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A novel missense variant in ACAA1 contributes to early-onset Alzheimer’s disease,impairs lysosomal function,and facilitates amyloid-p pathology and cognitive decline

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2920-2935页

作者： Rongcan Luo Yu Fan Jing Yang Maosen Ye Deng-Feng Zhang Kun Guo Xiao Li Rui Bi Min Xu Lu-Xiu Yang Yu Li Xiaoqian Ran Hong-Yan Jiang Chen Zhang Liwen Tan Nengyin Sheng yong-gang yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnanChina Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnanChina State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Department of Psychiatry The First Affiliated Hospital of Kunming Medical UniversityKunmingChina Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Mental Health Institute of the Second Xiangya Hospital Central South UniverstyChangshaChina Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnanChina CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Alzheimer’s disease(AD)is characterized by progressive synaptic dysfunction,neuronal death,and brain atrophy,with amyloid-p(Ap)plaque deposits and hyperphosphorylated tau neurofibrillary tangle accumulation in the brain tissue,which all lead to loss of cognitive *** mutations in the well-known AD causal genes including APP,PSEN1,and PSEN2 impair a variety of pathways,including protein processing,axonal transport,and metabolic *** we identified a missense variant rs117916664(c.896T>C,***299Ser[p.N299S])of the acetyl-CoA acyltransferase 1(ACM1)gene in a Han Chinese AD family by whole-genome sequencing and validated its association with early-onset familial AD in an independent *** in vitro and in vivo evidence showed that ACAA1 p.N299S contributes to AD by disturbing its enzymatic activity,impairing lysosomal function,and aggravating the Ap pathology and neuronal loss,which finally caused cognitive impairment in a murine *** findings reveal a fundamental role of peroxisome-mediated lysosomal dysfunction in AD pathogenesis.

关键词： Alzheimer amyloid lysosomal

Infectivity of SARS-CoV-2 and protection against reinfection in rats

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Zoological Research 2022年第6期43卷 945-948页

作者： Dandan Yu Yanghaopeng Long Ling Xu Jian-Bao Han Jiawei Xi Jianlin Xu Lu-Xiu Yang Xiao-Li Feng Qing-Cui Zou Wang Qu Jiangwei Lin Ming-Hua Li yong-gang yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China

DEAR EDITOR,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pandemic remains an important global public health issue. In this study, we unexpectedly found that wildtype Sprague-Dawley(SD) rats can be infected with the SARS-CoV-2 prototype. Our results showed direct experimental evidence of the infectivity of SARS-CoV-2 infection, subsequent pathogenicity, and protection against reinfection in rats.

关键词： infection rats acute

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A cynomolgus monkey with naturally occurring Parkinson's disease

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National Science Review 2021年第3期8卷 17-20页

作者： Hao Li Ling-Yan Su Lixin Yang Min Li Qianjin Liu Zhenhui Li Yan Hu Hongwei Li Shihao Wu Wenchao Wang Yingzhou Hu Zhengbo Wang Joshua D.Rizak Baihui Huang Min Xu Jing Wu Long-Bao Lv Christoph W.Turck yong Yin yong-gang yao Bing Su Xintian Hu Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Shenzhen Key Laboratory for Molecular Biology of Neural Development Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and Manipulation The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences China Kunming College of Life Science University of Chinese Academy of Sciences Institute of Neuroscience CAS Key Laboratory of Primate Neurobiology State Key Laboratory of NeuroscienceChinese Academy of Sciences National Resource Center for Non-Human Primates Kunming Primate Research Center and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility) Kunming Institute of Zoology Chinese Academy of Sciences Max Planck Institute of Psychiatry Department of Translational Research in Psychiatry Department of Rehabilitation Medicine the Second People’s Hospital of Yunnan Province Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences KIZ–CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Evidence for the existence of monkeys with spontaneous Parkinson’s disease (PD) has been lacking. Here,we screened macaque colonies at the Kunming Primate Research Center(Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC) accredited), Kunming Institute of Zoology, Chinese Academy of Sciences, which has a large population of monkeys (>2400), to identify naturally occurring PD monkeys.

关键词： ALPHA-SYNUCLEIN

An artificial systems,computational experiments and parallel execution-based surface electromyogram-driven anti-disturbance zeroing neurodynamic strategy for upper limb human-robot interaction control

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 511-525页

作者： yongbai Liu Keping Liu gang Wang Jiliang Zhang yao Chou Zhongbo Sun Department of Mechanical Engineering Changchun University of TechnologyChangchunChina Department of Control Engineering Changchun University of TechnologyChangchunChina School of Electrical and Information Engineering Jilin Engineering Normal UniversityChangchunChina College of Information Science and Engineering Northeastern UniversityShenyangChina Department of Electrical and Computer Engineering Brigham Young UniversityProvoUtahUSA

In recent years,intelligent robots are extensively applied in the field of the industry and intelligent rehabilitation,wherein the human-robot interaction(HRI)control strategy is a momentous part that needs to be ***,the efficacy and robustness of the HRI control algorithm in the presence of unknown external disturbances deserve to be *** deal with these urgent issues,in this study,artificial systems,computational experiments and a parallel execution intelligent control framework are constructed for the HRI *** upper limb-robotic exoskeleton system is re-modelled as an artificial *** on surface electromyogram-based subject's active motion intention in the practical system,a non-convex function activated anti-disturbance zeroing neurodynamic(NC-ADZND)controller is devised in the artificial system for parallel interaction and HRI control with the practical ***,the linear activation function-based zeroing neurodynamic(LAF-ZND)controller and proportionalderivative(posterior deltoid(PD))controller are presented and *** results substantiate the global convergence and robustness of the proposed controller in the presence of different external *** addition,the simulation results verify that the NC-ADZND controller is better than the LAF-ZND and the PD controllers in respect of convergence order and anti-disturbance characteristics.

关键词： neural network pattern recognition robotics signal processing

The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks

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Zoological Research 2021年第6期42卷 834-844页

作者： Min-Sheng Peng Jian-Bo Li Zheng-Fei Cai Hang Liu Xiaolu Tang Ruochen Ying Jia-Nan Zhang Jia-Jun Tao Ting-Ting Yin Tao Zhang Jing-Yang Hu Ru-Nian Wu Zhong-Yin Zhou Zhi-gang Zhang Li Yu yong-gang yao Zheng-Li Shi Xue-Mei Lu Jian Lu Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunmingYunnan 650091China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Molbreeding Biotechnology Co. Ltd.ShijiazhuangHebei 050035China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunmingYunnan 650201China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650201China

Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks.A significant gap remains for the possible role of pangolins as a reservoir of SARS-CoV-2 related coronaviruses(SC2r-CoVs).Here,we screened SC2r-CoVs in 172 samples from 163 pangolin individuals of four species,and detected positive signals in muscles of four Manis javanica and,for the first time,one *** analysis of pangolin mitochondrial DNA traced their origins from Southeast *** in-solution hybridization capture sequencing,we assembled a partial pangolin SC2r-CoV(pangolin-CoV)genome sequence of 22895 bp(MP20)from the *** *** analyses revealed MP20 was very closely related to pangolin-CoVs that were identified in *** seized by Guangxi Customs.A genetic contribution of bat coronavirus to pangolin-CoVs via recombination was *** analysis revealed that the genetic diversity of pangolin-CoVs is substantially higher than previously *** the potential infectivity of pangolin-CoVs,the high genetic diversity of pangolin-CoVs alerts the ecological risk of zoonotic evolution and transmission of pathogenic SC2r-CoVs.

关键词： SARS-CoV-2 Pangolin Recombination Diversity Sequencing mtDNA

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Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1βand BDNF

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Neuroscience Bulletin 2024年第4期40卷 466-482页

作者： Shuxia Zhang Yeru Chen yongjie Wang Hongwei Wang Dandan yao gang Chen Department of Anesthesiology School of MedicineSir Run Run Shaw HospitalZhejiang UniversityHangzhou310016China Key Laboratory of Elemene Anti-Cancer Medicine of Zhejiang Province and Holistic Integrative Pharmacy Institutes Hangzhou Normal UniversityHangzhou311121China Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province Holistic Integrative Pharmacy InstitutesHangzhou Normal UniversityHangzhou311121China

Microtubule-associated protein Tau is responsible for the stabilization of neuronal microtubules under normal physiological *** attention has been focused on Tau’s contribution to cognition,but little research has explored its role in emotions such as pain,anxiety,and *** the current study,we found a significant increase in the levels of p-Tau(Thr231),total Tau,IL-1β,and brain-derived neurotrophic factor(BDNF)on day 7 after complete Freund's adjuvant(CFA)injection;they were present in the vast majority of neurons in the spinal dorsal *** of Mapt-shRNA recombinant adeno-associated virus into the spinal dorsal cord alleviated CFA-induced inflammatory pain and inhibited CFA-induced IL-1βand BDNF ***,Tau overexpression was sufficient to induce hyperalgesia by increasing the expression of IL-1βand ***,the activation of glycogen synthase kinase 3 beta partly contributed to Tau *** findings suggest that Tau in the dorsal horn could be a promising target for chronic inflammatory pain therapy.

关键词： Tau Inflammatory pain IL-1β BDNF

Soil conditioning of clay based on interface adhesion mechanism:Microscopic simulation and laboratory experiment

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Underground Space 2024年第5期18卷 239-255页

作者： yong Fang Bin Zhuo Ruyue Zhang Yubo Wang Liupan Dou Yuxiang yao Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China

Clogging frequently occurs in the cutter head,excavation chamber or screw conveyor when an earth pressure balance(EPB)shield machine is tunneling in soft or silty clay ground with high clay mineral *** this paper,montmorillonite,kaolinite,and illite were selected as research objects,and molecular dynamics simulation and laboratory experiment were *** the microscopic scale,dynamic contact behavior and interfacial mechanical behavior of the interface between clay minerals and water/surfactant solution was simulated and the interfacial adhesion and conditioning mechanism between clay minerals and water/surfactant solution was ***,sodium dodecyl benzene sulfonate surfactant was selected as the main composition of the soil ***,the adhesion stress before and after soil conditioning and the contact angles between clay minerals and water/surfactant solution were tested and analyzed at the macroscopic *** result shows that the contact angle between droplet and clay mineral surface is an important parameter to characterize soil *** simulation rules of the microscopic contact angle are consistent with the experiment ***,the adsorption energy between microscopic substances is dominated by electrostatic force,which can reflect the adhesion stress between macroscopic *** adhesion stress can be effectively decreased by adding the surfactant to the soil conditioner.

关键词： EPB clogging Clay minerals Microscopic simulation Mechanism analysis Laboratory experiment Adhesion stress

The impact of special issues

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Zoological Research 2015年第2期36卷 64-64页

作者： yong-gang yao Yun ZHANG Kunming Institute of Zoology Chinese Academy of Sciences

With support from many authors from many different scientific fields,Zoological Research（ZR）successfully released eight special issues from 2011 to 2014 on various topics,including Animal Ecology and Resources,Animal Genetic Diversity,Development and Evolution,Fish Diversity and Primates and Animal Models of Human *** special issues strongly align with our aims and scope,

关键词： The impact of special issues

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Shaking table test on a tunnel-group metro station in rock site under harmonic excitation

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1362-1377页

作者： Ruozhou LI Weiguo HE Xupeng yao Qingfei LI Dingli ZHANG yong YUAN Department of Geotechnical Engineering Tongji UniversityShanghai 200092China China Railway Liuyuan Group Co. Ltd.Tianjin 300308China Key Laboratory of Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China

A tunnel-group metro station built in rock site is composed of a group of *** tunnels and their interconnections can show inconsistent responses during an *** study investigates the dynamic responses of such a metro station in a rock site,by shaking table *** lining structures of each tunnel and surrounding rock are modeled based on the similitude law;foam concrete and gypsum are used to model the ground-structure system,keeping relative stiffness consistent with that of the prototype.A series of harmonic waves are employed as excitations,input along the transverse and longitudinal direction of the shaking *** discrepant responses caused by the structural irregularities are revealed by measurement of acceleration and strain of the *** characteristics are identified by the transfer function method in white noise *** test results show that the acceleration response and strain response of the structure are controlled by the *** particular,the acceleration amplification effect at the opening section of the station hall is more significant than that at the standard section under transverse excitation;the amplification effect of the structural opening is insignificant under longitudinal excitation.

关键词： metro station tunnel-group shaking table test harmonic excitation dynamic response