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Arsenic trioxide downregulates the expression of annexin II in bone marrow cells from patients with acute myelogenous leukemia

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Chinese Medical Journal 2009年第17期122卷 1969-1973页

作者： ZHANG Xiao-hui HU yu BAO Li JIANG Qian YANG Ling-hua LU Xi-jing HONG Mei XIA Ling-hui GUO Tao SHEN guan-xin ZHU Hong-hu ZHAO Ting SONG Shan-jun Department of Hematology Union Hospital Tongji MedicalCollege of Huazhong University of Science and TechnologyWuhan Hubei 430022 China Institute of Hematology Peking University People's HospitalBeijing 100044 China Department of Hematology Second Clinical Medical College otShanxi Medical University Taiyuan Shanxi 030001 China Department of Immunology Tongji Medical College of HuazhongUniversity of Science and Technology Wuhan Hubei 430022China

Background Most patients with acute myelogenous leukemia （AML） suffer from disordered hemostasis. We have previously shown that annexin II （Ann II）, a high-affinity co-receptor for plasminogen/tissue plasminogen activator, plays a central role in primary hyperfibrinolysis in patients with acute promyelocytic leukemia （APL）. The expression of Ann II in cells from patients with major subtypes of AML and the effect of arsenic trioxide （As203） on Ann II expression in AML cells were investigated to determine whether As203-mediated downregulation of Ann II could restore hemostatic stability. Methods A total of 103 patients （48 females and 55 males; age, 19-58 years） were included. Plasma samples were collected before and after treatment as well as after complete remission. Ann II and plasminogen activation were measured in leukemic cells during treatment with 1 pmol/L As203. Results Before AS203 treatment, Ann II mRNA expression （real-time PCR） was the highest in M3 cells （P 〈0.05）, higher in M5 cells than that in M1, M2, M4, and M6 cells （P〈0.001）, and positively correlated with Ann II protein expression （flow cytometry）（r=0.752, P 〈0.01）. Exposure for up to 120 hours to As203 （1 μmol/L） had no significant effect on Ann II protein in M1 and M2 leukemic cells, but decreased Ann II protein expression twofold within 48 hours of exposure in M3 cells （P 〈0.05） and twofold within 96 hours in M5 cells （P 〈0.05）. The rate of plasmin generation was higher in APL, M5, and M4 cells than in M1, M2, and M6 cells. Conclusions As203 may reduce hyperfibrinolysis in AML by downregulation of Ann 11. Furthermore, As2O3 affects more than one form of AML （APL, M4 and M5）, suggesting its potential role in their management.

关键词： arsenic trioxide annexin II acute myelogenous leukemia

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稳定伞作用下对救生伞开伞动载影响研究

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南京航空航天大学学报 2023年第2期55卷 209-216页

作者：高春鹏姚裕官本和王颖伊余强张鑫华航空工业航宇救生装备有限公司襄阳441003 南京航空航天大学航空学院南京210016

在救生伞高速空投试验过程中,由于救生伞系统在做非均加速非定常运动的同时又受到假人姿态的影响,常规空投试验获取的开伞动载数据往往离散度较大,无法真实反映救生伞的开伞性能。本文针对救生伞的前置体影响特性,提出了一种采用增加稳... 详细信息

在救生伞高速空投试验过程中,由于救生伞系统在做非均加速非定常运动的同时又受到假人姿态的影响,常规空投试验获取的开伞动载数据往往离散度较大,无法真实反映救生伞的开伞性能。本文针对救生伞的前置体影响特性,提出了一种采用增加稳定伞的方法对假人自由飞阶段的姿态进行控制,并对不同工况下假人运动过程进行了仿真分析,通过3种工况的空投试验验证研究假人姿态对开伞动载的影响,对开伞时间、开伞速度、开伞动载、假人角速度以及速度损失等试验数据的相关性进行了分析。研究表明假人姿态控制对开伞程序没有影响,与不控制假人姿态试验程序相比更接近于该型救生伞前置体的实际工况。从试验数据结果分析,假人姿态控制后可以改善开伞动载数据的离散性,提高开伞动载试验数据的真实性,最大开伞动载数据可以减小8.9%。

关键词：救生伞空投试验姿态控制开伞动载

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单极调制单周控制有源电力滤波器

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电力自动化设备 2006年第2期26卷 43-46页

作者：余凤兵梁冠安华南理工大学电力学院广东广州510640

单周控制单相有源电力滤波器(APF)有双极调制和单极调制2种调制方式。采用双极调制方式单周控制APF补偿后的电源电流中存在直流分量。在阐述单极调制单周控制APF工作原理的基础上,根据开关器件的动作过程,设计了控制器中的逻辑电路;分... 详细信息

单周控制单相有源电力滤波器(APF)有双极调制和单极调制2种调制方式。采用双极调制方式单周控制APF补偿后的电源电流中存在直流分量。在阐述单极调制单周控制APF工作原理的基础上,根据开关器件的动作过程,设计了控制器中的逻辑电路;分析了系统的全局稳定条件,从而获得APF交流侧滤波电感的设计依据;最后,利用Matlab软件对系统带非线性负载时的补偿性能进行仿真。仿真结果表明,单极调制单周控制APF能有效补偿非线性负载所导致的谐波和无功电流,补偿后电源电流中不含直流分量;且与双极调制方式相比,单极调制方式在一定程度上降低了开关损耗,是单周控制APF中很有前景的一种调制方式。

关键词：单极调制单周控制有源电力滤波器直流分量

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Epidemiological Study of Sepsis in China： Protocol of a Cross-sectional Survey

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Chinese Medical Journal 2016年第24期129卷 2967-2973页

作者： Yi Yang Jian-Feng Xie Kai-Jiang yu Chen Yao Jian-Guo Li Xiang-Dong guan Jing Yan Xiao-Chun Ma Yan Kang Cong-Shan Yang Xiao-Qing Yao Hong-Cai Shang Hai-Bo Qiu Department of Critical Care Medicine Zhongda Hospital School of Medicine Southeast University Nanjing Jiangsu 210009 China Department of Critical Care Medicine The Third Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150040 China Clinical Research Center Peking University First Hospital Beijing 100034 China Department of Critical Care Medicine Zhongnan Hospital Wuhan University Wuhan Hubei 430071 China Department of Surgical Critical Care Medicine The First Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Critical Care Medicine Zhejiang Hospital Hangzhou Zhejiang 310030 China Department of Critical Care Medicine The First Affiliated Hospital of China Medical University Shenyang Liaoning 110001 China Department of Critical Care Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China Tianjin Chase Sun Pharmaceutical Co. Ltd. Tianjin 300170 China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen Hospital Beijing University of Chinese Medicine Beijing 100700 China

Background： Sepsis is the leading cause of death among critically ill patients. Herein, we conducted a national survey to provide data on epidemiology and treatment of sepsis in the clinical practice in China, which has no detailed epidemiological data available on sepsis. Methods： This was a prospective cross-sectional survey from December 1, 2015 to January 31, 2016 in all provinces/municipalities of the mainland of China. The primary outcome of this study was the incidence of sepsis, and the secondary outcome was its etiology in China. Patients with sepsis admitted to the Intensive Care Units were included in this study. The demographic, physiological, bacteriological, and therapeutic data of these patients were recorded. The incidence of sepsis was estimated using the data from the sixth census in China, reported by the Chinese National Health and Family Planning Commission and the National Bureau of Statistics as the standard population. The independent risk factors for increased mortality from sepsis were calculated. Conclusions： This study indicated the incidence and outcome of sepsis in China. It also showed the most common etiology of different sites and types of infection, which could guide empiric antibiotic therapy. Moreover, it provided information on the independent risk factors for increased mortality due to sepsis. The findings provide evidence to guide clinical management and may help improve the outcome in septic patients.

关键词： Epidemiology Incidence National Survey Outcome Sepsis

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DDAH2(-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study

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Neural Regeneration Research 2021年第8期16卷 1592-1597页

作者： Ying Fan Qiang Gao Jia-Xin guan Lei Liu Ming Hong Li Jun Li Wang Hai-Feng Ding Li-Hong Jiang Bo-yu Hou Mei Li Zhi-Qiang Song De-Qin Sun Chao-Qi Yan Lan Ma Department of Geriatrics The 2nd Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Department of Geriatrics Tongling Municipal HospitalTonglingAnhui ProvinceChina Department of Cardiovascular Medicine Shanxi Cardiovascular HospitalTaiyuanShanxi ProvinceChina Physical Examination Center The 2nd Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang ProvinceChina

Cerebrovascular endothelial dysfunction is involved in the progression of leukoaraiosis. Asymmetric dimethylarginine is a competitive inhibitor of nitric oxide, which is highly expressed in patients with leukoaraiosis. Dimethylarginine dimethylaminohydrolase(DDAH) is a hydrolytic enzyme that is primarily responsible for eliminating asymmetric dimethylarginine, and it plays a role in the pathogenesis of cardiovascular and cerebrovascular diseases. The DDAH2 subtype is expressed in organs rich in induced nitric oxide synthase, including the heart, the placenta, and the cerebral endothelium during cerebral ischemia, in the stress state, or under neurotoxicity. Overexpression of the DDAH2 gene can inhibit asymmetric dimethylarginine-induced peripheral circulating endothelial cell dysfunction. However, it is unknown whether this polymorphism regulates plasma asymmetric dimethylarginine levels in patients with leukoaraiosis. In this doubleblind study, we recruited 46 patients with leukoaraiosis and 46 healthy, matched controls. Plasma asymmetric dimethylarginine levels were determined using enzyme-linked immunoassays. Genomic DNA was isolated from whole blood samples, and polymerase chain reaction, Sma I restriction enzyme digestion, restriction fragment length polymorphisms, and agarose electrophoresis were used to detect DDAH2(-449 G/C) gene polymorphisms. The results revealed that 95.65% of leukoaraiosis patients had recessive genetic models(GG and CG), while 89.13% of healthy control subjects had dominant genetic models(CC and CG). There was a significant difference in the genotype composition ratio between leukoaraiosis patients and healthy controls(P = 0.0002). The frequency of G alleles in the leukoaraiosis patients(71.74%) was significantly higher than in healthy controls, whereas the frequency of C alleles was lower(χ~2 = 13.9580, P = 0.0002). Furthermore, asymmetric dimethylarginine concentrations in subjects with the GG genotype were significantly higher than in subjects with the CG and CC genotypes(Kruskal–

关键词： leukoaraiosis dimethylarginine dimethylaminohydrolase 2 gene polymorphism allele asymmetric dimethylarginine nitric oxide endothelial dysfunction cerebrovascular diseases clinical trial

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Age-specific differences in non-cardiac comorbidities among elderly patients hospitalized with heart failure: a special focus on young-old, old-old, and oldest-old

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Chinese Medical Journal 2019年第24期132卷 2905-2913页

作者： Meng-Xi Yang Hui An Xue-Qiang Fan Li-yuan Tao Qiang Tu Li Qin Li-Fang Zhang Dong-Ping Feng yu Wang Li Sun Si Gao Wen-Zhuo guan Jin-Gang Zheng Jing-Yi Ren Department of Cardiology China-Japan Friendship HospitalBeijing 100029China Department of Cardiology Hebei General HospitalShijiazhuangHebei 050051China Department of Cardiovascular Surgery China-Japan Friendship HospitalBeijing 100029China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China State Key Laboratory for Molecular and Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100039China Department of Laboratory Medicine Peking University People's HospitalBeijing 100044China

Background:Despite the growing epidemic of heart failure(HF),there is limited data available to systematically compare noncardiac comorbidities in the young-old,old-old,and oldest-old patients hospitalized for HF.The precise differences will add valuable information for better management of HF in elderly patients.Methods:A total of 1053 patients aged 65 years or older hospitalized with HF were included in this study.Patients were compared among three age groups:(1)young-old:65 to 74 years,(2)old-old:75 to 84 years,and(3)oldest-old:≥85 years.Clinical details of presentation,comorbidities,and prescribed medications were recorded.Results:The mean age was 76.7 years and 12.7%were 85 years or older.Most elderly patients with HF(97.5%)had at least one of the non-cardiac comorbidities.The patterns of common non-cardiac comorbidities were different between the young-old and oldestold group.The three most common non-cardiac comorbidities were anemia(53.6%),hyperlipidemia(45.9%),and diabetes(42.4%)in the young-old group,while anemia(73.1%),infection(58.2%),and chronic kidney disease(44.0%)in the oldest-old group.Polypharmacy was observed in 93.0%elderly patients with HF.Additionally,29.2%patients were diagnosed with infection,and 67.0%patients were prescribed antibiotics.However,60.4%patients were diagnosed with anemia with only 8.9%of them receiving iron repletion.Conclusions:Non-cardiac comorbidities are nearly universal in three groups but obviously differ by age,and inappropriate medications are very common in elderly patients with HF.Further treatment strategies should be focused on providing optimal medications for age-specific non-cardiac conditions.

关键词： Heart failure Elderly Non-cardiac comorbidity Polypharmacy

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Study on Biological Activity of New Compound SYP-260

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Journal of Northeast Agricultural University(English Edition) 2022年第3期29卷 21-27页

作者： Liu Shao-wu Wang Li-zeng Chang Xiu-hui Fan Xiao-xi Ban Lan-feng Zhang Jun-long Song yu-quan guan Ai-ying Liu Chang-ling State Key Laboratory of the Discovery and Development of Novel Pesticide Shenyang Sinochem Agrochemicals R&D Co.Ltd.Shenyang 110021ChinaSeptember

SYP-260 is one of the novel pyrimidine structure chemicals.The biological activity of new compound SYP-260 was tested in this paper using different bioassay methods in the laboratory.Experimental results indicated that the values of median lethal concentration(LC50,72 h)of new compound SYP-260 against broad bean aphid,green peach aphid and cotton aphid were 0.1708,0.2455 and 0.2632 mg·L-1,respectively.The LC50 of new compound SYP-260 was 0.8892 mg·L-1 against adult mite and the ovicidal activity of new compound SYP-260 was 0.7166 mg·L-1.The LC50 of new compound SYP-260 was 22.1991,71.6915,79.6149 and 42.5698 mg·L-1 against oriental armyworm,diamondback moth,corn borer and beet armyworm,respectively.And at the concentration of 50 mg·L-1,the bioassay result showed that new compound SYP-260 could be absorbed by host plant roots.The temperature bioassay result indicated that new compound SYP-260 was a positive temperature coefficient chemical.So new compound SYP-260 had excellent biological activity against nine different insect targets,such as broad bean aphid,green peach aphid and carmine spider mite.Moreover,this new compound had systemic action,too.Therefore,new compound SYP-260 had good bioactivity against many kinds of insect targets with novel chemical structures.

关键词： SYP-260 pyrimidine structure chemical biological activity action characteristic

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不同权力结构下考虑制造商失望规避行为的低碳供应链决策研究

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运筹与管理 2023年第2期32卷 45-52页

作者：徐浩鑫于天阳关志民曲优东北大学工商管理学院辽宁沈阳110169 山东科技大学经济与管理学院山东青岛266590

本文以一个具有失望规避行为的制造商与一个完全理性的零售商所构成的低碳供应链为研究对象,考虑了低碳技术创新投资的不确定性,分别在制造商主导(MS)、零售商主导(RS)及双方权力对等(Nash)三种渠道权力结构下,通过构建相应的博弈模型... 详细信息

本文以一个具有失望规避行为的制造商与一个完全理性的零售商所构成的低碳供应链为研究对象,考虑了低碳技术创新投资的不确定性,分别在制造商主导(MS)、零售商主导(RS)及双方权力对等(Nash)三种渠道权力结构下,通过构建相应的博弈模型探讨低碳供应链最优减排水平与定价等相关决策问题。在此基础上,进一步对比分析了三种权力结构下的最优结果。研究表明:失望规避程度与单位低碳产品减排水平及制造商效用负相关;制造商主导时,其效用最大,但单位低碳产品减排水平最低,零售商主导和权力对等两种情形下的单位低碳产品减排水平(或制造商效用)存在关于减排成本系数及失望规避程度的阀值效应。此外,通过数值分析发现零售商期望利润在自身主导时最高,在双方权力对等时次之,在制造商主导时最低;而供应链总期望利润在制造商主导时最低,在其他两种情形下的大小关系同样存在关于减排成本系数及失望规避程度的阈值效应。

关键词：失望规避权力结构供应链管理低碳减排技术创新有效性

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Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss

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Chinese Medical Journal 2016年第8期129卷 946-952页

作者： Feng-Jiao Li Da-Yong Wang Hong-Yang Wang Li Wang Feng-Bo Yang Lan Lan Jing guan Zi-Fang Yin UII Rosenhall Lan yu Sten Hellstrom Xi-Jun Xu Mao-Li Duan Qiu-Ju Wang Department of Otolaryngology-Head and Neck Surgery Institute of Otolaryngology Chinese PLA General Hospital Beijing 100853 China Department of Otolaryngology-Head and Neck Surgery Kunming General Hospital Kunming Medical University Kunming Yunnan 650032 China Department of Audiology and Neurotology Karolinska University Hospital 17176 Stockholm Sweden Department of Clinical Science Intervention and Technology Karolinska Institute 171 76 Stockholm Sweden

Background：The prevalence of sudden sensorineural hearing loss in children （CSSNHL） is consistently increasing.However,the pathology and prognosis of CSSNHL are still poorly understood.This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL.Methods：One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study.These patients were analyzed for clinical characteristics,audiological characteristics,laboratory examinations,and prognostic factors.Results：Among the 136 patients （151 ears）,121 patients （121 ears,80.1%） were diagnosed with unilaterally CSSNHL,and 15 patients （30 ears,19.9%） with bilateral CSSNHL.The complete recovery rate of CSSNHL was 9.3%,and the overall recovery rate was 37.7%.We found that initial degree of hearing loss,onset of treatment,tinnitus,the ascending type audiogram,gender,side of hearing loss,the recorded auditory brainstem response （ABR）,and distortion product otoacoustic emissions （DPOAEs） had prognostic significance.Age,ear fullness,and vertigo had no significant correlation with recovery.Furthermore,the relevant blood tests showed 30.8% of the children had abnormal white blood cell （WBC） counts,22.1% had elevated homocysteine levels,65.8% had high alkaline phosphatase （ALP）,33.8% had high IgE antibody levels,and 86.1% had positive cytomegalovirus （CMV） IgG antibodies.Conclusions：CSSNHL commonly occurs unilaterally and results in severe hearing loss.Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery,while positive prognostic factors include tinnitus,gender,the ascending type audiogram,early treatment,identifiable ABR waves,and DPOAEs.Age,vertigo,and ear fullness are not correlated with the recovery.Some serologic indicators,including the level of WBC,platelet,homocysteine,ALP,positive CMV IgG antibody,fibrinogen,and some

关键词： Audiological Characteristics Children Laboratory Examinations Prognostic Factors Sudden Hearing Loss

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花生肽的制备及其美拉德反应产物风味特性研究

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食品安全质量检测学报 2022年第14期13卷 4665-4673页

作者：于珍布冠好王美月赵晨宇河南工业大学粮油食品学院郑州450001

目的制备水解度较高的花生肽并研究其美拉德反应产物的风味特性。方法从花生粕中提取花生蛋白,利用碱性和风味蛋白酶双酶分步酶解制备花生肽,以水解度和蛋白质回收率为指标,确定酶解工艺条件。当肽糖质量比为10:1、温度为105℃时,研究... 详细信息

目的制备水解度较高的花生肽并研究其美拉德反应产物的风味特性。方法从花生粕中提取花生蛋白,利用碱性和风味蛋白酶双酶分步酶解制备花生肽,以水解度和蛋白质回收率为指标,确定酶解工艺条件。当肽糖质量比为10:1、温度为105℃时,研究美拉德反应时间(0~100min)对花生肽美拉德产物结构和风味的影响。结果酶解制备花生肽最佳工艺条件为:6000 U/g碱性蛋白酶酶解120 min,450 U/g风味蛋白酶酶解150 min,在此条件下花生蛋白的水解度为20.26%;美拉德反应结果表明,随着反应时间的增加,花生肽中游离氨基酸含量逐渐下降,褐变程度逐渐增加,美拉德产物风味感官评分呈现先增加后减小的趋势;光谱分析表明,美拉德反应后其肽链的空间结构发生改变且产生了一些有色物质前体;通过气相色谱-质谱仪分析,共检测出54种挥发性物质,与未添加木糖的花生肽相比,花生肽-木糖美拉德反应产生更多的吡嗪类、呋喃类、酮类、酯类等挥发性香气化合物。结论本研究通过优化酶解工艺制备花生肽,并探究花生肽美拉德反应产物的风味特性,为天然香料的开发提供理论依据。

关键词：花生肽双酶酶解美拉德反应风味

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