检索结果-南通市图书馆

Ethylene Oligomerization by (dppe)MCl_2 [M = Fe(II), Co(II),Ni(II)] Complexes/EAO

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第12期12卷 1115-1118页

作者： yu liang zhang Ming Xing QIAN Ren HE State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116012

The catalytic properties of a series of (dppe) MCl2 [M = Fe(II), Co(II), Ni(II)] in combination with EAO (ethylaluminoxane) for ethylene oligomerization have been investigated. Treatment of the bidentate phosphine metal complexes with EAO in toluene generated in situ active catalysts which catalyze oligomerizaton of ethylene to low-carbon olefins. The effects of reaction temperature, ratios of n(Al) : n(M) and reaction periods on catalytic activity and product distribution have been studied. The activity of cobalt complex with EAO at 200C was 4021 g/g(Co)h, and the selectivity of C4-10 olefins is 95.5%.

关键词： Ethylene oligomerization bidentate phosphine complexes EAO a-olefins.

Nonlocal effect on resonant radiation force exerted on semiconductor coupled quantum well nanostructures

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第6期28卷 349-356页

作者： Jin-Ke zhang Ting-Ting zhang yu-liang zhang Guang-Hui Wang Dong-Mei Deng Guangzhou Key Laboratory for Special Fiber Photonic Devices South China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices South China Normal UniversityGuangzhou 510006China

Based on the microscopic nonlocal optical response theory, the resonant radiation force exerted on a semiconductorcoupled quantum well nanostructure(CQWN), induced by the nonlocal interaction between lasers and electrons in conduction bands, is investigated for two different polarized states. The numerical results show that the spatial nonlocality of optical response can cause a radiation shift(blue-shift) for the spectrum of the resonant radiation force, which is dependent on the CQWN width ratio, the barrier height, and polarized states sensitively. It is also confirmed that the resonant radiation force is steerable by the incident and polarized directions of incident light. This work may provide an advantageous method for detecting internal quantum properties of nanostructures, and open novel and raising possibilities for optical manipulation of nano-objects using laser-induced radiation force.

关键词： nonlocal effect resonant radiation force coupled quantum well

Efficacy of Xuebijing injection for the treatment of coronavirus disease 2019 via network pharmacology

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2020年第4期5卷 201-215页

作者： yu-liang zhang Qian Cui Dou zhang Xin Ma Guo-Wei zhang College of Traditional Chinese Medicine Hebei UniversityBaoding 071000China

Background:To evaluate the mechanism of Chinese patent drug Xuebijing(XBJ)injection in the treatment of a new coronavirus disease 2019(COVID-19)based on network pharmacology and molecular docking ***:The TCMSP database was employed to collect and screen the active ingredients of the Chinese herb contained in the XBJ *** GeneCards database and STRING database were applied to collect and expand the targets of COVID-19 and compare and screen the related targets of COVID-19 by XBJ *** was employed to build a network connecting Chinese medicine,compounds,targets,disease,and topology analysis was performed via the Network Analyzer to screen the key ingredients and *** software of Schrödinger molecular docking was used to verify the binding activity of the key ingredients of XBJ injection and the key targets of *** platform and DAVID database were utilized to conduct Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes analysis on the key targets of COVID-19 treated by XBJ ***:Eight key compounds and 15 key targets were screened and verified by molecular docking;these key compounds included luteolin,quercetin,baicalein,and *** key targets included DPP4,AR,ESR1,CALM1,and protein kinase *** Ontology analysis involved an apoptosis and hypoxia reaction and the changes in blood vessel *** Encyclopedia of Genes and Genomes analysis involved signaling pathways of hypoxia inducible factor-1,VEGF,and PI3K/AKT/NF-κ***:The mechanism of XBJ injection when used to treat COVID-19 should be further investigated as the key compounds in XBJ regulated the expression of key targets such as protein kinase 1,VEGF-A,B-cell lymphoma-2,and TNF,which affected the COVID-19 receptors such as angiotensin-converting enzyme 2 and signaling pathways like hypoxia inducible factor-1,PI3K-Akt,and NF-κB,which alleviated the inflammation,respiratory distress,and hypoxia caused by CO

关键词： Network pharmacology Molecular docking COVID-19 Xuebijing injection Luteolin Quercetin

Expression and significance of MMP-9 and MDM2 in the oncogenesis of lung cancer in rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 585-588页

作者： De-Hui zhang liang-yu zhang Dong-Jie Liu Fang Yang Jin-Zao Zhao Department of Oncology Daqing Oilfield General Hospital

Objective:To observe the expression of matrix metalloproteinase-9(MMP-9)and mouse double minute 2 homolog(MDM2)in the oncogenesis of lung cancer in rats and to explore their clinical ***:A total of 140 rats were selected,of which 20 were selected randomly as the control group;and the remaining 120 as the observation *** observation group was injected with benzopyrene to establish diseases model such as tissue proliferation,abnormal proliferation and lung *** the MMP-9 levels of lung tissue by enzyme-linked assay,detected the MDM2 levels of lung tissue by immunochemistry ***:The MMP-9 and MDM2 expression of the lung cancer group and the abnormal proliferation group were significantly higher than that in the tissue proliferation group and the control group,the difference was significant(P0.05).The MDM2 and MMP-9 expression were increased in turn in the small cell carcinoma,squamous cell carcinoma and adenocarcinoma,the difference was statistically significant(P0.05),and there is no significant difference of the MMP-9and MDM2 expressions between stageⅠand stageⅡ(P>0.05).Conclusions:The expression of MMP-9 and MDM2 in lung tissue was associated with lung disease and lung cancer,both of them may be involved in the development and metastasis of lung *** detection can be used as therapy and prognostic indicators for lung cancer.

关键词： Lung cancer Adenocarcinoma MDM2 MMP-9

Monitoring the Hydrolysis of Olive Oil Catalyzed by Lipase via Acid Value Detection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2007年第2期23卷 196-199页

作者： GAO Gui ZHENG liang-yu zhang Zuo-ming HAN Si-ping CAO Sui-gui Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China

Hydrolysis of olive oil catalyzed by Candida lipolytica lipase was investigated. The relative concentration of the components in the product was determined by using high performance liquid chromatography（HPLC）. Furthermore, a novel rapid method to detect the hydrolytic process of olive oil was developed based on the relationship between the acid value and the relative concentration of the different components.

关键词： Lipase Hydrolysis Olive oil Glyeefide Acid value

Bioinformatic Analysis of BBTV Satellite DNA in Hainan

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2011年第4期26卷 279-284页

作者： Nai-tong yu Tuan-cheng Feng yu-liang zhang Jian-hua Wang Zhi-xin Liu Institute of Tropical Bioscience and Biotechnology CA TAS Haikou 571101 China

Banana bunchy top virus (BBTV),family Nanaviridae,genus Babuvirus,is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana *** is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific *** this study we isolated,cloned and sequenced a BBTV sample from Hainan Island,*** results from sequencing and bioinformatics analysis indicate this isolate represents a satellite DNA component with 12 DNA sequences *** also predicted the physical and chemical properties,structure,signal peptide,phosphorylation,secondary structure,tertiary structure and functional domains of its encoding protein,and compare them with the corresponding quantities in the replication initiation protein of BBTV DNA1.

关键词： Banana bunchy top virus Satellite Prediction

Human Papillomavirus Type 16 Mutant E7 Protein Induces Oncogenic Transformation via Up-regulation of Cyclin A and cdc25A

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2008年第5期23卷 352-362页

作者： Jin-hua LIU yu-liang zhang Li-qin ZHU Yin-yu XU Min ZHAO Xin-xing WU Department of Clinical Laboratory General Hospital of Wuhan Iron ＆ Steel Company Wuhan 430080 China Institute of Medical Virology Wuhan University school of Medicina/state key Laboratory of Virology Wuhan 430071 China

A new mutant human papillomavirus type 16 E7 gene, termed HPV16 HBE7, was isolated from cervical carcinoma biopsy samples from patients in an area with high incidence of cervical cancer (Hubei province, China). A previous study showed that the HPV16 HBE7 protein was primarily cytoplasmic while wild-type HPV16 E7 protein, termed HPV16 WE7, was concentrated in the nucleus. With the aim of studying the biological functions of HPV16 HBE7, the transforming potential of HPV16 HBE7 in NIH/3T3 cells was detected through observation of cell morphology, cell proliferation assay and anchorage-independent growth assay. The effect of HPV16 HBE7 on cell cycle was examined by flow cytometry. Dual-luciferase reporter assay and RT-PCR were used to investigate the influence of HPV16 HBE7 protein on the expression of regulation factors associated with G1/S checkpoint. The results showed that HPV16 HBE7 protein, as well as HPV16 WE7 protein, held transformation activity. NIH/3T3 cells expressing HPV16 HBE7 could easily transition from G1 phase into S phase and expressed high level of cyclin A and cdc25A. These results indicated HPV16 mutant E7 protein, located in the cytoplasm, induces oncogenic transformation of NIH/3T3 cells via up-regulation of cyclin A and cdc25A.

关键词： HPV16 Mutant E7 Transformation Cell cycle

Risk of cardiovascular death in patients with hepatocellular carcinoma based on the Fine-Gray model

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 844-856页

作者： yu-liang zhang Zi-Rong Liu Zhi Liu Yi Bai Hao Chi Da-Peng Chen Ya-Min zhang Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of cancers worldwide,ranking fifth among men and seventh among women,resulting in more than 7 million deaths *** the development of medical tech-nology,the 5-year survival rate of HCC patients can be increased to 70%.How-ever,HCC patients are often at increased risk of cardiovascular disease(CVD)death due to exposure to potentially cardiotoxic treatments compared with non-HCC ***,CVD and cancer have become major disease burdens ***,further research is needed to lessen the risk of CVD death in HCC patient *** This study was conducted on the basis of the Surveillance,Epidemiology,and End Results database and included HCC patients with a diagnosis period from 2010 to *** independent risk factors were identified using the Fine-Gray model.A nomograph was constructed to predict the CVM in HCC *** nomograph performance was measured using Harrell’s concordance index(C-index),calibration curve,receiver operating characteristic(ROC)curve,and area under the ROC curve(AUC)***,the net benefit was estimated via decision curve analysis(DCA).RESULTS The study included 21545 HCC patients,of whom 619 died of ***(5 cm:2.090(1.543-2.830),P<0.001],surgery(no)[0.376(0.297-0.476),P<0.001],and chemotherapy(none/unknown)[0.578(0.472-0.709),P<0.001]were independent risk factors for CVD death in HCC *** discrimination and calibration of the nomograph were *** C-index values for the training and validation sets were 0.736 and 0.665,*** AUC values of the ROC curves at 2,4,and 6 years were 0.702,0.725,0.740 in the training set and 0.697,0.710,0.744 in the validation set,*** calibration curves showed that the

关键词： Hepatocellular carcinoma Cardiovascular disease deaths Fine-Gray model Risk factor Nomograph Predict

Design,synthesis and biological evaluation of novel glucokinase activators

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第1期22卷 73-76页

作者： Yong Qiang Li yu liang zhang Sheng Quan Hu yu Ling Wang Hong Rui Song Zhi Qiang Feng Lei Lei Quan Liu Zhu Fang Shen Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

关键词： Diabetes Glueokinase activators Benzamide derivatives