When MAGE meets RING:insights into biological functions of MAGE proteins

作     者：Yue Feng Jinlan Gao Maojun Yang 

作者机构：MOE Key Laboratory of BioinformaticsTsinghua UniversityBeijing 100084China Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China National Laboratory of Medical Molecular BiologyPeking Union Medical CollegeTsinghua UniversityBeijing 100084China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2011年第2卷第1期

页      面：7-12页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by NSFC 31030020 to Maojun Yang 

主　　题：MAGE cancer testis antigen RING ubiquitin ligase TRIM28 

摘      要：The melanoma antigen(MAGE)family proteins are well known as tumor-specific antigens and comprise more than 60 genes,which share a conserved MAGE homology domain(MHD).Type I MAGEs are highly expressed cancer antigens,and they play an important role in tumorigenesis and cancer cell ***,several MAGE proteins were identified to interact with RING domain proteins,including a sub-family of E3 ubiquitin *** binding mode between MAGEs and RING proteins was investigated and one important structure of these MAGE-RING complexes was solved:the MAGE-G1-NSE1 *** and biochemical studies indicated that MAGE proteins could adjust the E3 ubiquitin ligase activity of its cognate RING partner both in vitro and in ***,the underlying mechanism was not fully ***,we review these exciting advances in the studies on MAGE family,suggest potential mechanisms by which MAGEs activate the E3 activity of their binding RING proteins and highlight the anticancer potential of this family proteins.