitoring inverse microemulsion methyl methacrylate.

Advances in the construction of diverse SuFEx linkers

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National Science Review 2023年第6期10卷 226-244页

作者： Daming zeng Wei-ping Deng Xuefeng Jiang Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism School of Pharmacy East China University of Science and Technology Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University

Sulfur fluoride exchange(SuFEx),a new generation of click chemistry,was first presented by Sharpless,Dong and co-workers in *** to the high stability and yet efficient reactivity of the SⅥ-F bond,SuFEx has found widespread applications in organic synthesis,materials science,chemical biology and drug discovery.A diverse collection of SuFEx linkers has emerged,involving gaseous SO2F2and SOF4hubs;SOF4-derived iminosulfur oxydifluorides;O-,N-and C-attached sulfonyl fluorides and sulfonimidoyl fluorides;and novel sulfondiimidoyl *** review summarizes the progress of these SuFEx connectors,with an emphasis on analysing the advantages and disadvantages of synthetic strategies of these connectors based on the SuFEx concept,and it is expected to be beneficial to researchers to rapidly and correctly understand this field,thus inspiring further development in SuFEx chemistry.

关键词： SuFEx SuFEx linker SVI–F bond synthetic strategy

Bioinspired flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure

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Nano Research 2021年第10期14卷 3643-3652页

作者： Han-ping Yu Ying-jie Zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The synthetic hydrogels with high water contents are promising for various applications,however,they usually exhibit low mechanical *** this work,inspired by the natural biological soft tissues,whose hierarchically ordered fibrous structures result in high strength and good flexibility,a flexible,high-strength,and versatile hydrogel with the fiberboard-and-mortar hierarchically ordered structure(HFMOS)is developed based on ultralong hydroxyapatite(HAP)nanowires and polyacrylic acid(PAA).The as-prepared HFMOS hydrogel has a high water content(~70 wt.%),dense structure,and excellent mechanical properties,and these properties are similar to those of the human cartilage and are superior to many hydrogels reported in the *** excellent mechanical properties of the HFMOS hydrogel originate from the combination of the fiberboard-and-mortar hierarchically ordered structure,reinforcement of ultralong HAP nanowires,strong interfacial strength,and multiple energy dissipation ***,thanks to the controllable components and injection procedure,the HFMOS hydrogel with a Janus structure is prepared for particular *** HFMOS hydrogel possesses abundant ordered water channels,and can be used for loading,release,and directed delivery of various functional ***,the as-prepared flexible,high-strength,and versatile HFMOS hydrogel possesses a great potential for various applications such as water purification,pollution treatment,biomedicine,nanofluidic devices,and high-performance structural materials.

关键词： hydrogel nanowire hydroxyapatite ordered structure

Transforming bulk alkenes and alkynes into fine chemicals enabled by single-atom site catalysis

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Nano Research 2022年第9期15卷 7840-7860页

作者： ping Guo Hongyuan Liu jie Zhao Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China

The addition and substitution reactions across a variety of alkenes and alkynes have been playing an important role in organic *** particular,catalyses enabled by homogeneous complexes as well as heterogenous nanomaterials have been much received attentions over *** with these blooming progresses in these fields,single-atom site catalysts(SACs)exhibit outstanding performances in terms of reactivity and selectivity,thus providing a new powerful strategy to upgrade these bulk ***,we summarize the reactions of alkenes and alkynes enabled by SACs,in which catalytic hydrogenation,hydrosilylation,hydroboration,hydroformylation,and cross coupling have been ***,preparations and fine structures of the corresponding SACs have been described,therefore providing a better understanding and overview to address the origin of catalytic activity in the reported examples.

关键词： single-atom site catalysts(SACs) alkenes alkynes

中药调控成骨细胞铁死亡治疗激素性股骨头坏死

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中国组织工程研究 2025年第1期29卷 185-192页

作者：张绵钰韩杰曾浩陈相汕高振罡广西中医药大学研究生学院广西壮族自治区南宁市530000 广西中医药大学附属瑞康医院广西壮族自治区南宁市530011

背景:有研究发现成骨细胞铁死亡可作为重要的发病机制诱导激素性股骨头坏死的发生与发展。随着祖国医学的发展,有学者发现某些中药单体、中药复方及中成药等可通过多种通路机制调控成骨细胞铁死亡,最终起到治疗激素性股骨头坏死的作用... 详细信息

背景:有研究发现成骨细胞铁死亡可作为重要的发病机制诱导激素性股骨头坏死的发生与发展。随着祖国医学的发展,有学者发现某些中药单体、中药复方及中成药等可通过多种通路机制调控成骨细胞铁死亡,最终起到治疗激素性股骨头坏死的作用。目的:探讨成骨细胞铁死亡与激素性股骨头坏死的关系及中草药调控成骨细胞铁死亡治疗激素性股骨头坏死的作用机制,为激素性股骨头坏死的诊治提供新的思路。方法:以“铁死亡,激素性股骨头坏死,成骨细胞,中草药,糖皮质激素,铁代谢,活性氧,谷胱甘肽过氧化物酶”为中文检索词,以“ferroptosis,Hormonal necrosis of the femoral head,osteoblast,Chinese herbal medicine,glucocorticoid,iron metabolism,ROS,GPX4”为英文检索词,检索中国知网、Pub Med、万方及维普数据库,筛选各数据库建库至2023年成骨细胞铁死亡与激素性股骨头坏死及中草药干预调控研究相关的文章,最终纳入74篇文献进行综述分析。结果与结论:(1)成骨细胞铁死亡在激素性股骨头坏死发病中起重要作用。(2)成骨细胞铁死亡的发生受到多种机制通路调控,如细胞内铁超载引起铁死亡;细胞发生脂质过氧化损伤细胞膜引起铁死亡;细胞膜上胱氨酸/谷氨酸逆向转运蛋白通过影响谷胱甘肽水平和谷胱甘肽过氧化物酶4活性,从而诱导铁死亡;细胞内发生芬顿反应产生大量活性氧引起铁死亡等。(3)中药单体淫羊藿苷等、中药复方青娥丸等及中成药补肾活血颗粒等均可通过调控成骨细胞铁死亡的发生,有助于防治激素性股骨头坏死。(4)目前关于成骨细胞铁死亡相关机制尚不明确,继续深入探明两者的作用机制,有望为临床治疗激素性股骨头坏死提供新选择。

关键词：股骨头坏死铁死亡中医药成骨细胞糖皮质激素铁代谢活性氧谷胱甘肽谷胱甘肽过氧化物酶脂质过氧化

ON GREEN'S FUNCTION FOR HYPERBOLIC-PARABOLIC SYSTEMS

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Acta Mathematica Scientia 2009年第6期29卷 1556-1572页

作者： Tai-ping Liu Yanni zeng Department of Mathematics Stanford University Stanford CA 94305 USA Department of Mathematics University of Alabama at Birmingham Birmingham AL 35294 USA

We study the Green＇s function for a general hyperbolic-parabolic system, including the Navier-Stokes equations for compressible fluids and the equations for magnetohydrodynamics. More generally, we consider general systems under the basic Kawashima- Shizuta type of conditions. The first result is to make precise the secondary waves with subscale structure, revealing the nature of coupling of waves pertaining to different characteristic families. The second result is on the continuous differentiability of the Green＇s function with respect to a small parameter when the coefficients of the system are smooth functions of that parameter. The results significantly improve previous results obtained by the authors.

关键词： Green's functions hyperbolic-parabolic systems conservation laws Navier-Stokes equations for compressible fluids