Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development

作     者：Mengyu Shi Ziyang Chen Meiqi Chen Jingping Liu Jing Li Zhe Xing Xiaogang Zhang Shuaijun Lv Xinyao Li Shaowen Zuo Shi Feng Ying Lin Gang Xiao Liping Wang Yumei He 

作者机构：Department of ImmunologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Department of Laboratory Medicinethe Third Affiliated Hospital of Southern Medical UniversitySouthern Medical UniversityGuangzhouChina Department of Obstetrics and GynecologyNanfang HospitalSouthern Medical UniversityGuangzhouChina The First Affiliated Hospital of Shenzhen UniversityReproductive Medicine CentreShenzhen Second People’s HospitalShenzhenChina Microbiome Medicine CenterDepartment of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Single Cell Technology and ApplicationSouthern Medical UniversityGuangzhouChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第7期

页      面：1692-1707页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grants from the following institutions:the High-level Talent Start-up Funding of Southern Medical University the National Natural Science Foundation of China(grant numbers:31700061,81971420 and 81991511) the Guangdong Special Support Program for Youth Science and Technology Innovation Talents(grant number:2019TQ05Y585) the National Natural Science Foundation of Guangdong(grant number:2019A1515011435) the Science and Technology Program of Guangzhou(grant number:201904010073) 

主　　题：Polymorphonuclear myeloid-derived suppressor cells Class E scavenger receptor 1 Immunotolerance 

摘      要：The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful *** studies have shown that myeloid-derived suppressor cells(MDSCs)play an important role in maintaining feto-maternal tolerance,little is known about the role of MDSCs in pregnancies with intrauterine growth retardation(IUGR).Here,we reported that the activation of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)during pregnancy was closely associated with fetal *** humans,class E scavenger receptor 1(SR-E1),a distinct marker for human PMN-MDSCs,was used to investigate PMN-MDSC function during *** activation of SR-E1+PMN-MDSCs was observed in all stages of pregnancy,accompanied by high cellular levels of ROS and arginase-1 activity,mediated through STAT6 ***,SR-E1+PMN-MDSCs in pregnancies with IUGR showed significantly lower suppressive activity,lower arginase-1 activity and ROS levels,and decreased STAT6 phosphorylation level,which were accompanied by an increase in inflammatory factors,compared with those in normal ***,the population of SR-E1+PMN-MDSCs was negatively correlated with the adverse outcomes of newborns from pregnancies with *** mice,decreases in cell population,suppressive activity,target expression levels,and STAT6 phosphorylation levels were also observed in the pregnancies with IUGR compared with the normal pregnancies,which were rescued by the adoptive transfer of PMN-MDSCs from pregnant ***,the growth-promoting factors(GPFs)secreted by placental PMN-MDSCs in both humans and mice play a vital role in fetal *** findings collectively support that PMN-MDSCs have another new role in pregnancy,which can improve adverse neonatal outcomes.