检索结果-南通市图书馆

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SYNTHESIS OF 3-BUTYliDENE-5-HYDROXYPHTHAliDE

引用

Chinese Chemical Letters 1993年第4期4卷 295-296页

作者： Shao Bai li Zhi Wei WANG Xiao Ping FANG yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University,Lanzhou 730000

3-Butylidene-5-hydroxyphthalide(1)was prepared from 4-hydroxy- benzoic acid(2).

关键词： ppm HNMR cm IR SYNTHESIS OF 3-BUTYliDENE-5-HYDROXYPHTHAliDE TMEDA HRMS OCH

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Investigation on Precipitation Hardening High Strength IF Steel Sheet for Automotive Application

引用

Journal of Iron and Steel Research International 2011年第S1期18卷 742-746页

作者： WANG Xu,liU Ren-dong,WANG Ke-qiang,GUO Jin-yu,lin li,XU Rong-jie (Automobile and Home Appliance Steel Institute of Ansteel Company limited Technology Centre,Anshan 114009,liaoning,China) Ansteel Co Ltd Technol Ctr Automobile & Home Appliance Steel Inst Anshan 114009 Liaoning Peoples R China

High strength IF steel sheets with sufficient formability had been extensively used in automotive *** this paper,a new type of high strength cold-rolled IF steel with higher carbon and niobium contents was *** plastic and continuous annealing were performed on thermo-mechanical *** transformation points were tested by thermal expansion *** microscopy and transmission election microscope (TEM) were used to analyze the microstructure and the secondary precipitates of the *** results showed,the ductibility temperature range was from 950℃ to 1250℃ and the transformation points were 887℃ and 913℃ *** grain size of this steel was smaller than that of conventional high strength IF *** the mean time,there were many fine Nb(C,N) precipitates distributed in the intra-granular regions and the PFZ (precipitate free zone) were formed in the neighborhood of grain *** to the unique micro-structural feature,the yield strength and the yield ratio of the steel were decreased while the tensile strength was *** the increasing of the annealing temperature,the strength decreased,the total elongation A50,r-value at 15% strain and n-value were all *** order to obtain the favorable mechanical properties,the skin-pass rolling rate should be chosen at 0.6-0.8%.

关键词： high strength IF steel precipitation hardening grain refinement precipitate free zone (PFZ)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ASYMMETRIC　MICHAEL－TYPE　ALKYLATION　OF　CHIRAL　IMINES　DIASTEREOSELECTIVE　SYNTHESIS　OF（＋）－α－CYPERONE　AND　（－）－10－EPI－α－CYPERONE

引用

Chinese Chemical Letters 1996年第8期7卷 695-696页

作者： Zhao Ming XIONG Jiong YANG yu lin li Ren An liAO Zheng Ming li(State Key Laboratory of Applied Organic Chemistry and Instute of Organic Chemistry, Lanzhou University,Lanzhou 730000, State Key Laboratory of Elemento-Organic Chendsny, Nankai University, State Key Lab. of Appl. Organ. Chem. Instute of Organic Chemistry Lanzhou University Lanzhou 730000 State Key Lab. Elemento-Organ. Chem. Nankai University Tianjin 300071

A novel diastereoselective route to (+)-a-cyperone(1) and (-)-10-epi-a-Cyperone(2) hasbeen developed. The key step involves an asymmetric Michael addition of the correSPonding chiralimine, derived from R-(+)-dihydroca... 详细信息

关键词： EPI ALKYLATION AND

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SYNTHESIS OF 5α-(17R,20R)-14,15-SECOCHOLESTANE

引用

Chinese Chemical Letters 1990年第3期1卷 215-218页

作者： Tong Shuang li yu lin li Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 Xiao Tian liANG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050

The synthesis of 5α-(17R,20R)-14,15-secocholestane from cholesterol was reported.

关键词： ppm SECOCHOLESTANE SYNTHESIS OF 5

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论中国古代山水诗审美意境的空间感

引用

山东大学学报（哲学社会科学版） 2005年第2期 151-154页

作者：于林立山东大学文学与新闻传播学院山东济南250100

中国古代山水诗意境的研究对于理解我国古代诗歌意境的形成有非常重要的作用。山水诗是由意象的不同空间组合而产生意境的,所以意境在山水诗中表现为空间感。空间感是通过诗歌意象间的节奏、数量的组合以及动词的运用实现的。同时空间... 详细信息

中国古代山水诗意境的研究对于理解我国古代诗歌意境的形成有非常重要的作用。山水诗是由意象的不同空间组合而产生意境的,所以意境在山水诗中表现为空间感。空间感是通过诗歌意象间的节奏、数量的组合以及动词的运用实现的。同时空间感根据不同的形成方式分为突破型和层次型。空间感产生于中国特有的宇宙意识和生命意识的结合。

关键词：中国古代山水诗意境意象空间感

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

冷轧钢板表面锆化膜的制备及电化学性能分析

引用

表面技术 2018年第5期47卷 208-214页

作者：郝玉林生海黎敏首钢集团有限公司技术研究院用户技术研究所北京100043

目的研究冷轧钢板表面状态对在其表面制备锆化膜性能的影响。方法以A、B、C三种不同品种的冷轧钢板为基材,在其表面制备锆化转化膜。使用扫描电子显微镜及电化学分析方法研究基材的表面状态。使用X射线荧光光谱测厚仪、辉光放电光谱仪... 详细信息

目的研究冷轧钢板表面状态对在其表面制备锆化膜性能的影响。方法以A、B、C三种不同品种的冷轧钢板为基材,在其表面制备锆化转化膜。使用扫描电子显微镜及电化学分析方法研究基材的表面状态。使用X射线荧光光谱测厚仪、辉光放电光谱仪及扫描电子显微电镜分析锆化转化膜的膜重、Zr元素随深度的分布状态及表面形貌,并分析锆化膜的电化学性能,结果 A、B、C三种基材的开路电位依次是-0.66、-0.61、-0.55 V,电荷传输电阻依次是647.9、798.8、1161?·cm^2,说明3种基材的表面活性依次减弱,表面导电能力减弱。A、B、C三种钢材表面制备的锆化膜膜重依次是87.28、65.39、31.48 mg/m^2,电荷传输电阻依次是863.7、920.8、2724?·cm^2。结论钢板表面活性会显著影响表面锆化膜的性能。钢板表面活性越大,其在锆化液中的活性也越大,锆化反应越剧烈,其表面沉积的锆化膜膜重越大,耐蚀性越弱。钢板表面沉积锆化膜后,耐蚀性增强。

关键词：冷轧钢板表面活性锆化膜耐蚀性电荷传输电阻膜重

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

LOW-VALENT TITANIUM INDUCED REDUCTIVE COUPlinG REACTION OF AROMATIC α-HYDROXY KETONES

引用

Chinese Chemical Letters 1992年第4期3卷 279-280页

作者： Zi Jie HOU li dun liU~(**) yu lin li State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry of Lanzhou Univercity, Lanzhou 730000 Ningxia Medical College, Yinchuan 750004

Treatment of aromatic α-hydroxy ketones with an activated Ti(O) reagent, prepared by reduction of TiCl_3 with a Zn-Cu couple, effects an intermolecular coupling reaction leading to the (Z)-1, 2, 3, 4-tetrarvl-2-buten... 详细信息

关键词： ppm HYDROXY KETONES LOW-VALENT TITANIUM INDUCED REDUCTIVE COUPlinG REACTION OF AROMATIC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Regional Variation in Mammography Use among Insured Women 40-49 Years Old： Impact of a USPSTF Guideline Change

引用

Journal of Health Science 2015年第4期3卷 174-182页

作者： Jacqueline M. Hirth Yong-Fang Kuo yu-li lin Abbey B. Berenson Department of Obstetrics & Gynecology Center for Interdisciplinary Research in Women's Health University of Texas MedicalBranch Galveston 77555 TX USA Preventive Medicine and Community Health Office of Biostatistics University of Texas Medical Branch Galveston 77555 TX USA

Purpose： The impact of the USPSTF （US Preventive Services Task Force） recommendation that 40-49 year old women should no longer routinely receive screening mammography in November 2009 in different regions of the US is unknown. Methods： The authors conducted a retrospective cohort study using medical claims from administrative health records from privately insured 40-59 year old women enrolled between 2005 and 2012 to evaluate biennial screening trends. Results： There was a slight decrease in mammography usage among 40-49 year old US women after the 2008-2009 biennial period （p 〈 0.001）. There were some regional differences in mammography trends, with the West showing the greatest difference in odds of 40-49 year olds receiving a mammography in 2011-2012 compared to 2008-2009 （OR： 0.93; 95% CI： 0.91-0.94）. Although trends for 50-59 year olds mirrored that of 40-49 year olds, the younger age group had a stronger decline in 2009-2010 and 2010-2011. Conclusions： These findings show that USPSTF guideline changes made some differences in mammography usage among 40-49 year olds, but adherence was uneven across regions.

关键词： Mammography screening screening guidelines adherence cancer prevention.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Separation of a minor lignan from Sinopodophyllum emodi using HSCCC combined MPLC guided by HPLC/MS

Separation of a minor lignan from Sinopodophyllum emodi usin...

引用

中国化学会第十届全国天然有机化学学术会议

作者： Yong-ling liu Tao Chen Deng-Lang Zou Chen Chen yu-lin li Key Laboratory of Tibetan medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences

＜正＞An efficient method using high performance liquid chromatography coupled with mass spectrometry（HPLC/MS）,medium pressure liquid chromatography（MPLC）and high-speed counter-current chromatography（HSCCC）was successfully established for rapid screening,identification,enrichment and separation of a minor lignan 4’-demethyldeoxypodophyllotoxin from Sinopodophyllum *** this work,the crude extract was

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：