Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

作     者：Henry F.Duncan Yoshifumi Kobayashi Michaela Kearney Emi Shimizu 

作者机构：Division of Restorative Dentistry&PeriodontologyDublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral BiologyRutgers School of Dental MedicineNewarkNJUSA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第27卷第9期

页      面：574-593页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1003[医学-口腔医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 10[医学] 

基　　金：supported by the following grants to Emi Shimizu National Institute of Dental and Craniofacial Research(NIDCR) grant number R01DE025885 R01DE031812 and a Fulbright Health Impact award 2019 to Henry F.Duncan.The authors have no conflicts of interest to declare 

主　　题：Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping 

摘      要：This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora