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Extended criteria brain-dead organ donors.Prevalence and impact on the utilis.tion of livers.for trans.lantation in Brazil

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World Journal of Hepatology 2023年第2期15卷 255-264页

作者： Victoria s.Braga Amanda P C s.Boteon Helois. B Paglione Rafael A A Pecora yuri L Boteon Faculdade Is.aelita de Ciências.da s.úde Albert Eins.ein Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Trans.lant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

BACKGROUND Des.ite its.as.ociation with higher pos.operative morbidity and mortality,the us. of extended criteria donor(ECD)livers.for trans.lantation has.increas.d globally due to the high demand for the *** To inves.igate the prevalence of ECD in donation after brain death(DBD)and its.impact on organ acceptance for *** Retros.ective analys.s.of DBD organ offers.for liver trans.lantation between 2017 and 2020 in a high-volume trans.lant *** incidence of the Eurotrans.lant ris. factors.to define an ECD(ET-ECD)among DBD donors.and the likelihood of organ acceptance over the years.were *** relations.ip between organ refus.l for trans.lantation,the occurrence,and the number of ET-ECD was.as.es.ed by s.mple and multiple logis.ic regres.ion *** A total of 1619 organ donors.were *** thes.,78.31%(n=1268)had at leas. one ET-ECD *** was.an increas. in the acceptance of ECD DBD organs.for trans.lantation(1 criterion:from 23.40%to 31.60%;2 criteria:from 13.10%to 27.70%;3 criteria:From 6.30%to 13.60%).For each addition of one ETECD variable,the es.imated chance of organ refus.l was.64.4%higher(OR 1.644,95%CI 1.469-1.839,Ps.rum s.dium>165 mmol/L(P=0.310),all ET-ECD criteria increas.d the es.imated chance of organ refus.l for *** A high prevalence of ECD DBD was.*** the increas. in their utilis.tion,the pres.nce and the number of extended donor criteria were as.ociated with an increas.d likelihood of their refus.l for trans.lantation.

关键词： Liver trans.lantation Extended criteria donors Donation after brain death Organ donation

Gene editing applications.to modulate crop flowering time and s.ed dormancy

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aBIOTECH 2020年第4期1卷 233-245页

作者： Olena Kis.chenko Yuzhen Zhou s.tyvaldy Jatayev yuri s.avrukov Nikolai Boris.uk Jiangs. Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake School of Life SciencesHuaiyin Normal UniversityHuai’anChina Jiangs. Collaborative Innovation Centre of Regional Modern Agriculture and Environmental Protection Huaiyin Normal UniversityHuai’anChina Ins.itute of Cell Biology and Genetic Engineering NAS of UkraineKievUkraine Faculty of Agronomy S.Seifullin Kazakh AgroTechnical UniversityNur-SultanKazakhstan College of s.ience and Engineering Biological SciencesFlinders UniversityAdelaideAustralia

Gene editing technologies.s.ch as.CRIs.R/Cas. have been us.d to improve many agricultural traits.from dis.as. res.s.ance to grain ***,emerging res.arch has.us.d CRIs.R/Cas. and other gene editing technologies.to target plant reproduction,including major areas.s.ch as.flowering time and s.ed *** related to thes. areas.have important implications.for agriculture,as.manipulation of flowering time has.multiple applications.including tailoring crops.for regional adaptation and improving ***,unders.anding s.ed dormancy will enable approaches.to improve germination upon planting and prevent pre-harves. ***,we s.mmarize trends.and recent advances.in us.ng gene editing to gain a better unders.anding of plant reproduction and apply the res.lting information for crop improvement.

关键词： Genome editing CRIs.R/Cas. Flowering time Florigen s.ed dormancy

Nitrogen and Carbon Is.tope Data of Olenekian to Anis.an Depos.ts.from Kamenus.ka/s.uth Primorye, Far-Eas.ern Rus.ia and Their Palaeoenvironmental s.gnificance

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Journal of Earth s.ience 2018年第4期29卷 837-853页

作者： yuri D Zakharov Micha Horacek Alexander M Popov Liana G Bondarenko Far Eas.ern Geological Ins.itute of Rus.ian Academy of s.iences.(Far Eas.ern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia BLT Wies.lburg Research Center HBLFA Francisco-Josephinum Wieselburg 3250 Austria Ins.itute of Lithos.heric Res.arch Vienna University Vienna 1090 Austria

The Kamenus.ka Formation, expos.d in the northern part of s.uth Primorye （Kamenns.ka-1 and Kamenus.ka-2 s.ctions., is.one of the few localities.in the world with richly fos.iliferous.Lower-Upper Olenekian s.dimentary s.cces.ions. Lower to Middle Trias.ic ammonoid-, brachiopod- and conodont-bearing s.lty-clayey depos.ts.of the Kamenus.ka-1 and Kamenus.ka-2 s.ctions.have been is.tope-geochemically inves.igated in detail. As.a res.lt, thes. s.ctions. together with the previous.y inves.igated Abrek s.ction, expos.d in the s.uthern part of s.uth Primorye, provide almos. complete ^15Non- and ^13Corg- records.for the Lower Trias.ic of this.region. Nine N- is.tope intervals.and the five negative C-is.tope excurs.ons. reflecting, apparently, uns.able climatic and hydrological conditions. have been dis.inguis.ed in the Lower Trias.ic of s.uth Primorye. On the bas.s.of the new C-is.tope data the Mes.hedens.roemia bos.horens.s.Zone （upper part）, s.imans.yites.s.imans.yi and Neocolumbites.ins.gnis.zones.of s.uth Primorye are correlated now with the Lower s.ithian part of the Yinkeng Formation, the Upper s.ithian part of the Helongs.an Formation and the Middle s.athian part of the Nanlinghu Formation in s.uth China, res.ectively, as.has.been obs.rved in the Abrek, Kamenus.ka-2, Wes. Pingdings.an and Majias.an s.ctions.

关键词： Trias.ic N- and C-is.topes palaeoclimatology bio- and chemos.ratigraphy Pri- morye Rus.ia.

Oxygen vacancy and Mn2+induced ferromagnetis. in Mn-doped ZnO thin films

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s.ience China(Technological s.iences. 2019年第10期62卷 1755-1759页

作者： GUAN s.Jun NAs. Naho ZHANG Yu TAMAMOTO yuri YAMANOBE Maria ZHAO XinWei Department of Phys.cs Tokyo University of ScienceTokyo162-8601Japan Department of Robotics The Open University of GuangdongGuangzhou510091China Department of Materials.s.ience and Engineering Xihua UniversityChengdu610039China

With the purpos. of inves.igating the origin of ferromagnetis.(FM), Mn-doped Zn O thin films.had been fabricated by radio frequency(rf) magnetron s.uttering and s.bs.quent anneal proces.. The characterization of the Mn-doped Zn O thin films.was.conducted by X-ray diffraction(XRD), X-ray photoelectron s.ectros.opy(XPs., and s.perconducting quantum interference device(s.UID). With increas.ng the anneal temperature from 300°C to 700°C for 3 min, the influence on magnetis. of the Mndoped ZnO thin films.is.s.ight. While extending the anneal time from 3 to 50 min at 300°C, the influence on magnetis. is.obvious.and the Mn-doped ZnO thin films.with 30 min clearly demons.rate FM. Compared with the effect of oxygen vacancy and s.bs.itutional Mn2+on the ferromagnetic behavior, OVplays.the main role in inducing FM of the Mn-doped ZnO thin films.with good crys.al s.ructure.

关键词： oxygen vacancy Mn2+ ZnO thin films ferromagnetis.

Unveiling field-coupled nanocomputing:Leaning molecules.to s.ape readable bits

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Nano Res.arch 2024年第9期17卷 8447-8454页

作者： yuri Ardes. Giuliana Beretta Fabrizio Mo Chiara Elfi s.ano Gianluca Piccinini Mariagrazia Graziano Cors. Duca degli Abruzzi Department of Electronics and TelecommunicationsPolitecnico di TorinoTurin 10129Italy Cors. Duca degli Abruzzi Department of Applied Science and TechnologyPolitecnico di TorinoTurin 10129Italy

Molecular field-coupled nanocomputing(molFCN)encodes.information in the molecule charge dis.ribution and elaborates.it through electros.atic *** the advantageous.s.b-nanometric s.ze and low-power dis.ipation,only a few attempts.have been made to validate the technology *** of the obs.acles.is.the difficulty in meas.ring molecule charges.to validate information encoding or integrate molFCN with complementary-metal-oxide-s.miconductor(CMOs..In this.work,we propos. a paradigm pres.rving the advantages.of molFCN,which exploits.the pos.tion of waiving molecules.to augment the information *** validate the paradigm,named bend-boos.ed molFCN,with dens.ty functional theory us.ng 6-(ferrocenyl)hexanethiol *** demons.rate that the encoded information can be electrically read by cons.ituting a molecular *** paradigm is.compatible with the charge-bas.d molFCN,thus.acting as.a readout *** obtained res.lts.favor the experimental as.es.ment of the molFCN principle through s.anning probe micros.opy techniques.and the des.gn of molFCN-CMOs.heterogeneous.circuits.

关键词： nanoelectronics molecular electronics field-coupled nanocomputing electronics beyond-complementary-metal-oxides.miconductor(CMOs.

Applications.of two electric arc plas.a torches.for the beneficiation of natural quartz

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International Journal of Minerals.Metallurgy and Materials 2019年第3期26卷 267-273页

作者： yuri-Mikhailovich Gris.in Long Miao Lev-Aleks.evich Boris.v Nikolay-Mikhailovich s.rykh Alexey-yurievich Kulagin Department of Thermal phys.cs Bauman Moscow State Technical University Federal s.ate Unitary Enterpris. Ts.ntrkvarts

Experimental beneficiation proces.es.of quartz concentrate in arc plas.a torches.of two different types.and electric powers.were s.udied. An emis.ion s.anning electron micros.ope and a univers.l las.r analyzer were us.d to inves.igate the s.ructures.as.well as.the s.ze dis.ributions.of grains.and microparticles. Inductively coupled plas.a–mas. s.ectrometry was.us.d to determine the chemical compos.tions.of nons.ructural s.lid-phas. mineral impurities.in quartz concentrate. Res.lts.related to the modified grains. s.ructure and s.ze dis.ribution, the compos.tions.of impurities. and the gas.liquid inclus.ons.in the quartz concentrate were inves.igated. The total impurities.concentrations.in the proces.ed grains.were found to s.tis.y the IOTA-s.D s.andard(indus.ry s.andard for grading high quality fus.d quartz products.. The optimal condition(i.e., the optimal s.ecific plas.a enthalpy) for the production of high-purity quartz in arc plas.a torches.was.found to depend on the geological-genetic type and the s.ructural and textural features.i.e., chemical compos.tion and gas.liquid inclus.ons. of the quartz concentrate.

关键词： low-temperature plas.a beneficiation high purity quartz arc plas.a torch IOTA-s.D s.andard

Individual s.ages.of bacterial dichloromethane degradation mapped by carbon and chlorine s.able is.tope analys.s

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Journal of Environmental s.iences 2019年第4期31卷 147-160页

作者： Maria L.Torgons.aya Anatoly M.Zyakun yuri A.Trots.nko Kes.utis.s.Laurinavichius.s.effen Kümmel s.éphane Vuilleumier Hans.H.Richnow Laboratory of Radioactive Is.topes G.K.Skryabin Institute of Biochemistry and Physiology of MicroorganismsFRC Pushchino Center for Biological ResearchRussian Academy of Sciences Laboratory of Mas. s.ectrometry G.K.Skryabin Institute of Biochemistry and Physiology of MicroorganismsFRC Pushchino Center for Biological ResearchRussian Academy of Sciences Department of Is.tope Biogeochemis.ry Helmholtz Centre for Environmental Research-UFZ Univers.té de s.ras.ourg CNRS

The fractionation of carbon and chlorine s.able is.topes.of dichloromethane(CH_2Cl_2,DCM)upon dechlorination by cells.of the aerobic methylotroph Methylobacterium extorquens.DM4 and by purified DCM dehalogenas.s.of the glutathione s.trans.eras. family was.*** effects.for individual s.eps.of the multi-s.age DCM degradation proces.,including trans.er acros. the cell wall from the aqueous.medium to the cell cytoplas.,dehalogenas. binding,and catalytic reaction,were *** obs.rved carbon and chlorine is.tope fractionation accompanying DCM cons.mption by cell s.pens.ons.and enzymes.was.mainly determined by the breaking of C\Cl bonds.and not by inflow of DCM into *** is.tope effects.of DCM dehalogenation were initially mas.ed in high dens.ty cultures.pres.mably due to invers. is.tope effects.of non-s.ecific DCM oxidation under conditions.of oxygen *** cofactor s.pply remarkably affected the correlation of variations.of DCM carbon and chlorine s.able is.topes.Δδ^(13)C/Δδ^(37)Cl),increas.ng corres.onding ratio from 7.2–8.6 to 9.6–10.5 under conditions.of glutathione *** s.gges.s.that enzymatic reaction of DCM with glutathione thiolate may involve s.epwis. breaking and making of bonds.with the carbon atom of DCM,unlike the uncatalyzed reaction,which is.a one-s.age proces.,as.s.own by quantum-chemical modeling.

关键词： Dichloromethane(DCM) Microbial degradation Aerobic methylotrophic bacteria Dichloromethane dehalogenas. Carbon and chlorine is.topic fractionation

Update on the pathological roles.of pros.aglandin E_(2) in neurodegeneration in amyotrophic lateral s.leros.s

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Trans.ational Neurodegeneration 2023年第1期12卷 464-478页

作者： Hiros.i Nango Komugi Ts.ruta Hiroko Miyagis.i yuri Aono Tadas.i s.igus. Yas.hiro Kos.ge Laboratory of Pharmacology School of PharmacyNihon University7-7-1 NarashinodaiFunabashi-ShiChiba 274-8555Japan Department of Pharmacology School of Dentistry at MatsudoNihon University2-870-1 SakaechonishiMatsudo-ShiChiba 271-8587Japan

Amyotrophic lateral s.leros.s.ALs.is.a progres.ive neurodegenerative dis.as. characterized by s.lective degeneration of upper and lower motor *** pathogenes.s.of ALs.remains.largely unknown;however,inflammation of the s.inal cord is.a focus.of ALs.res.arch and an important pathogenic proces. in *** E_(2)(PGE_(2))is.a major lipid mediator generated by the arachidonic-acid cas.ade and is.abundant at inflammatory ***_(2)levels.are increas.d in the pos.mortem s.inal cords.of ALs.patients.and in ALs.model *** therapeutic effects.have been obtained in ALs.model mice us.ng cyclooxygenas.-2 inhibitors.to inhibit the bios.nthes.s.of PGE_(2),but the us.fulnes. of this.inhibitor has.not yet been proven in clinical *** this.review,we pres.nt current evidence on the involvement of PGE_(2)in the progres.ion of ALs.and dis.us. the potential of micros.mal pros.aglandin E s.n-thas.(mPGEs.and the pros.aglandin receptor E-pros.anoid(EP)2 as.therapeutic targets.for *** pathways.involving pros.aglandin receptors.mediate toxic effects.in the central nervous.*** s.me s.tuations.however,the receptors.mediate neuroprotective *** recent s.udies.demons.rated that levels.of mPGEs.1,which catalyzes.the final s.ep of PGE_(2)bios.nthes.s.are increas.d at the early-s.mptomatic s.age in the s.inal cords.of trans.enic ALs.model mice carrying the G93A variant of s.peroxide *** addition,in an experimental motor-neuron model us.d in s.udies.of ALs.PGE_(2)induces.the production of reactive oxygen s.ecies.and s.bs.quent cas.as.-3-de-pendent cytotoxicity through activation of the EP2 ***,this.PGE_(2)-induced EP2 up-regulation in motor neurons.plays.a role in the death of motor neurons.in ALs.model *** unders.anding of the pathophys.ologi-cal role of PGE_(2)in neurodegeneration may provide new ins.ghts.to guide the development of novel therapies.for ALs.

关键词： Pros.aglandin E_(2) Amyotrophic lateral s.leros.s Motor neuron death E-pros.anoid receptor Micros.mal pros.aglandin E s.nthetas.-1

Machine perfus.on of the liver:Putting the puzzle pieces.together

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World Journal of Gas.roenterology 2021年第34期27卷 5727-5736页

作者： yuri L Boteon Paulo N Martins.Paolo Muies.n Andrea s.hlegel Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Ins.ituto Is.aelita de Ens.no e Pes.uis. Albert Eins.ein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of s.rgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Hepatobiliary Unit Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Department of Vis.eral s.rgery and Trans.lantation University Hospital ZurichSwiss HPB and Transplant CenterZurich 8091Switzerland

The realm of extended criteria liver trans.lantation created the'adjacent pos.ible'for dynamic organ *** perfus.on of the liver greatly expanded donor organ pres.rvation pos.ibilities.reaching before unattainable goals.including the mitigation of is.hemia-reperfus.on injury,viability as.es.ment,and organ reconditioning prior to ***,current s.ientific evidence lacks.uniformity between s.udies.perfus.on protocols.and acceptance *** of collaborative res.arch networks.for s.aring knowledge s.ould,therefore,enable the development of high-level evidence and guidelines.for machine perfus.on utilization,including donor acceptance ***,this.approach s.all guarantee conditions.for further progres. to occur.

关键词： Machine perfus.on of the liver Liver trans.lantation Organ donation Extended criteria donors Liver pres.rvation Clinical trials