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中国科学院研究生院学报 2011年第4期28卷 424-430页

作者：高振龙胡晓予中国科学院研究生院数学科学学院北京100049

得到了二重随机序列{ξn,j;n,j≥1}随机和的重对数律, 其中{ξn,j;n,j≥1}是相互独立的且对任意的正整数n, {ξn,j;j≥1}有相同分布.

关键词：二重随机序列重对数律随机变量序列的随机和

Wide dynamic detection range of methane gas based on enhanced cavity absorption spectroscopy

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Chinese Physics B 2022年第4期31卷 244-248页

作者： yu Wang Bo-Kun Ding Kun-Yang Wang Jiao-Xu Mei Ze-Lin Han Tu Tan Xiao-Ming gao Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230026China University of Science and Technology of China Hefei 230026China Anhui Advanced Spectroscopy Optical-electric S&T Co. Ltd.

Integrated cavity output spectroscopy(ICOS) is an effective technique in trace gase *** strong absorption due to the long optical path of this method makes it challenging in the application scenes that have large gas concentration fluctuation,especially when the gas concentration is *** this paper,we demonstrate an extension of the dynamic range of ICOS by using a detuned laser combined with an off-axis integrating *** this,we improve the upper limit of the dynamic detection range from 0.1%(1000 ppm) to 20% of the gas *** method provides a way of using ICOS in the applications with unpredictable gas concentrations such as gas leak detection,ocean acidification,carbon sequestration,etc.

关键词： integrated cavity output spectroscopy(ICOS) trace gas wide dynamic detection absorption positions

When MAGE meets RING:insights into biological functions of MAGE proteins

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Protein & Cell 2011年第1期2卷 7-12页

作者： yue Feng Jinlan gao Maojun Yang MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Center for Structural Biology School of Life SciencesTsinghua UniversityBeijing 100084China National Laboratory of Medical Molecular Biology Peking Union Medical CollegeTsinghua UniversityBeijing 100084China

The melanoma antigen(MAGE)family proteins are well known as tumor-specific antigens and comprise more than 60 genes,which share a conserved MAGE homology domain(MHD).Type I MAGEs are highly expressed cancer antigens,and they play an important role in tumorigenesis and cancer cell ***,several MAGE proteins were identified to interact with RING domain proteins,including a sub-family of E3 ubiquitin *** binding mode between MAGEs and RING proteins was investigated and one important structure of these MAGE-RING complexes was solved:the MAGE-G1-NSE1 *** and biochemical studies indicated that MAGE proteins could adjust the E3 ubiquitin ligase activity of its cognate RING partner both in vitro and in ***,the underlying mechanism was not fully ***,we review these exciting advances in the studies on MAGE family,suggest potential mechanisms by which MAGEs activate the E3 activity of their binding RING proteins and highlight the anticancer potential of this family proteins.

关键词： MAGE cancer testis antigen RING ubiquitin ligase TRIM28

Brain Macrophages:Close or Distant Relatives?

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Neuroscience Bulletin 2021年第2期37卷 278-280页

作者： Kelei Cao Yaling Hu Zhihua gao Department of Neurobiology and Department of Neurology of Second Affiliated Hospital Institute of NeuroscienceNHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of MedicineHangzhou 310058China

The concept of a mononuclear phagocyte system in which tissue-resident macrophages arise from the circulating monocytes has been dogma in immunology for more than half a century[1].While monocytes do give rise to macrophages under certain conditions,recent studies clearly dem on strate that monocytes do not primarily contribute to most adult tissue-resident macrophage pools under the steady state[2].Instead,the majority of adult tissue-resident macrophages are derived from erythromyeloid progenitors(EMPs)in the yolk sac that seed tissue before birth[2].

关键词： primarily progenitor arise

Performance Analysis and Evaluation of Geometric Parameters in Stereo Deflectometry

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Engineering 2018年第6期4卷 806-815页

作者： Yongjia Xu Feng gao Xiangqian Jiang EPSRC Future Advanced Metrology Hub University of HuddersfieldHuddersfield HD1 3DHUK

This paper presents a novel geometric parameters analysis to improve the measurement accuracy of stereo *** deflectometry can be used to obtain form information for freeform specular surfaces.A measurement system based on stereo deflectometry typically consists of a fringe-displaying screen,a main camera,and a reference *** arrangement of the components of a stereo deflectometry system is important for achieving high-accuracy *** this paper,four geometric parameters of a stereo deflectometry system are analyzed and evaluated:the distance between the main camera and the measured object surface,the angle between the main camera ray and the surface normal,the distance between the fringe-displaying screen and the object,and the angle between the main camera and the reference *** influence of the geometric parameters on the measurement accuracy is *** are performed using simulated and experimental *** experimental results confirm the impact of these parameters on the measurement accuracy.A measurement system based on the proposed analysis has been set up to measure a stock concave *** a comparison of the given surface parameters of the concave mirror,a global measurement accuracy of 154.2 nm was achieved.

关键词： Optical metrology Error analysis Stereo deflectometry Three-dimensional shape measurement Performance evaluation Simulation

Revisiting the benchmark problem of starting control of combustion engines

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Control Theory and Technology 2019年第2期17卷 148-155页

作者： Jiangyan ZHANG Zhenhui XU Jinwu gao State Key Laboratory of Automotive Simulation and Control Changchun Jilin 130025China Department of Control Science and Engineering Jilin UniversityChangchun Jilin 130025China Col lege of Mechanical and Electronic Engineering Dalian Minzu UniversityDalian Liaoning 116600China Department of Engineering and Applied Sciences Sophia UniversityTokyo102-8554Japan

Starting of combustion engines is a typical transient operating mode that has sigrdficant influence to the engine *** to the distinct variations in the pathes of air intake and fuel injection,the model of the engine system contains considerable uncertain *** search effective control schemes that guarantee desired performance,engine starting control is proposed as a benchmark challenge *** a challenging result,a model-based control scheme is developed *** this work,the benchmark problem is revisited and a modification for the fuel injection path control of the previous work is proposed by integrating a time sequence regressive based parameter tuning *** by the benchmark problem simulator shows that although the new strategy has simple structure,similar control performance is ***,the new strategy has potential extensibility with learning based methods to further improve the performance of the benchmark problem on engine starting control.

关键词： Combustion engine starting control transient performance benchmark challenging

UKF在基于修正罗德里格参数的飞行器姿态确定中的应用

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宇航学报 2005年第2期26卷 164-167页

作者：张红梅邓正隆高玉凯哈尔滨工业大学控制科学与工程系哈尔滨150001

UKF是一种新的非线性滤波方法,在状态的时间更新阶段直接使用非线性模型,不引入线性化误差,而且不必计算Jacobi矩阵,相对于扩展卡尔曼滤波(EKF)不仅能提高滤波精度,而且更容易实现。修正的罗德里格参数(MRPs)是一种飞行器姿态参数,相对... 详细信息

UKF是一种新的非线性滤波方法,在状态的时间更新阶段直接使用非线性模型,不引入线性化误差,而且不必计算Jacobi矩阵,相对于扩展卡尔曼滤波(EKF)不仅能提高滤波精度,而且更容易实现。修正的罗德里格参数(MRPs)是一种飞行器姿态参数,相对于四元数姿态参数,用MRPs表示飞行器的姿态时,状态误差方差不会产生奇异性,并且能在一定程度上减小估计的计算量。本文针对MRPs表示的无陀螺飞行器姿态系统,利用UKF设计了姿态估计器,并通过仿真验证了算法的有效性。

关键词： UKF 姿态确定修正的罗德里格参数

Feasibility analysis of high excess pressure cockpit using material substitution based on strain energy

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Science China(Technological Sciences) 2014年第3期57卷 598-606页

作者： gao HaiPeng LIU Meng WANG Jun School of Aeronautic Science and Engineering Beihang University

The design concept of high excess pressure cockpit has been proposed as a solution to solve the ergonomics problems caused by cockpit *** address the contradiction among mass,economy,maneuverability and environment ergonomics,considering the composite advantages of high strength and lightweight,the feasibility analysis concept of high excess pressure cockpit based on material substitution is proposed in the *** on the strain energy analysis on finite element model,the iteration design method of equal stiffness and lightening effect analysis on material substitution are presented,The weight reduction effect after material substitution can be evaluated intuitively by using equal stiffness *** calculation result of cockpit indicates that the lightening effect can reach 35.09%.Because of the complexity of cockpit design,bi-level optimization method is proposed and performed by means of the First-Order Radio *** research shows that the method can achieve good *** feasibility of high excess pressure cockpit is studied from the aspect of the relationship between excess pressure and mass,and the research demonstrates that,due to the utilization of T300/4211 in place of 6061 alloy,the excess pressure of cockpit increases from 35 to 45 kPa,a 28.57%increase,while the cockpit mass is decreased by 12.56%.Thus,the contradiction among mass,economy and environment ergonomics can be coordinated,which can provide a reference for the design of high excess pressure cockpit.

关键词： high excess pressure cockpit material substitution strain energy environmental ergonomics cockpit mass

A potential strategy for treating atherosclerosis： improving endothelial function via AMP-activated protein kinase

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Science China(Life Sciences) 2018年第9期61卷 1024-1029页

作者： Feng gao Jiemei Chen Haibo Zhu State Key Laboratory for Bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100050 China

Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum(ER) stress, and *** has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase(AMPK) is an important metabolic switch that plays a crucial role in lipid metabolism and inflammation. However, recent evidence indicates that AMPK could be a target for atherosclerosis by improving endothelial function. For instance, activation of AMPK inhibits the production of reactive oxygen species induced by mitochondrial dysfunction, ER stress, and NADPH oxidase. Moreover, activation of AMPK inhibits the production of pro-inflammatory factors induced by dyslipidemia and hyperglycemia and restrains production of perivascular adipose tissue-released adipokines. AMPK activation prevents endothelial dysfunction by increasing the bioavailability of nitric oxide. Therefore, we focused on the primary risk factors involved in endothelial dysfunction, and summarize the features of AMPK in the protection of endothelial function, by providing signaling pathways thought to be important in the pathological progress of risk factors.

关键词： atherosclerosis AMP-activated protein kinase cardiovascular diseases inflammation autophagy

longitudinal Vibration Analysis of Marine Riser During Installation and Hangoff in Ultra Deepwater

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Computer Modeling in Engineering & Sciences 2016年第4期111卷 357-373页

作者： Yanbin Wang Deli gao Jun Fang MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China

This paper is concerned with the problem of longitudinal vibration of a 3,000 m long disconnected drilling riser during installation and hangoff *** natural frequency,amplitude of vibration displacement and vibration force of longitudinal vibration have been determined with consideration of the damping effect of the sea *** show the natural frequency of riser under these two situations are both decrease with the increase of water *** natural frequency of riser in installation operation is bigger than that in hangoff *** vibration displacement in hangoff configuration is bigger than that in installation while the vibration force in hangoff configuration is smaller than that in installation *** the condition of resonance,the vibration displacement increase along riser from top end to the bottom end while the vibration force increase along riser from riser bottom end to the top end.

关键词： Marine riser Installation Hangoff longitudinal vibration