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Neural Regeneration Research 2023年第7期18卷 1495-1496页

作者： UCCAODeokhoLee yohei tomita Kazuno Negishi Toshihide Kurihara Department of Ophthalmology Keio University School of MedicineShinanomachiShinjuku-kuJapan

Ischemic retinopathy is a retinal disease caused by ischemic *** is a common pathologic mechanism in various retinal disorders and diseases such as age-related macular degeneration,diabetic retinopathy,glaucoma,or vascular occlusion(Osborne et al.,2004).Although various murine models have been developed to understand a series of metabolic mechanisms induced by retinal ischemia and further used to test promising therapeutics,effective treatment in ischemic retinopathy has not been clearly *** is associated with the notion that the contributing pathologic metabolic pathways might be enormously complex.

关键词： retinopathy degeneration

Seismic assessment of two multi-tiered pagodas damaged by the 2015 Nepal earthquake

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Earthquake Engineering and Engineering Vibration 2021年第2期20卷 453-469页

作者： yohei Endo Toshikazu Hanazato Department of Architecture Shinshu University4-17-1 WakasatoNagano 380-8553Japan Department of Architecture Mie University1577 Kurimamachiya-chōTsuMie 514-8507MieJapan

A seismic assessment of two multi-tier pagodas by numerical analysis is presented *** Changu Narayan temple and the Kumbeshwar temple in Nepal are used as the case *** pagodas are built of brick masonry in earthen mortar,with timber columns and *** Changu Narayan temple is a two-tier pagoda,and was seriously damaged during the 2015 Gorkha *** Kumbeshwar temple is a five-tier pagoda,and its top-tier collapsed due to the Gorkha earthquake.A seismic assessment was carried out using finite element(FE)*** FE models were prepared,and dynamic identification tests and penetrometer tests were *** analysis and nonlinear dynamic analysis were performed as part of the seismic *** main shock of the 2015 Gorkha earthquake was considered as the input *** behavior between the two pagodas was compared with the collapse mechanisms and damage patterns observed in the actual *** comparison suggested common structural features of multi-tier *** study is dedicated to providing a better understanding of the seismic behavior of multi-tier pagoda-type structures and provides suggestions for their effective analysis.

关键词： masonry multi-tier pagoda seismic assessment nonlinear dynamic analysis FEM analysis

Evolution of the “Neutral” : Diverse Forms of Wide-Compatibility Haplotypes at the Locus for Reproductive Isolation

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Molecular Plant 2020年第4期13卷 539-540页

作者： yohei Koide Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan

One of the biggest questions in evolutionary biology is how biological species *** biological species are groups of interbreeding natural populations reproductively isolated from other such groups(Mayer,1942),reproductive isolation is the key process of the *** various isolating barriers,postzygotic barriers ranging from maladaptation to inviability or sterility in the offspring have attracted biologists’attention because of the problem of the evolution of the“unfit”offspring.A clear model to solve this problem is the Dobzhansky-Muller(DM)model(Figure 1;Coyne and Orr,2004),in which incompatibilities are generally caused by an interaction between the genes that have functionally diverged in each population without selection opposing any intermediate step(Coyne and Orr,2004).

关键词： Figure Forms breeding

Synthesis and sintering of samarium rich SmS_x and its electrical property

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Journal of Rare Earths 2016年第10期34卷 1042-1047页

作者： Liang Li Shinji Hirai yohei Tasaki Department of Materials Science and Engineering Muroran Institute of Technology

Non-stoichiometric samarium monosulfide（SmS_x, 0.55≤x≤1.2） was synthesized from Sm_2S_3 and SmH_3 at 1273 K for 3 h under vacuum. The influence of reaction ratio of Sm_2S_3 to SmH_3 on the fabrication of SmS_x was investigated. The fabrication of SmS required the molar ratio of Sm_2S_3 to SmH_3 above 1. Lattice parameter of synthetic SmS_x increased firstly and then decreased to saturate following with the addition of SmH_3 content. SmS_x compact was sintered at 1373 K by spark plasma sintering. Density of synthetic SmS_x was about 99% of theory density. Seebeck coefficient of n-type semiconductor Sm Sx decreased as temperature rose. The absolute value was distributed between 170–280 μV/K. The electrical resistivity of SmS_x（0.86≤x≤1.07） decreased with temperature increasing and showed similar temperature dependence. The surplus Sm which randomly distributed in the SmS_x（0.55≤x≤0.75） matrix led to a remarked reduction of electrical resistivity. The optimized power factor for SmS_（0.6） and Sm S_（0.75） could reach 1500 μW/（K^2·m） at 600 K.

关键词： samarium monosulfide SmH_3 Seebeck coefficient electrical resistivity rare earths

Large Eddy Simulation of Swirling Jet in a Bluff-Body Burner

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Journal of Thermal Science 2005年第1期14卷 28-33页

作者： yohei FUJIMOTO Yuzo INOKUCHI Nobuhiko YAMASAKI Department of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581JapanDepartment of Aeronautics and Astronautics Kyushu-University 6-10-1HakozakiHigashikuFukuoka812-8581Japan

The large eddy simulation (LES) is applied to an unconfined swirling flow of an air surrounding a bluff-body having a central jet of air, and the complicated flowfield that involves the recirculation and vortex breakdown is investigated. The Smagorinsky model is used as the sub-grid scale model. The results of the present numerical simulation are compared with the experimental data of the mean and stochastic root mean square (RMS) variations of two velocity components. Although the inflow conditions are specified in a simple manner, the obtained numerical results are in reasonable agreement with the experiments, except for a part of RMS variation values near downstream of the bluff body. The present numerical calculations can successfully reproduce the two characteristics of the flow, i.e., an upstream recirculation zone established just downstream of the burner plane and the additional recirculation zone established at the more downstream location.

关键词： large eddy simulation swirl bluff-body recirculation.

Computational fluid dynamics simulation of Hyperloop pod predicting laminar–turbulent transition

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Railway Engineering Science 2020年第1期28卷 97-111页

作者： Nathalie Nick yohei Sato Department of Mechanical and Process Engineering Swiss Federal Institute of TechnologyETH ZurichLEO B 9.1Leonhardstrasse 278092 ZurichSwitzerland Nuclear Energy and Safety Research Division Paul Scherrer InstituteForschungsstrasse 1115232 Villigen PSISwitzerland

Three-dimensional compressible flow simulationswere conducted to develop a Hyperloop pod. Thenovelty is the usage of Gamma transition model, in whichthe transition from laminar to turbulent flow can be ***, a mesh dependency study was undertaken,showing second-order convergence with respect to themesh refinement. Second, an aerodynamic analysis for twodesigns, short and optimized, was conducted with thetraveling speed 125 m/s at the system pressure 0.15 *** concept of the short model was to delay the transitionto decrease the frictional drag;meanwhile that of theoptimized design was to minimize the pressure drag bydecreasing the frontal area and introduce the transitionmore toward the front of the pod. The computed resultsshow that the transition of the short model occurred moreon the rear side due to the pod shape, which resulted in 8%smaller frictional drag coefficient than that for the optimizedmodel. The pressure drag for the optimized designwas 24% smaller than that for the short design, half ofwhich is due to the decrease in the frontal area, and theother half is due to the smoothed rear-end shape. The totaldrag for the optimized model was 14% smaller than that forthe short model. Finally, the influence of the systempressure was investigated. As the system pressure and theReynolds number increase, the frictional drag coefficientincreases, and the transition point moves toward the front,which are the typical phenomena observed in the transitionregime.

关键词： Computational fluid dynamics(CFD) Drag Subsonic compressible flow Hyperloop Laminar-turbulent transition

Synthesis of Nitrogen-doped Titania by Solvothermal Reactions in Alcohols

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过程工程学报 2006年第3期6卷 472-476页

作者： Tsugio Sato yohei Aida Masakazu Komatsu 殷澍 Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

Nitrogen-doped titania nanoparticles were obtained by the homogeneous precipitation in hexamethylenetetraminetitanium trichloride-alcohol aqueous solutions at 90 ℃ followed by heating at 190 ℃. Anatase, rutile and brookite were obtained, where the crystallite size, specific surface area and color greatly changed as 5～50 nm, 20～200 m2/g and light gray to yellow, depending on the solvent and pH. The products after calcination were yellow, indicating doping with nitrogen ion. All colored titania showed photocatalytic activity under visible light irradiation for the oxidative decomposition of nitrogen monoxide in air. Especially, the nanoparticles of anatase type nitrogen-doped titania obtained using methanol aqueous solution showed excellent photocatalytic activity.

关键词： nitrogen-doped titania solvothermal synthesis alcohol photocatalysis nitrogen monoxide decomposition

A Fine-Grained Runtime Power/Performance Optimization Method for Processors with Adaptive Pipeline Depth

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Journal of Computer Science & Technology 2011年第2期26卷 292-301页

作者：姚骏 Shinobu Miwa Hajime Shimada Shinji tomita Graduate School of Information Science Nara Institute of Science and Technology School of Engineering Tokyo University of Agriculture and Technology Graduate School of Informatics Kyoto University Institute for Integrated Cell-Material Sciences Kyoto University

Recently, a method known as pipeline stage unification （PSU） has been proposed to alleviate the increasing energy consumption problem in modern microprocessors. PSU achieves a high energy efficiency by employing a changeable pipeline depth and its working scheme is eligible for a fine control method. In this paper, we propose a dynamic method to study fine-grained program interval behaviors based on some easy-to-get runtime processor metrics. Using this method to determine the proper PSU configurations during the program execution, we are able to achieve an averaged 13.5% energydelay-product （EDP） reduction for SPEC CPU2000 integer benchmarks, compared to the baseline processor. This value is only 0.14% larger than the theoretically idealized controlling. Our hardware synthesis result indicates that the proposed method can largely decrease the hardware overhead in both area and delay costs, as compared to a previous program study method which is based on working set signatures.

关键词： dynamic optimization energy saving fine-grained pipeline stage unification workload analysis

Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome

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Journal of Integrative Plant Biology 2010年第7期52卷 679-691页

作者： Motonori tomita Munenori Asao Aya Kuraki Molecular Genetics Laboratory Faculty of AgricultureTottori University

New classes of repetitive DNA elements were effectively identified by isolating small fragments of the elements from the wheat genome. A wheat A genome library was constructed from Triticum monococcum by degenerate cleavage with EcoO1091, the recognition sites of which consisted of 5＇-PuGGNCCPy-3＇ multi-sequences. Three novel repetitive sequences pTm6, pTm69 and pTm58 derived from the A genome were screened and tested for high copy number using a blotting approach, pTm6 showed identity with integrase domains of the barley Tyl-Copia-retrotransposon BARE-1 and pTm58 showed similarity to the barley Ty3-gypsy-like retrotransposon Romani. pTm69, however, constituted a tandem array with useful genomic specificities, but did not share any identity with known repetitive elements. This study also sought to isolate wheat D-genome-specific repetitive elements regardless of the level of methylation, by genomic subtraction. Total genomic DNA of Aegilops tauschii was cleaved into short fragments with a methylation-insensitive 4 bp cutter, Mbol, and then common DNA sequences between Ae. tauschii and Triticum turgidum were subtracted by annealing with excess T. turgidum genomic DNA. The D genome repetitive sequence pAt1 was isolated and used to identify an additional novel repetitive sequence family from wheat bacterial artificial chromosomes with a size range of 1 395-1 850 bp. The methods successfully led pathfinding of two unique repetitive families.

关键词： DNA Effective Isolation of Retrotransposons and Repetitive DNA Families from the Wheat Genome AABB

β-Arrestin 1(ARRB1) serves as a molecular marker of the peripheral circadian rhythm

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International Journal of Oral Science 2019年第4期11卷 307-314页

作者： Tatsunosuke tomita Taisuke Mori Yoshiaki Onishi Biomedical Research Institute National Institute of Advanced Industrial Science and Technology(AIST)DBT-AIST International Laboratory for Advanced Biomedicine(DAILAB)Higashi 1-1-1TsukubaJapan Molecular Pathology Division and Diagnostic Pathology Division National Cancer Center Research InstituteTsukiji 5-5-1Chuo-kuTokyoJapan

The control of the circadian rhythm is important for health because it regulates physiological functions and is associated with health *** aimed to identify a circadian biomarker of health status in human saliva,since collecting saliva is non-invasive,straightforward,and *** 500 genes potentially controlled by the salivary clock identified using chromatin immunoprecipitation(ChIP)assays,22 of them showed reasonable transcriptional responses according to a DNA array in a salivary model *** these 22 genes,ARRB1,which is expressed in human salivary glands,was also expressed in model HSG cells at the transcriptional and translational *** profile of ARRB1 expression in human saliva was circadian,suggesting that ARRB1 could serve as a candidate circadian biomarker in *** compared ARRB1 with other biomarkers in salivary samples from jetlagged *** circadian profile of ARRB1 reflected the time lag more than the profile of melatonin,whereas the profiles of cortisol andα-amylase did not reflect the time ***,these findings suggest that salivary ARRB1 could serve as a candidate biomarker that could be used to monitor the internal body clock.

关键词： salivary circadian straight