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Hybrid ionic thermoelectric and photocatalytic materials(i-TEPC):a new choice for energy harvesting

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Science China Chemistry 2024年第7期67卷 2127-2129页

作者： Qikai Li mao yu Weishu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

Ionic thermoelectric(i-TE)material is a kind of new functional material that can convert heat energy into electric energy,which is of great significance for renewable energy technologies and sustainable development[1].The fundamental constitution of i-TE material mainly comprises an electrolyte matrix,ion providers and redox pairs.

关键词： energy harvesting convert

Comparative transcriptome analysis between rhesus macaques(Macaca mulatta) and crab-eating macaques(M. fascicularis)

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Zoological Research 2024年第2期45卷 299-310页

作者： yu-Xiang mao Yamei Li Zikun Yang Ning Xu Shilong Zhang Xuankai Wang Xiangyu Yang Qiang Sun Yafei mao Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science&Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai 201210China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Genetic Evolution&Animal Models Chinese Academy of SciencesKunmingYunnan 650201China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Zhiyuan College Shanghai Jiao Tong UniversityShanghai 200240China Center for Genomic Research International Institutes of MedicineFourth Affiliated HospitalZhejiang UniversityYiwuZhejiang 322000China

Understanding gene expression variations between species is pivotal for deciphering the evolutionary diversity in phenotypes. Rhesus macaques(Macaca mulatta, MMU)and crab-eating macaques(M. fascicularis, MFA) serve as crucial nonhuman primate biomedical models with different phenotypes. To date, however, large-scale comparative transcriptome research between these two species has not yet been fully explored. Here, we conducted systematic comparisons utilizing newly sequenced RNA-seq data from84 samples(41 MFA samples and 43 MMU samples)encompassing 14 common tissues. Our findings revealed a small fraction of genes(3.7%) with differential expression between the two species, as well as 36.5% of genes with tissue-specific expression in both macaques. Comparison of gene expression between macaques and humans indicated that 22.6% of orthologous genes displayed differential expression in at least two tissues. Moreover,19.41% of genes that overlapped with macaque-specific structural variants showed differential expression between humans and macaques. Of these, the FAM220A gene exhibited elevated expression in humans compared to macaques due to lineage-specific duplication. In summary,this study presents a large-scale transcriptomic comparison between MMU and MFA and between macaques and humans. The discovery of gene expression variations not only enhances the biomedical utility of macaque models but also contributes to the wider field of primate genomics.

关键词： Crab-eating macaques Rhesus macaques Comparative transcriptomics Biomedical models Nonhuman primates RNA-seq Duplicated genes

Iterative physical optics method based on efficient occlusion judgment with bounding volume hierarchy technology

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Journal of Electronic Science and Technology 2024年第1期22卷 1-12页

作者： Yang Su yu-mao Wu Jun Hu Key Laboratory for Information Science of Electromagnetic Waves(MoE) School of Information Science and TechnologyFudan UniversityShanghai200433China School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

This paper builds a binary tree for the target based on the bounding volume hierarchy technology,thereby achieving strict acceleration of the shadow judgment process and reducing the computational complexity from the original O(N^(3))to O(N^(2)logN).Numerical results show that the proposed method is more efficient than the traditional method.It is verified in multiple examples that the proposed method can complete the convergence of the current.Moreover,the proposed method avoids the error of judging the lit-shadow relationship based on the normal vector,which is beneficial to current iteration and convergence.Compared with the brute force method,the current method can improve the simulation efficiency by 2 orders of magnitude.The proposed method is more suitable for scattering problems in electrically large cavities and complex scenarios.

关键词： Bounding volume hierarchy Cavity scattering Iterative physical optics(IPO)

Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

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National Science Review 2023年第2期10卷 107-122页

作者： Jun-Ma yu Rui Hu yu mao Yingju Tai Sen Qun Zhi Zhang Danyang Chen Yan Jin Department of Anesthesiology The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Department of Biophysics and Neurobiology Division of Life Sciences and Medicine University of Science and Technology of China Stroke Center and Department of Neurology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China

Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely uncharacterized.Herein we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPLGlu) to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HLGlu),driving allodynia in mouse models of chronic pain.Optogenetic inhibition of this VPLGlu→S1HLGlucircuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control mice.In addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2) were increased in VPLGluneurons under conditions of chronic pain.Using in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPLGluneurons abrogated the rise in S1HLGluneuronal activity while alleviating allodynia in mice with chronic pain.With these data,we propose that dysfunction in HCN2 channels in the VPLGlu→S1HLGluthalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain.

关键词： chronic pain HCN2 channels neural circuit in vivo recordings

Novel sandwich structured glass fiber Cloth/Poly(ethylene oxide)-MXene composite electrolyte

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Nano Materials Science 2024年第1期6卷 60-67页

作者： yu-Qin mao Guang-He Dong Wei-Bin Zhu yuan-Qing Li Pei Huang Shao-yun Fu College of Aerospace Engineering Chongqing UniversityChongqing400044China State Key Laboratory of Power Transmission Equipment and System Security and New Technology Chongqing UniversityChongqing400044China

Recently,poly(ethylene oxide)(PEO)-based solid polymer electrolytes have been attracting great attention,and efforts are currently underway to develop PEO-based composite electrolytes for next generation high performance all-solid-state lithium metal batteries.In this article,a novel sandwich structured solid-state PEO composite electrolyte is developed for high performance all-solid-state lithium metal batteries.The PEO-based composite electrolyte is fabricated by hot-pressing PEO,LiTFSI and Ti_(3)C_(2)T_(x) MXene nanosheets into glass fiber cloth(GFC).The as-prepared GFC@PEO-MXene electrolyte shows high mechanical properties,good electrochemical stability,and high lithium-ion migration number,which indicates an obvious synergistic effect from the microscale GFC and the nanoscale MXene.Such as,the GFC@PEO-1 wt%MXene electrolyte shows a high tensile strength of 43.43 MPa and an impressive Young's modulus of 496 MPa,which are increased by 1205%and 6048%over those of PEO.Meanwhile,the ionic conductivity of GFC@PEO-1 wt%MXene at 60℃ reaches 5.01×10^(-2) S m^(-1),which is increased by around 200%compared with that of GFC@PEO electrolyte.In addition,the Li/Li symmetric battery based on GFC@PEO-1 wt%MXene electrolyte shows an excellent cycling stability over 800 h(0.3 mA cm^(-2),0.3 mAh cm^(-2)),which is obviously longer than that based on PEO and GFC@PEO electrolytes due to the better compatibility of GFC@PEO-1 wt%MXene electrolyte with Li anode.Furthermore,the solid-state Li/LiFePO_(4) battery with GFC@PEO-1 wt%MXene as electrolyte demonstrates a high capacity of 110.2–166.1 mAh g^(-1) in a wide temperature range of 25–60C,and an excellent capacity retention rate.The developed sandwich structured GFC@PEO-1 wt%MXene electrolyte with the excellent overall performance is promising for next generation high performance all-solid-state lithium metal batteries.

关键词： Solid polymer electrolyte Ti_(3)C_(2)T_(x)MXene Poly(ethylene oxide) Glass fiber cloth All-solid-state Li metal Battery

Application of cardiovascular 3-dimensional printing in Transcatheter aortic valve replacement

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Cell Regeneration 2022年第1期11卷 365-373页

作者： Yanyan Ma yu mao Guangyu Zhu Jian Yang Department of Cardiovascular Surgery Xijing HospitalAir Force Medical University127 Changle West RoadXi’an 710032ShaanxiChina School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’anChina

Transcatheter aortic valve replacement(TAVR)has been performed for nearly 20years,with reliable safety and efficacy in moderate-to high-risk patients with aortic stenosis or regurgitation,with the advantage of less trauma and better prognosis than traditional open surgery.However,because surgeons have not been able to obtain a full view of the aortic root,3-dimensional printing has been used to reconstruct the aortic root so that they could clearly and intui-tively understand the specific anatomical structure.In addition,the 3D printed model has been used for the in vitro simulation of the planned procedures to predict the potential complications of TAVR,the goal being to provide guidance to reasonably plan the procedure to achieve the best outcome.Postprocedural 3D printing can be used to understand the depth,shape,and distribution of the stent.Cardiovascular 3D printing has achieved remarkable results in TAVR and has a great potential.

关键词： 3D printing Transcatheter aortic valve replacement Models Aortic root

Experimental study on NO_(x)emission characteristics under oxy-fuel combustion

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Clean Energy 2023年第3期7卷 595-601页

作者： Haibo Wu Zhiyong An Kai Zhang yu mao Zhimin Zheng Zhaohui Liu Tianjin Guoneng Panshan Power Generation Co. LtdTianjin301907China China Energy Investment Corporation Beijing100011China Dongfang Boiler(Group)Co. Ltd.Zigong643001China Anhui University of Technology MaanshanAnhui243099China Huazhong University of Science and Technology WuhanHubei430074China

This study focuses on the emission characteristics of NO_(x)under oxy-fuel combustion conditions.A comparative analysis with air combustion was performed.NO_(x)emission,control measures and influence factors under different working conditions were studied.Experiments were carried out on a 3-MWth test platform and a laboratory platform.The‘π’-type furnace was adopted,with the fur-nace width of 2.6 m,depth of 2.0 m and height of 10.5 m for the 3-MWth coal-fired boiler.NO_(x)emissions at different oxygen concen-trations and different air distribution were investigated;the effects of H2O and CO_(2)concentration on denitrification efficiency and SO_(2)/SO_(3)conversion rate were explored.Experiment results suggest that,compared with air combustion,NO concentration(volume basis)at the furnace outlet under oxy-fuel combustion is higher than that of air combustion,but the amount of NO_(x)emissions in the discharged gas significantly decrease compared to the air combustion conditions.In addition,the formation of NO_(x)can be effectively controlled through staged combustion.Furthermore,the selective catalytic reduction(SCR)denitrification efficiency and the con-version rate of SO_(2)to SO_(3)decreases when the CO_(2)concentration and the H2O content increase,indicating that CO_(2)and H2O have an adverse effect on the performance of the catalyst.Additionally,compared with CO_(2)concentration,H2O content has a greater effect on catalyst performance.

关键词： experimental research NO_(x) oxy-fuel combustion SO_(2)/SO_(3)

Iron oxide nanoparticles:A promising approach for diagnosis and treatment of cardiovascular diseases

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Nano Research 2023年第11期16卷 12453-12470页

作者： Xue Bao yu mao Guangxiang Si Lina Kang Biao Xu Ning Gu Cardiovascular Disease Research Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolMedical SchoolNanjing UniversityNanjing 210093China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China

Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases(CVDs),it remains a leading cause of mortality and morbidity worldwide.This underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease burden.Iron oxide nanoparticles(IONPs),with their unique magnetism and bioproperties,have shown great potential in this regard.In this review,we will begin with a brief overview of the synthesis and properties of IONPs.We will then focus on the latest applications of IONPs in CVDs,including diagnosis and treatment.The use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field,and will be addressed in a separate section.The translational potential and challenges of IONPs will also be discussed.In conclusion,ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively,and offer more personalized and efficient options for the diagnosis and treatment of CVDs.

关键词： atherosclerosis cardiovascular disease diagnosis iron oxide nanoparticles theranostic treatment

Investigation on small molecule-aptamer dissociation equilibria based on antisense displacement probe

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Food Science and Human Wellness 2023年第4期12卷 1257-1264页

作者： Lei Wang Lili Yao Qihui Ma yu mao Hao Qu Lei Zheng School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China

Food safety is a major issue to public health and have attracted global attention.Fast,sensitive,and reliable detection methods for food hazardous substances is highly desirable.Aptamers which can bind to the target molecules with high affinity and specificity represent an attractive tool for the recognition of food hazardous substances,which play an important role in the development and application of new food safety detection technology.But current assays for characterizing small molecule-aptamer binding are limited by either the mass sensitivity or the size differentiation ability.Herein,we proposed a comprehensive method for assessing the dissociation equilibria of small molecule-aptamer,which is immobilized-free under ambient conditions.The design employs the Le Chatelier’s principle and could be used to effectively measure small molecule-aptamer interactions.ATP binding aptamer and anti-aflatoxin B1 aptamer were used as the model system to determine their affinity,in which their dissociation equilibria measurements are in excellent close to their previous work.Due to the simplicity and sensitivity of this new method,we believe that it could be recommended as an effective tool for characterizing small molecule-aptamer interactions and promote the further application of small molecular aptamer in food safety.

关键词： Aptamer Small molecule Dissociation equilibria Antisense displacement probe Le Chatelier’s principle