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液体活检在肺癌管理中新技术的发展和临床应用的拓展

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Science Bulletin 2024年第10期69卷 1556-1568页

作者：陈克终何越王文香袁晓秋 david P.Carbone 杨帆 Department of Thoracic Surgery Peking University People’s HospitalBeijing 100044China Peking University People’s Hospital Thoracic Oncology Institute&Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer Beijing 100044China Peking University Health Science Center Beijing 100191China Thoracic Oncology Center Ohio State UniversityColumbus 43026USA

Lung cancer is an exceedingly malignant tumor reported as having the highest morbidity and mortality of any cancer worldwide,thus posing a great threat to global *** the growing demand for precision medicine,current methods for early clinical detection,treatment and prognosis monitoring in lung cancer are hampered by certain *** have found that during the formation and development of a tumor,molecular substances carrying tumor-related genetic information can be released into body *** biopsy(LB),a method for detecting these tumor-related markers in body fluids,maybe a way to make progress in these *** recent years,LB technology has undergone rapid ***,this review will provide information on technical updates to LB and its potential clinical applications,evaluate its effectiveness for specific applications,discuss the existing limitations of LB,and present a look forward to possible future clinical ***,this paper will introduce technical updates from the prospectives of engineering breakthroughs in the detection of membrane-based LB biomarkers and other improvements in sequencing ***,it will summarize the latest applications of liquid biopsy for the early detection,diagnosis,treatment,and prognosis of lung *** will present the interconnectedness of clinical and laboratory issues and the interplay of technology and application in LB today.

关键词： Liquid biopsy techniques Lung cancer Circulating tumor cells Circulating tumor DNA Sequencing technology Clinical application

AI for science: Predicting infectious diseases

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Journal of Safety Science and Resilience 2024年第2期5卷 130-146页

作者： Alexis Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu Jiaojiao Wang yue Xiang Da Xie Xi Lu Institute of Automation Chinese Academy of SciencesUniversity of Chinese Academy of SciencesBejing 100090China Systems Engineering Cornll UniversityIthacaNY 14853USA david Eccles School of Business the University of UtahUtahUSA Collge of Electrical Engineering Sichuan UniversityChina Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering Southeast UniversityNanjing 210096China

The global health landscape has been persistently challenged by the emergence and re-emergence of infectious *** epidemiological models,rooted in the early 2oth century,have provided foundational in-sights into disease ***,the intricate web of modern global interactions and the exponential growth of available data demand more advanced predictive *** is where AI for Science(AI4S)comes into play,offering a transformative approach by integrating artificial intelligence(Al)into infectious disease *** paper elucidates the pivotal role of AI4s in enhancing and,in some instances,superseding tradi-tional epidemiological *** harnessing AI's capabilities,AI4S facilitates real-time monitoring,sophisticated data integration,and predictive modeling with enhanced *** comparative analysis highlights the stark contrast between conventional models and the innovative strategies enabled by *** essence,Al4S represents a paradigm shift in infectious disease *** addresses the limitations of traditional models and paves the way for a more proactive and informed response to future *** we navigate the complexities of global health challenges,Al4S stands as a beacon,signifying the next phase of evolution in disease prediction,characterized by increased accuracy,adaptability,and efficiency.

关键词： AI for science(AI4S) Data integration Global healthchallenges Infectious disease prediction Predictive modeling Real-timemonitoring

Driving factors behind multiple populations

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 172-181页

作者： Ruoyun Huang Baitian Tang Chengyuan Li Doug Geisler Mario Mateo Ying-Yi Song Holger Baumgardt Julio A.Carballo-Bello yue Wang Jundan Nie Bruno Dias JoséG.Fernández-Trincado School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China Departamento de Astronomía Universidad de ConcepcionConcepcionChile Instituto de Investigación Multidisciplinario en Ciencia y Tecnología Universidad de La SerenaLa SerenaChile Departamento de Astronomía Facultad de CienciasUniversidad de La SerenaChile Department of Astronomy University of MichiganAnn Arbor 48109USA david A.Dunlap Department of Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada Dunlap Institute for Astronomy&Astrophysics University of TorontoToronto ON M5S 3H4Canada School of Mathematics and Physics The University of QueenslandSt.Lucia QLD 4072Australia Instituto de Alta Investigación Universidad de TarapacáAricaChile CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Instituto de Astrofísica Departamento de Ciencias FísicasFacultad de Ciencias ExactasUniversidad Andres BelloSantiagoChile Instituto de Astronomía Universidad Católica del NorteAntofagastaChile

Star clusters were historically considered simple stellar populations,with all stars sharing the same age and initial chemical ***,the presence of chemical anomalies in globular clusters(GCs),called multiple stellar populations(MPs),has challenged star formation theories in dense *** studies show that mass,metallicity,and age are likely controlling parameters for the manifestation of *** the limit between clusters with/without MPs in physical parameter space is crucial to reveal the driving mechanism behind their *** this study,we look for MP signals in Whiting 1,which is traditionally considered a young *** the Magellan telescope,we obtained low-resolution spectra withinλλ=3850-5500?for eight giants of Whiting *** measured the C and N abundances from the CN and CH spectral indices.C and N abundances have variations comparable with their measurement errors(~0.1 dex),suggesting that MPs are absent from Whiting *** these findings with literature studies,we propose a limit in the metallicity *** compactness index parameter space,which relatively clearly separates star clusters with/without MPs(GCs/open clusters).This limit is physically *** a larger scale,the galactic environment determines cluster compactness and metallicity,leading to metal-rich,diffuse,old clusters formed ex *** proposed limit also impacts our understanding of the formation of the Sagittarius dwarf galaxy:star clusters formed after the first starburst(age≤8-10 Gyr).These clusters are simple stellar populations because the enriched galactic environment is no longer suitable for MP formation.

关键词： stellar galactic galaxy

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai david BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei yueming Song yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang Li‑Yong Zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger david Kahl Jun Su Daniel Odell Xin‑yue Li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi Jiang Luo‑Huan Wang Zi‑Ming Li Lu‑Yang Song Liang‑Ting Sun Qi Wu Jia‑Qing Li Bao‑Qun Cui Li‑Hua Chen Rui‑Gang Ma Er‑Tao Li Gang Lian Yao‑De Sheng Zhi‑Hong Li Bing Guo Wei‑Ping Liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

达格列净在血糖控制不佳肥胖2型糖尿病患者临床治疗中的效果观察

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反射疗法与康复医学 2024年第16期5卷 75-77,92页

作者：岳晓燕张大卫荣成市人民医院内分泌风湿病科山东威海 264300 荣成市人民医院心内科山东威海 264300

目的探讨达格列净在血糖控制不佳肥胖 2 型糖尿病患者临床治疗中的效果.方法选择 2022 年10月—2023年10 月该院收治的 104例肥胖 2 型糖尿病患者为研究对象,按随机数字表法将其分为对照组与观察组,各52例.对照组采用二甲双胍缓释片治... 详细信息

目的探讨达格列净在血糖控制不佳肥胖 2 型糖尿病患者临床治疗中的效果.方法选择 2022 年10月—2023年10 月该院收治的 104例肥胖 2 型糖尿病患者为研究对象,按随机数字表法将其分为对照组与观察组,各52例.对照组采用二甲双胍缓释片治疗,观察组采用二甲双胍缓释片联合达格列净治疗.比较两组血糖指标、血脂指标、胰岛功能指标、身体质量指数、腹围指标及不良反应发生情况.结果治疗前,两组血糖指标、血脂指标、胰岛功能指标、身体质量指数及腹围指标比较,组间差异无统计学意义(P＞0.05):治疗后,观察组空腹血糖、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、胰岛素抵抗指数、身体质量指数及腰围指标水平均低于对照组,胰岛β细胞功能指数、空腹胰岛素、空腹C肽水平均高于对照组,组间差异有统计学意义(P＜0.05).两组不良反应发生率比较,差异无统计学意义(P＞0.05).结论达格列净治疗效果优于利格列汀,其降血糖、血脂及改善胰岛功能、减轻患者体重及缩小腹围的作用更佳,且安全性良好.

关键词： 2型糖尿病肥胖二甲双胍缓释片达格列净

The schizophrenia/bipolar disorder candidate gene GNB1L is regulated in human temporal cortex by a cis-acting element located within the 3'-region

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Neuroscience Bulletin 2015年第1期31卷 43-52页

作者： yue Sun Yu Tao Jian Wang david Saffen Institutes of Brain Science Fudan University School of Biological Sciences Fudan University Department of Cellular and Genetic Medicine School of Basic Medical SciencesFudan University Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Shanghai Ocean UniversityMinistry of Education Key Laboratory for Medical Neurobiology Fudan University

22q 11.2 deletion syndrome（DS） is a complex developmental disorder with a high incidence of psychiatric illnesses,including schizophrenia and mood *** studies have identified Guanine Nucleotide Binding Protein（G protein）Beta Polypeptide 1-Like（GNB1L）,located within the 1.5 Mbp 22q11.2 DS critical region,as a candidate liability gene for schizophrenia and bipolar *** this study,we used mRNA expression measurements in Han Chinese postmortem temporal cortex and linkage disequilibrium（LD） analysis to show that GNB1 L is regulated by a cis-acting genetic variant within the 3＇-region of the ***,this variant is located within an LD block that contains all of the common SNPs previously shown to associate with schizophrenia and bipolar disorder in Han Chinese and Caucasian *** to our expectations,re-analysis of previously published case-control study data in light of our mRNA expression results implies that the GNB1 L highexpression allele is the risk allele for schizophrenia and bipolar disorder in the Han Chinese population.

关键词： GNB1L schizophrenia linkage disequilibrium eQTLs cis-regulatory variants

Composite microcapsules with enhanced mechanical stability and reduced active ingredient leakage

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Particuology 2016年第3期14卷 40-46页

作者： yue Long Kai Song david York Zhibing Zhang Jon A. Preecea School of Chemistry University of Birmingham Edgbaston Birmingham B 15 2TT UK Laboratory of Bio-lnspired Smart Interface Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China Institute of Particle Science & Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9J UK School of Chemical Engineering University of Birmingham Edgbaston Birmingham B15 2TT UK

A calcium shellac （CS） matrix was used to encapsulate polymeric melamine formaldehyde microcapsules （A） or CaCO3 nanoparticles-stabilized microcapsules （B）, both of which encapsulated an oil-based active ingredient, producing A-CS or B-CS composite microcapsules. The mechanical properties and oil release profiles of the composite microcapsules were evaluated. The composite microcapsules showed enhanced mechanical stability and reduced leakage of the active ingredient hv one order of magnitude.

关键词： Composite Microcapsule Calcium shellac Mechanical property Control release Perfume oil

低分子量有机酸(苹果酸)对方解石-氟的吸附/沉淀反应影响

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地球科学与环境学报 2024年第4期46卷 499-512页

作者：李振炫冯添禧吴超越张大鹏王逸朱珠桂尉竣向育斌 david DECROOCQ 南京信息工程大学江苏省大气环境与装备技术协同创新中心/江苏省大气环境监测与污染控制高技术重点实验室江苏南京210044 南京信息工程大学气候与环境变化教育部国际合作联合实验室江苏南京210044 生态环境部南京环境科学研究所江苏南京210042 南京信息工程大学化学与材料学院江苏南京210044 里尔大学地球科学学院诺尔里尔59650

低分子量有机酸常对矿物的表面反应(吸附/沉淀)产生影响,从而影响矿物的溶解、矿化等过程,进而影响环境地球化学进程中元素的迁移稳定性。苹果酸作为一种广泛存在于自然界中的有机酸,是植物通过代谢过程分泌的副产品。通过批量平衡法开... 详细信息

低分子量有机酸常对矿物的表面反应(吸附/沉淀)产生影响,从而影响矿物的溶解、矿化等过程,进而影响环境地球化学进程中元素的迁移稳定性。苹果酸作为一种广泛存在于自然界中的有机酸,是植物通过代谢过程分泌的副产品。通过批量平衡法开展了苹果酸对方解石-氟的吸附/沉淀反应的影响研究,旨在深入理解有机酸在地球化学过程中的作用。结果表明:①初始pH值为7.7条件下,对于低浓度氟(≤5 mg·L^(-1)),随着苹果酸浓度的升高,其对氟去除的抑制作用呈增强趋势;对于中、高浓度氟(25或60 mg·L^(-1)),氟去除主导机制为CaF 2沉淀反应,苹果酸的抑制作用对其影响不大,但其表面吸附反应导致pH值升高和钙浓度下降。②初始pH值为8.3条件下,对于低浓度氟(≤20 mg·L^(-1)),苹果酸对氟去除仍有抑制作用;苹果酸与Ca 2+的络合反应促使pH值和钙浓度上升;对于中浓度氟(60 mg·L^(-1)),氟去除主导机制为CaF 2沉淀反应,20 mg·L^(-1)苹果酸已对其产生抑制作用,随着苹果酸浓度继续升高,pH值先降后升,钙浓度持续上升,彰显了苹果酸络合反应的效应;对于高浓度氟(100 mg·L^(-1)),100 mg·L^(-1)苹果酸能极大抑制CaF 2沉淀反应,对应的pH值未超过无苹果酸时,对应的钙浓度仍低于其空白背景值,暗示了CaF 2沉淀反应的主导性。③初始pH值为8.7条件下,对于低浓度氟(≤5 mg·L^(-1)),苹果酸对氟去除的抑制作用有所减弱,但其络合反应产生的效应十分显著,导致pH值和钙浓度上升;对于高浓度氟(240 mg·L^(-1)),氟去除主导机制为CaF 2沉淀反应,该反应随着苹果酸浓度的升高而受到抑制,对应的钙浓度不断上升彰显苹果酸络合反应的效应,而pH值的下降也表明了CaF 2沉淀反应的主导性。本研究深入探讨了氟元素在方解石矿物界面上的吸附、迁移和转化过程,为理解氟的迁移稳定性提供了新的视角和理论基础,同时对富含有机酸环境中方解石矿物的稳定性评估具有重要意义,也为氟在其他矿物上的迁移转化研究提供借鉴。

关键词：方解石氟苹果酸溶液化学吸附溶解络合沉淀