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A new approach for inversion of receiver function for crustal structure in the depth domain

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Earth and Planetary Physics 2022年第1期6卷 83-95页

作者： TianYu Zheng yumei he Yue Zhu Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China University of Chinese Academy of Sciences Beijing 100049China

A method for reconstructing crustal velocity structure using the optimization of stacking receiver function amplitude in the depth domain,named common conversion amplitude(CCA)inversion,is presented.The conversion amplitude in the depth domain,which represents the impedance change in the medium,is obtained by assigning the receiver function amplitude to the corresponding conversion position where the P-to-S conversion occurred.Utilizing the conversion amplitude variation with depth as an optimization objective,imposing reliable prior constraints on the structural model frame and velocity range,and adopting a stepwise search inversion technique,this method efficiently weakens the tendency of easily falling into the local extremum in conventional receiver function inversion.Synthetic tests show that the CCA inversion can reconstruct complex crustal velocity structures well and is especially suitable for revealing crustal evolution by estimating diverse velocity distributions.Its performance in reconstructing crustal structure is superior to that of the conventional receiver function imaging method.

关键词： crustal imaging receiver function depth domain inversion

Research on the scatter features of the PKiKP/PcP amplitude ratio and the inner core boundary density contrasts beneath Northeast Asia

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Science China Earth Sciences 2021年第5期64卷 716-727页

作者： Haodong ZHANG Yinshuang AI yumei he Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100049China University of Chinese Academy of Sciences Beijing 100101China

Quantifying the density contrasts of the Earth’s inner core boundary(ICB)is crucial to understand core-mantle coupling and the generation of the geodynamo.The PKiKP/PcP amplitude ratio is commonly used to obtain the density contrast at the ICB,but its applications are limited by scattered observed data.In this study,we selected the PKiKP and PcP phases reflected at the same region of inner-core and core-mantle boundaries beneath Northeast Asia from different earthquakes for the first time,and the observations suggested that the PKiKP/PcP amplitude ratio is widely scattered.We also compared the PKiKP and PcP amplitudes,which demonstrated that the scatter cannot be attributed only to ICB anomalies but might also arise from raypath differences and heterogeneities throughout the crust and mantle.By fitting the observed PKiKP/PcP amplitude ratio,we obtained a density contrast of approximately 0.65 g cm^(-3) and a compressional velocity contrast of approximately 0.87 km s^(-1) at the ICB beneath Northeast Asia.The larger contrast values indicate the possible occurrence of local crystallization occurring at the inner core surface.

关键词： Northeast Asia Inner core boundary PKiKP/PcP amplitude ratio Density contrast

Morphology and possible origins of the Perm anomaly in the lowermost mantle of Earth

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Earth and Planetary Physics 2021年第1期5卷 105-116页

作者： yumei he LianXing Wen Yann Capdeville Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Mohe Observatory of Geophysics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Laboratory of Seismology and Physics of Earth’s Interior School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Department of Geosciences State University of New York at Stony BrookStony BrookNew YorkUSA Laboratoire de Planétologie et Géodynamique de Nantes UMR6112CNRSUniversitéde NantesNantesFrance

We have constrained a small-scale,dome-shaped low-velocity structure near the core-mantle boundary(CMB)of Earth beneath Perm(the Perm anomaly)using travel-time analysis and three-dimensional(3-D)forward waveform modeling of seismic data sampling of the mantle.The best-fitting dome-shaped model centers at 60.0°E,50.5°N,and has a height of 400 km and a radius that increases from 200 km at the top to 450 km at the CMB.Its velocity reduction varies from 0%at the top to–3.0%at 240km above the CMB to–3.5%at the CMB.A surrounding 240-km-thick high-velocity D''structure has also been detected.The Perm anomaly may represent a stable smallscale chemical pile in the lowermost mantle,although the hypothesis of a developing mantle plume cannot be ruled out.

关键词： seismic velocity structure core-mantle boundary Perm anomaly chemical pile

The transcription factor CsS40 negatively regulates TCS1 expression and caffeine biosynthesis in connection to leaf senescence in Camellia sinensis

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Horticulture Research 2023年第9期10卷 194-206页

作者： Xinzhuan Yao Hufang Chen Antao Ai Fen Wang Shanshan Lian Hu Tang Yihe Jiang Yujie Jiao yumei he Tong Li Litang Lu College of Tea Sciences Institute of Plant Health&MedicineThe Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education)Guizhou UniversityGuiyang 550025China School of Biological Science and Agriculture Qiannan Normal University for NationalitiesDuyun 558000China

Caffeine is considered as one of the most important bioactive components in the popular plant beverages tea,cacao,and coffee,but as a wide-spread plant secondary metabolite its biosynthetic regulation at transcription level remains largely unclear.here,we report a novel transcription factor Camellia sinensis Senescnece 40(CsS40)as a caffeine biosynthesis regulator,which was discovered during screening a yeast expression library constructed from tea leaf cDNAs for activation of tea caffeine synthase(TCS1)promoter.Besides multiple hits of the non-self-activation CsS40 clones that bound to and activated TCS1 promoter in yeast-one-hybrid assays,a split-luciferase complementation assay demonstrated that CsS40 acts as a transcription factor to activate the CsTCS1 gene and EMSA assay also demonstrated that CsS40 bound to the TCS1 gene promoter.Consistently,immunofluorescence data indicated that CsS40-GFP fusion was localized in the nuclei of tobacco epidermal cells.The expression pattern of CsS40 in‘Fuding Dabai’developing leaves was opposite to that of TCS1;and knockdown and overexpression of CsS40 in tea leaf calli significantly increased and decreased TCS1 expression levels,respectively.The expression levels of CsS40 were also negatively correlated to caffeine accumulation in developing leaves and transgenic calli of‘Fuding Dabai’.Furthermore,overexpression of CsS40 reduced the accumulation of xanthine and hypoxanthine in tobacco plants,meanwhile,increased their susceptibility to aging.CsS40 expression in tea leaves was also induced by senescence-promoting hormones and environmental factors.Taken together,we showed that a novel senescence-related factor CsS40 negatively regulates TCS1 and represses caffeine accumulation in tea cultivar‘Fuding Dabai’.The study provides new insights into caffeine biosynthesis regulation by a plant-specific senescence regulator in tea plants in connection to leaf senescence and hormone signaling.

关键词： S40 caffeine TCS

“三全育人”视域下高职心理健康教育协同模式研究

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普洱学院学报 2024年第1期40卷 132-134页

作者：何玉梅芜湖职业技术学院安徽芜湖241003

“三全育人”理念强调全员参与、全过程覆盖、全方位育人,旨在为高职学生提供全面的心理健康支持。通过构建教育协同模式,可以有效地实现这一目标,尤其是在应对学生多样化和个性化需求方面显示出独特优势。高校应采取构建全员参与的教... 详细信息

“三全育人”理念强调全员参与、全过程覆盖、全方位育人,旨在为高职学生提供全面的心理健康支持。通过构建教育协同模式,可以有效地实现这一目标,尤其是在应对学生多样化和个性化需求方面显示出独特优势。高校应采取构建全员参与的教育网络、强化全过程跟踪与支持、探索全方位多维度的教育内容与方法、建立有效的反馈与优化机制等策略,提升大学生心理健康教育的有效性,为学生的全面发展提供坚实基础。

关键词：三全育人高职教育心理健康教育协同模式

Application of traditional Chinese therapy in sports medicine

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Sports Medicine and health Science 2021年第1期3卷 11-20页

作者： Liang Kang Peijie Liu Aishi Peng Bingxin Sun yumei he Zenghao Huang Minjia Wang Yushi Hu Benxiang he Institute of Sports Medicine and health Chengdu Sport UniversityChengdu610041China School of Sports Medicine and health Chengdu Sport UniversityChengdu610041China Sport Hospital Affiliated to Chengdu Sport University Chengdu610041China

Chinese herbs have been used as dietary supplements to improve exercise performance.However,evidence-based studies for the use of Chinese herbs in sports remain scarce.Traditional Chinese therapy(TCT),a form of traditional Chinese non-pharmacological intervention,has remained in use for thousands of years in sports medicine.TCT is beneficial for sports injuries and in enhancing skill development,and is becoming increasingly popular among athletes,fitness enthusiasts,and individuals who regularly exercise.The therapeutic effects of TCT have been demonstrated by clinical and experimental studies,but using these modalities still is associate with potentially adverse effects.Further well-designed studies are necessary to confirm the efficacy of TCT in sports medicine.This review aims to summarize the application of TCT,discuss the issues surrounding TCT clinical research,and provide suggestions for applying traditional Chinese methods in the field of sports medicine.

关键词： Traditional Chinese therapy Sports medicine Acupuncture Moxibustion Cupping Tui Na

百令胶囊联合西医常规治疗糖尿病肾病的药物经济学研究

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药物流行病学杂志 2024年第3期33卷 277-290页

作者：何玉梅李薇朱贺韩晟北京大学医药管理国际研究中心北京100191 北京大学药学院北京100191

目的评估百令胶囊联合西医常规疗法对比西医常规疗法治疗糖尿病肾病的经济性。方法利用Meta分析探讨百令胶囊联合西医常规疗法(百令胶囊组)对比西医常规疗法(对照组)治疗糖尿病肾病的有效性和安全性。基于我国卫生体系角度,通过建立... 详细信息

目的评估百令胶囊联合西医常规疗法对比西医常规疗法治疗糖尿病肾病的经济性。方法利用Meta分析探讨百令胶囊联合西医常规疗法(百令胶囊组)对比西医常规疗法(对照组)治疗糖尿病肾病的有效性和安全性。基于我国卫生体系角度,通过建立决策树模型开展成本-效果分析,综合评价2种治疗方案的短期经济性。有效性指标为总有效率,研究时限为3个月。采用单因素敏感性分析、概率敏感性分析及情境分析评价结果的稳定性。结果 Meta分析共纳入34项研究,涉及患者3 114例,结果显示,当治疗时间为3个月时,百令胶囊组总有效率高于对照组[RR=1.32,95%CI(1.25,1.39),P <0.001],且两组安全性相当。从增量成本-效果比来看,相比于单用西医常规疗法,百令胶囊联合西医常规疗法每提升一个效果所增加成本为5233元;敏感性分析结果显示,百令胶囊每日剂量、百令胶囊组总有效率对结果的影响较大,当意愿支付阈值高于5 150元时,百令胶囊联合西医常规疗法更经济的概率高于50%。结论当治疗时间为3个月时,与单纯西医常规疗法相比,百令胶囊联合西医常规疗法对意愿支付阈值高于5 150元的糖尿病肾病患者来说更具经济学价值。

关键词：百令胶囊糖尿病肾病 Meta分析成本-效果分析药物经济学

Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development

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Cellular & Molecular Immunology 2021年第7期18卷 1692-1707页

作者： Mengyu Shi Ziyang Chen Meiqi Chen Jingping Liu Jing Li Zhe Xing Xiaogang Zhang Shuaijun Lv Xinyao Li Shaowen Zuo Shi Feng Ying Lin Gang Xiao Liping Wang yumei he Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Department of Laboratory Medicine the Third Affiliated Hospital of Southern Medical UniversitySouthern Medical UniversityGuangzhouChina Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhouChina The First Affiliated Hospital of Shenzhen University Reproductive Medicine CentreShenzhen Second People’s HospitalShenzhenChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Single Cell Technology and Application Southern Medical UniversityGuangzhouChina

The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful pregnancy.Although studies have shown that myeloid-derived suppressor cells(MDSCs)play an important role in maintaining feto-maternal tolerance,little is known about the role of MDSCs in pregnancies with intrauterine growth retardation(IUGR).here,we reported that the activation of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)during pregnancy was closely associated with fetal growth.In humans,class E scavenger receptor 1(SR-E1),a distinct marker for human PMN-MDSCs,was used to investigate PMN-MDSC function during pregnancy.Continuous activation of SR-E1+PMN-MDSCs was observed in all stages of pregnancy,accompanied by high cellular levels of ROS and arginase-1 activity,mediated through STAT6 signaling.However,SR-E1+PMN-MDSCs in pregnancies with IUGR showed significantly lower suppressive activity,lower arginase-1 activity and ROS levels,and decreased STAT6 phosphorylation level,which were accompanied by an increase in inflammatory factors,compared with those in normal pregnancies.Moreover,the population of SR-E1+PMN-MDSCs was negatively correlated with the adverse outcomes of newborns from pregnancies with IUGR.In mice,decreases in cell population,suppressive activity,target expression levels,and STAT6 phosphorylation levels were also observed in the pregnancies with IUGR compared with the normal pregnancies,which were rescued by the adoptive transfer of PMN-MDSCs from pregnant mice.Interestingly,the growth-promoting factors(GPFs)secreted by placental PMN-MDSCs in both humans and mice play a vital role in fetal development.These findings collectively support that PMN-MDSCs have another new role in pregnancy,which can improve adverse neonatal outcomes.

关键词： Polymorphonuclear myeloid-derived suppressor cells Class E scavenger receptor 1 Immunotolerance

相对湿度对浸渍纸层压实木复合地板坯料热处理净化降醛效果影响研究

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中国人造板 2024年第6期31卷 33-35页

作者：叶昌海何玉梅张建陈燕成都市美康三杉木业有限公司成都611130 成都市绿色快线环保科技有限公司成都611130

为探研在相同温度下,不同相对湿度对浸渍纸层压实木复合地板坯料热处理净化降醛效果的影响,设定恒定温度60℃,在不同相对湿度条件下,对浸渍纸层压实木复合地板坯料进行1 h热处理净化试验。研究结果显示,在温度60℃、相对湿度为25%时,降... 详细信息

为探研在相同温度下,不同相对湿度对浸渍纸层压实木复合地板坯料热处理净化降醛效果的影响,设定恒定温度60℃,在不同相对湿度条件下,对浸渍纸层压实木复合地板坯料进行1 h热处理净化试验。研究结果显示,在温度60℃、相对湿度为25%时,降醛率为20.0%,降醛效果最为显著。随着湿度增加,降醛率逐渐降低,当相对湿度为60%时,降醛率甚至呈现负向增长。说明在热处理净化时,适当合理的加湿有利于浸渍纸层压实木复合地板坯料中的甲醛释放。

关键词：甲醛释放干燥器法热处理净化相对湿度相对降醛率