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World Journal of Gastroenterology 2008年第4期14卷 518-523页

作者： Xiao-Ming Wang Zhen-yu Yin Ren-xiang yu you-yuan Peng Ping-Guo Liu Guo-Yang Wu Department of Hepatobillary Surgery of Zhongshan Hospital Digestive DiseaseInstitute of Xiamen University Xiamen 361004 Fujian ProvinceChina

AIM: To evaluate the preventive effects of phosph-orus-32 glass microspheres (P32-GMS) in the recurrence of massive hepatocellular carcinomas (HCCs) after tumor resection. METHODS: Twenty-nine patients with massive HCCs received local P32-GMS implantation after liver tumors were removed,while the other 38 patients with massive HCCs were not treated with P32-GMS after hepatectomies. The radioactivity of the blood,urine and liver were examined. The complications,HCC recurrence and overall survival rates in the patients were analyzed. RESULTS: P32-GMS implanted in the liver did not cause systemic absorption of P32. There were no significant differences of postoperative complications between the patients with and without P32-GMS treatment. The short-term (six months and 1 year) and long-term (2,3 and over 3 years) recurrence rates in patients who received P32-GMS radiotherapy were signifi cantly decreased,and the overall survival rates in this group were signifi cantly improved. CONCLUSION: P32-GMS implantation in the liver can significantly decrease the postoperative recurrence and improve the overall survival in HCCs patients after hepatectomy. This therapy may provide an innovative method in prevention of HCC recurrence after operation.

关键词： Hepatocellular carcinoma Recurrence Phosphorus-32 glass microspheres Hepatectomy

Current status of China’s critical care medicine big data platform and future prospects

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Chinese Medical Journal 2021年第14期134卷 1684-1686页

作者： Long-xiang Su Sheng-Jun Liu xiang Zhou Mei-Li Duan Jian Liu Bin Ouyang Bing-yu Qin Hong-Liang Wang Xue Wang Lei Xu xiang-you yu Fei-Hu Zhou yun Long Department of Critical care medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Department of Postdoctoral Residency Program Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Department of Critical Care Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Critical Care Medicine The First Hospital of Lanzhou UniversityLanzhouGansu 730000China Department of Critical Care Medicine The First Affiliated Hospital of Sun-YatSen HospitalGuangzhouGuangdong 510080China The Department of Critical Care Medicine Henan Provincial People’s HospitalZhengzhouHenan 450003China Department of Critical Care Medicine The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Critical Care Medicine First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Critical Care Medicine Tianjin Third Central HospitalTianjin 300170China Department of Critical Care Medicine The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830054China Department of Critical Care Medicine First Medical CenterChinese PLA General HospitalBeijing 100853China

Overview The term“Big Data”originated at the 11th Electronic Materials Conference World Annual Conference,which originally referred to the large amount of data generated by the application of technology.[1]Medical big data includes not only the medical history and examination data accumulated during patient hospitalization,but also patient-related follow-up data,prognostic data from outpatient,emergency,and medical insurance settlement departments as well as clinical experiment *** far,it has profound applications in the various specialties of medicine.[2-4]However,intensive care medicine(ICU)is different from other medical *** comparison with clinical practice data,medical data in ICU have the following characteristics:large scale,rapid production,diverse dimensions,inaccuracies,heterogeneity,incompleteness,complexity,and privacy concerns.[5]In fact,in the process of constructing major ICU databases in China and worldwide,these databases have been optimized at great *** heterogeneity as an example。

关键词： originated dimensions constructing

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关注神经重症患者迟发性脑缺血的治疗

中国实用内科杂志 2019年第12期39卷 1040-1044,1047页

作者：李祥王毅于湘友新疆医科大学第一附属医院重症医学中心

迟发性脑缺血(delayed cerebral ischemia,DCI)是一种严重威胁重症患者生命安全的疾病,也是导致蛛网膜下腔出血后患者致残、致死的主要原因。但因患者神经功能损害严重、临床表现不明显、诊断困难等原因,不被临床医生重视。从强调宏观(... 详细信息

迟发性脑缺血(delayed cerebral ischemia,DCI)是一种严重威胁重症患者生命安全的疾病,也是导致蛛网膜下腔出血后患者致残、致死的主要原因。但因患者神经功能损害严重、临床表现不明显、诊断困难等原因,不被临床医生重视。从强调宏观(血管痉挛)到注重微观(微循环障碍、自主调节功能受损等)的病理生理过程转变是理解DCI的基础;早期诊断及有效的治疗则是防治DCI的关键。文章通过复习文献,对DCI的定义、监测技术、治疗手段等做一阐述,探讨DCI的综合防治策略。

关键词：迟发性脑缺血蛛网膜下腔出血监测技术重症治疗

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基于免疫遗传算法的多机器人环境探索

沈阳工业大学学报 2018年第3期40卷 299-303页

作者：段勇王宇喻祥尤沈阳工业大学信息科学与工程学院沈阳110870

针对多机器人环境探索中的任务分配和路径规划问题,将环境中所有待探索的任务点根据短距离优先策略分配至个体机器人,利用改进的免疫遗传算法对机器人分配到的任务点进行优化探索,提出了带有初始任务点优化的路径规划方法,使机器人能够... 详细信息

针对多机器人环境探索中的任务分配和路径规划问题,将环境中所有待探索的任务点根据短距离优先策略分配至个体机器人,利用改进的免疫遗传算法对机器人分配到的任务点进行优化探索,提出了带有初始任务点优化的路径规划方法,使机器人能够不重复并且高效地遍历工作环境中的所有探索点.通过建立多机器人仿真实验系统,随机产生环境中的任务点和机器人等数据信息,并在此条件下对本文方法进行实验验证.结果表明,本文方法能够有效地实现多机器人环境探索问题.

关键词：多机器人免疫遗传算法环境探索任务分配路径规划抗体浓度适应度最邻近算法

不同剂量乌司他丁对体外循环患者炎症反应及呼吸功能的影响

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中国危重病急救医学 2009年第11期21卷 664-667页

作者：于湘友范丽丽新疆医科大学第一附属医院重症医学科乌鲁木齐830054

目的研究不同剂量乌司他丁在体外循环（CPB）心脏直视手术中对肺损伤的保护作用机制。方法采用前瞻性随机对照研究方法，选择42例心脏瓣膜置换术患者，随机分为对照组、乌司他丁8kU／kg组（U1组）及乌司他丁12kU／kg组（U2组），3组分... 详细信息

目的研究不同剂量乌司他丁在体外循环（CPB）心脏直视手术中对肺损伤的保护作用机制。方法采用前瞻性随机对照研究方法，选择42例心脏瓣膜置换术患者，随机分为对照组、乌司他丁8kU／kg组（U1组）及乌司他丁12kU／kg组（U2组），3组分别于麻醉诱导后术前（T1）及停止CPB1h（T2）、4h（T3）、24h（T4）取静脉血，检测血浆肿瘤坏死因子-α（TNF—α）、白细胞介素-6（IL-6）、IL-10的浓度；同时测定动脉血气，对比观察氧合指数（PaO2／FiO2）及呼吸指数（RI）。结果①3组患者T1时血浆TNF-α、IL-6和IL-10比较差异均无统计学意义（P均〉0．05），T2～4时则均显著升高（P〈0．05或P〈0．01）。与对照组比较，U1、U2组T2～4时血浆TNF—α、IL-6浓度降低，IL-10浓度升高，且U2组变化较U1组明显（P〈0．05或P〈0．01）。③3组患者T1时PaO2／FiO2、RI比较差异均无统计学意义（P均〉0．05），T2～4时则出现PaO2／FiO2减少、RI值增大（P〈0．05或P〈0．01）。与对照组比较，U1、U2组T2～4时PaO2／FiO2增大、RI值减小，且U2组变化较U1组更为显著（P〈0．05或P〈0．01）。结论在CPB过程中，乌司他丁能明显抑制促炎因子TNF-α、IL-6的产生，上调抗炎因子IL-10的释放，减轻肺损伤，改善CPB术后肺功能，并呈剂量-效应关系。

关键词：乌司他丁体外循环肺损伤促炎因子抗炎因子肺功能心脏瓣膜置换术

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重症患者两种撤机方式的比较

临床麻醉学杂志 2011年第4期27卷 360-361页

作者：于湘友钟琳新疆医科大学第一附属医院重症医学科乌鲁木齐830054 武警8660部队医院

目的比较SmartCare/PS(SC)和压力支持通气(PSV)模式在重症患者中的撤机效果。方法将41例行机械通气的重症患者,在满足临床撤机条件后,随机分为SC组(n=21)和PSV组(n=20),分别采用SC和PSV模式撤机。记录撤机时间、总通气时间(TVT)、人工... 详细信息

目的比较SmartCare/PS(SC)和压力支持通气(PSV)模式在重症患者中的撤机效果。方法将41例行机械通气的重症患者,在满足临床撤机条件后,随机分为SC组(n=21)和PSV组(n=20),分别采用SC和PSV模式撤机。记录撤机时间、总通气时间(TVT)、人工操作次数,以及再插管率、气管切开率、气胸发生率和呼吸机相关肺炎(VAP)发生率。结果 SC组撤机时间、TVT较PSV组明显缩短(P<0.05);SC组人工操作次数较PSV组明显减少(P<0.05);两组再插管率、气管切开率、气胸发生率和VAP发生率差异无统计学意义。结论 SC模式可缩短重症患者的撤机时间、TVT和减轻医务人员工作量。

关键词：智能化撤机撤机时间总通气时间呼吸机相关肺炎

Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units： a prospective cohort study

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Chinese Medical Journal 2013年第23期126卷 4409-4416页

作者： WEN Ying JIANG Li XU yuan QIAN Chuan-yun LI Shu-sheng QIN Tie-he CHEN Er-zhen LIN Jian-dong AI yu- hang WU Da-wei WANG yu-shan SUN Ren-hua HU Zhen-jie CAO xiang-yuan ZHOU Fa-chun HE Zhen-yang ZHOU Li-hua AN you-zhong KANG Yan MA Xiao-chun yu xiang-you ZHAO Ming-yan XI Xiu-ming DU Bin Department of Critical Care Medicine Fuxing Hospital Capital Medical University Beijing 100038 China Department of Critical Care Medicine Beijing Tongren HospitalCapital Medical University Beijing 100730 China Department of Emergency Medicine First Affiliated Hospital of Kunming Medical College Kunming Yunnan 650032 China Department of Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science & TechnologyWuhan Hubei 430030 China Department of Critical Care Medicine Guangdong General HospitalGuangzhou Guangdong 510080 China Department of Emergency Medicine Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China Department of Critical Care Medicine First Affiliated Hospital ofFuiian Medical University Fuzhou Fujian 350005 China Department of Critical Care Medicine Xiangya Hospital CentralSouth University Changsha Hunan 410008 China Department of Critical Care Medicine Qilu Hospital Shandong University Jinan Shandong 250012 China Department of Emergency and Critical Care Medicine The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Critical Care Medicine Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China Department of Critical Care Medicine Hebei Medical University Fourth Hospital Shijiazhuang Hebei 050011 China Department of Critical Care Medicine Affiliated Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Critical Care Medicine First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Department of Critical Care Medicine Hainan Provincial People's Hospital Haikou Hainan 570311 China Department of Critical Care Medicine Affiliated Hospital of Inner Mongolia Medical College Huhhot Inner Mongolia 010050 China Department of Critical Care Medicine Peking University People's Hospital Beijing 100044 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 61004

Background Acute kidney injury （AKI） has been recognized as a major healthcare problem affecting millions of patients ***,epidemiologic data concerning AKI in China are still *** objectives of this study were to characterize AKI defined by RIFLE criteria,assess the association with hospital mortality,and evaluate the impact of AKI in the context of other risk *** This prospective multicenter observational study enrolled 3,063 consecutive patients from 1 July 2009 to 31 August 2009 in 22 ICUs across China's *** excluded patients who were admitted for less than 24 hours （n=1623）,younger than 18 years （n=127）,receiving chronic hemodialysis （n=29）,receiving renal transplantation （n=1） and unknown reasons （n=28）.There were 1255 patients in the final *** was diagnosed and classified according to RIFLE *** There were 396 patients （31.6％） who had AKI,with RIFLE maximum class R,I,and F in 126 （10.0％）,91 （7.3％）,and 179 （14.3％） patients,*** function deteriorated in 206 patients （16.4％）.In comparison with non AKI patients,patients in the risk class on ICU admission were more likely to progress to the injury class （odds ratio （OR） 3.564,95％ confidence interval （CI） 1.706-7.443,P =0.001],while patients in the risk class （OR 5.215,95％ CI 2.798-9.719,P ＜0.001） and injury class （OR 13.316,95％ CI 7.507-23.622,P ＜0.001） had a significantly higher probability of deteriorating into failure *** adjusted hazard ratios for 90-day mortality were 1.884 for the risk group,3.401 for the injury group,and 5.306 for the failure *** The prevalence of AKI was high among critically ill patients in Chinese *** comparison with non-AKI patients,patients with RIFLE class R or class I on ICU admission were more susceptibility to progression to class I or class *** RIFLE criteria were robust and correlated well with clinical deterioration and mortality.

关键词： acute kidney injury intensive care units mortality prevalence risk factors

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao xiang Feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Value of Kidney Disease Improving Global Outcomes Urine Output Criteria in Critically III Patients： A Secondary Analysis of a Multicenter Prospective Cohort Study

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Chinese Medical Journal 2016年第17期129卷 2050-2057页

作者： Jun-Ping Qin xiang-you yu Chuan-yun Qian Shu-Sheng Li Tie-He Qin Er-Zhen Chen Jian-Dong Lin yu-Hang Ai Da-Wei Wu De-Xin Liu Ren-Hua Sun Zhen-Jie Hu xiang-yuan Cao Fa-Chun Zhou Zhen-Yang He Li-Hua Zhou you-Zhong An Yan Kang Xiao-Chun Ma Ming-Yan Zhao Li Jiang yuan Xu Bin Du Medical Intensive Care Unit Peking Union Medical College Hospital Beijing 100730 China Department of Critical Care Medicine Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Critical Care Medicine First Affiliated Hospital Xinjiang Medical University Urumqi Xinjiang 830054 China Department of Emergency Medicine and Medical Intensive Care Unit The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department o1 Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Critical Care Medicine Guangdong General Hospital Guangzhou Guangdong 510080 China Department of Emergency Medicine Ruijin Hospital Shanghai Jiao Tong University Shanghai 200025 China Department of Critical Care Medicine The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian 350005 China Department of Critical Care Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Critical Care Medicine Qilu Hospital Shandong University Jinan Shandong 250012 China Department of Emergency and Critical Care Medicine The Second Hospital of Jilin University Changchun Jilin 130041 China Department of Critical Care Medicine Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 China Department of Critical Care Medicine Hebei Medical University Fourth Hospital Shijiazhuang Hebei 050011 China Department of Critical Care Medicine Affiliated Hospital of Ningxia Medical University Yinchuan Ningxia 750004 China Department of Emergency and Intensive Care Medicine The First Affiliated Hospital Chongqing Medical University Chongqing 400016 China Department of Critical Care Medicine Hainan Provincial People's Hospital Haikou Hainan 570311 China Department of Critical Care Medicine The Affiliated Hospital of Inner Mongolia Medical College Hohhot Inner Mongolia 010050 China Department of C

Background： Urine output （UO） is an essential criterion of the Kidney Disease Improving Global Outcomes （KD1GO） definition and classification system tbr acute kidney injury （AKI）, of which the diagnostic value has not been extensively studied. We aimed to determine whether AKI based on KDIGO UO criteria （KDtGOLro） could improve the diagnostic and prognostic accuracy, compared with KDIGO serum creatinine criteria （KDIGOscr）.Methods： We conducted a secondary analysis of the database of a previous study conducted by China Critical Care Clinical Trial Group （CCCCTG）, which was a 2-month prospective cohort study （July 1,2009 to August 31,2009） involving 3063 patients in 22 tertiary Intensive Care Units in Mainland of China. AKI was diagnosed and classified separately based on KDIGOt,o and KDlGOsc,. Hospital mortality of patients with more severe AKI classification based on KDIGOvo was compared with other patients by univariate and multivariate regression analyses. Results： The prevalence of AKl increased from 52.4% based on KDIGOscr to 55.4% based on KD1GOsc~ combined with KDIGOuo. KDIGOv~~ also restllted in an upgrade of AKI classification in 7.3% of patients, representing those with more severe AK1 classification based on KDIGOvo. Compared with non-AKI patients or those with maximum AKI classification by KDIGOscr, those with maximum AKI classification by KDIGOuo had a significantly higher hospital mortality of 58.4% （odds ratio [OR]： 7.580, 95% confidence interval [CI]： 4.141-13.873, P 〈 0.001）. In a multivariate logistic regression analysis, AKI based on KDIGOuo （OR： 2.891, 95% CI： 1.964-4.254, P 〈 0.001）, but not based on KDIGOscr （OR： 1.322, 95% CI： 0.902-1.939, P = 0.152）, was an independent risk factor for hospital mortality. Conclusion： UO was a criterion with additional value beyond creatinine criterion for AKI diagnosis and classification, which can help identify a group of patients with high risk of death.

关键词： Acute Kidney Injury Critically Ill Mortality Serum Creatinine Urine Output

两种肺复张方法治疗急性呼吸窘迫综合征的效果比较

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中华急诊医学杂志 2010年第7期19卷 749-752页

作者：于湘友陈淑萍于朝霞新疆医科大学第一附属医院ICU 乌鲁木齐830054

目的探讨和比较控制性肺膨胀（sustained inflation,SI）和压力控制通气（pressure controlled ventilation,PCV）用于急性呼吸窘迫综合征（ARDS）患者肺复张的效果,及其对血流动力学和呼吸力学方面的影响.方法对10例ARDS患者采取随... 详细信息

目的探讨和比较控制性肺膨胀（sustained inflation,SI）和压力控制通气（pressure controlled ventilation,PCV）用于急性呼吸窘迫综合征（ARDS）患者肺复张的效果,及其对血流动力学和呼吸力学方面的影响.方法对10例ARDS患者采取随机对照实验,在镇静、非肌松状态下,先后采用SI[40cmH2O（1 cmH2O=0.0981 kPa）,40 s]和PCV（20 cmH2O,2 min）进行肺复张,中间间隔洗脱期.收集两种方法复张前（T0）、复张后5 min（T2）、1 h（T3）的血气分析、血流动力学指标、呼吸力学指标和复张中（T1）的呼吸力学与血流动力学指标.收集数据行单因素重复测量方差分析.结果（1）两种方法T2和T3时点PaO2较T0均明显改善（P〈0.05）,方法间差异无统计学意义（P〉0.05）.PaCO2在各时点差异均无统计学意义（P〉0.05）.（2）两种方法T1时点CI均下降（P〈0.05）,方法间无差异（P〉0.05）.HR、MAP在各时点差异均无统计学意义（P〉0.05）.（3）两种方法T2和T3时点FRC较T0均增加（P〈0.05）,T1时点CS均有所改善（P〈0.05）,方法之间差异无统计学意义（P〉0.05）,Pplat在各时点差异均无统计学意义（P〉0.05）.结论 SI和PCV肺复张对ARDS患者PaO2、FRC、肺复张中Cs均有明显改善,肺复张对CI均有影响,两种方法效果相同.

关键词：急性肺损伤急性呼吸窘迫综合征肺复张血流动力学呼吸力学