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Unresectable esophageal cancer treated with multiple chemotherapies in combination with chemoradiotherapy:A case report

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World Journal of Clinical Cases 2021年第12期9卷 2801-2810页

作者： Masahiro Yura Kazuo Koyanagi Asuka Hara Keita Hayashi Yuki Tajima Yasushi Kaneko Hiroto Fujisaki Akira Hirata Kiminori Takano Kumiko Hongo Kikuo Yo Kimiyasu Yoneyama yoshifumi tamai Reiko Dehari Motohito Nakagawa Department of Surgery Hiratsuka City HospitalKanagawa 2540065Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 2591193Japan Department of Radiology Hiratsuka City HospitalKanagawa 2540065Japan Department of Surgical Pathology Hiratsuka City HospitalKanagawa 2540065Japan

BACKGROUND Definitive chemoradiotherapy(dCRT)using cisplatin plus 5fluorouracil(CF)with radiation is considered the standard treatment for unresectable locally advanced T4 esophageal squamous cell carcinoma(ESCC).Recently,induction chemotherapy has received attention as an effective treatment *** SUMMARY We report a successful case of a 59-year-old female with unresectable locally advanced T4 ESCC treated by two additional courses of chemotherapy with CF after induction chemotherapy with docetaxel,cisplatin and fluorouracil(DCF)followed by *** esophagogastroduodenoscopy(EGD)detected a type 2 advanced lesion located on the middle part of the esophagus,with *** tomography detected the primary tumor with suspected invasion of the left bronchus and 90°of direct contact with the aorta,and upper mediastinal lymph node *** findings from biopsy revealed squamous cell *** initially performed induction chemotherapy using three courses of DCF,but the lesion was still evaluated unresectable after DCF ***,we subsequently performed dCRT treatment(CF and radiation).After dCRT,prominent reduction of the primary tumor was recognized but a residual tumor with ulceration was detected by *** the patient had some surgical risk,we performed two additional courses of CF and achieved a clinically complete *** 14 mo from last administration of CF chemotherapy,recurrence has not been detected by computed tomography and EGD,and biopsy from the scar formation has revealed no cancer *** We report successful case with tumor remnants even after DCF and subsequent dCRT,for whom a complete response was finally achieved with two additional courses of CF *** CF chemotherapy could be one radical treatment option for residual ESCC after treatment with induction DCF followed by dCRT to avoid salvage surgery,especially for high-risk patients.

关键词： Unresectable esophageal cancer Induction docetaxel,cisplatin and fluorouracil Chemoradiotherapy Complete response Additional chemotherapy Case report

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论北朝墓志的性质与制作

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复旦学报（社会科学版） 2024年第4期66卷 42-48页

作者： [日]窪添慶文王典典(译) 东洋文库日本东京东京大学大学院人文社会系研究科

北朝墓志是近年推动中国中古史研究取得重要进展的关键史料。本文在充分吸收近年中古碑志研究新动向的基础上,围绕“为什么要制作墓志”这一朴素的设问进行了相当全面的省思与探索。北朝时期墓葬的营建基于时人的冥界观,置于其中的墓志... 详细信息

北朝墓志是近年推动中国中古史研究取得重要进展的关键史料。本文在充分吸收近年中古碑志研究新动向的基础上,围绕“为什么要制作墓志”这一朴素的设问进行了相当全面的省思与探索。北朝时期墓葬的营建基于时人的冥界观,置于其中的墓志却缺乏宗教色彩,主要反映了丧家之愿,期望志主的功德能在冥界永存。墓志以行状为素材撰成,可视为被死者带入冥界的具有“公”之意义的文书。丧家提供行状给墓志撰者,收到墓志文稿后仍需根据具体情况进行若干调整,在此过程中容易产生“异刻”现象。夫妇合葬却不制作妻子墓志的现象也不容忽视。不是单独聚焦于墓志,需要在墓葬整体中对墓志进行考察。

关键词：北朝墓志冥界观行状异刻

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Behavior of Vaneless Diffuser Stall in a Centrifugal Compressor

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Journal of Thermal Science 2022年第1期31卷 3-12页

作者： AGARI Yuki YAMAO yoshifumi FUJISAWA Nobumichi OHTA Yutaka Department of Applied Mechanics and Aerospace Engineering Waseda UniversityTokyo 169-8555Japan

The rotating stall in a centrifugal compressor with a vaneless diffuser was investigated both experimentally and numerically with focus on the effect of the internal flow field within the impeller on the diffuser *** numerical analysis,the boundary layer separation at the impeller outlet was found to play an important role in the expansion and rotation processes of the diffuser *** particular,the expanded boundary layer separation near the hub side at the outlet of the main blade(M.B.)suction surface passage was considered to be the main cause of the expansion and rotation processes.A longitudinal vortex existed at the throat of the ***,and the mass flow rate in the *** was significantly reduced by the blockage *** addition,the longitudinal vortex induced the rolling up flow near the hub side at the impeller ***,the boundary layer separation expanded.

关键词： centrifugal compressor vaneless diffuser pressure and velocity measurement CFD rotating stall

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Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan yoshifumi Kobayashi Michaela Kearney Emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

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Appropriate Heart Rate in a Patient with Repaired Tetralogy of Fallot

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Congenital Heart Disease 2022年第6期17卷 647-652页

作者： Aya Miyazaki Hideki Uemura Yasuyo Takeuchi Junya Tomida Yasuo Ono yoshifumi Fujimoto Norie Mitsushita Akio Ikai Department of Transitional Medicine Division of Congenital Heart DiseaseShizuoka General HospitalShizuokaJapan Congenital Heart Disease Center Nara Medical UniversityKashiharaJapan Department of Cardiology Shizuoka General HospitalShizuokaJapan Department of Clinical Engineering Shizuoka General HospitalShizuokaJapan

Appropriate heart rate in a failing pulmonary ventricle remains unknown, particularly in congenital heart diseasewith unique hemodynamics. A 71-year-old male with repaired tetralogy of Fallot and a pacemaker for a sinusnode dysfunction suffered from heart failure symptoms with preserved left ventricular function. Simply changingthe pacemaker’s lower rate from 60 to 75 bpm, New York Heart Association classification improved from III to II,and hemodynamic parameters drastically improved. We regarded this case as informative. Appropriate heart ratecould be higher in congenital patients with failing right and non-failing left ventricles than in adults with malfunctioningLV.

关键词： Heart rate repaired tetralogy of Fallot failing right ventricle pacemaker lower rate the right-left ventricular interaction

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iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel

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Bioactive Materials 2022年第8期7卷 290-301页

作者： yoshifumi Kobayashi Julie Nouet Erdenechimeg Baljinnyam Zain Siddiqui Daniel HFine Diego Fraidenraich Vivek A.Kumar Emi Shimizu Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Cell Biology and Molecular Medicine Rutgers New Jersey Medical SchoolNewarkNJ07103USA Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative *** study aimed to replicate the characteristics of dental pulp tissue by using cranial neural crest(CNC)-like cells(CNCLCs);these cells were generated by modifying several steps of a previously established method for deriving NC-like cells from induced pluripotent stem cells(iPSCs).CNC is the anterior region of the neural crest in vertebrate embryos,which contains the primordium of dental pulp cells or *** produced CNCLCs showed approximately 2.5-12,000-fold upregulations of major CNC marker ***,the CNCLCs exhibited remarkable odontoblastic differentiation ability,especially when treated with a combination of the fibroblast growth factors(FGFs)FGF4 and *** FGFs induced odontoblast marker genes by 1.7-5.0-fold,as compared to bone morphogenetic protein 4(BMP4)*** a mouse subcutaneous implant model,the CNCLCs briefly fated with FGF4+FGF9 replicated dental pulp tissue characteristics,such as harboring odontoblast-like cells,a dentin-like layer,and vast neovascularization,induced by the angiogenic self-assembling peptide hydrogel(SAPH),*** acts as a versatile biocompatible scaffold in the canal *** study demonstrated a successful collaboration between regenerative medicine and SAPH technology.

关键词： Regenerative endodontics iPSC Cranial neural crest Fibroblast growth factor Odontoblastic differentiation Angiogenic self-assembling peptide hydrogel

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Throughfall and stemflow chemical dynamics of Satoyama, a traditional secondary forest system under threat in Japan

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Journal of Forestry Research 2022年第3期33卷 813-826页

作者： Satoshi Asaoka Fuyuhiko Sumikawa yoshifumi Watanabe Waqar Azeem Jadoon Masaki Ohno Nobumichi Shutoh Yuki Wakamatsu Lawrence M.Liao Akane Kanazawa Yuka Sato Natsumi Fujiwara Graduate School of Integrated Sciences for Life Hiroshima University1-4-4 KagamiyamaHigashi-Hiroshima739-8528Japan Research Center for Inland Seas Kobe University5-1-1 FukaeminamiHigashinadaKobe658-0022Japan Naragakuen Senior High School 430 YamadaYamatokoriyamaNara639-1093Japan Department of Environmental Sciences Faculty of Natural and Computational SciencesHazara UniversityDhodiaMansehra21130Khyber PakhtunkhwaPakistan Niigata University of Pharmacy and Applied Life Sciences 265-1 HigashijimaAkihaNiigata956-8603Japan Faculty of Science and Engineering Kindai University3-4-1 KowakaeHigashi-OsakaOsaka577-8502Japan Department of Maritime Science and Technology Japan Coast Guard Academy5 WakabaKureHiroshima737-8512Japan

The term 'Satoyama' refers to traditional and unique secondary forests in Japan that occupy intermediate zones between villages ('sato') and hills or mountains ('yama'). Satoyama landscapes help sustain ecosystem services and the diversity of secondary natural environments. As Japan relies more heavily on foreign timber imports, the traditional role of Satoyama in providing forest products has diminished, and this has led to their abandonment and poor management. The chemical behavior of cations, anions, and dissolved organic matter in throughfall and stemflow from one such threatened Satoyama system in central Japan was investigated. From autumn to winter, the atmospheric deposition of sulfates and nitrates was 2.5–6.0 times higher compared to the amounts in summer due to the intrusion of air masses from the Asian continent. The dissolved organic matter in the throughfall and stemflow was composed mainly of humic substances and protein derivatives. The deposition fluxes of dissolved organic carbon from throughfall (7.31–10.1 g m^(−2) a^(−1)) and stemflow (1.79–3.84 g m^(−2) a^(−1)) in this study were within ranges seen in temperate forests in previous studies. The deposition flux of sulfates was low compared to that in other forest types because canopy interaction was lower, suggesting higher canopy openness than in primary forests. If a shift from a mixed species Satoyama forest to a conifer-dominated forest occurs after the mass mortality of oak, the deposition flux of dissolved organic carbon and K^(+) might decrease by 33% and 62%, respectively, while NO_(3)^(−) might increase by 20%. In the near future, the degradation of Satoyama landscapes might change the levels of dissolved organic carbon and nitrogen loads, resulting in imbalances in river-ocean linkages affecting forested catchments and aquatic ecosystems in Japan.

关键词： Atmospheric deposition Dissolved organic matter Humic substance Mass mortality Oak trees Sustainable development goals

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Surface Activities of Calix [4]resorcinarenes Bearing Four Hydrophobic Chains and Its Solubilization for Organic Compounds

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Chemical Research in Chinese Universities 2002年第2期18卷 206-210页

作者： LI Bo yoshifumi KOIDE Kunio ESUMI Toyota Central R&D Labs. Inc.411YokomichiNagakuteAichi 4801192Japan Departemnt of Applied Chemistry and Institute of Colloid and Interface Science Science University of Tokyo

Calix resorcinarenes bearing four hydrophobic side chains ( Ar-Rn, Ar-Ph, and Ar-N) orient stably on water oil interface and show high solubilization capacities for organic compounds, such as long chain alcohols, benzene, toluene and dyes. The capacities are high even near the cmc of polyalkylated calix resorcinarenes, but the solubilities of organic compounds(solubilizates) decrease with the increase of the size of the solubilizates. Ar-R 6, with a chain length of six carbons, is the most effective among Ar-R n , Ar-Ph, and Ar-N; 11 fold mol of hexanol is dissolved in 2×10 -3 mol/L Ar-R 6. Moreover, Ar-R n bearing four alkyl side chains solubilizes the chain alcohols of the same chain length mostly. The solubilization capacities are presumably brought by inclusion in a large cavity of the polyalkylated calix resorcinarenes and by an efficient orientation of the solubilizates.

关键词： Calix resorcinarene Hydrophobic chain Polyalkylate Solubilizate

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A PERIODICALLY LOCALIZED TRAVELING WAVE STATE OF BINARY FLUID CONVECTION WITH HORIZONTAL FLOWS

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Journal of Hydrodynamics 2006年第2期18卷 199-205页

作者： NING Li-zhong QI Xin HARADA yoshifumi YAHATA Hideo Institute of Hydraulic Engineering Xi＇an University of Technology Xi＇an 710048 China Department of Applied Physics Faculty of Engineering Fukui University Bunkyo 3-9-11 Fukui 910 Japan Department of Materials Science Faculty of Science Hiroshima University Higashi-Hiroshima 739 Japan

In this paper, the convection structure in a rectangular channel with a horizontal flow was studied for the aspect ratio ГA=12 and the separation ratio ψ=-0.11. Our simulations were preformed by solving the hydrodynamic equations using the SIMPLE method. In the system of binary fluid convection with a horizontal flow, a Periodically Localized Traveling Wave （PLTW） state was found. It has similar behavior to classical Rayleigh-Benard convection in a binary fluid mixture, but the region and wave number of convection change periodically with time. The instability of PLTW depends on the Rayleigh number r and the intensity of horizontal flows Re for given ψ. Thus, the PLTW convection results from the competition between the horizontal flow and the counter-propagating wave near the onset of convection.

关键词： convection horizontal flow periodicity,localized traveling wave state

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Development of perianal ulcer as a result of acute fulminant amoebic colitis

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World Journal of Gastroenterology 2012年第34期18卷 4794-4797页

作者： Takayuki Torigoe yoshifumi Nakayama Koji Yamaguchi Department of Surgery 1 School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan

We report a case of acute fulminant amoebic colitis that resulted in the development of a perianal ulcer in a 29-year-old Japanese homosexual man with acquired immunodeficiency syndrome (AIDS). The patient was admitted to our hospital with a persistent perianal abscess that was refractory to antibiotic therapy adminis-tered at another hospital. On admission, we observed a giant ulcer in the perianal region. At first, cytomega-lovirus colitis was suspected by blood investigations. Ganciclovir therapy was initiated; however, the patient developed necrosis of the skin around the anus during therapy. We only performed end-sigmoidostomy and necrotomy to avoid excessive surgical invasion. Histopathological examination of the surgical specimen revealed the presence of trophozoite amoebae, indicating a final diagnosis of acute fulminant amoebic colitis. The patient's postoperative course was favorable, and proctectomy of the residual rectum was performed 11 mo later. Amoebic colitis is one of the most severe complications affecting patients with AIDS. Particularly, acute fulminant amoebic colitis may result in a poor prognosis; therefore, staged surgical therapy as a lessinvasive procedure should be considered as one of the treatment options for these patients.

关键词：尖锐暴发性的阿米巴的大肠炎 Perianal 溃疡获得的免疫不全症候群 Cytomegalovirus 大肠炎上演外科

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