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Lifestyle improvement and the reduced risk of cardiovascular disease:the China-PAR project

Journal of Geriatric Cardiology 2023年第11期20卷 779-787页

作者： ying-ying JIANG Fang-Chao liu Chong SHEN Jian-Xin LI Ke-Yong HUANG Xue-Li YANG Ji-Chun CHEN Xiao-Qing liu Jie CAO Shu-Feng CHEN Ling YU ying-Xin ZHAO Xian-Ping WU Lian-Cheng ZHAO ying LI Dong-Sheng HU Jian-Feng HUANG Xiang-Feng LU Dong-Feng GU Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijingChina Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijingChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouChina Department of Cardiology Fujian Provincial HospitalFuzhouChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanChina Sichuan Center for Disease Control and Prevention ChengduChina Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CenterShenzhenChina School of Medicine Southern University of Science and TechnologyShenzhenChina

BACKGROUND The benefits of healthy lifestyles are well recognized. However, the extent to which improving unhealthy lifestyles reduces cardiovascular disease(CVD) risk needs to be discussed. We evaluated the impact of lifestyle improvement on CVD incidence using data from the China-PAR project(Prediction for Atherosclerotic Cardiovascular Disease Risk in China).METHODS A total of 12,588 participants free of CVD were followed up for three visits after the baseline examination. Changes in four lifestyle factors(LFs)(smoking, diet, physical activity, and alcohol consumption) were assessed through questionnaires from the baseline to the first follow-up visit. Cox proportional hazard models were used to estimate hazard ratios(HRs) and corresponding 95% confidence intervals(CIs). The risk advancement periods(RAPs: the age difference between exposed and unexposed participants reaching the same incident CVD risk) and population-attributable risk percentage(PAR%) were also *** A total of 909 incident CVD cases occurred over a median follow-up of 11.14 years. Compared with maintaining 0-1healthy LFs, maintaining 3–4 healthy LFs was associated with a 40% risk reduction of incident CVD(HR = 0.60, 95% CI: 0.45–0.79)and delayed CVD risk by 6.31 years(RAP:-6.31 [-9.92,-2.70] years). The PAR% of maintaining 3–4 unhealthy LFs was 22.0%compared to maintaining 0-1 unhealthy LFs. Besides, compared with maintaining two healthy LFs, improving healthy LFs from 2to 3–4 was associated with a 23% lower risk of CVD(HR = 0.77, 95% CI: 0.60–0.98).CONCLUSIONS Long-term sustenance of healthy lifestyles or improving unhealthy lifestyles can reduce and delay CVD risk.

关键词： hazard maintaining alcohol

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Si-doped Li_(6)PS_(5)I with enhanced conductivity enables superior performance for all-solid-state lithium batteries

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Chinese Chemical Letters 2024年第10期35卷 479-484页

作者： liang Ming Dan liu Qiyue Luo Chaochao Wei Chen liu Ziling Jiang Zhongkai Wu Lin Li Long Zhang Shijie Cheng Chuang Yu State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Scienceand TechnologyWuhan430074China School of Chemistry and Chemical Engineering Huazhong University of Science and TechnologyWuhan 430074China State Grid Hubei Electric Power Research Institute Wuhan 430077China College of Physics and Energy Fujian Normal UniversityFuzhou 350117China

Lithium argyrodites Li_(6)PS_(5)X(X=Cl,Br,I)show great potential as solid electrolytes for solid-state lithium batteries due to their high Li-ion conductivities and excellent electrode ***,the relatively low conductivity of Li_(6)PS_(5)I(10^(-6)m S/cm)compared to the other two compositions limits its ***,Si-doped Li_(6.5)P_(0.5)Si_(0.5)S_(5)I electrolyte is designed and synthesized with superior high conductivity of 3.6 mS/*** characterization proves the increase due to the anion disorder and volume expansion caused by ***,the poor interfacial stability between layered oxide cathode Li Ni_(0.6)Co_(0.2)Mn_(0.2)O_(2)and Li_(6.5)P_(0.5)Si_(0.5)S_(5)I inhibits its battery *** introducing Li_(3)InCl6electrolyte in the configuration,the corresponding battery delivers high initial discharge capacity of 150.2m Ah/g and superior cyclability during 250 cycles at 0.5 *** work offers design strategy to obtain Li_(6)PS_(5)I-based electrolytes for high performance solid-state batteries.

关键词： Argyrodite electrolyte Li_(6.5)P_(0.5)Si_(0.5)S_(5)I All-solid-state lithiumbatteries Stability Electrochemical performance

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酮体代谢与肾脏疾病

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四川大学学报（医学版） 2023年第6期54卷 1091-1096页

作者：刘颖马良付平四川大学华西医院肾脏内科成都610041 四川大学华西医院肾脏病研究所成都610041

生酮饮食限制葡萄糖供能,刺激脂肪分解氧化生酮,使循环中酮体水平升高。酮体在肝细胞线粒体基质中产生,β-羟丁酸(beta-hydroxybutyrate, BHB)为酮体的主要成分。本文对酮体的代谢、BHB在肾脏疾病中的功能作用进行综述。酮体通过血液循... 详细信息

生酮饮食限制葡萄糖供能,刺激脂肪分解氧化生酮,使循环中酮体水平升高。酮体在肝细胞线粒体基质中产生,β-羟丁酸(beta-hydroxybutyrate, BHB)为酮体的主要成分。本文对酮体的代谢、BHB在肾脏疾病中的功能作用进行综述。酮体通过血液循环分布到代谢活跃的组织作为替代能源供能;BHB作为信号分子,介导多种细胞信号转导,参与多种疾病的发生发展过程。BHB对多种肾脏疾病也具有保护和治疗作用,通过抗氧化、抑制炎症与应激机制改善糖尿病肾病、慢性肾脏病、急性肾损伤、多囊肾病等肾脏疾病的预后。现有的研究聚焦于酮体在免疫细胞中调节炎症、氧化应激反应中的作用,循环中酮体水平升高对肾脏足细胞、肾小管细胞代谢的影响仍未有定论;对肾脏疾病中足细胞损伤、足细胞衰老的作用仍需进一步研究。

关键词：酮体肾脏疾病抗炎抗氧化综述

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Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative dues for subtyping schizophrenia patients

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Journal of Molecular Cell Biology 2019年第8期11卷 678-687页

作者： liang Ma Edmund T.Rolls Xiuqin liu Yuting liu Zeyu Jiao Yue Wang Weikang Gong Zhiming Ma Fuzhou Gong Lin Wan CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China National Center of Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Computer Science University of Warwick Coventry CV4 7AL UK Oxford Centre for Computational Neuroscience Oxford 0X2 7JF UK School of Mathematics and Physics University of Science and Technology Beijing Beijing 100083 China School of Science Beijing Jiaotong University Beijing 100044 China Centre for Computational Systems Biology School of Mathematical Sciences Fudan University Shanghai 200433 China CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China

Analysis Unking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains ***, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PANSS) to explore the etiology of schizophrenia. With 72 drug-naive schizophrenic first episode patients (FEPs) and 73 matched heathy controls, we identified 108 genes, from schizophrenia risk genes, that correlated significantly with GMV, which are highly co-expressed in the brain during development. Among these 108 candidates, 19 distinct genes were found associated with 16 brain regions referred to as hot clusters (HCs), primarily in the frontal cortex, sensory-motor regions and temporal and parietal *** patients were subtyped into three groups with distinguishable PANSS scores by the GMV of the identified HCs. Furthermore, we found that HCs with common GMV among patient groups are related to genes that mostly mapped to pathways relevant to neural signaling, which are associated with the risk for *** results provide an integrated view of how genetic variants may affect brain structures that lead to distinct disease *** method of multi-scale analysis that was described in this research, may help to advance the understanding of the etiology of schizophrenia.

关键词： Schizophrenia PANSS multi-scale analysis hot cluster grey matter volume pathway

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Modified gelatin with quaternary ammonium salts containing epoxide groups

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Chinese Chemical Letters 2014年第8期25卷 1193-1197页

作者： Ya-Ming liu Xiao Cui Chuan-Ming Hao Fu-Rong Tao Jun-ying Li Shandong Provincial Key Laboratory of Fine Chemicals Qilu University of Technology School of Marine Science and Engineering Tianjin University of Science and Technology

An EPDDMAC-GE polymer （hydrophilic molecule） has been synthesized based on epoxypropyl dodecyl dimethyl ammonium chloride （EPDDMAC） and gelatin. A DEEPSAC-GE polymer （hydrophobic molecule） has been synthesized based on diethyl-2,3-epoxypropyl-[3-methyldimethoxyl] silpropyl ammonium chloride （DEEPSAC） and gelatin. Compared with initial gelatin, the gelatin modified with quaternary ammonium salts containing epoxide groups exhibits stronger antibacterial activity.

关键词： Quaternary ammonium salts Epoxide group Gelatin Modified

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Metal-organic framework-derived porous shuttle-like vanadium oxides for sodium-ion battery application

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Nano Research 2018年第1期11卷 449-463页

作者： Yangsheng Cai Guozhao Fang Jiang Zhou Sainan liu Zhigao Luo Anqiang Pan Guozhong Cao I Shuquan liang School of Materials Science and Engineering Central South University Changsha 410083 China Key Laboratory of Nonferrous Metal Materials Science and Engineering Ministry of Education Central South University Changsha 410083 China Department of Materials and Engineering University of Washington Seattle WA 98195-2120 USA

Vanadium oxides with a layered structure are promising candidates for both lithium-ion batteries and sodium-ion batteries （SIBs）. The self-template approach, which involves a transformation from metal-organic frameworks （MOFs） into porous metal oxides, is a novel and effective way to achieve desirable electrochemical performance. In this stud~ porous shuttle-like vanadium oxides （i.e., V205, V203/C） were successfully prepared by using MIL-88B （V） as precursors with a specific calcination process. As a proof-of-concept application, the as- prepared porous shuttle-like VaOdC was used as an anode material for SIBs. The porous shuttle-like V203/C, which had an inherent layered structure with metallic behavior, exhibited excellent electrochemical properties. Remarkable rate capacities of 417, 247, 202, 176, 164, and 149 mAh.g-1 were achieved at current densities of 50, 100, 200, 500, 1,000, and 2,000 mA.g-1, respectively. Under cycling at 2 A.g-1, the specific discharge capacity reached 181 mAh.g-1, with a low capacity fading rate of 0.032% per cycle after 1,000 cycles. Density functional theory calculation results indicated that Na ions preferred to occupy the interlamination rather than the inside of each layer in the V203. Interestingly, the special layered structure with a skeleton of dumbbell-like V-V bonds and metallic behavior was maintained after the insertion of Na ions, which was beneficial for the cycle performance. We consider that the MOF precursor of MIL-88B （V） can be used to synthesize other porous V-based materials for various applications.

关键词： vanadium oxides metal-organic frameworks porous structure density functional theory(DFT) calculation sodium-ion batteries

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Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

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Chinese Chemical Letters 2009年第6期20卷 680-683页

作者： Hua Bing Zhang Ji Jun Xue Xiao Long Zhao De Gang liu ying Li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 PR China

Two novel steroid-linked nitrogen mustard conjugates la and lb were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate la exhibited obvious increasing of activities.

关键词： Steroid Nitrogen mustards Synthesis Biological activity

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Fabrication of single-walled carbon nanotube-based highly sensitive gas sensors

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Science China(Technological Sciences) 2013年第1期56卷 32-35页

作者： XU Ke TIAN XiaoJun WU ChengDong liu Jian LI MengXin SUN ying WEI FaNan School of Information & Control Engineering Shenyang Jianzhu University State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of Sciences School of Information Science and Engineering Northeastern University

A highly sensitive single-walled carbon nanotube(SWCNT)-based ammonia(NH3) gas detector is manufactured by orderly assembling SWCNT using the dielectrophoretical(DEP) *** force microscopy(AFM) and scanning electron microscopy(SEM) images revealed that SWCNTs were assembled between the *** were affected by the electrophoretic force which was carried out by the related theoretical analysis in a nonuniform electric *** SWCNT field effect transistors geometry was *** electrical performance of NH3 gas sensor with the SWCNT field effect transistors geometry was tested before and after the adoption of NH3 at room *** results indicated that the efficient assembly of SWCNT was obtained by the applied alternating current voltage with frequency of 2 MHz and amplitude of 10 *** SWCNTs-based gas sensor had high sensitivity to NH3,and the electrical conductance of NH3 gas sensor reduced two times after interaction with *** SWCNTs surface gas molecules were removed by means of ultraviolet ray irradiation for 10 ***,the fabricated NH3 gas sensor could be *** is a clear evidence that the adsorption of NH3 on the SWCNT channel is easy to be *** theoretical results are consistent with recent experiments.

关键词： single-walled carbon nanotube field effect transistor assembly dielectrophoresis ammonia gas sensor

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Effects of Micronutrients on Oxidative Stress and Islet Function in Type 1 Diabetes Mellitus Rats:Relationships to Th2 Type Cytokines,Interleukin-4,and Interluekin-10

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Chemical Research in Chinese Universities 2007年第6期23卷 701-704页

作者： ZHANG Gui-zhen LI Mei-hua SONG Yang liu Ting GAO Shen SUN ying Department of Central Research The Third Clinical College Jilin University Changchun 130033 P. R. China Department of Allergy ＆ Clinical Immunology Faculty of Medicine Imperial College School National Heart ＆ Lung Institute Dovehouse Street London SW3 6LY UK

To observe the effects of the micronutrients on oxidative and autoimmune destruction of islets so as to prevent a person from the onset and development of type 1 Diabetes Mellitus （T1DM）, the interleukin-4 and interleukin-10 expressions of lymphocytes in peripheral blood and spleen of T1DM rats were determined by flow cytometry. GSH-Px activity and MDA level in the rats＇ pancreas were measured using biochemical methods. The insulin contents in serum and β cell insulin secret storage were tested by RIA and IHC, respectively. There was an increase in the percentages of IL-4 and IL-10 positive lymphocytes in the peripheral blood and spleen of the groups of rats supplemented with various combinations of micronutrients（p 〈0.01 and p 〈0.05, respectively） ; the blood glucose concentration decreased （p 〈 0. 05 ） ; both the functional β cell in islets and the insulin content in pancreatic tissue increased （p 〈 0. 05 and p 〈0. 01 ） ; the GSH-Px activity and MDA level of pancreas in the rats enhanced and decreased respectively（p 〈0. 01 and p 〈 0. 05）. The results suggest that micronutrients may alleviate the islet lesions by upregulating the expressions of IL-4 and IL-10 and lowering oxidative stress in diabetic rats .

关键词： Immanohistochemistry Oxidative stress Micronutrients T1 DM Interleukin-4 Interluekin-10

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Optimizing high-coordination shell of Co-based single-atom catalysts for efficient ORR and zinc-air batteries

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Journal of Energy Chemistry 2024年第8期95卷 306-314,I0007页

作者： Yugang Qi Qing liang Kexin Song Xinyan Zhou Meiqi liu Wenwen Li Fuxi liu Zhou Jiang Xu Zou Zhongjun Chen Wei Zhang Weitao Zheng Key Laboratory of Automobile Materials MOE School of Materials Science&Engineering Electron Microscopy Centerand International Center of Future ScienceJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012JilinChina Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Atom-level modulation of the coordination environment for single-atom catalysts(SACs)is considered as an effective strategy for elevating the catalytic *** the MNxsite,breaking the symmetrical geometry and charge distribution by introducing relatively weak electronegative atoms into the first/second shell is an efficient way,but it remains challenging for elucidating the underlying mechanism of ***,a practical strategy was reported to rationally design single cobalt atoms coordinated with both phosphorus and nitrogen atoms in a hierarchically porous carbon derived from metal-organic frameworks.X-ray absorption spectrum reveals that atomically dispersed Co sites are coordinated with four N atoms in the first shell and varying numbers of P atoms in the second shell(denoted as Co-N/P-C).The prepared catalyst exhibits excellent oxygen reduction reaction(ORR)activity as well as zinc-air battery *** introduction of P atoms in the Co-SACs weakens the interaction between Co and N,significantly promoting the adsorption process of ^(*)OOH,resulting in the acceleration of reaction kinetics and reduction of thermodynamic barrier,responsible for the increased intrinsic *** discovery provides insights into an ultimate design of single-atom catalysts with adjustable electrocatalytic activities for efficient electrochemical energy conversion.

关键词： Electrocatalytic Oxygen reduction reaction Single atom catalyst Shell coordination optimization

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