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Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

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Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan yoshifumi kobayashi Michaela Kearney Emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

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iPSC-derived cranial neural crest-like cells can replicate dental pulp tissue with the aid of angiogenic hydrogel

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Bioactive Materials 2022年第8期7卷 290-301页

作者： yoshifumi kobayashi Julie Nouet Erdenechimeg Baljinnyam Zain Siddiqui Daniel HFine Diego Fraidenraich Vivek A.Kumar Emi Shimizu Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Cell Biology and Molecular Medicine Rutgers New Jersey Medical SchoolNewarkNJ07103USA Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA

The dental pulp has irreplaceable roles in maintaining healthy teeth and its regeneration is a primary aim of regenerative *** study aimed to replicate the characteristics of dental pulp tissue by using cranial neural crest(CNC)-like cells(CNCLCs);these cells were generated by modifying several steps of a previously established method for deriving NC-like cells from induced pluripotent stem cells(iPSCs).CNC is the anterior region of the neural crest in vertebrate embryos,which contains the primordium of dental pulp cells or *** produced CNCLCs showed approximately 2.5-12,000-fold upregulations of major CNC marker ***,the CNCLCs exhibited remarkable odontoblastic differentiation ability,especially when treated with a combination of the fibroblast growth factors(FGFs)FGF4 and *** FGFs induced odontoblast marker genes by 1.7-5.0-fold,as compared to bone morphogenetic protein 4(BMP4)*** a mouse subcutaneous implant model,the CNCLCs briefly fated with FGF4+FGF9 replicated dental pulp tissue characteristics,such as harboring odontoblast-like cells,a dentin-like layer,and vast neovascularization,induced by the angiogenic self-assembling peptide hydrogel(SAPH),*** acts as a versatile biocompatible scaffold in the canal *** study demonstrated a successful collaboration between regenerative medicine and SAPH technology.

关键词： Regenerative endodontics iPSC Cranial neural crest Fibroblast growth factor Odontoblastic differentiation Angiogenic self-assembling peptide hydrogel

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Cells and material-based strategies for regenerative endodontics

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Bioactive Materials 2022年第8期7卷 234-249页

作者： Zain Siddiqui Amanda M.Acevedo-Jake Alexandra Griffith Nurten Kadincesme Kinga Dabek Dana Hindi Ka Kyung Kim yoshifumi kobayashi Emi Shimizu Vivek Kumar Department of Biomedical Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Oral Biology Rutgers School of Dental MedicineNewarkNJ07103USA Department of Endodontics Rutgers School of Dental MedicineNewarkNJ07103USA Department of Chemicals and Materials Engineering New Jersey Institute of TechnologyNewarkNJ07102USA Department of Biology New Jersey Institute of TechnologyNewarkNJ07102USA

The carious process leads to inflammation of pulp *** care options include root canal treatment or *** procedures,however,result in the loss of tooth vitality,sensitivity,and *** capping and dental pulp regeneration are continually evolving techniques to regenerate pulp tissue,avoiding necrosis and loss of *** studies have successfully employed stem/progenitor cell populations,revascularization approaches,scaffolds or material-based strategies for pulp *** we outline advantages and disadvantages of different methods and techniques which are currently being used in the field of regenerative *** also summarize recent findings on efficacious peptide-based materials which target the dental niche..

关键词： Regenerative endodontics Pulp regeneration Tissue engineering Stem cells Scaffolds

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Involvement of gonadal soma-derived factor in the reproduction of teleosts

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Aquaculture and Fisheries 2024年第3期9卷 417-421页

作者： Tohru kobayashi Laboratory of Molecular Reproductive Biology Institute for Environmental SciencesUniversity of ShizuokaShizuoka422-8526Japan Graduate School of Pharmaceutical and Nutritional Sciences University of ShizuokaShizuoka422-8526Japan

Gonadal soma-derived factor(Gsdf)is a member of the transforming growth factor beta(TGF-β)superfamily and a teleost-specific *** studies suggested that Gsdf promotes spermatogonial proliferation;however recent reports have shed light on its role in sex differentiation based on expression profiles and gain-and loss-of-function *** paper discusses the involvement of Gsdf in gonadal sex differentiation and sex changes in teleosts.

关键词： Teleosts Medaka Gsdf Sex determination Sex differentiation Sex change Pituitary

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Comparison of incidence of acute kidney injury after robot-assisted radical prostatectomy with that after open retropubic and extraperitoneal laparoscopic radical prostatectomies in patients with prostate cancer

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Current Urology 2024年第2期18卷 139-143页

作者： Shunsuke Sato Toshiaki Tanaka Takeshi Maehana Kohei Hashimoto Ko kobayashi Naoya Masumori Department of Urology Sapporo Medical UniversitySapporoJapan

Background:We retrospectively evaluated the postoperative renal function in patients who had undergone radical prostatectomy to compare the incidences of postoperative acute kidney injury(AKI)among the patients who had undergone robot-assisted radical prostatectomy(RARP),retropubic radical prostatectomy(RRP),and extraperitoneal laparoscopic radical prostatectomy(exLRP).Materials and methods:Patients with prostate cancer who had undergone radical prostatectomy at our institution between 2008 and 2014 were ***-assisted radical prostatectomy was performed using an intraperitoneal approach in a 25-degree Trendelenburg position,whereas other procedures were performed with the patient in the supine *** evaluated the serum creatinine levels and estimated glomerular filtration rates immediately after surgery and on postoperative day *** evaluated the incidence of AKI after prostatectomy using the Acute Kidney Injury Network criteria of the Kidney Disease:Improving Global Outcomes ***:A total of 150 consecutive patients were included,with each of the 3 groups(RARP,RRP,and exLRP)comprising 50 *** AKI was observed in 15(30.0%),1(2.0%),and 3(6.0%)patients in the RARP,RRP,and exLRP groups,*** 1 AKI was observed in all the patients except *** incidence of AKI in RARP group was significantly higher than that in the other groups(p<0.001).In the RARP group,the serum creatinine level was significantly elevated immediately after the surgery;however,it returned to baseline on postoperative day *** procedures were the only independent factor associated with AKI ***:This study suggest that compared with RRP and exLRP,RARP is associated with a higher incidence of postoperative AKI,although most patients recover ***-abdominal pneumoperitoneum may contribute to AKI onset.

关键词： Acute kidney injury Renal function Prostatectomy

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Fundamental Study on Response Properties of Structures Constructed on Lunar Regolith

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Open Journal of Earthquake Research 2024年第1期13卷 27-40页

作者： Yuji Miyamoto Takaharu Nakano Toshio kobayashi Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan SANSEI Inc. Tokyo Japan

The Artemis Program, for constructing the lunar base, is in progress. How to design and construct architectural and civil engineering structures in the lunar environment has become an important issue. The lunar surface is covered with soft sand, called regolith, and it is required to protect lunar bases and structures, as well as internal precision equipment, against vibrational disturbances such as moonquakes and meteorite collisions. Therefore, in this study, the static and cyclic triaxial compression tests of the regolith simulant were conducted. The reference strain and equivalent damping factor of the regolith simulant were smaller compared to sandy soil on Earth. In addition, a shaking table test using model specimens was conducted on the response properties of regolith ground alone and structures set on regolith ground. The buried foundation and pile foundation notably suppressed the horizontal response attributed to the rocking component compared to a direct foundation.

关键词： Lunar Development Regolith Soil-Structure Interaction Triaxial Compression Test Shaking Table Test

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TiO₂-PES Fibrous Composite Material for Ammonia Removal Using UV-A Photocatalyst

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 1-19页

作者： Anh Phuong Le Thi Masaru Ohshiro Takaomi kobayashi Department of Science and Technology Innovation Nagaoka University of Technology Nagaoka Japan Kasai Corporation Niigata Japan

This study focused on the development and characterization of TiO2-PES composite fibers with varying TiO2 loading amounts using a phase inversion process. The resulting composite fibers exhibited a sponge-like structure with embedded TiO2 nanoparticles within a polymer matrix. Their photocatalytic performance for ammonia removal from aqueous solutions under UV-A light exposure was thoroughly investigated. The findings revealed that PeTi8 composite fibers displayed superior adsorption capacity compared to other samples. Moreover, the study explored the impact of pH, light intensity, and catalyst dosage on the photocatalytic degradation of ammonia. Adsorption equilibrium isotherms closely followed the Langmuir model, with the results indicating a correlation between qm values of 2.49 mg/g and the porous structure of the adsorbents. The research underscored the efficacy of TiO2 composite fibers in the photocatalytic removal of aqueous under UV-A light. Notably, increasing the distance between the photocatalyst and the light source resulted in de-creased hydroxyl radical concentration, influencing photocatalytic efficiency. These findings contribute to our understanding of TiO2 composite fibers as promising photocatalysts for ammonia removal in water treatment applications.

关键词： Ammonia Removal Photocatalyst TiO2-PES Composite Fiber Fibrous Material

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Unroofing Technique for Anomalous Origin of the Left Coronary Artery from the Right Sinus of Valsalva: Report of a Case

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World Journal of Cardiovascular Surgery 2024年第6期14卷 69-77页

作者： Keisuke Morimoto Futoshi kobayashi Hiromu Horie Yuki Sakaguchi Einosuke Mizuta Department of Cardiovascular Surgery Sanin Rosai Hospital Yonago Japan Department ofCardiology Sanin Rosai Hospital Yonago Japan

Anomalous origin of the left coronary artery (AOLCA) from the right sinus of Valsalva constitutes a rare congenital coronary artery anomaly. Patients with an anomalous left main coronary artery face a significantly higher risk of sudden cardiac death compared to those with an anomalous right coronary artery. The anomalous coronary artery traversing between the ascending aorta and the pulmonary artery markedly heightens the risk of myocardial ischemia, arrhythmia, and sudden death. Symptomatic patients often exhibit a longer intramural course of the coronary artery, which may necessitate earlier intervention or influence the choice of surgical repair method. Surgical intervention is advocated for patients with this anomaly, even in the absence of symptoms. For anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva with an intramural course, coronary unroofing is the preferred revascularization procedure. This report presents a case of AOLCA originating from the right sinus of Valsalva, treated surgically using the unroofing technique for the aortic intramural segment of the anomalous coronary artery traversing between the great vessels. The unroofing technique is recommended for treating AOLCA with an extensive intramural course that does not involve the commissure.

关键词： Unroofing Technique Anomaly of Coronary Artery Anomalous Origin of Left Coronary Artery

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Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota Kami Keishiro Aoki Tomoyuki Satake Tatsushi kobayashi Motokazu Sugimoto Shin kobayashi Masaru Konishi Naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

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Static Stretching Combined with Conscious Slower Breathing May Increase Parasympathetic Activity and Reduce Stress in Adult Women

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Health 2024年第3期16卷 242-256页

作者： Mami Sakurai Yasushi Ikarashi Masahiro Tabuchi Ailing Hu Takuji Yamaguchi Hiroyuki kobayashi Department of Hospital Administration Juntendo University Graduate School of Medicine Tokyo Japan Department of Beauty & Wellness Professional University of Beauty & Wellness Yokohama Japan Department of Personalized Kampo Medicine Juntendo University Graduate School of Medicine Tokyo Japan

Background: Women are thought to be more susceptible to stress than men in a stressful society, and reducing stress is crucial for women to maintain their health. Static stretching (SST) is applied in various fields to not only increase muscle flexibility but also reduce stress. Additionally, conscious slower breathing (CSB) predominates parasympathetic activity, causing a relaxing effect. These results indicate that combining SST and CSB may be more useful in reducing stress. However, to the best of our knowledge, the effect of this combination remains unclear. Objective: This study aimed to elucidate the effects of the combination of SST and CSB on autonomic activity and stress in adult women. Methods: Eleven healthy Japanese adult female participants performed SST with nonconscious natural breathing for 20 min. The same participants performed SST in combination with CSB (2 s inspiratory and 4 s expiratory) for 20 min on another day. Salivary cortisol and chromogranin A levels were measured before and after stretching as stress markers of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system. The coefficient of variation of the R-R interval (CVR-R) and high-frequency component (HF), which reflect parasympathetic nerve activity, and heart rate and low-frequency component (LF)/HF ratio, which reflect sympathetic nerve activity, were measured before, during, and after stretching. Results: SST decreased cortisol levels but with no significant changes in chromogranin A, heart rate, CVR-R, HF, or LF/HF ratio. The combination of SST and CSB increased CVR-R and HF levels in addition to decreasing cortisol levels but with no significant changes in chromogranin A, heart rate, or LF/HF levels. Conclusion: These results indicate that the combination of SST and CSB may increase parasympathetic activity and reduce stress. However, future randomized controlled trials with larger sample sizes should support this conclusion.

关键词： Static Stretching Conscious Slower Breathing Autonomic Activity Heart Rate Variability Stress

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